Abstract：
:The cataleptogenic effect of delta 9-THC was compared to its discriminative stimulus effects in rats. The ED50s for the discriminative stimulus and catalepsy were 0.8 and 4.0 mg/kg, respectively, while their time courses were very similar. The ED50 of delta 9-THC for catalepsy in experimentally naive rats was not different from that in rats trained with the drug discrimination procedure, indicating that the cataleptogenic effect was not appreciably attenuated by long-term exposure to low doses of delta 9-THC. Pharmacologically, the catalepsy produced by delta 9-THC more closely resembled that of haloperidol than of morphine, since anticholinergic pretreatment eliminated the delta 9-THC-induced catalepsy while pre-treatment with naloxone had no effect. Although the cataleptogenic effect of delta 9-THC could be pharmacologically manipulated by anticholinergic pre-treatment, its discriminative stimulus effects were not changed in the same animals. These results demonstrate that distinctive mechanisms of action exist for these cannabinoid-induced behaviors.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Prescott WR,Gold LH,Martin BRdoi
10.1007/BF02244975subject
Has Abstractpub_date
1992-01-01 00:00:00pages
117-24issue
1eissn
0033-3158issn
1432-2072journal_volume
107pub_type
杂志文章abstract：:We have previously obtained evidence that the mesoamygdaloid dopamine projection modulates the acquisition of a conditioned response (CR) elicited by presentation of a conditioned stimulus (CS) predicting the availability of a natural (sucrose) reward. This property was found to be dependent upon D3, but not D1 or D2,...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050771
更新日期：1998-12-01 00:00:00
abstract：:The effects of 6-OHDA lesions of dopamine terminals within the amygdala were investigated on i) (+) amphetamine-induced locomotor hyperactivity and ii) the acquisition of intravenous self-administration of (+) amphetamine. The lesioned rats exhibited increased locomotor activity in response to (+) amphetamine (0.75 an...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00176851
更新日期：1988-01-01 00:00:00
abstract：RATIONALE:Neurosteroids are implicated in various stages of drug dependence, including the acquisition phase, tolerance, and withdrawal. The neurosteroid allopregnanolone is also able to substitute for drugs with abuse potential and possesses reinforcing properties. OBJECTIVES:The effects of acute treatment with, and ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-0111-7
更新日期：2006-06-01 00:00:00
abstract：:Neuroleptic-free schizophrenic patients received caerulein, a potent analogue of cholecystokinin octapeptide, in a fixed- and rising-dose schedule. In addition, neuroleptic-treated patients received a single dose of the peptide with a 4-week follow-up. No significant change in mental status was observed after any of t...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00180843
更新日期：1986-01-01 00:00:00
abstract：:Chronic tolerance to ethanol-induced sleep, motor impairment (moving belt test), and hypothermia were examined in two lines of rats that had been selectively bred for their different initial sensitivities to ethanol. In agreement with previous work (Mayer et al. 1982, 1983), the least-affected (LA) rats were found to ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00432218
更新日期：1985-01-01 00:00:00
abstract：BACKGROUND:Alcohol drinking may lead to increased aggression in certain individuals, and both fighting and drinking increase levels of dopamine and serotonin in mesocorticolimbic structures. Assessing the dynamic changes in these neurotransmitters during the course of drinking and fighting has remained challenging. OB...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0637-3
更新日期：2007-04-01 00:00:00
abstract：:The effect of lithium on serotonin (5-HT)-mediated responses in the brain was assessed by measuring changes in the prolactin (PRL) and growth hormone (GH) responses to L-tryptophan (LTP) in eight normal subjects. On the 4th day of lithium treatment the PRL responses were significantly enhanced, and this enhancement wa...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00179198
更新日期：1986-01-01 00:00:00
abstract：:The effects of naloxone on diazepam-induced release of behavior in aversive situations were investigated in rats. Naloxone (0.5 and 1 mg/kg-1) suppressed diazepam-induced eating in an unfamiliar situation and reduced (1 mg/kg-1) spontaneous food intake. Naloxone (1 mg/kg-1) canceled the increased lever pressing produc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426529
