Cocaine enhances memory storage in mice.

abstract：:Growth hormone (hGH) responses to centrally acting dopamine agonists were used as indices of CNS dopaminergic function in order to test hypotheses implicating dopaminergic alteration in the etiopathology of schizophrenia. Apomorphine, a direct acting dopamine receptor agonist, and L-Dopa, an indirect agonist dependent...

journal_title：Psychopharmacology

authors： Rotrosen J,Angrist BM,Gershon S,Sachar EJ,Halpern FS

更新日期：1976-12-21 00:00:00

abstract：:Food reward has been associated with activation of noradrenergic mechanisms in the brain. Using rats trained to press a lever for food reward, we have investigated the effects of 6-hydroxydopamine lesions, which severly depleted hypothalamic noradrenaline, on the willingness of the rats to press the lever for food rew...

journal_title：Psychopharmacology

authors： Kruk ZL,Millar J

更新日期：1979-06-28 00:00:00

abstract：:The purpose of this study was to determine if multiple aspects of drug and food-reinforced behavior could be measured in a single study. Drug or food seeking can be observed under four conditions: 1) internal drug or food cues and external stimulus cues present; self-administration, 2) only internal cues present; prim...

journal_title：Psychopharmacology

authors： Foltin RW,Evans SM

更新日期：1997-08-01 00:00:00

abstract：RATIONALE:Attentional bias for alcohol-related cues is associated with the motivation to drink alcohol, possibly because attentional bias increases craving. OBJECTIVES:We examined whether an experimentally induced attentional bias would influence subjective and behavioural indices of the motivation to drink. METHODS:...

journal_title：Psychopharmacology

authors： Field M,Eastwood B

更新日期：2005-12-01 00:00:00

abstract：RATIONALE:The endocannabinoid system has been implicated in the pathogenesis of major depression (MD) as well as in the mediation of antidepressant drug effects. OBJECTIVES:To analyze CNR1 gene variants in MD and clinical response to citalopram (selective serotonin re-uptake inhibitors [SSRI]). METHODS:The role of CN...

journal_title：Psychopharmacology

authors： Mitjans M,Serretti A,Fabbri C,Gastó C,Catalán R,Fañanás L,Arias B

更新日期：2013-06-01 00:00:00

abstract：:When tested in adulthood, male rats that had been treated daily with 50 mg/kg hydroxyzine HCl SC at 10--29 or 23--29 days of age were significantly facilitated in performance of delayed spontaneous alternation relative to saline-injected rats. Treatment at 10--16 days of age did not produce significant facilitation in...

journal_title：Psychopharmacology

authors： Isseroff A

更新日期：1980-01-01 00:00:00

abstract：:To confirm the conclusions from a previous study supporting the usefullness of electropupillogram (E.P.G.) in predicting clinical response, data from three separate studies with hyperkinetic and learning disabled (L.D.) children treated with stimulants were surveyed. Change in extent of pupillary contraction (E.C.) af...

journal_title：Psychopharmacology

authors： Bhatara V,Arnold LE,Knopp W,Smeltzer DJ

更新日期：1978-04-28 00:00:00

abstract：:Methamphetamine (MAP: 1 and 2 mg/kg SC) and caffeine (CAF: 1, 3, 10 and 30 mg/kg SC) dose-dependently increased ambulation in mice. Repeated administration (5 times at 3 to 4-day intervals) of MAP, but not CAF, induced sensitization to its effect. Furthermore, the mice repeatedly receiving CAF showed no significant ch...

journal_title：Psychopharmacology

authors： Kuribara H

更新日期：1994-10-01 00:00:00

abstract：:Brain 5-hydroxytryptamine (5-HT) was depleted in rats by intraventricular injection with 5,7-dihyroxytryptamine (5,7-DHT) prior to feeding rats a liquid diet containing ethanol. After withdrawal of ethanol, withdrawal reactions were significantly less severe in 5-HT-depleted rats than control rats. Sleeping times afte...

journal_title：Psychopharmacology

authors： Wood JM

更新日期：1980-01-01 00:00:00

abstract：INTRODUCTION:The present study was designed to investigate the rewarding effects induced by tramadol and its active metabolite O-desmethyltramadol (M1) under a neuropathic pain-like state. RESULTS:In opioid receptor binding and G protein activation, we confirmed that M1, but not tramadol, showed mu-opioid receptor (MO...

