Abstract:
:Mature rats (starting weight at least 270 g) were treated daily with cannabis extract (daily THC dose 20 mg/kg) for 3 months. After a 1- to 4-month drug-free period, residual effects on a variety of behaviors were studied. No residual effects were found in learning of an eight-arm radial maze task, nor on a differential reinforcement of low-rate responding (DRL-20) task, nor on open field activity. On the other hand, two-way shuttle box avoidance learning was facilitated by previous cannabis treatment, since cannabis-treated rats exhibited shorter mean latencies to avoid footshock than vehicle controls. The findings indicate greater vulnerability of immature organisms (previous studies) than mature organisms (the present study) to long-term effects of chronic cannabis administration.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Stiglick A,Kalant Hdoi
10.1007/BF00429660subject
Has Abstractpub_date
1985-01-01 00:00:00pages
436-9issue
4eissn
0033-3158issn
1432-2072journal_volume
85pub_type
杂志文章abstract::The present study compared the acute subject-rated and performance-impairing effects of trazodone and triazolam in seven healthy humans. Trazodone (50, 100 and 200 mg), triazolam (0.125, 0.25, 0.50 mg) and placebo were administered orally in a double-blind, crossover design. Drug effects were measured approximately 30...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130050259
更新日期:1997-05-01 00:00:00
abstract::The differential sensitivity of young and elderly healthy adults to the impairment effects of benzodiazepines was assessed by tasks with several levels of difficulty. Using a double-blind procedure, single doses of placebo, alprazolam (0.75 and 1.5 mg) and triazolam (0.25 and 0.5 mg) were ingested orally by 10 young m...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245796
更新日期:1990-01-01 00:00:00
abstract::The behavioral profile of corticotropin-releasing factor (CRF) in mediating anxiogenic-like and aversive responses to stressors may be particularly relevant for dependence and withdrawal in drug-experienced organisms. Moreover, stressful aspects of drug exposure in the drug naive organism may also induce CRF system ac...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050563
更新日期:1998-04-01 00:00:00
abstract::Nine human subjects were exposed to a multiple fixed-ratio (FR) differential-reinforcement-of-low-rate (DRL) schedule of monetary reinforcement. Presses on a manipulandum requiring relatively high force were occasionally followed by an increased money total displayed on a computer screen. Subjects were exposed to the ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00177913
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Ketamine, a non-competitive N-methyl-D: -aspartic acid antagonist, has been widely used for anaesthetic purposes. At sub-anaesthetic dosage, it induces a dissociative state similar to schizophrenia. The discovery of this effect on dissociative state has led to its use as a pharmacological model of schizophre...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1797-8
更新日期:2010-05-01 00:00:00
abstract:RATIONALE:The hallucinatory effect and potential abuse of salvinorin A, the major ingredient of Salvia divinorum, has not been documented in animals. OBJECTIVE:The effects of salvinorin A on the zebrafish (Danio rerio) model, through its swimming behavior and conditioned place preference (CPP) task, was studied. MATE...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0639-1
更新日期:2007-03-01 00:00:00
abstract::The behavioral responses to separate and combined administration of the D1 agonist SKF-38393 and the D2 agonist quinpirole following acute dopamine (DA) depletion via alpha-methyl-p-tyrosine (AMPT) or AMPT/reserpine were examined in infant (10-day-old) and weanling (21-day-old) rat pups. At both ages, AMPT pretreatmen...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244963
更新日期:1992-01-01 00:00:00
abstract::This study examined the role of the serotonin 5-HT2 receptor in motor function by examining the effect of antagonists on the motor performance of a cranial nerve reflex, the nictitating membrane (NM) reflex of the rabbit. The NM reflex was elicited by varying intensities of a tactile stimulus and the magnitudes of the...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050820
更新日期:1999-01-01 00:00:00
abstract::We investigated the striatal dopamine-2 (D2) receptor occupancy caused by different antipsychotic substances in 18 psychotic patients (16 with schizophrenic and two with schizoaffective disorder according to DSM-IV) with single photon emission computed tomography (SPECT) using 123I-iodobenzamide (IBZM) as tracer subst...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s002130050409
更新日期:1997-10-01 00:00:00
abstract:RATIONALE:A previously reported pharmacokinetic interaction between bromperidol and carbamazepine, an inducer of cytochrome P450 (CYP) 3A4, suggests possible involvement of CYP3A4 in the metabolism of bromperidol. OBJECTIVE:We investigated pharmacokinetic interaction between bromperidol and itraconazole, a potent inhi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130051048
更新日期:1999-07-01 00:00:00
abstract::DL-2-amino-5-phosphonovaleric acid (AP-5), which blocks glutamatergic transmission at the NMDA-preferring receptor, was injected into the antero-dorsal striatum of rats. AP-5-induced behavioural changes were assessed i) using a stereotypy rating scale and ii) using an experimental chamber designed to quantify sniffing...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00172883
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:Intermittent footshock stress reliably reinstates extinguished alcohol-taking behavior in drug-free rats, but the neurochemical events involved in this effect are not known. OBJECTIVE:We studied here whether two main modulators of stress responses, corticotropin-releasing factor (CRF) and corticosterone, are...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000411
更新日期:2000-06-01 00:00:00
abstract:AIM:It is widely assumed that the upcoming therapeutics for Alzheimer's disease will require to act on more than one target to be effective. We investigated here whether a combination of the nicotinic receptor allosteric modulator/cholinesterase inhibitor galantamine can act synergistically with the type 4 serotonin re...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4664-z
更新日期:2017-08-01 00:00:00
abstract::Chronic administration of the benzodiazepine (BZ) receptor agonist chlordiazepoxide (CDP) produced tolerance to its motor-impairing effects but little or no tolerance to its hypothermic effects or to its amnesic effects in the radial arm maze. Male Sprague-Dawley rats were pretreated for 14 days with CDP (25 mg/kg, b....
