Abstract：
RATIONALE:Pramipexole is a dopamine agonist which binds selectively to dopamine D(3) and D(2) receptors. There is evidence that, in addition to its beneficial effects in parkinsonism, this compound may also be of value in addressing symptomatology associated with depressive diseases. OBJECTIVES:The present study was aimed at investigating behavioral effects of pramipexole that may indicate possible antidepressant properties. METHODS:We measured how different doses of pramipexole influence nocturnal locomotion and operant responding after prolonged conditioning of a schedule of FI 2 min (FI2) in female NMRI mice. RESULTS:The present data indicate that active doses of pramipexole inhibit nocturnal locomotion during the first hour after administration and later elevate activity in mice. After prolonged FI conditioning some of the mice changed to a pattern of lowered responding prior to reinforcement ("low temporal control") whereas others maintained the typical high increase of responding prior to reinforcement ("high temporal control"). Additionally, low oral doses of pramipexole increase operant behavior in "low temporal control" mice prior to reinforcement leaving the pattern of operant responding of "high temporal control" mice unchanged. CONCLUSIONS:Based on other preclinical data and initial clinical results, we speculate that these effects may reflect anti-anhedonic/antidepressive properties of pramipexole.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Lehr Edoi
10.1007/s00213-002-1199-7subject
Has Abstractpub_date
2002-10-01 00:00:00pages
495-500issue
3-4eissn
0033-3158issn
1432-2072journal_volume
163pub_type
杂志文章abstract：:Physostigmine (1.0mg) or placebo were administered intravenously over 1-h period to seven male normal volunteers beginning 35 min after sleep onset. The results indicate that physostigmine induced the onset of REM sleep but did not significantly alter the duration of individual REM sleep periods. Physostigmine signifi...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00426799
更新日期：1978-06-15 00:00:00
abstract：:Animal and human studies have demonstrated that, depending upon the sequence of alcohol presentation, long-term memory of events can either be enhanced or diminished. In the present study a similar phenomenon is demonstrated in the neuronal excitability of slices of hippocampus from guinea pig brains. Alcohol given af...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426380
更新日期：1984-01-01 00:00:00
abstract：:Using a conditioned avoidance procedure in rats, the present study examined the ability of 8-OH-DPAT, ritanserin, and prazosin to alter the effects of the dopamine antagonists, raclopride and haloperidol, on avoidance- and on escape responding. The 5-HT1A agonist 8-OH-DPAT (0.16 mg/kg) significantly enhanced the inhib...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050124
更新日期：1996-11-01 00:00:00
abstract：BACKGROUND:Postmortem and positron emission tomography (PET) studies have reported several alterations in serotonin 1A receptor (5-HT(1A)) binding parameters in patients with schizophrenia. This study examines 5-HT(1A) availability in vivo in individuals with schizophrenia and schizo-affective disorder. MATERIALS AND ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0543-8
更新日期：2006-12-01 00:00:00
abstract：RATIONALE:Cocaine-seeking behavior can be investigated in rodents using the conditioned place preference (CPP) paradigm, in which the drug-paired environment serves as a conditioned stimulus. Such approach allowed to previously demonstrate the importance of the neuromodulatory sigma1 (sigma1) receptor in acquisition of...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-1814-x
更新日期：2004-09-01 00:00:00
abstract：:Evaluation of the efficacy of antidepressant agents needs to take into account factors which increase the "effect size", such as dosage, treatment duration, the use of two-phase trials, and pattern analysis of responders. Although many patients are thought to receive inadequate doses of antidepressants, relatively few...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/BF02246244
更新日期：1992-01-01 00:00:00
abstract：RATIONALE:Latent inhibition (LI), namely, poorer performance on a learning task involving a previously pre-exposed non-reinforced stimulus, is disrupted in the rat by the dopamine (DA) releaser amphetamine which produces and exacerbates psychotic (positive) symptoms, and this is reversed by treatment with typical and a...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-002-1313-x
更新日期：2003-09-01 00:00:00
