Facilitation of delayed spontaneous alternation behavior in adult rats following early hydroxyzine treatment: differential sensitivity in late infancy.

abstract：:The present experiment examined effects of nicotine on body weight of male and female rats when Oreo cookies, potato chips, laboratory chow, and water were available. Body weight and eating behavior were measured for 17-day periods before, during, and after nicotine or saline administration. There was an inverse relat...

journal_title：Psychopharmacology

authors： Grunberg NE,Popp KA,Winders SE

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Higher rates of delay discounting, or impulsive choice, may be related to relapse during abstinence reinforcement interventions for cigarette smoking, and a transdermal nicotine patch may attenuate delay discounting. OBJECTIVE:The objectives of this study are to assess the relation between delay discounting ...

journal_title：Psychopharmacology

authors： Dallery J,Raiff BR

更新日期：2007-03-01 00:00:00

abstract：:CSF GABA levels were not significantly different in a group of drug-free psychotic patients compared to a group of psychotic patients at two points during haloperidol treatment or a neurological comparison group. In the untreated group, CSF GABA was significantly negatively correlated with clinical ratings of anxiety ...

journal_title：Psychopharmacology

authors： Bowers MB Jr,Gold BI,Roth RH

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Accumulating evidence for the presence of GABA(A) ρ receptors within the amygdala which differ from other members of the GABA(A) receptor family in both subunit composition and functional properties has been recently obtained. OBJECTIVES:This work was conducted to study whether GABA(A) ρ receptors may have a...

journal_title：Psychopharmacology

authors： Flores-Gracia C,Nuche-Bricaire A,Crespo-Ramírez M,Miledi R,Fuxe K,Pérez de la Mora M

更新日期：2010-12-01 00:00:00

abstract：RATIONALE:Buprenorphine is an opioid agonist-antagonist under development in the United States as a sublingual medication for treatment of opioid dependence. Buprenorphine may be abused; therefore, tablets combining buprenorphine with naloxone have been developed with the intent of reducing the abuse risk in people phy...

journal_title：Psychopharmacology

authors： Strain EC,Stoller K,Walsh SL,Bigelow GE

更新日期：2000-03-01 00:00:00

abstract：RATIONALE:Neuroanatomical evidence suggests that GABAergic deficits and progressive cortical atrophy occur with schizophrenia. OBJECTIVE:To evaluate the hypothesis that neurodevelopmental deficits affect neurodegeneration occurring with schizophrenia, this study examined a novel animal model for schizophrenia-related ...

journal_title：Psychopharmacology

authors： Abekawa T,Ito K,Nakato Y,Koyama T

更新日期：2011-06-01 00:00:00

abstract：:Recent work with humans and animals has suggested that the cholinergic system plays an important role in the active control of attention. This study was designed to investigate the effects of scopolamine upon subjects' ability to utilize knowledge of the spatial probability bias in a display in the detection of briefl...

journal_title：Psychopharmacology

authors： Dunne MP,Hartley LR

更新日期：1986-01-01 00:00:00

abstract：:The opioid antagonist effects of systemically administered nor-binaltorphimine (nor-BNI) were evaluated against the kappa agonists CI-977, U69,593, U50,488, ethylketocyclazocine (EKC), Mr2034 and bremazocine, the mu agonist morphine and the alkaloid delta agonist BW-373U86 in the acetic acid-induced writhing assay in ...

journal_title：Psychopharmacology

authors： Broadbear JH,Negus SS,Butelman ER,de Costa BR,Woods JH

更新日期：1994-07-01 00:00:00

abstract：RATIONALE:(1S,3aS)-8-(2,3,3,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198), a non-peptidic agonist for the opioid receptor-like1 (ORL1) receptor, exhibits anxiolytic properties in stressful conditions. OBJECTIVE:The present study was aimed at evaluating whether activation of ...

journal_title：Psychopharmacology

authors： Ciccocioppo R,Biondini M,Antonelli L,Wichmann J,Jenck F,Massi M

更新日期：2002-05-01 00:00:00

abstract：:The phase of highly focused, repetitive behavior (stereotypy) induced by amphetamine in rats emerges after an initial period of locomotor activation. To assess the neuronal correlates of this behavioral transition, single-unit activity was recorded from the dorsal striatum of awake, unrestrained rats. Units were first...

