Abstract:
RATIONALE:Alcohol intoxication can dampen negative affective reactions to stressors. Recently, it has been proposed that these acute anxiolytic effects of alcohol may extend to dampening of negative affective reactions to error commission during cognitive control tasks. Nonetheless, empirical verification of this claim is lacking. OBJECTIVES:Test the acute effect of alcohol on negative affective reactions to errors during an effort-demanding cognitive control task. METHODS:Healthy, young adult social drinkers (N = 96 [49 women], 21-36 years old) were randomly assigned to consume alcohol (0.80 g/kg; n = 33 [15 female]), active placebo (0.04 g/kg; n = 33 [18 women]), or a non-alcoholic control beverage (n = 30 [16 women]) before completing the Eriksen flanker task. Corrugator supercilii (Corr) activation, a psychophysiological index of negative affect, was tracked across the task. Two neurophysiological reactions to errors, the error-related negativity (ERN) and the error positivity (Pe), were also measured. RESULTS:Erroneous actions increased Corr activation in the control and (to a lesser extent) placebo groups, but not in the alcohol group. Error-induced Corr activation was coupled to ERN and Pe in the control, but not in the alcohol and placebo groups. Error-induced Corr activation was not coupled to post-error performance adjustments in any group. CONCLUSIONS:The ability of alcohol to dampen error-related negative affect was verified. It was also shown that placebo alone can disrupt coupling of affective and (neuro)cognitive reactions to errors. Although its behavioral relevance remains to be demonstrated, more attention should be paid to the role of affect in action monitoring and cognitive control processes.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Cofresí RU,Bartholow BDdoi
10.1007/s00213-020-05619-4subject
Has Abstractpub_date
2020-11-01 00:00:00pages
3383-3397issue
11eissn
0033-3158issn
1432-2072pii
10.1007/s00213-020-05619-4journal_volume
237pub_type
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