Directional running in mice: effects of cocaine and chlorpromazine.

abstract：BACKGROUND AND RATIONALE:More than two decades ago, Wise proposed his "anhedonia hypothesis" to explain the role of dopamine in motivated behaviors. The hypothesis posits that dopamine mediates the pleasure experienced by reward obtainment. However, some experimental findings have contested this hypothesis and several ...

journal_title：Psychopharmacology

authors： Barbano MF,Cador M

更新日期：2007-04-01 00:00:00

abstract：:The effects of amphetamine on the partial punishment effect (PPE) at one trial per day, were examined. Two groups of animals were trained to run in a straight alley. The continuously reinforced (CRF) group received food reward on every trial. The partially punished (PP) group received food reward on every trial but in...

journal_title：Psychopharmacology

authors： Weiner I,Bercovitz H,Feldon J

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:Ayahuasca is a traditional South American psychoactive beverage and the central sacrament of Brazilian-based religious groups, with followers in Europe and the United States. The tea contains the psychedelic indole N,N-dimethyltryptamine (DMT) and beta-carboline alkaloids with monoamine oxidase-inhibiting pr...

journal_title：Psychopharmacology

authors： Barbanoj MJ,Riba J,Clos S,Giménez S,Grasa E,Romero S

更新日期：2008-02-01 00:00:00

abstract：:The effects of ethanol have been studied in three strains of mice (DBA 2J, albino, and C57 BL/6J) having different populations of opiate receptors. Acute ethanol treatment induces a significant increase in striatal dopamine metabolism only in the mouse strains (C57 and albino) that are rich in enkephalinergic receptor...

journal_title：Psychopharmacology

authors： Barbaccia ML,Reggiani A,Spano PF,Trabucchi M

更新日期：1981-01-01 00:00:00

abstract：:Twenty-one depressed patients participated in a study that assessed the predictability of amitriptyline (AT) dosage based on plasma drug concentrations after a single dose. In 11 patients maintained on a fixed dose regimen, the 18-h single-dose level was confirmed to be predictive of steady-state levels. The dose for ...

journal_title：Psychopharmacology

authors： Madakasira S,Khazanie PG,Sato TL

更新日期：1984-01-01 00:00:00

abstract：:Keypecking in one group of pigeons was maintained under schedules in which food was presented only when a specified number of responses was followed by a 30-s pause without a response. d-Amphetamine and pentobarbital increased low rates of responding (and, thus, decreased food presentation) only after initial injectio...

journal_title：Psychopharmacology

authors： Smith JB,McKearney JW

更新日期：1977-07-18 00:00:00

abstract：INTRODUCTION:Smoking rates among depressed individuals is higher than among healthy subjects, and nicotine alleviates depressive symptoms. Nicotine increases serotonergic and noradrenergic neuronal activity and facilitates serotonin and noradrenaline release. In mice, acute nicotine administration enhances the activity...

journal_title：Psychopharmacology

authors： Andreasen JT,Nielsen EO,Redrobe JP

更新日期：2009-08-01 00:00:00

abstract：:Measurements of the amplitude and latency of the P3b component of the event-related potential (ERP), simple reaction time (SRT) and four psychomotor tests (VAS, DSST, DSp and CFF) were made on 12 male subjects (aged 19-24 years) 1.0-1.5 and 4.0-4.5 h after single oral doses of triprolidine (7.5 mg), terfenadine (60 mg...

journal_title：Psychopharmacology

authors： Swire FM,Marsden CA,Barber C,Birmingham AT

更新日期：1989-01-01 00:00:00

abstract：:Rats that are placed in a novel environment containing a probe will explore the environment and the probe. Exploration of the probe is reduced when the probe is electrified. We here report that chlordiazepoxide blocks this inhibition, and have determined some of the pharmacological features of this new experimental pr...

journal_title：Psychopharmacology

authors： Meert TF,Colpaert FC

更新日期：1986-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVE:Depression symptoms are now recognized to be the predominant cause of disability for bipolar disorder (BD) patients. The treatment strategies for the depressed phase of BD remain more anecdotal than data-based. Olanzapine has been investigated as an alternative to antidepressants and a mood stab...

journal_title：Psychopharmacology

authors： Wang M,Tong JH,Huang DS,Zhu G,Liang GM,Du H

更新日期：2014-07-01 00:00:00

abstract：:The effect of the dopamine receptor antagonist haloperidol on the development of sensitization to ethanol-induced increases in locomotor activity was examined in DBA/2J mice. In Experiment 1, different groups of mice were given saline or ethanol (2 g/kg) immediately before each of four locomotor activity sessions (48-...

