Initial nicotine sensitivity in humans as a function of impulsivity.

abstract：RATIONALE:The widespread deficits in cognitive flexibility observed across psychiatric disorders call for improved rodent tests to understand the biology of cognitive flexibility and development of better psychotherapeutics. Current reversal learning paradigms have a forced-choice setup that challenges the interpretati...

journal_title：Psychopharmacology

authors： Odland AU,Sandahl R,Andreasen JT

更新日期：2021-02-01 00:00:00

abstract：RATIONALE:The efficacy of methadone for treating heroin dependence derives, in part, from suppression of opiate withdrawal and attenuation of the effects of heroin. OBJECTIVES:The purpose of this double-blind, within-subject, inpatient study was to determine whether larger doses of methadone, which are more effective ...

journal_title：Psychopharmacology

authors： Donny EC,Walsh SL,Bigelow GE,Eissenberg T,Stitzer ML

更新日期：2002-05-01 00:00:00

abstract：:The number of nerve cells in two different areas of the corpus striatum (i.e., ventrolateral and dorsomedial) was estimated in rat brain after long-term (36 weeks) treatment with the neuroleptic flupenthixol. Nine rats were given weekly injections of 4 mg/kg flupenthixol dissolved in Viscoleo i.m., and seven rats rece...

journal_title：Psychopharmacology

authors： Nielsen EB,Lyon M

更新日期：1978-09-15 00:00:00

abstract：:Transdermal nicotine has been shown to relieve nicotine withdrawal and to double smoking cessation rates compared to placebo in clinical trials. A 21 or 22 mg/day dose provides a steady state serum nicotine that is less than obtained from smoking. Limited information is available about higher nicotine patch doses. To ...

journal_title：Psychopharmacology

authors： Fredrickson PA,Hurt RD,Lee GM,Wingender L,Croghan IT,Lauger G,Gomez-Dahl L,Offord KP

更新日期：1995-12-01 00:00:00

abstract：RATIONALE:In drug-dependent individuals, the primary excessive motivation is for drugs. Studies also indicate altered interest for "natural" rewarding activities associated with motivational disorders that may be relevant to drug dependence. However, to date, the impact of drug dependence and withdrawal upon motivation...

journal_title：Psychopharmacology

authors： Rouibi K,Contarino A

更新日期：2012-06-01 00:00:00

abstract：:Sibutramine hydrochloride, a novel monoamine reuptake inhibitor antidepressant, has been studied to determine whether it alters dopaminergic function in the brain. Its effects have been compared with bupropion, a dopamine reuptake inhibitor, and methamphetamine, a dopamine reuptake inhibitor and releasing agent. Sibut...

journal_title：Psychopharmacology

authors： Heal DJ,Frankland AT,Gosden J,Hutchins LJ,Prow MR,Luscombe GP,Buckett WR

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Animal studies indicate that dopamine pathways in the ventral striatum code for the motivational salience of both rewarding and aversive stimuli, but evidence for this mechanism in humans is less established. We have developed a functional magnetic resonance imaging (fMRI) model which permits examination of t...

journal_title：Psychopharmacology

authors： McCabe C,Huber A,Harmer CJ,Cowen PJ

更新日期：2011-09-01 00:00:00

abstract：RATIONALE:Traditional remedies prepared from Ptychopetalum olacoides (PO) are used throughout the Amazon to alleviate age-related conditions. These formulas are mainly used by elders, and alleged effects may be related to the anticholinesterase properties identified in a standardized ethanol extract of this species [P....

journal_title：Psychopharmacology

authors： da Silva AL,Silva Martins Bd,Linck Vde M,Herrmann AP,Mai N,Nunes DS,Elisabetsky E

更新日期：2009-01-01 00:00:00

abstract：RATIONALE:Converging evidence suggests that dopaminergic and serotonergic mechanisms affect distinct aspects of cognitive performance. Experiments using the rodent five-choice reaction time task have established a critical role for dopaminergic mechanisms in the rat medial prefrontal cortex (mPFC), but have yielded onl...

journal_title：Psychopharmacology

authors： Passetti F,Dalley JW,Robbins TW

更新日期：2003-01-01 00:00:00

abstract：RATIONALE:Inhibition of glutamatergic N-methyl-D-aspartate (NMDA) receptors following the administration of NMDA receptor antagonists results in psychotic-like behaviour. Whereas it is known that pharmacological manipulation of dopaminergic and serotonergic pathways affect this drug-induced psychosis, a role for noradr...