更新日期：1980-01-01 00:00:00
abstract：:Serotonergic mechanisms have been implicated in the pathophysiology of depression and in the neuropharmacology of antidepressant treatment. One measure of central serotonergic function is the prolactin (PRL) response to IV L-tryptophan (L-TRP). We used the L-TRP test to assess the role of serotonin in the mechanism of...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245291
更新日期：1992-01-01 00:00:00
abstract：RATIONALE:Electronic cigarettes (ECs) are becoming popular alternatives for smokers, but there has been limited study of their abuse liability. OBJECTIVES:The objective of this study was to evaluate the abuse liability of three Vuse Solo ECs, ranging from 14 to 36 mg in nicotine content, relative to high- and low-abus...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-017-4665-y
更新日期：2017-09-01 00:00:00
abstract：RATIONALE:3,4-Methylenedioxymethamphetamine (MDMA or "ecstasy") causes serotonin neuron damage in laboratory animals. The serotonin system is known to be important in the regulation of mood. Previous research has shown that MDMA users score higher on self-report ratings of depression than controls. However, MDMA users ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1705-6
更新日期：2004-05-01 00:00:00
abstract：:The effects of dopamine agonists on self-stimulation are a matter of considerable dispute. Apomorphine has variously been reported to inhibit, have no effect on, or to facilitate lever-press self-stimulation. To investigate the possibility that these discrepancies may reflect peculiarities of the lever-press test situ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433261
更新日期：1980-01-01 00:00:00
abstract：:Passive avoidance learning was significantly impaired by atropine (5 mg/kg, IP) or scopolamine (0.5 mg/kg), but not by methyl-atropine (5 mg/kg) or methyl-scopolamine (0.5 mg/kg), from postnatal day 15 on. In contrast, an improvement was observed, not significant at 11 days and significant at 13 days, probably due to ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00449124
更新日期：1982-01-01 00:00:00
abstract：RATIONALE:New research findings in the field of neuroactive steroids strongly suggest that to understand their role in physiopathology, it is essential to accurately measure their tissue levels. Through his broad chemical expertise and extensive knowledge of steroids, Dr. Robert H. Purdy pioneered structure-activity re...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-014-3593-3
更新日期：2014-09-01 00:00:00
abstract：RATIONALE:The orexin/hypocretin system has recently been implicated in reward-seeking, especially for highly salient food and drug rewards. We reasoned that this system may be strongly engaged during periods of reward restriction, including food restriction. OBJECTIVES:This study examined the involvement of the orexin...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2902-y
更新日期：2013-03-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Footshock stress reliably reinstates heroin seeking in rats, but the time course of the development of this effect following drug withdrawal is not known. Here we studied the effect of intermittent footshock stress on reinstatement of heroin seeking following different withdrawal periods (1-66 ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100748
更新日期：2001-06-01 00:00:00
abstract：RATIONALE:Human behavioral pharmacology studies can examine how medications that target different neurotransmitter systems influence different aspects of smoking. Naltrexone and bupropion have been shown to alter ad lib smoking behavior; however, medication effects on nicotine reward in a cigarette choice paradigm have...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-004-2136-8
更新日期：2005-06-01 00:00:00
abstract：:Twelve healthy chronic schizophrenic patients were treated with the long-acting oral dopamine (DA) receptor blocker penfluridol (100 mg orally) for 6 weeks. Plasma prolactin (PRL) levels were measured during insulin-tolerance tests (ITT) performed at the end of the drug-free period (7-10 days) and during weeks 1 and 6...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427494
更新日期：1983-01-01 00:00:00
abstract：:Transdermal nicotine has been shown to relieve nicotine withdrawal and to double smoking cessation rates compared to placebo in clinical trials. A 21 or 22 mg/day dose provides a steady state serum nicotine that is less than obtained from smoking. Limited information is available about higher nicotine patch doses. To ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF02246542
