Lymphocyte beta-adrenergic receptor binding in panic disorder.

abstract：RATIONALE:It has been proposed that cannabinoid-1 receptor inverse agonists might be effective for smoking cessation. We evaluated this hypothesis with the cannabinoid-1 receptor inverse agonist taranabant. METHODS:Adults who smoked > or =10 cigarettes a day for >1 year and had an expired CO level of > or =10 ppm part...

journal_title：Psychopharmacology

authors： Morrison MF,Ceesay P,Gantz I,Kaufman KD,Lines CR

更新日期：2010-04-01 00:00:00

abstract：:Rats were trained to self-stimulate by interrupting a photobeam and brain stimulation was maintained for as long as the beam of light was broken. d-Amphetamine sulphate was then administered and response rate and total duration of stimulation were recorded. Both response rate and total duration were elevated by 1.0, 2...

journal_title：Psychopharmacology

authors： Zacharko RM,Wishart TB

更新日期：1979-08-08 00:00:00

abstract：:The neurochemical specificity of physiological, biochemical, and psychological responses to dextroamphetamine was tested by pretreating volunteers with haloperidol (0.014 mg/kg IM), propranolol (0.1 mg/kg IV), thymoxamine (0.1 mg/kg IV), or placebo prior to 0.3 mg/kg IV amphetamine. Healthy volunteers (N = 12) partici...

journal_title：Psychopharmacology

authors： Nurnberger JI Jr,Simmons-Alling S,Kessler L,Jimerson S,Schreiber J,Hollander E,Tamminga CA,Nadi NS,Goldstein DS,Gershon ES

更新日期：1984-01-01 00:00:00

abstract：:5-Hydroxytryptamine1A (5-HT1A) receptors have been shown to be suppressed by corticosteroid hormones in a variety of animal experimental paradigms. It has been suggested that this effect may be central to the pathophysiology of severe clinical depressive illness, a condition in which 5-HT1A receptor function is reduce...

journal_title：Psychopharmacology

authors： Porter RJ,McAllister-Williams RH,Lunn BS,Young AH

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:To compare matched paliperidone-ER- and olanzapine-treated schizophrenic patients on measures of glucose and lipid metabolism. METHODS:Eighty hospitalized patients with schizophrenia (DSM-IV) were randomly assigned to treatment with paliperidone ER or olanzapine for a period of 12 weeks. At baseline and ever...

journal_title：Psychopharmacology

authors： Hu S,Yao M,Peterson BS,Xu D,Hu J,Tang J,Fan B,Liao Z,Yuan T,Li Y,Yue W,Wei N,Zhou W,Huang M,Xu Y

更新日期：2013-11-01 00:00:00

abstract：:EEG measures have been shown to differ in human subjects who are at genetically increased risk for the development of alcoholism. In the present study, EEG was recorded in rats that were selectively bred for alcohol-preferring (P) and nonpreferring (NP) behaviors during an ethanol self-administration paradigm. In this...

journal_title：Psychopharmacology

authors： Robledo P,Lumeng L,Li TK,Ehlers CL

更新日期：1993-01-01 00:00:00

abstract：:This study examined the possibility that amphetamine-induced stereotypy and facilitation of memory consolidation are both mediated by amphetamine's stimulation of dopaminergic activity in the caudate nucleus. In the first experiment, rats were given pairings of a tone and a shock followed by SC amphetamine (2 mg/kg). ...

journal_title：Psychopharmacology

authors： Carr GD,White NM

更新日期：1984-01-01 00:00:00

abstract：:Benzodiazepines and other compounds which act at benzodiazepine binding sites have been shown previously to attenuate the acquisition of conditioned fear in rodents when administered before the acquisition session, an effect which may parallel the disruption of human memory produced by anxiolytics and sedatives. Such ...

journal_title：Psychopharmacology

authors： Sanger DJ,Joly D,Zivkovic B

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Lysergic acid diethylamide (LSD) differs from other types of hallucinogens in that it possesses direct dopaminergic effects. The exact nature of this component has not been elucidated. OBJECTIVE:The present study sought to characterize the effects of several dopamine D(4) agonists and antagonists on the disc...

journal_title：Psychopharmacology

authors： Marona-Lewicka D,Chemel BR,Nichols DE

更新日期：2009-04-01 00:00:00

abstract：:A novel form of experimentally-induced conflict behavior based on the conditioned suppression of drinking (CSD) is described and compared with two conventional animal models of human anxiety--a modified Geller-Seifter and an Estes-Skinner (Conditioned Emotional Response) procedure. The CSD procedure offered significan...