journal_title：Psychopharmacology

authors： Rebec GV,White IM,Puotz JK

更新日期：1997-04-01 00:00:00

abstract：:The four homoeopathic drugs, Gelsemium, Cannabis Indica, Graphites and Agaricus Muscarius, administered orally in 30th and 200th potencies on white rats, enhanced restraint-induced catalepsy in a similar manner to the two standard drugs pilocarpine and haloperidol (IP injection at 5 mg/kg). All the drugs tested differ...

journal_title：Psychopharmacology

authors： Sukul NC,Bala SK,Bhattacharyya B

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Hypericum perforatum L., known as St. John's wort (SJW), is used as a phytotherapeutic agent for the treatment of mild to moderate forms of depression. OBJECTIVES:The aim of the present study was to evaluate the effect of SJW extract (STW 3-VI; 250 and 500 mg/kg; p.o.) and fluoxetine (10 mg/kg, p.o.) on gene...

journal_title：Psychopharmacology

authors： Jungke P,Ostrow G,Li JL,Norton S,Nieber K,Kelber O,Butterweck V

更新日期：2011-02-01 00:00:00

abstract：:The effect of two subcutaneous injections of 0.6 mg nicotine, administered 40 min apart, was compared with placebo in four non-smoking subjects in a counter-balanced double-blind crossover design. The nicotine injections produced mean peak plasma nicotine concentrations of 5.3 ng/ml 10 min after the first injection an...

journal_title：Psychopharmacology

authors： Foulds J,McSorley K,Sneddon J,Feyerabend C,Jarvis MJ,Russell MA

更新日期：1994-06-01 00:00:00

abstract：RATIONALE:Despite the high prevalence of nicotine use in humans, robust nicotine self-administration has been difficult to demonstrate in laboratory animals. OBJECTIVES:A parametric analysis of nicotine self-administration was conducted to study its reinforcing effects in nonhuman primates. METHODS:Adult rhesus macaq...

journal_title：Psychopharmacology

authors： Kohut SJ,Bergman J

更新日期：2016-07-01 00:00:00

abstract：RATIONALE:Dopamine (DA) and glutamate (Glu) interactions in the mesocorticolimbic pathway may regulate motivation and reward and contribute to schizophrenia and drug abuse. We have recently demonstrated synergistic effects of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptor blockade and ...

journal_title：Psychopharmacology

authors： Clements RL,Greenshaw AJ

更新日期：2005-10-01 00:00:00

abstract：:Dopamine (DA), injected unilaterally into rat forebrain after pretreatment with a monoamine oxidase inhibitor, equipotently induced locomotor arousal when placed in the nucleus accumbens septi (a limbic site) and contralateral deviation of the head when placed in the corpus striatum (an extrapyramidal target); testing...

journal_title：Psychopharmacology

authors： Campbell A,Yeghiayan S,Baldessarini RJ,Neumeyer JL

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Children and adolescents will readily abuse household products that contain solvents such as toluene. It is likely that reinforcing exposures to toluene alter brain glucose metabolism. OBJECTIVE:Using an animal model of drug reinforcement, we sought to identify a metabolic signature of toluene abuse in the a...

journal_title：Psychopharmacology

authors： Schiffer WK,Lee DE,Alexoff DL,Ferrieri R,Brodie JD,Dewey SL

更新日期：2006-06-01 00:00:00

abstract：RATIONALE:Inattentional blindness (IB) is the inability to detect a salient yet unexpected task irrelevant stimulus in one's visual field when attention is engaged in an ongoing primary task. The present study is the first to examine the impact of both task difficulty and alcohol consumption on IB and primary task perf...

journal_title：Psychopharmacology

authors： Harvey AJ,Bayless SJ,Hyams G

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Although ethanol is frequently used in combination with other psychoactive drugs, the behavioral and pharmacological reasons for this form of polydrug abuse have not been well described. MATERIALS AND METHODS:Rhesus monkeys with indwelling intravenous catheters produced intravenous injections of ethanol (50...

journal_title：Psychopharmacology

authors： Winger G,Galuska CM,Hursh SR

更新日期：2007-09-01 00:00:00

abstract：:Forskolin, a diterpene isolated from the plant Coleus forskolii, activates the catalytic subunit of adenylate cyclase, resulting in a hormone receptor-independent increase in the intracellular production of cyclic AMP. This study was undertaken to assess the effect of chronic in vivo infusion of forskolin on noradrene...

