Neonatal domoic acid alters in vivo binding of [11C]yohimbine to α2-adrenoceptors in adult rat brain.

abstract：RATIONALE:Both central serotonergic and nicotinic systems play important roles in a variety of neurobehavioral functions; however, the interactions of these two systems have not been fully characterized. The current study served to determine the impact of a relatively selective 5-HT2A receptor antagonist, ketanserin, o...

journal_title：Psychopharmacology

authors： Rezvani AH,Caldwell DP,Levin ED

更新日期：2005-05-01 00:00:00

abstract：:In the majority of Parkinson's disease (PD) patients, long-term dopamine (DA) replacement therapy leads to dyskinesia characterized by abnormal involuntary movements (AIMs). There are various mechanisms of dyskinesia, such as the sensitization of striatal DA D1 receptors (D1R) and upregulation of DA D3 receptors (D3R)...

journal_title：Psychopharmacology

authors： Lanza K,Chemakin K,Lefkowitz S,Saito C,Chambers N,Bishop C

更新日期：2020-01-01 00:00:00

abstract：:Mood disorders, despite the widespread availability of monoamine-based antidepressant treatments, are associated with persistently high rates of disability, together with elevated rates of mortality due to suicide, cardiovascular disease, and other causes. The development of more effective treatments has been hindered...

journal_title：Psychopharmacology

authors： Bhattacharya A,Derecki NC,Lovenberg TW,Drevets WC

更新日期：2016-05-01 00:00:00

abstract：RATIONALE:The endocannabinoid system has been implicated in the pathogenesis of major depression (MD) as well as in the mediation of antidepressant drug effects. OBJECTIVES:To analyze CNR1 gene variants in MD and clinical response to citalopram (selective serotonin re-uptake inhibitors [SSRI]). METHODS:The role of CN...

journal_title：Psychopharmacology

authors： Mitjans M,Serretti A,Fabbri C,Gastó C,Catalán R,Fañanás L,Arias B

更新日期：2013-06-01 00:00:00

abstract：RATIONALE:Working memory performance may be improved or decreased by amphetamine, depending on baseline working memory capacity and amphetamine dosage. This variable effect suggests an optimal range of monaminergic activity for working memory, either below or above which it is compromised. We directly tested this possi...

journal_title：Psychopharmacology

authors： Tipper CM,Cairo TA,Woodward TS,Phillips AG,Liddle PF,Ngan ET

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Several theories propose alternative explanations for drug addiction. OBJECTIVES:We propose a general theory of transition to addiction that synthesizes knowledge generated in the field of addiction into a unitary explanatory frame. MAJOR PRINCIPLES OF THE THEORY:Transition to addiction results from a sequ...

journal_title：Psychopharmacology

authors： Piazza PV,Deroche-Gamonet V

更新日期：2013-10-01 00:00:00

abstract：:The behavioral effects following intrastriatal MPP+, the neurotoxic metabolite of MPTP, were evaluated in mice. Bilateral injections of 10 micrograms MPP+ to mice previously trained in the shuttle box paradigm produced a 66% decrease in striatal dopamine and significant deficits in all measures of conditioned avoidanc...

journal_title：Psychopharmacology

authors： Wagner GC,Walsh SL

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:The main psychoactive component of cannabis, delta-9-tetrahydrocannabinol (THC), can impair driving performance. Cannabidiol (CBD), a non-intoxicating cannabis component, is thought to mitigate certain adverse effects of THC. It is possible then that cannabis containing equivalent CBD and THC will differenti...

journal_title：Psychopharmacology

authors： Arkell TR,Lintzeris N,Kevin RC,Ramaekers JG,Vandrey R,Irwin C,Haber PS,McGregor IS

更新日期：2019-09-01 00:00:00

abstract：:Benzodiazepines and other compounds which act at benzodiazepine binding sites have been shown previously to attenuate the acquisition of conditioned fear in rodents when administered before the acquisition session, an effect which may parallel the disruption of human memory produced by anxiolytics and sedatives. Such ...

journal_title：Psychopharmacology

authors： Sanger DJ,Joly D,Zivkovic B

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:N-methyl-D-aspartate (NMDA) receptor antagonists (e.g., PCP, ketamine) have been shown to impair learning/memory. Well documented in animal models, only limited research in humans has been reported. Findings to date are similar to results of animal studies; however, antagonists are typically administered befo...

