Abstract:
:The effects of ethanol have been studied in three strains of mice (DBA 2J, albino, and C57 BL/6J) having different populations of opiate receptors. Acute ethanol treatment induces a significant increase in striatal dopamine metabolism only in the mouse strains (C57 and albino) that are rich in enkephalinergic receptors upon nigrostriatal dopaminergic fibers. After chronic ethanol, the same strains develop tolerance to striatal dihydroxyphenylacetic acid increase, while the striatal dopaminergic recognition sites become supersensitive. DBA mice, which have lower numbers of enkephalinergic receptors and higher levels of enkephalins in the striatum, fail to show changes in central dopaminergic function after acute or chronic ethanol treatment. Our results indicate the importance of an interaction between ethanol and opiate receptors in determining the neurochemical and behavioral effects of ethanol.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Barbaccia ML,Reggiani A,Spano PF,Trabucchi Mdoi
10.1007/BF00427106subject
Has Abstractpub_date
1981-01-01 00:00:00pages
260-2issue
3eissn
0033-3158issn
1432-2072journal_volume
74pub_type
杂志文章abstract:RATIONALE:The administration of heroin has been shown to inhibit the induction of nitric oxide, a molecule known to play a critical role in immune function. Previous research has shown that this alteration can be conditioned to environmental stimuli that have been associated with drug administration. However, it remain...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0673-z
更新日期:2007-05-01 00:00:00
abstract::Spontaneous and amphetamine-elicited locomotor activity in rats is reduced by most clinically effective antipsychotic drugs. We have recently demonstrated that intracerebroventricular infusion of kainic acid (KA), which produces cell loss in the hippocampus and other limbic-cortical brain regions, increases spontaneou...
journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1998-02-01 00:00:00
abstract:RATIONALE:There is a requirement to ensure that UK armed forces are provided with the best possible medical countermeasures to prevent or mitigate the effects of exposure to nerve agents. When pretreatments are under consideration, it is of particular importance to ensure that they do not in themselves give rise to adv...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1324-7
更新日期:2003-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174059
更新日期:1986-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1020-7
更新日期:2002-05-01 00:00:00
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2014-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2005-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-019-05223-1
更新日期:2019-07-01 00:00:00
abstract:RATIONALE:Thousands of adolescents start smoking daily but information on the effects of tobacco exposure on this age group is scarce. Moreover, the available animal models rely on the effects of nicotine, neglecting other neuroactive components of tobacco. OBJECTIVES:We investigated the effects of exposure of adolesc...
journal_title:Psychopharmacology
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doi:10.1007/s00213-014-3801-1
更新日期:2015-05-01 00:00:00
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doi:10.1007/s00213-020-05524-w
更新日期:2020-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-013-3384-2
更新日期:2014-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00496061
更新日期:1979-08-08 00:00:00
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doi:10.1007/s00213-008-1231-7
更新日期:2008-11-01 00:00:00
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更新日期:2017-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2016-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426711
更新日期:1977-05-09 00:00:00
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pub_type: 杂志文章
doi:10.1007/BF00179930
更新日期:1987-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1373-7
更新日期:2009-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100687
更新日期:2001-04-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:2003-08-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-1851-5
更新日期:2004-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02245204
更新日期:1994-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050635
更新日期:1998-06-01 00:00:00