journal_title：Psychopharmacology

authors： Suzdak PD,Browne RG

更新日期：1985-01-01 00:00:00

abstract：:The concentration of kynurenine in plasma from depressed patients and control subjects has been measured using a sensitive and specific method. The levels of kynurenine in the plasma of depressed patients and controls are not significantly different and are not influenced by age or sex. The severity of affective distu...

journal_title：Psychopharmacology

authors： Wood K,Harwood J,Coppen A

更新日期：1978-12-08 00:00:00

abstract：:The effect of delta 9-tetrahydrocannabinol (THC) on the locomotor activity-stimulating action of morphine has been investigated in mice. THC (10 mg/kg) has been found to potentiate morphine-induced hyperactivity. On the other hand, the stimulating action of morphine on motor activity strongly diminished in mice render...

journal_title：Psychopharmacology

authors： Ulkü E,Ayhan IH,Tulunay FC,Uran B,Kaymakçalan S

更新日期：1980-01-01 00:00:00

abstract：:Ibogaine is currently being investigated for its potential use as an anti-addictive agent. In the present study we sought to determine whether prior morphine exposure influences the ability of ibogaine to inhibit morphine-induced locomotor stimulation. Female Sprague-Dawley rats were pretreated once a day for 1-4 days...

journal_title：Psychopharmacology

authors： Pearl SM,Johnson DW,Glick SD

更新日期：1995-10-01 00:00:00

abstract：:In order to study the role of dopamine (DA) in the regulation of seizure mechanisms in man, a non-emetic dose of apomorphine, a direct stimulant of DA receptors, was administered to eight patients effected by different types of epilepsy. The EEG changes induced by apomorphine administration in comparison to those elic...

journal_title：Psychopharmacology

authors： Del Zompo M,Tocco F,Marrosu F,Passino N,Corsini GU

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:Aminoadamantanes represent a class of NMDA glutamate receptor antagonists that reduce alcohol consumption and may prevent alcohol-induced neuronal adaptations and side effects. OBJECTIVE:Behavioral specificity of memantine and amantadine on alcohol drinking in a schedule-induced polydipsia (SIP) task was inv...

journal_title：Psychopharmacology

authors： Escher T,Call SB,Blaha CD,Mittleman G

更新日期：2006-09-01 00:00:00

abstract：:Ten rats were trained to lever press for food reward on a schedule of differential reinforcement of low rates of response with a 20-s criterion (DRL 20). Ten more were trained on a new schedule of punishment, designed to be comparable to DRL 20 - differential punishment of high rates of response (DPH 20). Under this s...

journal_title：Psychopharmacology

authors： Salmon P,Gray JA

更新日期：1985-01-01 00:00:00

abstract：:Lymphocyte beta adrenergic receptor binding using [125I]CNP was determined in patients with panic disorder (N = 4) or agoraphobia with panic attacks (N = 17) and age- and sex-matched healthy subjects (N = 22). The patients showed a significantly lower number of beta-adrenergic receptor binding sites and a significantl...

journal_title：Psychopharmacology

authors： Brown SL,Charney DS,Woods SW,Heninger GR,Tallman J

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Lithium is the most widely prescribed mood stabilizer, but the precise mechanism of lithium is unresolved. OBJECTIVE:We examine the effects of the administration of therapeutically relevant concentrations of lithium on the expression of brain-derived neurotrophic factor (BDNF) and its receptor, Trk B, as wel...

journal_title：Psychopharmacology

authors： Fukumoto T,Morinobu S,Okamoto Y,Kagaya A,Yamawaki S

更新日期：2001-10-01 00:00:00

abstract：RATIONALE:Approximately 20 million adults in the USA have an alcohol use disorder (AUD). There are clinical and preclinical data suggesting that psychedelics may have benefits for AUD. OBJECTIVE:To investigate the effects of the synthetic psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) on the behavioral effects of e...

journal_title：Psychopharmacology

authors： Oppong-Damoah A,Curry KE,Blough BE,Rice KC,Murnane KS

更新日期：2019-12-01 00:00:00

abstract：:Abnormal beta-adrenergic receptor (betaAR) density in the brains of suicide victims has been reported, although results of studies are inconsistent. Ethanol modifies betaAR-mediated signal transduction. Moreover abnormal betaAR function has been implicated in alcoholism. BetaAR antagonists, which were used as ligands ...

journal_title：Psychopharmacology

authors： Gurguis GN,Turkka J,Laruelle M,Kleinman J,Linnoila M

更新日期：1999-07-01 00:00:00