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244749
更新日期:1994-06-01 00:00:00
abstract:RATIONALE:Psychomotor stimulants can induce psychotic states in humans that closely resemble those observed in patients with idiopathic schizophrenia. Attentional and sensorimotor gating impairments are observed in schizophrenic patients using the latent inhibition (LI) and prepulse inhibition (PPI) behavioral assays, ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1254-4
更新日期:2003-09-01 00:00:00
abstract::Benzodiazepines and other compounds which act at benzodiazepine binding sites have been shown previously to attenuate the acquisition of conditioned fear in rodents when administered before the acquisition session, an effect which may parallel the disruption of human memory produced by anxiolytics and sedatives. Such ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00181243
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:Synthesis of ligands inactive or with low activity at α₁ GABA(A) receptors has become the key concept for development of novel, more tolerable benzodiazepine (BZ)-like drugs. WYS8, a remarkably (105 times) α₁-subtype selective partial positive modulator, may serve as a pharmacological tool for refining the ro...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3143-4
更新日期:2013-11-01 00:00:00
abstract:RATIONALE:Pramipexole is a dopamine agonist which binds selectively to dopamine D(3) and D(2) receptors. There is evidence that, in addition to its beneficial effects in parkinsonism, this compound may also be of value in addressing symptomatology associated with depressive diseases. OBJECTIVES:The present study was a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1199-7
更新日期:2002-10-01 00:00:00
abstract::The influence of mepiprazole (EMD 16,923), a new pyrazol-ylalkyl-piperazine derivative, on the uptake of 3H-norepinephrine (NE), 3H-dopamine (DA), and 3H-serotonin (5-HT) into rat brain synaptosomes from cerebral cortex, corpus striatum, and hypothalamus was investigated in comparison with several psychotropic drugs, ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00496865
更新日期:1976-08-17 00:00:00
abstract::Adult rats that were gestationally exposed to cocaine and control offspring were examined for their sensitivity to challenge doses of cocaine. Offspring were derived from Sprague-Dawley dams that had received subcutaneous injections of 40 mg/kg per 3 cc cocaine hydrochloride daily on gestational days 8-20, pair-fed da...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244870
更新日期:1994-09-01 00:00:00
abstract:RATIONAL:Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors. OBJECTIVES:We investigated the role of leptin and ghrelin in the augmentation of heroin seekin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05415-9
更新日期:2020-03-01 00:00:00
abstract:RATIONALE:The phenomenon of sensitization has been theoretically implicated in mediating various aspects of drug addiction. Recent dose-response studies demonstrated that pretreatment with the putative antiaddictive agent, ibogaine (IBO), and a synthetic iboga alkaloid congener, 18-methoxycoronaridine (18-MC), increase...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000478
更新日期:2000-08-01 00:00:00
abstract::The development of tolerance to the behavioral and biochemical effects of ethanol was studied. Rats were made tolerant to ethanol by the administration of daily ethanol injections (3 g/kg, IP) for 7 and 28 days. Tolerance developed both to the behavioral (hypothermic, sedative) and biochemical (accumulation of dopamin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244097
更新日期:1990-01-01 00:00:00
abstract::Chronic tolerance to ethanol-induced sleep, motor impairment (moving belt test), and hypothermia were examined in two lines of rats that had been selectively bred for their different initial sensitivities to ethanol. In agreement with previous work (Mayer et al. 1982, 1983), the least-affected (LA) rats were found to ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00432218
更新日期:1985-01-01 00:00:00
abstract::Both muscarinic antagonists, such as scopolamine, and benzodiazepine receptor (BZR) agonists, such as diazepam, produce a reliable impairment in the performance of one trial passive avoidance. Such deficits are frequently interpreted as drug-induced amnesia. However, these deficits could also result from a learning im...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245247
更新日期:1995-03-01 00:00:00
abstract:RATIONALE:The characterization of self-administration (SA) under extended access conditions is necessary for the development of addiction models. OBJECTIVE:The purposes of this experiment were to investigate: (1) dose effects on the initiation of cocaine SA under extended access conditions; (2) predictable individual ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100744
更新日期:2001-08-01 00:00:00
abstract::Haloperidol disposition has been associated with reversible metabolism: it is reversibly reduced to its metabolite, reduced haloperidol, which has less pharmacologic activity than the parent compound. To characterize the interconversion process, six healthy male schizophrenics were administered a single dose of 10 mg ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02253726
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:Several studies have suggested that modulation of the glutamatergic system via metabotropic glutamate receptors (mGlu) could be a new and efficient way to achieve antipsychotic-like activity. OBJECTIVES:Here, we decided to investigate the possible role of the group III mGlu receptor ligands, LSP1-2111, the g...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2502-2
更新日期:2012-04-01 00:00:00
abstract:RATIONALE:Studies have shown that social drinkers are poor estimators of alcohol-induced impairment. Underestimates of blood alcohol concentration and other indices of intoxication are associated with decisions to perform risky behaviors, such as operating a motor vehicle. It is possible that self-evaluations of impair...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-004-1964-x
更新日期:2005-02-01 00:00:00
abstract::The effects of ethanol have been studied in three strains of mice (DBA 2J, albino, and C57 BL/6J) having different populations of opiate receptors. Acute ethanol treatment induces a significant increase in striatal dopamine metabolism only in the mouse strains (C57 and albino) that are rich in enkephalinergic receptor...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427106
更新日期:1981-01-01 00:00:00