journal_title：Psychopharmacology

authors： Nakamura A,Narita M,Miyoshi K,Shindo K,Okutsu D,Suzuki M,Higashiyama K,Suzuki T

更新日期：2008-10-01 00:00:00

abstract：RATIONALE:The non-selective nicotinic acetylcholine receptor (nAChR) agonist nicotine has been argued to improve attention via enhanced filtering of irrelevant stimuli. Here, we tested this hypothesis in the context of smooth pursuit eye movements (SPEMs), an oculomotor function previously shown to improve with nicotin...

journal_title：Psychopharmacology

authors： Meyhöfer I,Kasparbauer AM,Steffens M,Ettinger U

更新日期：2019-07-01 00:00:00

abstract：:N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON 954) causes a reproducible rest tremor in mice, of rapid onset and short duration with no associated rigidity or akinesia and in the absence of any marked changes in body temperature or accompanying peripheral parasympathomimetic effects. This tremor ca...

journal_title：Psychopharmacology

authors： Coward DM,Doggett NS

更新日期：1977-04-29 00:00:00

abstract：:In order to study the role of dopamine (DA) in the regulation of seizure mechanisms in man, a non-emetic dose of apomorphine, a direct stimulant of DA receptors, was administered to eight patients effected by different types of epilepsy. The EEG changes induced by apomorphine administration in comparison to those elic...

journal_title：Psychopharmacology

authors： Del Zompo M,Tocco F,Marrosu F,Passino N,Corsini GU

更新日期：1983-01-01 00:00:00

abstract：:It was shown previously that behavioural effects of apomorphine (locomotor activation and stereotyped behaviour) can be conditioned when they are associated with well-defined environmental stimuli. In the present study, the hypothesis was tested that glutamatergic mechanisms play an important role either in formation ...

journal_title：Psychopharmacology

authors： Welsch-Kunze S,Kuschinsky K

更新日期：1990-01-01 00:00:00

abstract：:Monoamine oxidase inhibitors (MAOIs) are widely accepted as effective antidepressants. Unfortunately their use has been limited by their capacity to potentiate dietary tyramine (the so called "cheese effect") and their interaction with other drugs. The latter poses a particular problem for patients undergoing anaesthe...

journal_title：Psychopharmacology

authors： Hill S,Yau K,Whitwam J

更新日期：1992-01-01 00:00:00

abstract：:The effects of methylglucamine orotate (MGO) were studied on polygraphic sleep recordings in rats for 8 h per day between 8 a.m. and 4 p.m. MGO (225 mg/kg) was injected intraperitoneally immediately prior to the onset of recording. In the acute experiment, the effect of MGO was compared to pre- and post-drug control d...

journal_title：Psychopharmacology

authors： Wetzel W,Ott T,Matthies HK,Matthies H

更新日期：1984-01-01 00:00:00

abstract：:The interaction between pimozide (a selective D2-dopamine receptor antagonist) and d-amphetamine on the operant performance of rats maintained under variable-interval schedules of positive reinforcement was examined. In Experiment 1, eight rats responded under variable-interval 30-s and variable-interval 300-s. Pimozi...

journal_title：Psychopharmacology

authors： Morley MJ,Bradshaw CM,Szabadi E

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:2-Bromoterguride, a dopamine D2 receptor partial agonist with antagonist properties at serotonin 5-HT2A receptors and α2C-adrenoceptors, meets the prerequisites of a putative atypical antipsychotic drug (APD). We recently showed that 2-bromoterguride is effective in tests of positive symptoms of schizophrenia...

journal_title：Psychopharmacology

authors： Tarland E,Franke RT,Fink H,Pertz HH,Brosda J

更新日期：2018-01-01 00:00:00

abstract：RATIONALE:Alcohol intoxication can dampen negative affective reactions to stressors. Recently, it has been proposed that these acute anxiolytic effects of alcohol may extend to dampening of negative affective reactions to error commission during cognitive control tasks. Nonetheless, empirical verification of this claim...

journal_title：Psychopharmacology

authors： Cofresí RU,Bartholow BD

更新日期：2020-11-01 00:00:00

abstract：:Rats were trained to self-stimulate by interrupting a photobeam and brain stimulation was maintained for as long as the beam of light was broken. d-Amphetamine sulphate was then administered and response rate and total duration of stimulation were recorded. Both response rate and total duration were elevated by 1.0, 2...