abstract：:The effects of monoamine oxidase inhibitors (MAOIs) that selectively inhibit the MAO-A or MAO-B forms of MAO were studied in rats performing under a differential-reinforcement-of-low-rate 72-s (DRL 72-s) schedule of reinforcement. Clorgyline and CGP11'305A, irreversible and reversible MAO-A inhibitors, respectively, i...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00177554
更新日期：1988-01-01 00:00:00
abstract：:The present study assessed the discriminative stimulus effects of the delta-opioid agonist [D-Pen2-D-Pen5]enkephalin (DPDPE) in pigeons. Food-restricted pigeons were trained to discriminate between i.c.v injections of 100 micrograms [D-Pen2-D-Pen5]enkephalin (DPDPE) and saline in a two-key operant procedure; acquisiti...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:This study examined whether the anticholinergic potency of the clinically superior antipsychotic drug clozapine contributes to clozapine's anatomically-selective functional inhibition of the mesolimbic dopamine (DA) system, using an electrical brain-stimulation reward (BSR) paradigm in rats that has been previously sh...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246960
更新日期：1993-01-01 00:00:00
abstract：RATIONALE:Intermittent footshock stress effectively reinstates extinguished heroin-, cocaine- and alcohol-taking behaviors, but not behaviors previously maintained by food reinforcers. Here we tested further the generality of the phenomenon of stress-induced reinstatement by determining the effect of footshock on reins...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050992
更新日期：1999-05-01 00:00:00
abstract：RATIONALE:Batteries of tests that are thought to measure different aspects of anxiety-related behaviour are used to characterise mice after genetic or pharmacological manipulation. However, because of the potentially confounding effects of repeated testing and natural intra-individual variations in behaviour over time,...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-1873-0
更新日期：2010-07-01 00:00:00
abstract：:There is little evidence concerning the effects of caffeine in doses typical of one cup of tea. The present study investigated the effect of 60 mg caffeine, consumed in either tea or hot water, on performance on a subset of the CANTAB test battery. Eight males participated in a practice session and four test sessions....
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050746
更新日期：1998-11-01 00:00:00
abstract：:Neither acquisition learning nor 24-h retention was significantly altered by 6-hydroxydopamine intracerebral injections which depleted forebrain noradrenaline (NA) to less than 5% of control values. The absence of passive avoidance impairment cannot be ascribed to functional recovery following the lesion (indicated by...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427627
更新日期：1979-11-01 00:00:00
abstract：RATIONALE:Rats, like humans, are susceptible to the reinforcing effects of reward-related stimuli presented within a compound stimulus array, putatively analogous to the so-called near-miss effect. We have previously demonstrated using a rodent slot machine task (rSMT) that the reward expectancy these stimuli elicit is...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4355-1
更新日期：2016-09-01 00:00:00
abstract：RATIONALE:The party drug ecstasy is frequently used in combination with other drugs like marihuana and alcohol. In addition, a substantial proportion of the MDMA users has claimed to drive a car when under the influence of MDMA and/or other drugs. OBJECTIVE:To assess the effects of MDMA and alcohol, combined and alone...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-006-0434-z
更新日期：2006-09-01 00:00:00
abstract：:The effects of 6-OHDA lesions of dopamine terminals within the amygdala were investigated on i) (+) amphetamine-induced locomotor hyperactivity and ii) the acquisition of intravenous self-administration of (+) amphetamine. The lesioned rats exhibited increased locomotor activity in response to (+) amphetamine (0.75 an...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00176851
更新日期：1988-01-01 00:00:00
abstract：RATIONALE:Evidence suggesting that the endogenous cannabinoid (eCB) system can be manipulated to facilitate or impair extinction of learned behaviours has important consequences for opiate withdrawal and abstinence. We demonstrated that the fatty acid amide hydrolase (FAAH) inhibitor URB597, which increases eCB levels,...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3798-5
更新日期：2015-05-01 00:00:00
abstract：RATIONALE:We hypothesized that valerian root might prevent cognitive dysfunction in coronary artery bypass graft (CABG) surgery patients through stimulating serotonin receptors and anti-inflammatory activity. OBJECTIVES:The aim of this study was to evaluate the effect of Valeriana officinalis root extract on preventio...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-014-3716-x
