Roles of delta and mu opioid receptors in mediating the effects of enkephalins on avoidance conditioning.

abstract：:In a double-blind comparison of haloperidol decanoate and fluphenazine decanoate given 4-weekly for 60 weeks as maintenance therapy in 38 chronic schizophrenic in-patients, plasma haloperidol, fluphenazine and prolactin levels were measured at regular intervals by radioimmunoassay. After the first injection, the mean ...

journal_title：Psychopharmacology

authors： Wiles DH,McCreadie RG,Whitehead A

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Previously, we have shown that d-amphetamine (AMPH) was more potent than d-methamphetamine (METH) at increasing extracellular levels of dopamine (DA) in the prefrontal cortex (PFC) at doses that had similar effects in the nucleus accumbens. Since working memory depends on PFC DA, it was postulated that AMPH w...

journal_title：Psychopharmacology

authors： Shoblock JR,Maisonneuve IM,Glick SD

更新日期：2003-11-01 00:00:00

abstract：RATIONALE:Whilst the deleterious effects of alcohol on retrospective remembering have been widely documented, no study has yet objectively determined alcohol's effects on prospective memory (PM)--remembering to do something in the future. OBJECTIVES:With this aim, the present study determined the acute effects of alco...

journal_title：Psychopharmacology

authors： Leitz JR,Morgan CJ,Bisby JA,Rendell PG,Curran HV

更新日期：2009-08-01 00:00:00

abstract：RATIONALE:Rivastigmine patches are used for patients with Alzheimer's disease (AD), but little is known about the serum concentration of rivastigmine and its metabolite or clinical adherence in relation to skinfold thickness after rivastigmine patch application. OBJECTIVES:The aim of this study was to examine the asso...

journal_title：Psychopharmacology

authors： Chou PS,Jhang KM,Huang LC,Wang WF,Yang YH

更新日期：2019-04-01 00:00:00

abstract：:A group of 14 schizophrenics who remained symptomatic after neuroleptic treatment received either 0.02 mcg/kg CCK-8 or saline placebo intravenously. Thereafter, 13 received the alternative infusion as a crossover treatment. A second group of 16 such patients received 0.04 mcg/kg CCK-8 or saline intravenously and, ther...

journal_title：Psychopharmacology

authors： Peselow E,Angrist B,Sudilovsky A,Corwin J,Siekierski J,Trent F,Rotrosen J

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:The touchscreen continuous trial-unique non-matching-to-location task (cTUNL) has been developed to optimise a battery of tasks under NEWMEDS (Novel Methods leading to New Medication in Depression and Schizophrenia, http://www.newmeds-europe.com ). It offers novel task features of both a practical and a theor...

journal_title：Psychopharmacology

authors： Oomen CA,Hvoslef-Eide M,Kofink D,Preusser F,Mar AC,Saksida LM,Bussey TJ

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:Early onset of heroin use during adolescence might increase chances of later drug addiction. Prior work from our laboratory suggests, however, that adolescent male rats are actually less sensitive than adults to some enduring effects of heroin self-administration. In the present study, we tested two likely c...

journal_title：Psychopharmacology

authors： Doherty JM,Frantz KJ

更新日期：2013-02-01 00:00:00

abstract：INTRODUCTION:Locomotor sensitization, defined as the progressive and enduring enhancement of the motor stimulant effects elicited by repeated exposure to drugs of abuse, is the consequence of drug-induced cellular neuroadaptations that likely contribute to addictive behavior. Neuroadaptations within the dopaminergic sy...

journal_title：Psychopharmacology

authors： Morice E,Denis C,Giros B,Nosten-Bertrand M

更新日期：2010-01-01 00:00:00

abstract：RATIONALE:(1S,3aS)-8-(2,3,3,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198), a non-peptidic agonist for the opioid receptor-like1 (ORL1) receptor, exhibits anxiolytic properties in stressful conditions. OBJECTIVE:The present study was aimed at evaluating whether activation of ...

journal_title：Psychopharmacology

authors： Ciccocioppo R,Biondini M,Antonelli L,Wichmann J,Jenck F,Massi M

更新日期：2002-05-01 00:00:00

abstract：RATIONALE:Previous studies have shown that the effect of setting on drug-taking is substance specific in both humans and rats. In particular, we have shown that when the setting of drug self-administration (SA) coincides with the home environment of the rats (resident rats), the rats tend to prefer heroin to cocaine. T...

journal_title：Psychopharmacology

authors： Montanari C,Stendardo E,De Luca MT,Meringolo M,Contu L,Badiani A

更新日期：2015-07-01 00:00:00

abstract：RATIONALE:Noncontingent administration of amphetamine into the ventral striatum or systemic nicotine increases responses rewarded by inconsequential visual stimuli. When these drugs are contingently administered, rats learn to self-administer them. We recently found that rats self-administer the GABA(B) receptor agonis...

journal_title：Psychopharmacology

authors： Vollrath-Smith FR,Shin R,Ikemoto S

更新日期：2012-03-01 00:00:00

abstract：RATIONALE:The dopaminergic system, particularly D2-like dopamine receptors, has been strongly implicated in reward processing. Animal studies have emphasized the role of phasic dopamine (DA) signaling in reward-related learning, but these processes remain largely unexplored in humans. OBJECTIVES:To evaluate the effect...