journal_title：Psychopharmacology

authors： LaPorte DJ,Blaxton TA,Michaelidis T,Robertson DU,Weiler MA,Tamminga CA,Lahti AC

更新日期：2005-07-01 00:00:00

abstract：:Depression is common in patients with senile dementia of the Alzheimer type (SDAT) and may precede the onset of the dementia; the underlying biological and neurotransmitter mechanisms may be common to both diseases, so far as norepinephrine lesions are concerned. The major routes of metabolism of amines in the brain u...

journal_title：Psychopharmacology

authors： Chan-Palay V

更新日期：1992-01-01 00:00:00

abstract：:The effects of acutely or chronically administered carbamazepine were studied in rats submitted to the modified Geller-Seifter conflict test. Diazepam was used as a standard anxiolytic. The results showed an increase in punished response after carbamazepine, as observed with diazepam, leading to the suggestion of an a...

journal_title：Psychopharmacology

authors： Almeida RN,Leite JR

更新日期：1990-01-01 00:00:00

abstract：:Male rats of the Long-Evans strain were divided into two equal groups of nine each and given either 7.0 mg/kg trimethyltin (TMT) or 0.9% saline by intragastric gavage. The pattern of self-selection of alcohol in concentrations of 3%--30% was examined in both groups at 21 and 150 days following the gavage. The TMT-trea...

journal_title：Psychopharmacology

authors： Myers RD,Swartzwelder HS,Dyer RS

更新日期：1982-01-01 00:00:00

abstract：:A paradigm for assessing benzodiazepine receptor sensitivity was developed using intravenous midazolam in normal volunteers. After administration of incremental doses of midazolam, alterations in saccadic eye movement parameters and psychological self ratings were assessed. Significant changes included dose-dependent ...

journal_title：Psychopharmacology

authors： Ball DM,Glue P,Wilson S,Nutt DJ

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Delivering nicotine in the way smokers seek is likely to be the key factor in e-cigarette (EC) success in replacing cigarettes. We examined to what degree different types of EC mimic nicotine intake from cigarettes. METHODS:Twelve participants ('dual users' of EC and cigarettes) used their own brand cigaret...

journal_title：Psychopharmacology

authors： Hajek P,Przulj D,Phillips A,Anderson R,McRobbie H

更新日期：2017-03-01 00:00:00

abstract：RATIONALE:Previous behavioral and biochemical studies suggest that allosteric coupling processes initiated by benzodiazepines, barbiturates and neuroactive steroids can be sub-categorized on the basis of their sensitivities to antagonism by increased atmospheric pressure. However, biochemical evidence supporting this h...

journal_title：Psychopharmacology

authors： Davies DL,McCauley LD,Bolger MB,Alkana RL

更新日期：2001-10-01 00:00:00

abstract：:Rats were trained to self-administer cocaine in 1-h sessions on a fixed ratio 5 (FR5) schedule of reinforcement. Acquisition was carried out at a unit dose of 0.3 mg/kg and responding was then stabilized at cocaine doses of 0.1, 0.3, and 1.0 mg/kg/infusion. Pretreatments with naltrexone (0.1-10 mg/kg, SC) 20 min prior...

journal_title：Psychopharmacology

authors： Corrigall WA,Coen KM

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Depressive disorders are conditions that often require continuous treatment, and it is therefore important to evaluate the consequences of prolonged administration. There are few studies assessing cognitive functions of depressed patients after long-term use of antidepressants. OBJECTIVES:This study evaluate...

journal_title：Psychopharmacology

authors： Gorenstein C,de Carvalho SC,Artes R,Moreno RA,Marcourakis T

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVES:Recent studies using positron emission tomography (PET) have established the relationship between an intravenous dose of cocaine and the percentage occupancy of the dopamine transporter in humans, and have documented the requirement of more than 50% occupancy for perception of the "high". The present experim...

journal_title：Psychopharmacology

authors： Gatley SJ,Volkow ND,Gifford AN,Fowler JS,Dewey SL,Ding YS,Logan J

更新日期：1999-09-01 00:00:00

abstract：INTRODUCTION:Prior activation of the kappa opioid system by repeated stress or agonist administration has been previously shown to potentiate the rewarding properties of subsequently administered cocaine. In the present study, intermittent and uncontrollable footshock, a single session of forced swim, or acute administ...