更新日期：2015-03-01 00:00:00
abstract：:To investigate the mood response of schizophrenic subjects to psychostimulant challenge, 29 neuroleptic-treated subjects (22 with schizophrenia and 7 with schizoaffective disorder) in clinical remission received two infusions, one with methylphenidate 0.5 mg/kg and the other with normal saline, under double-blind cond...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02244317
更新日期：1991-01-01 00:00:00
abstract：:Sibutramine hydrochloride, a novel monoamine reuptake inhibitor antidepressant, has been studied to determine whether it alters dopaminergic function in the brain. Its effects have been compared with bupropion, a dopamine reuptake inhibitor, and methamphetamine, a dopamine reuptake inhibitor and releasing agent. Sibut...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245152
更新日期：1992-01-01 00:00:00
abstract：:The present study employed an animal model of drug relapse in which previously extinguished heroin self-administration behavior was reinstated following a single reinforced trial. Male albino rats were trained to traverse a straight-alley for a reinforcer consisting of a single IV injection of 0.06 mg/kg diacetylmorph...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246658
更新日期：1996-04-01 00:00:00
abstract：RATIONALE:A variety of behavioral procedures have been developed to assess cannabinoid activity in mice; however, the feasibility of establishing Delta(9)-THC as a discriminative stimulus in mice has not been documented. OBJECTIVE:One goal was to establish Delta(9)-THC as a discriminative stimulus in mice; after havin...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-007-0900-2
更新日期：2008-07-01 00:00:00
abstract：:Phencyclidine combined with footshock stress produced a greater increase in the homovanillic acid content of prefrontal cortex than either phencyclidine or footshock alone. Phencyclidine decreased both substance P and substance K in the ventral tegmental area. The results suggest that phencyclidine and footshock activ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02439600
更新日期：1987-01-01 00:00:00
abstract：RATIONALE:Pindolol has been reported to shorten the onset of antidepressant action of selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) as well as to increase their efficacy. It has been postulated that pindolol enhances the antidepressant effect of SSRIs by blocking somatodendritic 5-HT1A aut...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130000470
更新日期：2000-07-01 00:00:00
abstract：RATIONALE:Repeated intermittent exposure to ketamine has rapid and long-lasting antidepressant effects, but the abuse potential has only been assessed at high doses. Furthermore, while females are more susceptible to depression and more sensitive to ketamine's antidepressant-like effects, the abuse potential for ketami...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4470-z
更新日期：2017-02-01 00:00:00
abstract：:Twelve healthy male volunteers took part in a double-blind randomised cross-over study composed of three treatment sessions: remoxipride 100 mg; remoxipride 100 mg plus biperiden 4 mg; and biperiden 4 mg. Plasma and urine concentrations of remoxipride and biperiden, plasma prolactin levels, salivary flow and adverse e...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02257403
更新日期：1993-01-01 00:00:00
abstract：:In rats with unilateral 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle, pretreatment with the D1 DA antagonists, SCH 23390 (7-chloro-8-hydroxy-2,3,4,5-tetrahydro-3-methyl-1-phenyl-1H-3-benzazepin e) and A66359 (1- 2-bromo-4,5-dimethoxybenzyl]-7-hydroxy-6-methoxy-2-methyl- 1,2,3,4 tetrahydroisoquinol...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246211
更新日期：1995-02-01 00:00:00
abstract：RATIONALE:The dopaminergic system has been proposed to mediate alcohol-induced locomotor activity, yet the mechanisms underlying this behavioral response remain poorly understood. OBJECTIVES:This study was conducted to investigate the role of dopamine D2-like receptors in mediating alcohol-induced behavioral responses...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4264-3
更新日期：2016-06-01 00:00:00
abstract：RATIONALE:Many of the biochemical, physiological, and behavioral effects of ethanol are known to be mediated by ionotropic glutamate receptors. Emerging evidence implicates metabotropic glutamate receptors (mGluRs) in the biobehavioral effects of ethanol and other drugs of abuse, but there is little information regardi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-0217-y
更新日期：2006-01-01 00:00:00
