Abstract:
RATIONALE:The orexin/hypocretin system has recently been implicated in reward-seeking, especially for highly salient food and drug rewards. We reasoned that this system may be strongly engaged during periods of reward restriction, including food restriction. OBJECTIVES:This study examined the involvement of the orexin (Orx) system in responding for sucrose, and in cue-induced reinstatement of extinguished sucrose-seeking, in ad libitum fed versus food-restricted male subjects. METHODS:Sprague-Dawley rats (n = 108) were trained to self-administer sucrose, and we determined the effects of pretreatment with the OxR1 receptor antagonist SB-334867 (SB; 10-30 mg/kg) on fixed ratio (FR) or progressive ratio (PR) sucrose self-administration, as well as on cue-induced reinstatement of sucrose-seeking. Finally, expression of the immediate early gene c-fos in Orx neurons was examined after self-administration, late extinction or cue-induced reinstatement of sucrose seeking. RESULTS:SB decreased lever responding (by about 1/3) and the number of reinforcers earned during FR, and less so during PR, schedules and decreased cue-induced reinstatement to sucrose-seeking to extinction levels, predominately in food-restricted rats. Additionally, Fos expression in Orx neurons in perifornical and dorsomedial hypothalamus was increased during extinction. CONCLUSIONS:These results indicate that signaling at the OxR1 receptor is involved in pronounced sucrose reinforcement, and reinstatement of sucrose-seeking elicited by sucrose-paired cues, in food-restricted subjects. These findings lead us to conclude that conditioned activation of Orx neurons increases motivation for food reward during food restriction.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Cason AM,Aston-Jones Gdoi
10.1007/s00213-012-2902-ysubject
Has Abstractpub_date
2013-03-01 00:00:00pages
155-65issue
1eissn
0033-3158issn
1432-2072journal_volume
226pub_type
杂志文章abstract:RATIONALE:Performance on progressive ratio schedules has been proposed as a means of assessing the effects of drugs on the value or "efficacy" of reinforcers. A mathematical model affords a basis for quantifying the effects of drugs on progressive ratio schedule performance. According to this model, the relation betwee...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-004-2049-6
更新日期:2005-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0543-8
更新日期:2006-12-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2001-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244921
更新日期:1993-01-01 00:00:00
abstract::Two experiments were conducted to test the hypothesis that tolerance to the hypothermic effect of ethanol fails to develop if rats are denied the unconditional stimulus represented by hypothermia. In both experiments, rats were injected with either ethanol (1.9 or 2.5 g/kg) or saline and given microwave hyperthermia (...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00175187
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000477
更新日期:2000-09-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00445554
更新日期:1989-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0062-z
更新日期:2005-10-01 00:00:00
abstract::Maternal pup searching behaviour of lactating house mice treated with apomorphine, haloperidol or saline was examined on a running board with a central depression as a nest. Pup searching was elicited by artificial ultrasonic stimuli: a female moved out from the nest either towards a 50 kHz tone (key stimulus) which i...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00174523
更新日期:1988-01-01 00:00:00
abstract::It has been suggested that anxiety may be a critical factor in certain forms of non-opioid environmental analgesia. In the present study, 5-min exposure to the elevated plus-maze test of anxiety (EPM) induced a mild, though enduring, elevation in tail-flick latencies in male mice. Pretreatment with the opiate antagoni...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02247133
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:Dopamine innervation of the nucleus accumbens is thought to have a major role in the biological processes underlying cocaine self-administration. Recent data suggest that dopamine innervation of the ventral pallidum (VP) may also play an important role. OBJECTIVES:This experiment was initiated to assess extr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000456
更新日期:2000-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00496071
更新日期:1979-08-08 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050999
更新日期:1999-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050536
更新日期:1998-03-01 00:00:00
abstract::In order to study trends in smoking withdrawal symptoms, 35 participants in a smoking cessation clinic completed four questionnaires daily for 2 weeks. The questionnaire dealt with a variety of symptoms which a factor analysis showed could be grouped into four factors: stimulation, desire to smoke, and physical and ps...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00634151
更新日期:1976-10-20 00:00:00
abstract::The suggestions that dopamine (DA) systems are involved in "motor control" and "reward" represent the classic working hypotheses on the behavioral functions of these systems. The research generated by these hypotheses has yielded results that are far more complicated than the simplest form of either hypothesis would i...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/BF02245133
更新日期:1992-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245494
更新日期:1992-01-01 00:00:00
abstract::Intravenous self-administration of d-amphetamine (0.25 mg/kg/injection) decreased in a dose-related fashion after injections of the dopaminergic agonists apomorphine and piribedil. The dopaminergic agonists appear to suppress amphetamine intake in the same way as do 'free' amphetamine injections, by extending drug sat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427393
更新日期:1978-07-19 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00430479
更新日期:1976-11-10 00:00:00
abstract::The novel nicotinic agonist 1-acetyl-4-methylpiperazine (AMP) has been studied in ligand-binding and behavioural studies. AMP methiodide potently inhibited [3H]-(-)-nicotine and [125I]-alpha-bungarotoxin binding to P2 membranes from rat brain and [125I]-alpha-bungarotoxin binding to rat skeletal muscles. AMP HCl also ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02251292
更新日期:1993-01-01 00:00:00
abstract:RATIONALE:Stress, a powerful precipitant of drug seeking during abstinence, may also accelerate the return to pathological patterns of intake after initial instances of drug reuse. OBJECTIVE:To explore the effect of stress on a learning process underlying relapse, this study assessed the effect of yohimbine on reacqui...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2640-1
更新日期:2012-07-01 00:00:00
abstract::Low doses of 8-OH-DPAT (62.5-250 micrograms/kg) were reinforcing in the place preference conditioning procedure, while a higher dose (1 mg/kg) supported a conditioned place aversion. The 5-HT synthesis inhibitor PCPA, and the DA antagonists pimozide and sulpiride, had no effect when administered alone, but abolished t...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244082
更新日期:1991-01-01 00:00:00
abstract:RATIONALE:Control of reward-seeking behavior under conditions of punishment is an important function for survival. OBJECTIVES AND METHODS:We designed a task in which rats could choose to either press a lever and obtain a food pellet accompanied by a footshock or refrain from pressing the lever to avoid footshock, in r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05398-7
更新日期:2020-03-01 00:00:00
abstract:RATIONALE:Clinical observations have shown that pain sensitivity is altered in some schizophrenic patients. OBJECTIVES:To study alterations in pain sensitivity, the ketamine model in schizophrenia research was employed. MATERIALS AND METHODS:Rats were subchronically injected with the dissociative anaesthetic ketamine...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0557-2
更新日期:2006-12-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245460
更新日期:1994-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1860-5
更新日期:2010-07-01 00:00:00
abstract:RATIONALE:Oleoyl glycine (OlGly), a recently discovered fatty acid amide that is structurally similar to N- acylethanolamines, which include the endocannabinoid, anandamide (AEA), as well as endogenous peroxisome proliferator-activated receptor alpha (PPARα) agonists oleoylethanolamide (OEA) and palmitoylethanolamide (...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05237-9
更新日期:2019-09-01 00:00:00