Abstract：
:There is little evidence concerning the effects of caffeine in doses typical of one cup of tea. The present study investigated the effect of 60 mg caffeine, consumed in either tea or hot water, on performance on a subset of the CANTAB test battery. Eight males participated in a practice session and four test sessions. In each test session, the participant consumed a different hot beverage and then, over approximately 90 min, completed nine tests from the CANTAB battery. The four beverages were created by crossing beverage identity (tea or hot water) and caffeine dose (0 or 60 mg). Significant speeding of reaction time by caffeine consumption was found in pattern recognition, delayed match to sample, and match to sample visual search. The effect on reaction time of 60 mg caffeine can be detected, and may be evident within minutes of consumption. Objective reports of immediate beneficial effects of consumption, most research has postponed measurement to coincide with peak plasma caffeine levels (Blanchard and Sawers 1983). The intention of the present study was to investigate the effects of consuming a single cup of tea on a variety of cognitive tests. Testing began immediately after consumption and lasted approximately 80 min.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Durlach PJdoi
10.1007/s002130050746subject
Has Abstractpub_date
1998-11-01 00:00:00pages
116-9issue
1eissn
0033-3158issn
1432-2072journal_volume
140pub_type
杂志文章abstract：RATIONALE:A substantial portion of cigarette smokers prefer menthol-flavored cigarettes. To date, however, no studies have examined whether menthol in cigarettes has central pharmacological effects. OBJECTIVE:We investigated psychophysiological and subjective effects of smoking menthol versus non-menthol cigarettes in...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050947
更新日期：1999-04-01 00:00:00
abstract：:The effects of fixed-ratio (FR) size, scopolamine, and the interactions between FR size and scopolamine were investigated in male F344 rats on working memory as assessed by spatial alternation behavior maintained under FR schedules of food presentation where the interval between trials was varied among values of 2, 4,...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244001
更新日期：1990-01-01 00:00:00
abstract：RATIONALE:Epilepsy is a debilitating seizure disorder that affects approximately 50 million people. Noradrenaline reduces neuronal excitability, has anticonvulsant effects and is protective against seizure onset. OBJECTIVE:We investigated the role of α2-adrenoceptors in vivo in a neonatal domoic acid (DOM) rat model o...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4416-5
更新日期：2016-10-01 00:00:00
abstract：RATIONALE:Acute cocaine administration produces an initial rewarding state followed by a dysphoric/anxiogenic "crash." OBJECTIVE:The objective of this study was to determine whether individual differences in the relative value of cocaine's positive and negative effects would account for variations in subsequent drug s...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-3873-6
更新日期：2015-07-01 00:00:00
abstract：RATIONALE:Consumption of alcohol begins during late adolescence in a majority of humans, and the greatest drinking occurs at 18-25 years then decreases with age. OBJECTIVES:The present study measured the differences in ethanol intake in relation to age at the onset of ethanol access among nonhuman primates to control ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3417-x
更新日期：2014-04-01 00:00:00
abstract：:Male volunteer subjects smoked one marijuana cigarette containing 100, 200, or 250 micrograms/kg delta-9-tetrahydrocannabinol (THC) and were tested on three perceptual-motor performance measures related to driving. Performance was measured and blood samples were collected for 24 h after smoking. The covariation betwee...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00427321
更新日期：1985-01-01 00:00:00
abstract：:Twenty-one (three groups of seven), men and women, 25-50 years of age were studied to determine whether or not rebound insomnia would increase the likelihood of self administering a benzodiazepine (triazolam 0.25 mg) hypnotic. The groups compared were patients with insomnia and disturbed sleep, insomnia and normal sle...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02245259
更新日期：1992-01-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Major depressive disorder (MDD) is associated with an increased risk for cardiovascular disease (CVD). Apart from biological and life style factors, the use of antidepressants and their potentially adverse effects might contribute to the increased CVD risk. Therefore, we compared cardiovascular...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4361-3
