Abstract:
OBJECTIVES:The aim of this study was to investigate the relationship between zolpidem use and the risk of acute pancreatitis in Taiwan. METHODS:In this population-based case-control study using the database from the Taiwan National Health Insurance Program from 2000 to 2011, we selected 4535 subjects aged 20-84 years with the first episode of acute pancreatitis as cases and 18,140 subjects without acute pancreatitis matched for sex, age, and index year as controls. Immediate use of zolpidem was defined as subjects who received at least one prescription for zolpidem within 7 days before the date of diagnosing acute pancreatitis. The absence of zolpidem prescription was defined as never use. The odds ratio (OR) and 95 % confidence interval (CI) were used to evaluate the risk of acute pancreatitis associated with zolpidem use and other comorbidities. RESULTS:After adjustment for confounding factors, the multivariable logistic regression model demonstrated that the adjusted OR of acute pancreatitis was 7.20 for immediate use of zolpidem (95 % CI 5.81, 8.92), when compared to those with never use of zolpidem. In further analysis, as a reference of subjects with never use of zolpidem and without any of these comorbidities including alcoholism, biliary stone, diabetes mellitus, hepatitis B, hepatitis C, and hypertriglyceridemia, the adjusted OR was 18.04 in those with immediate use of zolpidem and without any comorbidity (95 % CI 12.71, 25.60). The OR increased to 30.32 in subjects with immediate use of zolpidem and with any comorbidity (95 % CI 23.71, 38.79). CONCLUSIONS:Patients actively using zolpidem are at 7-fold increased odds of acute pancreatitis. Clinicians should be more cautious of acute pancreatitis risk among patients with any comorbidity studied when prescribing zolpidem.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Lai SW,Lin CL,Liao KFdoi
10.1007/s00213-014-3833-6subject
Has Abstractpub_date
2015-06-01 00:00:00pages
2043-8issue
12eissn
0033-3158issn
1432-2072journal_volume
232pub_type
杂志文章abstract:RATIONALE:Pramipexole is a dopamine agonist which binds selectively to dopamine D(3) and D(2) receptors. There is evidence that, in addition to its beneficial effects in parkinsonism, this compound may also be of value in addressing symptomatology associated with depressive diseases. OBJECTIVES:The present study was a...
journal_title:Psychopharmacology
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doi:10.1007/s00213-002-1199-7
更新日期:2002-10-01 00:00:00
abstract::Food intake of four adult male baboons (Papio c. anubis) was monitored during daily experimental sessions lasting 22 h. Food was available under a two-component operant schedule. Following completion of the first "procurement component" response requirement, access to food, i.e., a meal, became available under the sec...
journal_title:Psychopharmacology
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pub_type: 杂志文章
doi:10.1007/BF00442007
更新日期:1989-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00429199
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journal_title:Psychopharmacology
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-09-01 00:00:00
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更新日期:2014-12-01 00:00:00
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更新日期:2008-02-01 00:00:00
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doi:10.1007/s00213-013-3008-x
更新日期:2013-04-01 00:00:00
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更新日期:2005-07-01 00:00:00
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更新日期:1982-01-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1993-01-01 00:00:00
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更新日期:1989-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-09-01 00:00:00