journal_title：Psychopharmacology

authors： Kilts CD,Commissaris RL,Rech RH

更新日期：1981-01-01 00:00:00

abstract：:The in vivo potency of mazindol for binding to striatal dopamine transporters (DAT) was assessed by [123I]beta-CIT ([123I]2beta-carbomethoxy-3beta-(4-iodophenyl)tropane) single photon emission computed tomography (SPECT). Cocaine-dependent subjects (n = 12) underwent three SPECT scans; one before, between, and after s...

journal_title：Psychopharmacology

authors： Malison RT,McCance E,Carpenter LL,Baldwin RM,Seibyl JP,Price LH,Kosten TR,Innis RB

更新日期：1998-06-01 00:00:00

abstract：:Interactions of amygdala kindling and drug effects were explored in two experiments. Pretreatment with cocaine (40 mg/kg, IP) for 10 days did not significantly affect the rate of amygdala kindling compared to saline or non-kindled controls. In contrast, daily amygdala kindling with 200 microA for 0.5 s for 20 days sub...

journal_title：Psychopharmacology

authors： Post RM,Squillace KM,Pert A,Sass W

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:The endogenous oxytocin system has emerged as an inhibitor of drug-seeking and stress in preclinical models. OBJECTIVES:The goal of this study was to examine whether systemic oxytocin administration attenuated methamphetamine (METH)-seeking in rats pre-exposed to a predator odor threat. METHODS:In Experimen...

journal_title：Psychopharmacology

authors： Ferland CL,Reichel CM,McGinty JF

更新日期：2016-03-01 00:00:00

abstract：:A venous blood sample and an umbilical cord blood sample were obtained from five young women treated with the neuroleptic drug, cis(Z)-flupentixol decanoate in Viscoleo (intramuscularly) or flupentixol (orally) at the time of giving birth. In two cases amniotic fluid was also obtained, and from three of the mothers mi...

journal_title：Psychopharmacology

authors： Kirk L,Jørgensen A

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Cannabinoid antagonists purportedly have greater effects in reducing the intake of highly palatable food compared to less palatable food. However, this assertion is based on free-feeding studies in which the amount of palatable food eaten under baseline conditions is often confounded with other variables, suc...

journal_title：Psychopharmacology

authors： Buckley JL,Rasmussen EB

更新日期：2014-05-01 00:00:00

abstract：:Phenelzine (PLZ) is a non-selective monoamine oxidase (MAO) inhibitor commonly used to treat depression and panic disorder. In addition to increasing levels of biogenic amines in the brain, PLZ elevates brain levels of the amino acid gamma-aminobutyric acid (GABA; Baker et al. 1991; present study). Given the extensive...

journal_title：Psychopharmacology

authors： Parent MB,Habib MK,Baker GB

更新日期：1999-03-01 00:00:00

abstract：:In a placebo-controlled study, we investigated the influence of nicotine on late-day aviation performance in 15 non-smoking subjects. In a within-subjects design, subjects were tested on 2 days, each lasting 8 h and consisting of three 75-min simulator flights (late-afternoon practice, evening test, night test). Prior...

journal_title：Psychopharmacology

authors： Mumenthaler MS,Taylor JL,O'Hara R,Yesavage JA

更新日期：1998-11-01 00:00:00

abstract：RATIONALE:Pharmacokinetics of melatonin in children might differ from that in adults. OBJECTIVES:This study aims to establish a dose-response relationship for melatonin in advancing dim light melatonin onset (DLMO), sleep onset (SO), and reducing sleep onset latency (SOL) in children between 6 and 12 years with chroni...

journal_title：Psychopharmacology

authors： van Geijlswijk IM,van der Heijden KB,Egberts AC,Korzilius HP,Smits MG

更新日期：2010-10-01 00:00:00

abstract：RATIONALE:Stimulant medications for attention-deficit/hyperactivity disorder (ADHD) in adolescents remain controversial with respect to later development of cocaine abuse. Past research demonstrated that adolescent methylphenidate treatment increased several aspects of cocaine self-administration during adulthood using...

journal_title：Psychopharmacology

authors： Jordan CJ,Lemay C,Dwoskin LP,Kantak KM

更新日期：2016-12-01 00:00:00

abstract：:The performance of healthy volunteer subjects on an auditory latent inhibition (LI) paradigm was assessed following administration of a single oral dose of d-amphetamine or placebo. It was predicted that a low (5 mg), but not a high (10 mg), dose of d-amphetamine would disrupt LI. The prediction was supported with lef...