更新日期：1995-12-01 00:00:00
abstract：:Diazepam-sensitive (DS) and -resistant (DR) mice were selectively bred for increased and reduced sensitivity to the ataxic effects of diazepam (40 mg/kg). Other response differences between DS and DR mice may reflect pleiotropic effects of the genes fixed during their selection. These mice were tested for their sensit...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244976
更新日期：1992-01-01 00:00:00
abstract：RATIONALE:Naturally low prepulse inhibition (PPI) in DBA/2 mice is increased by marketed antipsychotics and compounds acting at novel targets relevant to schizophrenia. Whether other mouse strains with naturally low PPI respond similarly and could be translational models of schizophrenia is unknown. OBJECTIVE:Baseline...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-011-2196-5
更新日期：2011-06-01 00:00:00
abstract：:A double-blind, placebo-controlled, cross-over study in ten normal volunteers assessed the effects of the subcutaneous administration of adrenaline on platelet MAO activity, in an attempt to replicate previous findings of increased MAO activity following adrenaline. Platelet counts, cortisol plasma concentrations, and...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00430491
更新日期：1976-11-10 00:00:00
abstract：RATIONALE:The aversive effects of ∆(9)-tetrahydrocannabinol (THC) are mediated by activity at the kappa opioid receptor (KOR) as assessed in adult animals; however, no studies have assessed KOR involvement in the aversive effects of THC in adolescents. Given that adolescents have been reported to be insensitive to the ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-3970-6
更新日期：2015-09-01 00:00:00
abstract：RATIONALE:Spontaneous fluctuations in the size of the pupil in darkness are a recognized index of sleepiness, and these fluctuations can be quantitatively measured using the pupillographic sleepiness test (PST). The central noradrenergic system is believed to play a role in the maintenance of alertness, and there is ev...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s002130000398
更新日期：2000-05-01 00:00:00
abstract：RATIONALE:3,4-Methylenedioxymethamphetamine (MDMA) produces a long-term depletion of serotonin (5-HT) in the rat brain; this depletion may have some functional consequences. OBJECTIVE:The aim of the present study was to evaluate the acute effects of MDMA on the extracellular concentrations of dopamine and 5-HT, body t...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051143
更新日期：1999-11-01 00:00:00
abstract：:The effects of benztropine, scopolamine, atropine, methylatropine, amitriptyline, phencyclidine, and meperidine were determined alone and in conjunction with a behaviorally suppressing dose (0.05 mg/kg IM) of oxotremorine in pigeons responding under a multiple fixed-ratio 30 fixed-interval 5-min schedule of grain pres...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433492
更新日期：1981-01-01 00:00:00
abstract：:Maternal pup searching behaviour of lactating house mice treated with apomorphine, haloperidol or saline was examined on a running board with a central depression as a nest. Pup searching was elicited by artificial ultrasonic stimuli: a female moved out from the nest either towards a 50 kHz tone (key stimulus) which i...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00174523
更新日期：1988-01-01 00:00:00
abstract：OBJECTIVE:The aim of our study was to test whether ketamine produces an antidepressant effect in animal model of olfactory bulbectomy and assess the role of mammalian target of rapamycin (mTOR) pathway in ketamine's antidepressant effect. METHODS:Bulbectomized (OBX) rats and sham controls were assigned to four subgrou...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4256-3
更新日期：2016-06-01 00:00:00
abstract：RATIONALE:Reductions in cue-induced craving and subjective response to drugs of abuse are commonly used as initial outcome measures when testing novel medications for the treatment of addiction. Yet neither the relationship between these two measures at the individual level nor the moderating effects of pharmacotherapi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4607-8
更新日期：2017-07-01 00:00:00
abstract：:The importance of brain noradrenaline synthesis and receptor activation for the hyperkinesia induced by carbidopa plus L-Dopa in reserpine-treated or normal mice was analyzed in four different models. After pretreatment with reserpine and the monoamine oxidase inhibitor nialamide, the hyperkinesia induced by L-Dopa (2...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426571
更新日期：1977-11-15 00:00:00