journal_title：Psychopharmacology

authors： Broadbent J,Grahame NJ,Cunningham CL

更新日期：1995-08-01 00:00:00

abstract：RATIONALE:Modafinil is a well-tolerated psychostimulant drug with low addictive potential that is used to treat patients with narcolepsy or attention deficit disorders and to enhance vigilance in sleep-deprived military personal. So far, understanding of the cognitive enhancing effects of modafinil and the relevant neu...

journal_title：Psychopharmacology

authors： Müller U,Steffenhagen N,Regenthal R,Bublak P

更新日期：2004-12-01 00:00:00

abstract：:Previous work in this and another laboratory has shown that nicotine tablets improve the performance of a rapid information processing task and reduce the Stroop effect, whereas scopolamine has the opposite effects. The purpose of this study was to extend these previous findings by determining whether, when administer...

journal_title：Psychopharmacology

authors： Wesnes K,Revell A

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:The cerebral microdialysis technique has been widely used to monitor the release of 5-hydroxytryptamine (5-HT). The extracellular concentration of 5-HT has generally been shown to change after pharmacological manipulation as expected. Extracellular levels of the metabolite, 5-hydroxyindoleaceticacid (5-HIAA) ...

journal_title：Psychopharmacology

authors： Stenfors C,Ross SB

更新日期：2004-03-01 00:00:00

abstract：:Normal unoperated rats were tested for rotation (i.e., circling behavior) in a spherical "rotometer" and dose-response relationships were generated using d-amphetamine, apomorphine, L-Dopa, haloperidol, and scopolamine. The rotation induced by amphetamine was significantly antagonized by alpha-methyl-p-tyrosine and ha...

journal_title：Psychopharmacology

authors： Jerussi TP,Glick SD

更新日期：1976-06-23 00:00:00

abstract：RATIONALE:Second-generation antipsychotics occupy dopamine D2 receptors and act as antagonists or partial agonists at these receptors. While these drugs alleviate positive symptoms in patients with schizophrenia, they are less effective for treating cognitive deficits and negative symptoms. Dopamine D3 receptors are hi...

journal_title：Psychopharmacology

authors： Girgis RR,Slifstein M,D'Souza D,Lee Y,Periclou A,Ghahramani P,Laszlovszky I,Durgam S,Adham N,Nabulsi N,Huang Y,Carson RE,Kiss B,Kapás M,Abi-Dargham A,Rakhit A

更新日期：2016-10-01 00:00:00

abstract：:A novel self-stimulation methodology involving a fixed-interval (FI-5 s) schedule of reinforcement, microanalysis and threshold evaluation was used to investigate the effects of cocaine on rats lever pressing for electrical stimulation of the prefrontal cortex. Cocaine (15 mg/kg) increased medial prefrontal cortex (MP...

journal_title：Psychopharmacology

authors： McGregor IS,Atrens DM,Jackson DM

更新日期：1992-01-01 00:00:00

abstract：:Two 2-(di-n-propylamino)tetralin (DPAT) compounds, 8-OH-DPAT and 5-OH-DPAT, with reported effects on central 5-HT and DA receptors respectively, were tested for their effects on the acoustic startle response in rats. 8-OH-DPAT was given in doses of 0.25-2.0 mg/kg IP and 5-OH-DPAT in doses of 1.0-8.0 mg/kg IP. Both com...

journal_title：Psychopharmacology

authors： Svensson L,Ahlenius S

更新日期：1983-01-01 00:00:00

abstract：:The rabbit classical eyeblink conditioning paradigm was used to assess the effects of haloperidol on hippocampal function. Haloperidol disrupted hippocampal activity and conditioned responses (CRs) at low but not high conditioned stimulus (CS) intensities. The observed relationship of hippocampal activity and the CR s...

journal_title：Psychopharmacology

authors： Sears LL,Steinmetz JE

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:Recent data suggest that 5-HT7 receptors (5-HT7R) are involved in memory processes and, particularly, those related to novelty-induced arousal, even though this remains so far speculative and controversial. In order to assess the role of 5-HT7R in episodic-like memory, mice were administered 5-carboxamidotryp...

journal_title：Psychopharmacology

authors： Freret T,Paizanis E,Beaudet G,Gusmao-Montaigne A,Nee G,Dauphin F,Bouet V,Boulouard M