更新日期：2016-09-01 00:00:00
abstract：:Predicting what will happen in the future in terms of potential reward is essential in daily life. The aim of the current study was to investigate the neurotransmitter systems involved in the anticipation of reward value and probability. We hypothesized that dopaminergic and noradrenergic antagonism would affect antic...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05515-x
更新日期：2020-07-01 00:00:00
abstract：RATIONALE:Prepulse inhibition (PPI) and locomotor activity have been used to investigate the effects of antipsychotic and stimulant drugs and their underlying dopaminergic mechanisms. Whereas D2-like agonists consistently decreased PPI and increased locomotion in rats in previous studies, we recently reported that thes...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0511-3
更新日期：2007-04-01 00:00:00
abstract：RATIONALE:The exact role of delta opioid receptors in drug-induced conditioned place preference (CPP) remains debated. Under classical experimental conditions, morphine-induced CPP is decreased in mice lacking delta opioid receptors (Oprd1 (-/-)). Morphine self-administration, however, is maintained, suggesting that dr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2693-1
更新日期：2012-09-01 00:00:00
abstract：:The interaction between pimozide (a selective D2-dopamine receptor antagonist) and d-amphetamine on the operant performance of rats maintained under variable-interval schedules of positive reinforcement was examined. In Experiment 1, eight rats responded under variable-interval 30-s and variable-interval 300-s. Pimozi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00217071
更新日期：1987-01-01 00:00:00
abstract：:Following the stereotaxic implantation of chronic cannulae for intracerebroventricular (ICV) infusion, rats were given an alcohol preference test to establish their preferred concentration in comparison with water. After alcohol was removed, 15 mg/kg cyanamide was then injected subcutaneously for 4 days in order to ma...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00444688
更新日期：1989-01-01 00:00:00
abstract：RATIONALE:Previous work has shown that environmental enrichment alters amphetamine-induced locomotor activity and conditioned place preference. OBJECTIVE:The present study examined the effect of environmental enrichment on amphetamine self-administration. METHODS:Female and male rats were raised from 21 days of age i...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100720
更新日期：2001-05-01 00:00:00
abstract：RATIONALE:The involvement of glutamate in fear extinction is perhaps the most promising in terms of facilitating clinical interventions for posttraumatic stress disorder (PTSD). This study was aimed at elucidating the possible role of zif268 on the D-cycloserine (DCS) facilitation effect on extinction. OBJECTIVE:We in...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-4042-7
更新日期：2015-10-01 00:00:00
abstract：RATIONALE:Memantine is a potential treatment for alcoholic patients, yet few studies investigate the effect of concurrent treatment with memantine and ethanol on aggression. We evaluated aggressive behavior following ethanol consumption and treatment with glutamatergic drugs to characterize interactions between these c...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2734-9
更新日期：2012-11-01 00:00:00
abstract：RATIONALE:The endocannabinoid system has been implicated in the pathogenesis of major depression (MD) as well as in the mediation of antidepressant drug effects. OBJECTIVES:To analyze CNR1 gene variants in MD and clinical response to citalopram (selective serotonin re-uptake inhibitors [SSRI]). METHODS:The role of CN...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-2995-y
更新日期：2013-06-01 00:00:00
abstract：RATIONALE:Stress, a powerful precipitant of drug seeking during abstinence, may also accelerate the return to pathological patterns of intake after initial instances of drug reuse. OBJECTIVE:To explore the effect of stress on a learning process underlying relapse, this study assessed the effect of yohimbine on reacqui...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2640-1
更新日期：2012-07-01 00:00:00
abstract：RATIONALE:During the last few decades, alcohol use disorders (AUD) have reached an epidemic prevalence, yet social influences on alcoholism have not been fully addressed. Several factors can modulate alcohol intake. On one hand, stress can reinforce ethanol-induced behaviors and be an important component in AUD and alc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-019-05408-8
