Cannabinoid agonists differentially substitute for the discriminative stimulus effects of Delta(9)-tetrahydrocannabinol in C57BL/6J mice.

abstract：RATIONALE:Thousands of adolescents start smoking daily but information on the effects of tobacco exposure on this age group is scarce. Moreover, the available animal models rely on the effects of nicotine, neglecting other neuroactive components of tobacco. OBJECTIVES:We investigated the effects of exposure of adolesc...

journal_title：Psychopharmacology

authors： Abreu-Villaça Y,Filgueiras CC,Correa-Santos M,Cavina CC,Naiff VF,Krahe TE,Manhães AC,Ribeiro-Carvalho A

更新日期：2015-05-01 00:00:00

abstract：:We examined the possibility that anoxia at birth can alter behavioral sensitization to amphetamine during adulthood. Male rats born either vaginally or by Cesarean section with or without an additional 15-min period of anoxia received five once-daily injections of either d-amphetamine (2.0 mg/kg, i.p.) or vehicle or n...

journal_title：Psychopharmacology

authors： Brake WG,Boksa P,Gratton A

更新日期：1997-10-01 00:00:00

abstract：RATIONALE:Preclinical experimental models of pathological aggressive behavior are a sorely understudied and difficult research area. OBJECTIVES:How valid, reliable, productive, and informative are the most frequently used animal models of excessive aggressive behavior? METHODS:The rationale, key methodological featur...

journal_title：Psychopharmacology

authors： Miczek KA,de Boer SF,Haller J

更新日期：2013-04-01 00:00:00

abstract：RATIONALE:Marijuana and alcohol, when used separately and in combination, contribute to automobile accidents and failed sobriety tests of standing balance. However, the extent to which the drugs have additive effects on both of these measures is unknown. OBJECTIVES:This study was designed to compare directly the separ...

journal_title：Psychopharmacology

authors： Liguori A,Gatto CP,Jarrett DB

更新日期：2002-10-01 00:00:00

abstract：:The differential sensitivity of young and elderly healthy adults to the impairment effects of benzodiazepines was assessed by tasks with several levels of difficulty. Using a double-blind procedure, single doses of placebo, alprazolam (0.75 and 1.5 mg) and triazolam (0.25 and 0.5 mg) were ingested orally by 10 young m...

journal_title：Psychopharmacology

authors： Nikaido AM,Ellinwood EH Jr,Heatherly DG,Gupta SK

更新日期：1990-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVE:Because of the important role of dopamine in neurotransmission, it would be useful to be able to image brain dopamine receptor-mediated signal transduction in animals and humans. Administering the D1-D2 receptor agonist apomorphine may allow us to do this, as the D2-like receptor is reported to ...

journal_title：Psychopharmacology

authors： Bhattacharjee AK,Chang L,White L,Bazinet RP,Rapoport SI

更新日期：2008-05-01 00:00:00

abstract：:Four macaques with lesions of dorsolateral frontal cortex and 4 normal monkeys were injected with 1 mg/kg d-amphetamine. Observations of social behaviors and motor activity were conducted over a 1-month period. The results of this experiment show a partial dissociation of effects of amphetamines on behavior of normal ...

journal_title：Psychopharmacology

authors： Miller MH

更新日期：1976-05-05 00:00:00

abstract：RATIONALE:The effects of acute bouts of physical activity (PA) on Strength of Desire (SoD) and Desire to Smoke (DtS) using individual participant data (IPD) from 19 acute randomised controlled studies were quantified. However, there is a need to identify factors influencing this relationship. OBJECTIVES:To understand ...

journal_title：Psychopharmacology

authors： Haasova M,Warren FC,Ussher M,Janse Van Rensburg K,Faulkner G,Cropley M,Byron-Daniel J,Everson-Hock ES,Oh H,Taylor AH

更新日期：2014-04-01 00:00:00

abstract：:Single-dose pharmacokinetics of alprazolam was studied in 42 normal male volunteers (14 Caucasians, 14 American-born Asians, and 14 foreign-born Asians), after both oral and parenteral (IV) administration of a small dose (0.5 mg) of the test drug. Asians manifested significantly higher Cmax, larger AUC, slower CL and ...

journal_title：Psychopharmacology

authors： Lin KM,Lau JK,Smith R,Phillips P,Antal E,Poland RE

更新日期：1988-01-01 00:00:00

abstract：:The present study compared cocaine-induced hyperlocomotion and cocaine i.v. self-administration in DBA/2J and C57BL/6J mice. In the locomotor activity experiment, these strains were tested for hyperlocomotion after i.p. cocaine injection (0-60.0 mg/kg), using a Digiscan Animal Activity Monitoring System. In the cocain...