journal_title：Psychopharmacology

authors： Gray NS,Pickering AD,Hemsley DR,Dawling S,Gray JA

更新日期：1992-01-01 00:00:00

abstract：:This study tested placebo responses in psychomotor performance when caffeine or alcohol was expected. Fifty male university students were assigned to one of four placebo groups or to a no-treatment control group. Two groups received placebo caffeine and two received placebo alcohol. Subjects performed 12 trials on a p...

journal_title：Psychopharmacology

authors： Fillmore MT,Mulvihill LE,Vogel-Sprott M

更新日期：1994-07-01 00:00:00

abstract：:In the conditioned reinforcement paradigm, animals learn a new instrumental response reinforced solely by conditioned reward (a stimulus that has previously been associated with primary reward). It has been shown that psychostimulants potentiate responding for conditioned reward and there is evidence that the nucleus ...

journal_title：Psychopharmacology

authors： Kelley AE,Delfs JM

更新日期：1991-01-01 00:00:00

abstract：:The effects of the antiepilepsy drugs methsuximide and mephenytoin were examined in pigeons responding under a fixed-consecutive-number (FCN) schedule with and without an added external discriminative stimulus. On this schedule, food was delivered whenever subjects responded between 8 and 12 times on one response key ...

journal_title：Psychopharmacology

authors： Schlinger H,Wilkenfield J,Poling A

更新日期：1988-01-01 00:00:00

abstract：:The effects of 4 weeks of treatment with the selective monoamine oxidase (MAO) inhibiting antidepressant clorgyline and pargyline on the sleep of affectively disordered patients were studied. Both inhibitors resulted in near total suppression of REM sleep, a decrease in total sleep time, and an increase in the percent...

journal_title：Psychopharmacology

authors： Cohen RM,Pickar D,Garnett D,Lipper S,Gillin JC,Murphy DL

更新日期：1982-01-01 00:00:00

abstract：:The cataleptogenic effect of delta 9-THC was compared to its discriminative stimulus effects in rats. The ED50s for the discriminative stimulus and catalepsy were 0.8 and 4.0 mg/kg, respectively, while their time courses were very similar. The ED50 of delta 9-THC for catalepsy in experimentally naive rats was not diff...

journal_title：Psychopharmacology

authors： Prescott WR,Gold LH,Martin BR

更新日期：1992-01-01 00:00:00

abstract：:There is much evidence suggesting that the mesoamygdala dopaminergic (DAergic) system plays a crucial role in the formation and expression of fear conditioning, with both D1 and D2 receptors being involved. In addition, cannabinoid CB1 receptor (CB1R) signaling modulates DAergic pathways. The present study sought to d...

journal_title：Psychopharmacology

authors： Nasehi M,Hajian M,Ebrahimi-Ghiri M,Zarrindast MR

更新日期：2016-01-01 00:00:00

abstract：RATIONALE:Only a small percentage of individuals seeking treatment for their marijuana use achieves sustained abstinence, suggesting more treatment options are needed. OBJECTIVES:We investigated the effects of baclofen (study 1) and mirtazapine (study 2) in a human laboratory model of marijuana intoxication, withdrawa...

journal_title：Psychopharmacology

authors： Haney M,Hart CL,Vosburg SK,Comer SD,Reed SC,Cooper ZD,Foltin RW

更新日期：2010-08-01 00:00:00

abstract：RATIONALE:Reductions in cue-induced craving and subjective response to drugs of abuse are commonly used as initial outcome measures when testing novel medications for the treatment of addiction. Yet neither the relationship between these two measures at the individual level nor the moderating effects of pharmacotherapi...

journal_title：Psychopharmacology

authors： Roche DJO,Worley MJ,Courtney KE,Bujarski S,London ED,Shoptaw S,Ray LA

更新日期：2017-07-01 00:00:00

abstract：RATIONALE:The antidepressant action of acute nicotine administration in clinical and animal studies is well recognized. But the underlying mechanism for this effect has not been carefully discovered. OBJECTIVES:We attempted to evaluate the possible role of N-Methyl-D-aspartate (NMDA) receptors in the antidepressant-li...

journal_title：Psychopharmacology

authors： Haj-Mirzaian A,Kordjazy N,Haj-Mirzaian A,Ostadhadi S,Ghasemi M,Amiri S,Faizi M,Dehpour A

更新日期：2015-10-01 00:00:00

abstract：:Relationships between aging effects on apomorphine (AP)-induced stereotypy and AP concentrations in plasma and brain were studied in rats. In two separate behavioral studies, four groups of male Wistar rats (3, 6, 20, and 43 weeks of age) and two groups of female Wistar rats (5 and 35 weeks of age) were used, respecti...

journal_title：Psychopharmacology

authors： Watanabe H,Nakano S,Ogawa N

更新日期：1982-01-01 00:00:00