journal_title：Psychopharmacology

authors： Harkin A,Morris K,Kelly JP,O'Donnell JM,Leonard BE

更新日期：2001-03-01 00:00:00

abstract：RATIONALE:Prospective memory pervades our daily lives and failures can have detrimental consequences. This ability to execute delayed intentions may be impacted by stress, yet few studies have examined these effects. Moreover, as many cannabis users report using cannabis to cope with stress, it is important to understa...

journal_title：Psychopharmacology

authors： Cuttler C,Spradlin A,Nusbaum AT,Whitney P,Hinson JM,McLaughlin RJ

更新日期：2019-06-01 00:00:00

abstract：RATIONALE:Cannabinoid CB1 receptors are expressed in the prefrontal cortex, but their role in mediating executive functions such as behavioral flexibility is unclear. OBJECTIVE:The present study examined the effect of pharmacological activation or blockade of the cannabinoid CB1 receptors on behavioral flexibility usi...

journal_title：Psychopharmacology

authors： Hill MN,Froese LM,Morrish AC,Sun JC,Floresco SB

更新日期：2006-08-01 00:00:00

abstract：RATIONALE:It has been proposed that brain aldehyde dehydrogenase (ALDH) plays a role in the modulation of some psychopharmacological effects of ethanol. Diethyldithiocarbamate (DDTC), an ALDH inhibitor, elevates blood acetaldehyde levels in the presence of ethanol. Concurrent administration with 4-methylpyrazole (4-MP)...

journal_title：Psychopharmacology

authors： Escarabajal MD,Aragon CM

更新日期：2002-04-01 00:00:00

abstract：RATIONALE:The precise neural circuitry that encodes fear memory and its extinction within the brain are not yet fully understood. Fearful memories can be persistent, resistant to extinction, and associated with psychiatric disorders, especially post-traumatic stress disorder (PTSD). Here, we investigated the microtopog...

journal_title：Psychopharmacology

authors： Jacques A,Chaaya N,Hettiarachchi C,Carmody ML,Beecher K,Belmer A,Chehrehasa F,Bartlett S,Battle AR,Johnson LR

更新日期：2019-01-01 00:00:00

abstract：RATIONALE:Working memory performance may be improved or decreased by amphetamine, depending on baseline working memory capacity and amphetamine dosage. This variable effect suggests an optimal range of monaminergic activity for working memory, either below or above which it is compromised. We directly tested this possi...

journal_title：Psychopharmacology

authors： Tipper CM,Cairo TA,Woodward TS,Phillips AG,Liddle PF,Ngan ET

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:People with schizophrenia exhibit a high obesity rate. However, little is known about the prevalence of obesity and its relationship with clinical symptoms and metabolic indicators in first-episode drug-naïve (FEDN) schizophrenia. METHODS:Demographic and lipid parameters were gathered from 297 FEDN schizophr...

journal_title：Psychopharmacology

authors： Tian Y,Wang D,Wei G,Wang J,Zhou H,Xu H,Dai Q,Xiu M,Chen D,Wang L,Zhang XY

更新日期：2020-11-25 00:00:00

abstract：RATIONALE:Temporal differentiation of operant behaviour is sensitive to dopaminergic manipulations. Studies using the fixed-interval peak procedure implicated D2 dopamine receptors in these effects. Less is known about the effects of dopaminergic manipulations on temporal differentiation in other timing schedules. OBJ...

journal_title：Psychopharmacology

authors： Cheung TH,Bezzina G,Asgari K,Body S,Fone KC,Bradshaw CM,Szabadi E

更新日期：2006-04-01 00:00:00

abstract：:In the studies reported here, we investigated the effects of nicotine on memory for unrelated word lists. Nicotine was delivered through cigarette smoking, and memory performance was assessed using both intentional and incidental recall tasks, and employing an additional, indirect measure of memory. We report the resu...

journal_title：Psychopharmacology

authors： Rusted J,Graupner L,Warburton D

更新日期：1995-06-01 00:00:00

abstract：RATIONALE:Serotonin (5-HT) plays a key role in different aspects of value-based decision-making. A recent framework proposed that tonic 5-HT (together with dopamine, DA) codes future average reward expectations, providing a baseline against which possible choice outcomes are compared to guide decision-making. OBJECTIV...

journal_title：Psychopharmacology

authors： Neukam PT,Kroemer NB,Deza Araujo YI,Hellrung L,Pooseh S,Rietschel M,Witt SH,Schwarzenbolz U,Henle T,Smolka MN

更新日期：2018-07-01 00:00:00

abstract：:The concurrent influence of dopaminergic, sigma and muscarinic neurotransmitter systems in mediating cocaine-induced lethality is predicted by previous receptor binding results from our laboratories. The present results demonstrate that pharmacological manipulations of these predicted neurotransmitter systems alter th...