更新日期：2020-03-01 00:00:00
abstract：RATIONALE:Exposure to extreme stress has been suggested to produce long-term, detrimental alterations in the hypothalamic-pituitary-adrenal (HPA) axis leading to the development of mental disorders such as depression. Therefore, compounds that block the effects of stress hormones were investigated as potential therapeu...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-2164-z
更新日期：2005-07-01 00:00:00
abstract：:The binding kinetics of tritiated quinuclidinyl benzilate (QNB) were studied in membrane preparations from human parotid and rabbit submandibular glands. Inhibition of 3H-QNB was then used to compare the anticholinergic activity of lofepramine, desipramine, imipramine and amitriptyline for muscarinic receptor in the s...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00172861
更新日期：1986-01-01 00:00:00
abstract：RATIONALE/OBJECTIVES:Previous research has shown that ecstasy users are impaired in thinking and reasoning. The present study sought to explore the possibility that syllogistic reasoning errors in ecstasy users were due to an inability to construct a model of the premises due to working memory limitations. METHODS:Twe...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-0006-7
更新日期：2005-09-01 00:00:00
abstract：:The anti-withdrawal effect of clonidine was studied using quasi-morphine abstinence behaviour induced by dipropylacetate (DPA) in naive rats. Clonidine potently suppressed body shakes and locomotor activity (ID50 30 and 40 micrograms/kg IP respectively). Phenoxybenzamine and prazosine did not antagonize the anti-withd...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427276
更新日期：1983-01-01 00:00:00
abstract：:The behavioral profile of corticotropin-releasing factor (CRF) in mediating anxiogenic-like and aversive responses to stressors may be particularly relevant for dependence and withdrawal in drug-experienced organisms. Moreover, stressful aspects of drug exposure in the drug naive organism may also induce CRF system ac...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050563
更新日期：1998-04-01 00:00:00
abstract：:Rhesus monkeys were trained in a discrete-trials choice procedure and allowed to choose between intravenous injections of cocaine (0.01-1.0 mg/kg/injection) and food presentation (1 or 4 pellets; 1 g/pellet) during daily 7-h experimental sessions. When each reinforcer was available under a fixed-ratio (FR) 30 schedule...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245115
更新日期：1992-01-01 00:00:00
abstract：RATIONALE:F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical trial in patients with schizophrenia (Bitter et al. Neuropsych...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-019-05387-w
更新日期：2020-02-01 00:00:00
abstract：RATIONALE:Impulsive behaviour is a component of psychiatric disorders such as bipolar disorder, attention deficit hyperactivity disorder (ADHD), or personality disorders. Most experimental studies on impulsive behaviour punish impulsive choices by loss or delay of reward. In the present study, impulsive behaviour was p...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-2163-0
更新日期：2005-07-01 00:00:00
abstract：:The subjective, psychomotor, and physiological effects of analgesic doses of oral codeine and morphine were examined in 12 healthy volunteers. Subjects ingested placebo, morphine 20 or 40 mg, or codeine 60 or 120 mg in a randomized, double-blind, crossover design. The smaller and larger doses of each drug were putativ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130050757
更新日期：1998-11-01 00:00:00
abstract：RATIONALE:Control of reward-seeking behavior under conditions of punishment is an important function for survival. OBJECTIVES AND METHODS:We designed a task in which rats could choose to either press a lever and obtain a food pellet accompanied by a footshock or refrain from pressing the lever to avoid footshock, in r...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-019-05398-7
更新日期：2020-03-01 00:00:00
abstract：INTRODUCTION:Alcohol has been shown to increase smoking urges and smoking behavior. However, alcohol's effects on specific components of smoking behavior for nicotine versus non-nicotine factors and potential sex differences in this response have not been investigated. METHODS:Forty-two young male and female non-depen...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-009-1638-9
更新日期：2009-11-01 00:00:00