journal_title：Psychopharmacology

authors： Rocha BA,Odom LA,Barron BA,Ator R,Wild SA,Forster MJ

更新日期：1998-07-01 00:00:00

abstract：:Fourteen rats were trained to discriminate the effects of gamma-hydroxybutyrate (GHB) (sodium salt, 200 mg/kg) and saline in a two-lever choice task using a fixed ratio 10 schedule of water reinforcement. Intermediate responding, i.e., responding not fully appropriate for either training condition was observed in test...

journal_title：Psychopharmacology

authors： Winter JC

更新日期：1981-01-01 00:00:00

abstract：:In rats with unilateral 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle, pretreatment with the D1 DA antagonists, SCH 23390 (7-chloro-8-hydroxy-2,3,4,5-tetrahydro-3-methyl-1-phenyl-1H-3-benzazepin e) and A66359 (1- 2-bromo-4,5-dimethoxybenzyl]-7-hydroxy-6-methoxy-2-methyl- 1,2,3,4 tetrahydroisoquinol...

journal_title：Psychopharmacology

authors： Gnanalingham KK,Hunter AJ,Jenner P,Marsden CD

更新日期：1995-02-01 00:00:00

abstract：RATIONALE:Methamphetamine (METH) is a powerfully addictive stimulant associated with serious health conditions. Accumulating evidence suggests a role of oxidative stress in METH-induced behavioral abnormalities. Sulforaphane (SFN), found in cruciferous vegetables, is a potent antioxidant. It is of interest to determine...

journal_title：Psychopharmacology

authors： Chen H,Wu J,Zhang J,Fujita Y,Ishima T,Iyo M,Hashimoto K

更新日期：2012-07-01 00:00:00

abstract：INTRODUCTION:Alcohol has been shown to increase smoking urges and smoking behavior. However, alcohol's effects on specific components of smoking behavior for nicotine versus non-nicotine factors and potential sex differences in this response have not been investigated. METHODS:Forty-two young male and female non-depen...

journal_title：Psychopharmacology

authors： King A,McNamara P,Conrad M,Cao D

更新日期：2009-11-01 00:00:00

abstract：:Naloxone, an opioid receptor antagonist, attenuates a wide range of behavioral effects of d-amphetamine, such as the stimulation of motor activity. To investigate the pharmacological selectivity of the naloxone/amphetamine interaction, we assessed the effects of naloxone (5.0 mg/kg SC) upon motor activity induced in r...

journal_title：Psychopharmacology

authors： Jones DN,Holtzman SG

更新日期：1994-03-01 00:00:00

abstract：:This study examined and compared withdrawal signs and symptoms from cessation of 0, 2 and 4 mg nicotine gum. In addition, a comparison was made between nicotine gum versus cigarette withdrawal symptoms. Smokers first underwent cigarette deprivation for 4 days and then were randomly assigned to 0 (N = 16), 2 (N = 25), ...

journal_title：Psychopharmacology

authors： Hatsukami DK,Skoog K,Huber M,Hughes J

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Hypericum perforatum L., known as St. John's wort (SJW), is used as a phytotherapeutic agent for the treatment of mild to moderate forms of depression. OBJECTIVES:The aim of the present study was to evaluate the effect of SJW extract (STW 3-VI; 250 and 500 mg/kg; p.o.) and fluoxetine (10 mg/kg, p.o.) on gene...

journal_title：Psychopharmacology

authors： Jungke P,Ostrow G,Li JL,Norton S,Nieber K,Kelber O,Butterweck V

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVES:Previous studies have investigated the occupancy of the serotonin reuptake transporter (SERT) after clinical doses of citalopram and other selective serotonin reuptake inhibitors. In the present study, the occupancies of SERT after multiple doses of escitalopram and citalopram were compared using the radioli...

journal_title：Psychopharmacology

authors： Klein N,Sacher J,Geiss-Granadia T,Mossaheb N,Attarbaschi T,Lanzenberger R,Spindelegger C,Holik A,Asenbaum S,Dudczak R,Tauscher J,Kasper S

更新日期：2007-04-01 00:00:00

abstract：:The antagonist effects of clocinnamox were evaluated against opioid agonists, acting at mu, kappa and delta-receptors, in rhesus monkeys (n = 3-4) responding under a fixed-ratio 30 (FR 30) schedule for food delivery. Clocinnamox (0.032-0.1 mg/kg) dose-dependently antagonized fentanyl (0.001-0.32 mg/kg) after either a ...

journal_title：Psychopharmacology

authors： Butelman ER,Negus SS,Lewis JW,Woods JH

更新日期：1996-02-01 00:00:00

abstract：RATIONALE:Recently, we showed that 2-bromoterguride acted as a dopamine D2 receptor partial agonist, a serotonin 5-HT2A and α2C-adrenergic receptor antagonist, and exhibited antidopaminergic efficacy in amphetamine-induced locomotion (AIL) in rats without inducing catalepsy. OBJECTIVE:To extend our knowledge on the an...