journal_title：Psychopharmacology

authors： Redila VA,Chavkin C

更新日期：2008-09-01 00:00:00

abstract：:MA rats, bred for greater motor impairment following subhypnotic doses of ethanol, were found to be more sensitive to the hypnotic effects of phenobarbital and chloral hydrate than were LA rats. In addition, the previously reported finding of a difference between the two lines of rats in duration of loss of righting r...

journal_title：Psychopharmacology

authors： Riley EP,Shapiro NR,Lochry EA

更新日期：1979-02-28 00:00:00

abstract：RATIONALE:Caffeine is commonly believed to offset the acute effects of alcohol, but some evidence suggests that cognitive processes remain impaired when caffeine and alcohol are coadministered. OBJECTIVES:No previous study has investigated the separate and joint effects of alcohol and caffeine on conflict monitoring a...

journal_title：Psychopharmacology

authors： Bailey K,Amlung MT,Morris DH,Price MH,Von Gunten C,McCarthy DM,Bartholow BD

更新日期：2016-04-01 00:00:00

abstract：RATIONALE:The majority of volumetric magnetic resonance imaging (MRI) studies of the hippocampus in patients with bipolar disorder (BD) show no differences in hippocampal volume between patients and healthy controls. Significant variability, however, exists in the medication status of patients included in these studies...

journal_title：Psychopharmacology

authors： Yucel K,McKinnon MC,Taylor VH,Macdonald K,Alda M,Young LT,MacQueen GM

更新日期：2007-12-01 00:00:00

abstract：:The alcohol-preferring AA rats have previously been shown to drink more solution containing the opioid etonitazene than the alcohol-avoiding ANA rats. The present experiments were initiated to see whether the line difference in opioid and alcohol intake would persist if an intravenous (i.v.) route of self-administrati...

journal_title：Psychopharmacology

authors： Hyytiä P,Schulteis G,Koob GF

更新日期：1996-06-01 00:00:00

abstract：:The effect of lithium and rubidium on curiosity rearing, and locomotor activity in isolated and group-housed male mice (DBA/2 Han) was investigated. LiCl and RbCl were given with the drinking water (30 mol/l) during 3 weeks. The behaviour of the animals was tested before and after the chronical application of either l...

journal_title：Psychopharmacology

authors： Weischer ML

更新日期：1979-03-28 00:00:00

abstract：:Supersensitivity to serotonin during migraine attack has been previously observed. Since the attack has been attributed to a critical lowering of morphine-like factors, we can expect serotonin supersensitivity during morphine abstinence. Slight signs of morphine abstinence have also been induced in volunteers after mi...

journal_title：Psychopharmacology

authors： Sicuteri F,Del Bianco PL,Anselmi B

更新日期：1979-10-01 00:00:00

abstract：RATIONALE:Perospirone is a novel second-generation antipsychotic drug with high affinity to dopamine D(2) receptor and short half-life of plasma concentration. There has been no investigation of dopamine D(2) receptor occupancy in patients with schizophrenia and the time course of occupancy by antipsychotics with peros...

journal_title：Psychopharmacology

authors： Arakawa R,Ito H,Takano A,Okumura M,Takahashi H,Takano H,Okubo Y,Suhara T

更新日期：2010-05-01 00:00:00

abstract：RATIONALE:Recent studies have suggested that the salutary actions of clozapine in schizophrenia may be due to selective activation of M(1) muscarinic receptors by clozapine and/or its major active metabolite N-desmethylclozapine. OBJECTIVE:We systematically tested this hypothesis by screening a large number of psychoa...

journal_title：Psychopharmacology

authors： Davies MA,Compton-Toth BA,Hufeisen SJ,Meltzer HY,Roth BL

更新日期：2005-04-01 00:00:00

abstract：:Mice were trained on a one-trial inhibitory avoidance task and given immediate post-training intraperitoneal injections of cocaine (0.03-1.00 mg/kg). On a retention test 24 h later, the retention latencies of mice given the 0.10 mg/kg dose were significantly higher than those of the controls. The effect of cocaine on ...

journal_title：Psychopharmacology

authors： Introini-Collison IB,McGaugh JL

更新日期：1989-01-01 00:00:00

abstract：:Dosage regimen adjustments because of poor renal function are often assumed to be unnecessary for extensively metabolized antidepressants. This assumption is being increasingly questioned in recognition of the role of active drug metabolites. The purpose of this study was to assess the steady-state accumulation of the...

journal_title：Psychopharmacology

authors： DeVane CL,Laizure SC,Cameron DF

更新日期：1986-01-01 00:00:00