更新日期：2014-01-01 00:00:00

abstract：:The sensitivity of the dopaminergic hypothalamic pituitary system, as indicated by growth hormone (GH) release after apomorphine (0.5 mg SC), was studied in 11 chronic schizophrenic in-patients under long-term neuroleptic (NL) therapy and after 12 and 30 days' drug withdrawal. GH peak levels after a 12-day drug-free p...

journal_title：Psychopharmacology

authors： Müller-Spahn F,Ackenheil M,Albus M,May G,Naber D,Welter D,Zander K

更新日期：1984-01-01 00:00:00

abstract：:Amitriptyline and zimelidine significantly reduce the uptake of 5-HT into the blood platelets of depressive patients. The degree of inhibition is significantly correlated with the plasma drug level of amitriptyline. No significant relationship could be detected between the degree of inhibition of uptake and therapeuti...

journal_title：Psychopharmacology

authors： Coppen A,Rama Rao VA,Swade C,Wood K

更新日期：1979-05-25 00:00:00

abstract：:The effects of brofaremine (CGP 11 305A), a short-acting, reversible and selective inhibitor of MAO-A, on sleep, nocturnal penile tumescence (NPT) and hormonal secretion during the night were studied during a long-term trial. Three healthy males underwent sleep-EEG and NPT recordings during consecutive nights (1) unde...

journal_title：Psychopharmacology

authors： Steiger A,Holsboer F,Benkert O

更新日期：1987-01-01 00:00:00

abstract：:The anti-withdrawal effect of clonidine was studied using quasi-morphine abstinence behaviour induced by dipropylacetate (DPA) in naive rats. Clonidine potently suppressed body shakes and locomotor activity (ID50 30 and 40 micrograms/kg IP respectively). Phenoxybenzamine and prazosine did not antagonize the anti-withd...

journal_title：Psychopharmacology

authors： van der Laan JW,Weick G,Hillen FC

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:We have recently shown that post-extinction exposure of rats to a sub-threshold reminder shock can reactivate extinguished context-related freezing and found that chronic treatment with fluoxetine before fear extinction prevents this phenomenon. OBJECTIVES:In the present study, we examined whether these find...

journal_title：Psychopharmacology

authors： Deschaux O,Spennato G,Moreau JL,Garcia R

更新日期：2011-05-01 00:00:00

abstract：RATIONALE:The efficacy of methadone for treating heroin dependence derives, in part, from suppression of opiate withdrawal and attenuation of the effects of heroin. OBJECTIVES:The purpose of this double-blind, within-subject, inpatient study was to determine whether larger doses of methadone, which are more effective ...

journal_title：Psychopharmacology

authors： Donny EC,Walsh SL,Bigelow GE,Eissenberg T,Stitzer ML

更新日期：2002-05-01 00:00:00

abstract：RATIONALE:Nicotine displays rewarding and aversive effects, and while dopamine has been linked with nicotine's reward, the neurotransmitter(s) involved with aversion remains speculative. The kappa-dynorphinergic system has been associated with negative motivational and affective states, and whether dynorphin (Dyn) cont...

journal_title：Psychopharmacology

authors： Isola R,Zhang H,Tejwani GA,Neff NH,Hadjiconstantinou M

更新日期：2009-01-01 00:00:00

abstract：:Ten rats were trained to lever press for food reward on a schedule of differential reinforcement of low rates of response with a 20-s criterion (DRL 20). Ten more were trained on a new schedule of punishment, designed to be comparable to DRL 20 - differential punishment of high rates of response (DPH 20). Under this s...

journal_title：Psychopharmacology

authors： Salmon P,Gray JA

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:Lithium is the most widely prescribed mood stabilizer, but the precise mechanism of lithium is unresolved. OBJECTIVE:We examine the effects of the administration of therapeutically relevant concentrations of lithium on the expression of brain-derived neurotrophic factor (BDNF) and its receptor, Trk B, as wel...

journal_title：Psychopharmacology

authors： Fukumoto T,Morinobu S,Okamoto Y,Kagaya A,Yamawaki S

更新日期：2001-10-01 00:00:00

abstract：RATIONALE:Pramipexole is a dopamine agonist which binds selectively to dopamine D(3) and D(2) receptors. There is evidence that, in addition to its beneficial effects in parkinsonism, this compound may also be of value in addressing symptomatology associated with depressive diseases. OBJECTIVES:The present study was a...

journal_title：Psychopharmacology

authors： Lehr E

更新日期：2002-10-01 00:00:00