journal_title：Psychopharmacology

authors： Franke RT,Tarland E,Fink H,Pertz HH,Brosda J

更新日期：2016-08-01 00:00:00

abstract：:The behavioral effects of intraventricularly (IVT) administered (-)-nicotine on food-maintained behavior were studied. Rats responded by pressing a lever under various fixed ratio (FR) schedules. Infusion of 5 microgram of (-)-nicotine suppressed responding under an FR 16 schedule for 11-13 min. The effect was inverse...

journal_title：Psychopharmacology

authors： DeNoble VJ,Dragan VP,Carron L

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Low capacity of the central serotonergic system has been associated with impulsive behaviour. Both low platelet monoamine oxidase (MAO) activity and the short (S) allele of the serotonin transporter gene promoter region polymorphism (5-HTTLPR) are proposed to be markers of less efficient serotonergic function...

journal_title：Psychopharmacology

authors： Paaver M,Nordquist N,Parik J,Harro M,Oreland L,Harro J

更新日期：2007-11-01 00:00:00

abstract：:The effect of electroconvulsive shock (ECS) on the responsiveness to pain (measured by the hot-plate test) and on the characteristics of L-type calcium channels (measured as [3H]nitrendipine binding sites) in the cortex and hippocampus was tested on the Wistar rat. In animals receiving a single ECS, the calcium channe...

journal_title：Psychopharmacology

authors： Antkiewicz-Michaluk L,Michaluk J,Romańska I,Vetulani J

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Although both contain behaviourally significant concentrations of caffeine, tea is commonly perceived to be a less stimulating drink than coffee. At least part of the explanation for this may be that theanine, which is present in tea but not coffee, has relaxing effects. There is also some evidence that thean...

journal_title：Psychopharmacology

authors： Rogers PJ,Smith JE,Heatherley SV,Pleydell-Pearce CW

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Marchigian Sardinian alcohol-preferring (msP) rats exhibit innate preference for alcohol along with anxious phenotype. In these animals, two single-nucleotide polymorphisms in position -1,836 and -2,097 from the first start codon of the CRF1-R transcript have been found. MATERIALS AND METHODS:Here, we exa...

journal_title：Psychopharmacology

authors： Cippitelli A,Ayanwuyi LO,Barbier E,Domi E,Lerma-Cabrera JM,Carvajal F,Scuppa G,Li H,Ubaldi M,Heilig M,Roberto M,Ciccocioppo R

更新日期：2015-03-01 00:00:00

abstract：:Ten rats were trained to lever press for food reward on a schedule of differential reinforcement of low rates of response with a 20-s criterion (DRL 20). Ten more were trained on a new schedule of punishment, designed to be comparable to DRL 20 - differential punishment of high rates of response (DPH 20). Under this s...

journal_title：Psychopharmacology

authors： Salmon P,Gray JA

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Ketamine, a non-competitive N-methyl-D: -aspartic acid antagonist, has been widely used for anaesthetic purposes. At sub-anaesthetic dosage, it induces a dissociative state similar to schizophrenia. The discovery of this effect on dissociative state has led to its use as a pharmacological model of schizophre...

journal_title：Psychopharmacology

authors： Pouget P,Wattiez N,Rivaud-Péchoux S,Gaymard B

更新日期：2010-05-01 00:00:00

abstract：:Cortical and hippocampal EEGs in animal models of schizophrenia were compared to those obtained with psychotomimetics or antipsychotic agents by utilizing power spectral analysis. Models of positive schizophrenic symptoms were created with methamphetamine (MAP) and cocaine, and a model of both negative and positive sy...

journal_title：Psychopharmacology

authors： Yamamoto J

更新日期：1997-06-01 00:00:00

abstract：RATIONALE:Manipulations of the endocannabinoid system could potentially produce therapeutic effects with minimal risk of adverse cannabis-like side effects. Inhibitors of fatty acid amide hydrolase (FAAH) increase endogenous levels of the cannabinoid-receptor agonist, anandamide, and show promise for treating a wide ra...

journal_title：Psychopharmacology

authors： Panlilio LV,Thorndike EB,Nikas SP,Alapafuja SO,Bandiera T,Cravatt BF,Makriyannis A,Piomelli D,Goldberg SR,Justinova Z

更新日期：2016-05-01 00:00:00

abstract：RATIONALE:Virtually all cocaine self-administration studies have used a "unit dose" as a reinforcing stimulus; the subject is a passive recipient of an experimenter-selected dose. OBJECTIVES:The present experiments examined the consequence of requiring the subject to actively determine the dose and speed of each injec...

journal_title：Psychopharmacology

authors： Roberts DCS,Zimmer BA

更新日期：2020-09-01 00:00:00