journal_title：Psychopharmacology

authors： Ritz MC,George FR

更新日期：1997-02-01 00:00:00

abstract：RATIONALE:Understanding of the mechanisms of biotransformation of antidepressant drugs, and of their capacity to interact with other medications, is of direct relevance to rational clinical psychopharmacology. OBJECTIVES:To determine the human cytochromes P450 mediating the metabolism of nefazodone, and the inhibitory...

journal_title：Psychopharmacology

authors： von Moltke LL,Greenblatt DJ,Granda BW,Grassi JM,Schmider J,Harmatz JS,Shader RI

更新日期：1999-07-01 00:00:00

abstract：:Serotonergic mechanisms have been implicated in the pathophysiology of depression and in the neuropharmacology of antidepressant treatment. One measure of central serotonergic function is the prolactin (PRL) response to IV L-tryptophan (L-TRP). We used the L-TRP test to assess the role of serotonin in the mechanism of...

journal_title：Psychopharmacology

authors： McCance-Katz E,Price LH,Charney DS,Heninger GR

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Pavlovian conditioning with a discrete reward-predictive visual cue can elicit two classes of behaviors: "sign-tracking" (approach toward and contact with the cue) and "goal-tracking" (approach toward the site of reward delivery). Sign-tracking has been proposed to be linked to behavioral disorders involving ...

journal_title：Psychopharmacology

authors： Simon NW,Mendez IA,Setlow B

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:New psychoactive substances (NPS) are chemical analogues designed to mimic the effects of various classic recreational drugs of abuse including MDMA, LSD, and cannabis. NPS use is associated with concern about the acute and longer-term effects particular substances might have, with abuse and addiction as pot...

journal_title：Psychopharmacology

authors： Kuypers KPC,de Sousa Fernandes Perna EB,Dolder PC,Toennes SW,Theunissen EL,Mason NL,Hutten NRPW,Ramaekers JG

更新日期：2018-08-01 00:00:00

abstract：:A new benzamide, cis-N-(1-benzyl-2-methylpyrrolidin - 3 - yl) - 5 - chloro - 2 - methoxy - 4 - methylaminobenzamide (YM-09151-2) exhibited more potent and longer-lasting inhibitory effects on apomorphine-induced behaviours (stereotyped behaviour, emesis and hypothermia), and methamphetamine-induced stereotyped behavio...

journal_title：Psychopharmacology

authors： Usuda S,Nishikori K,Noshiro O,Maeno H

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Pharmacokinetics of melatonin in children might differ from that in adults. OBJECTIVES:This study aims to establish a dose-response relationship for melatonin in advancing dim light melatonin onset (DLMO), sleep onset (SO), and reducing sleep onset latency (SOL) in children between 6 and 12 years with chroni...

journal_title：Psychopharmacology

authors： van Geijlswijk IM,van der Heijden KB,Egberts AC,Korzilius HP,Smits MG

更新日期：2010-10-01 00:00:00

abstract：RATIONALE:Evidences indicate that methylglyoxal, a highly reactive metabolite of hyperglycemia, can enhance protein glycation, oxidative stress, or inflammation. Mangiferin, a polyphenol compound of C-glucoside, has many beneficial biological activities, including anti-inflammation, anti-oxidation, neuroprotection, cog...

journal_title：Psychopharmacology

authors： Liu YW,Zhu X,Yang QQ,Lu Q,Wang JY,Li HP,Wei YQ,Yin JL,Yin XX

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the relationship between zolpidem use and the risk of acute pancreatitis in Taiwan. METHODS:In this population-based case-control study using the database from the Taiwan National Health Insurance Program from 2000 to 2011, we selected 4535 subjects aged 20-84 years ...

journal_title：Psychopharmacology

authors： Lai SW,Lin CL,Liao KF

更新日期：2015-06-01 00:00:00

abstract：:Phenelzine (PLZ) is a non-selective monoamine oxidase (MAO) inhibitor commonly used to treat depression and panic disorder. In addition to increasing levels of biogenic amines in the brain, PLZ elevates brain levels of the amino acid gamma-aminobutyric acid (GABA; Baker et al. 1991; present study). Given the extensive...

journal_title：Psychopharmacology

authors： Parent MB,Habib MK,Baker GB

更新日期：1999-03-01 00:00:00

abstract：:The effect of delta 9-tetrahydrocannabinol (THC) on the locomotor activity-stimulating action of morphine has been investigated in mice. THC (10 mg/kg) has been found to potentiate morphine-induced hyperactivity. On the other hand, the stimulating action of morphine on motor activity strongly diminished in mice render...

journal_title：Psychopharmacology

authors： Ulkü E,Ayhan IH,Tulunay FC,Uran B,Kaymakçalan S

更新日期：1980-01-01 00:00:00