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Effects of nicotine on smooth pursuit eye movements in healthy non-smokers.

Abstract：

RATIONALE:The non-selective nicotinic acetylcholine receptor (nAChR) agonist nicotine has been argued to improve attention via enhanced filtering of irrelevant stimuli. Here, we tested this hypothesis in the context of smooth pursuit eye movements (SPEMs), an oculomotor function previously shown to improve with nicotine in some but not all studies. OBJECTIVES:In order to test whether nicotine improves performance particularly when the inhibition of distracting stimuli is required, SPEM was elicited in conditions with or without peripheral distractors. Additionally, different target frequencies were employed in order to parametrically vary general processing demands on the SPEM system. METHODS:Healthy adult non-smokers (N = 18 females, N = 13 males) completed a horizontal sinusoidal SPEM task at different target frequencies (0.2 Hz, 0.4 Hz, 0.6 Hz) in the presence or absence of peripheral distractors in a double-blind, placebo-controlled, cross-over design using a 2 mg nicotine gum. RESULTS:Nicotine increased peak pursuit gain relative to placebo (p < .001), but an interaction with distractor condition (p = .001) indicated that this effect was most pronounced in the presence of distractors. Catch-up saccade frequency was reduced by nicotine (p = .01), particularly at higher target frequencies (two-way interaction, p = .04). However, a three-way interaction (p = .006) indicated that the reduction with nicotine was strongest at the highest target frequency (0.6 Hz) only without distractors, whereas in the presence of distractors, it was strongest at 0.4-Hz target frequency. There were no effects of nicotine on subjective state measures. CONCLUSIONS:Together, these findings support a role of both distractor inhibition and general processing load in the effects of nicotine on smooth pursuit.

journal_name

Psychopharmacology (Berl)

journal_title

Psychopharmacology

authors

Meyhöfer I,Kasparbauer AM,Steffens M,Ettinger U

doi

10.1007/s00213-019-05223-1

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

2259-2271

issue

7

eissn

0033-3158

issn

1432-2072

pii

10.1007/s00213-019-05223-1

journal_volume

236

pub_type

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