Abstract:
RATIONALE:Preclinical experimental models of pathological aggressive behavior are a sorely understudied and difficult research area. OBJECTIVES:How valid, reliable, productive, and informative are the most frequently used animal models of excessive aggressive behavior? METHODS:The rationale, key methodological features, supporting data, and arguments as well as their disadvantages and limitations of the most frequently used animal models for excessive aggressive behavior are summarized and their validity and reliability are evaluated. RESULTS:Excessive aggressive behavior is validly and reliably seen in (1) a proportion of feral-derived rats and selectively bred mice; (2) rats with compromised adrenal function resulting in a hypoglucocorticoid state; (3) a significant minority of mice, rats, and monkeys after consumption of a moderate dose of alcohol; and (4) resident animals of various species after social instigation. Limitations of these procedures include restrictive animal research regulations, the requirement of expertise in surgical, pharmacological, and behavioral techniques, and the behaviorally impoverished mouse strains that are used in molecular genetics research. Promising recent initiatives for novel experimental models include aggressive behaviors that are evoked by optogenetic stimulation and induced by the manipulation of early social experiences such as isolation rearing or social stress. CONCLUSIONS:One of the most significant challenges for animal models of excessive, potentially abnormal aggressive behavior is the characterization of distinctive neurobiological mechanisms that differ from those governing species-typical aggressive behavior. Identifying novel targets for effective intervention requires increased understanding of the distinctive molecular, cellular, and circuit mechanisms for each type of abnormal aggressive behavior.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Miczek KA,de Boer SF,Haller Jdoi
10.1007/s00213-013-3008-xsubject
Has Abstractpub_date
2013-04-01 00:00:00pages
445-58issue
3eissn
0033-3158issn
1432-2072journal_volume
226pub_type
杂志文章abstract::The behavioral effects of repeated methylphenidate (MPH) treatment were assessed in the adult rat. Protein kinase A (PKA) and adenylyl cyclase (basal and DA-stimulated) activity in the dorsal striatum (i.e., caudate-putamen) were measured to determine whether MPH-induced alterations in these enzymes correlate with the...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050536
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02246046
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abstract::Previous studies have shown that dihydropyridine (DHP) calcium channel blockers can potentiate yawning induced by apomorphine in rats. The present study was undertaken to examine whether or not this interaction was seen with other compounds that induce yawning or if it represented a specific interaction with dopaminer...
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pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-02-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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