journal_title：Psychopharmacology

authors： Zacharko RM,Wishart TB

更新日期：1979-08-08 00:00:00

abstract：:The effect of delta 9-tetrahydrocannabinol (THC) on the locomotor activity-stimulating action of morphine has been investigated in mice. THC (10 mg/kg) has been found to potentiate morphine-induced hyperactivity. On the other hand, the stimulating action of morphine on motor activity strongly diminished in mice render...

journal_title：Psychopharmacology

authors： Ulkü E,Ayhan IH,Tulunay FC,Uran B,Kaymakçalan S

更新日期：1980-01-01 00:00:00

abstract：:The effects of naltrexone methobromide, a quaternary derivative of the opioid antagonist naltrexone, were investigated on deprivation (24 h)-induced water intake in the unilaterally cannulated rats. Naltrexone methobromide reduced post-deprivational water intake with an ED50 of 7.3 micrograms when tested at 30 min (pe...

journal_title：Psychopharmacology

authors： Ukai M,Holtzman SG

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Although both contain behaviourally significant concentrations of caffeine, tea is commonly perceived to be a less stimulating drink than coffee. At least part of the explanation for this may be that theanine, which is present in tea but not coffee, has relaxing effects. There is also some evidence that thean...

journal_title：Psychopharmacology

authors： Rogers PJ,Smith JE,Heatherley SV,Pleydell-Pearce CW

更新日期：2008-01-01 00:00:00

abstract：:The effects of long-term amphetamine treatment were evaluated on responding supported by self-stimulation of the substantia nigra. Rats repeatedly treated with d-amphetamine, and tested with a low dose of the drug that ordinarily has no behavioral effect, showed higher response rates than animals repeatedly treated wi...

journal_title：Psychopharmacology

authors： Kokkinidis L,Zacharko RM

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Emerging evidence from agonist-antagonist studies suggests a role for the dopamine D(3) receptor subtype in the regulation of PPI in animals, but such evidence is lacking for human subjects. OBJECTIVES:This study examines the effect of the preferential D(3) agonist ropinirole on PPI in humans. METHODS:PPI w...

journal_title：Psychopharmacology

authors： Giakoumaki SG,Roussos P,Frangou S,Bitsios P

更新日期：2007-10-01 00:00:00

abstract：RATIONALE:Clinical trials show that chronic cocaine users suffer from sleep disturbances and preclinical research has shown that acute sleep deprivation increases the rate of cocaine self-administration in rats. OBJECTIVE:This study examined the effect of cocaine self-administration on behavioral indices of sleep and ...

journal_title：Psychopharmacology

authors： Brutcher RE,Nader MA

更新日期：2013-09-01 00:00:00

abstract：RATIONALE:Despite the critical role attributed to phosphorylated extracellular signal regulated kinase (pERK1/2) in the nucleus accumbens (Acb) in the actions of addictive drugs, the effects of morphine on ERK1/2 phosphorylation in this area are still controversial. OBJECTIVES:In order to investigate further this issu...

journal_title：Psychopharmacology

authors： Rosas M,Porru S,Fenu S,Ruiu S,Peana AT,Papale A,Brambilla R,Di Chiara G,Acquas E

更新日期：2016-08-01 00:00:00

abstract：RATIONALE:Prepulse inhibition (PPI) refers to the reduction of the startle response magnitude when a startling stimulus is closely preceded by a weak stimulus. PPI is commonly used to measure sensorimotor gating. In rats, the PPI reduction induced by the dopamine agonist apomorphine can be reversed by systemic administ...

journal_title：Psychopharmacology

authors： Larrauri JA,Burke DA,Hall BJ,Levin ED

更新日期：2015-08-01 00:00:00

abstract：RATIONALE:It is important to study age-related differences that may put adolescents at risk for alcohol-related problems. Adolescents seem less sensitive to the aversive effects of ethanol than adults. Less is known of appetitive effects of ethanol and stress modulation of these effects. OBJECTIVES:This study aims to ...

journal_title：Psychopharmacology

authors： Acevedo MB,Pautassi RM,Spear NE,Spear LP

更新日期：2013-12-01 00:00:00

abstract：RATIONALE:Repeated methamphetamine (MA) use leads to increases in the incentive motivational properties of the drug as well as cognitive impairments. These behavioral alterations persist for some time following abstinence, and neuroadaptations in the structure and function of the prefrontal cortex (PFC) are particularl...

journal_title：Psychopharmacology

authors： Janetsian SS,Linsenbardt DN,Lapish CC

更新日期：2015-06-01 00:00:00