journal_title：Psychopharmacology

authors： Pizzagalli DA,Evins AE,Schetter EC,Frank MJ,Pajtas PE,Santesso DL,Culhane M

更新日期：2008-02-01 00:00:00

abstract：:7-Hydroxychlorpromazine (7-OHCPZ) has been identified and quantified in CSF from chlorpromazine (CPZ)-treated schizophrenic patients. The level of the metabolite in CSF was similar to that of CPZ. In serum the amount of 7-OHCPZ was about 30% of CPZ. The concentration of 7-OHCPZ in csf was positively and significantly ...

journal_title：Psychopharmacology

authors： Alfredsson G,Lindberg M,Sedvall G

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:3,4-methylenedioxymethamphetamine (MDMA, ecstasy) produces an acute release of 5-HT in the brain, together with increased locomotion and hyperthermia. OBJECTIVE:This study examined whether the acute functional changes of locomotor activity and body temperature are related to enhanced 5-HT release induced by ...

journal_title：Psychopharmacology

authors： Rodsiri R,Spicer C,Green AR,Marsden CA,Fone KC

更新日期：2011-02-01 00:00:00

abstract：:The importance of brain noradrenaline synthesis and receptor activation for the hyperkinesia induced by carbidopa plus L-Dopa in reserpine-treated or normal mice was analyzed in four different models. After pretreatment with reserpine and the monoamine oxidase inhibitor nialamide, the hyperkinesia induced by L-Dopa (2...

journal_title：Psychopharmacology

authors： Andén NE,Strömbom U,Svensson TH

更新日期：1977-11-15 00:00:00

abstract：:Previous studies have shown that dihydropyridine (DHP) calcium channel blockers can potentiate yawning induced by apomorphine in rats. The present study was undertaken to examine whether or not this interaction was seen with other compounds that induce yawning or if it represented a specific interaction with dopaminer...

journal_title：Psychopharmacology

authors： Bourson A,Moser PC

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Training in research ethics is crucial for psychiatric investigators. Addressing ethical dimensions of human subjects research requires knowledge about the rules and norms governing research; sensitivity to ethical implications of actions; and skills in ethics problem solving. Investigators in training who ar...

journal_title：Psychopharmacology

authors： Chen DT

更新日期：2003-12-01 00:00:00

abstract：:The effects of ethanol on locomotor activity and rotarod performance were measured in the rat. Apomorphine (4 mg/kg s.c.) antagonized and pimozide (0.75 - 1.50 mg/kg s.c.) enhanced the effects of a 2 g/kg dose of ethanol on rotarod performance. No such interaction was seen with pentobarbital, 25 mg/kg, a dose sufficie...

journal_title：Psychopharmacology

authors： Bacopoulos NG,Bize I,Levine J,Van Orden LS 3rd

更新日期：1979-01-31 00:00:00

abstract：:Rats treated weekly with cumulative doses (1-100 mg/kg, IP) of naltrexone develop an enhanced sensitivity to the operant response-rate decreasing effect of naltrexone. In the present experiment the pharmacological specificity of that enhanced sensitivity was determined by testing a variety of drugs for cross-sensitivi...

journal_title：Psychopharmacology

authors： Schindler CW,Goldberg SR,Katz JL

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Relapse to smoking is often precipitated by stress, yet little is known about the effects of nicotine withdrawal on responses to acute stress, or whether nicotine replacement reverses withdrawal-induced changes in stress response. OBJECTIVES:The aim of the present study is to use an effective social stressor...

journal_title：Psychopharmacology

authors： Wardle MC,Munafò MR,de Wit H

更新日期：2011-11-01 00:00:00

abstract：:The action of copper (CuSO4, 5 mg/kg, oral) on selected neuropharmacological actions of cannabis resin (CI, oral) was studied on albino rats and mice. Copper potentiated the barbiturate hypnosis-potentiating activity of CI in albino rats and mice and had no effect on hypothermic activity in albino rats. Single doses o...

journal_title：Psychopharmacology

authors： Singh PP,Das PK

更新日期：1978-04-11 00:00:00

abstract：:In neuroleptic therapy for psychotic illness, clinical improvement is produced more slowly than is central dopamine blockade, and its time course is highly variable between patients. A theory of neuroleptic-responsive psychotic illness thus requires more than dopamine blockade, though that appears to be the first step...

journal_title：Psychopharmacology

authors： Miller R

更新日期：1987-01-01 00:00:00

abstract：:Rats were made hyperphagic by 6-hydroxydopamine (6-OHDA) injected bilaterally into the ventral midbrain; then they were restricted to a 6 h/day feeding schedule and tested for appetite suppression with amphetamine and fenfluramine in randomized order. Amphetamine anorexia was diminished while fenfluramine anorexia was...

journal_title：Psychopharmacology

authors： Ahlskog JE,Randall PK,Hernandez L,Hoebel BG

更新日期：1984-01-01 00:00:00

abstract：:ApolipoproteinE (ApoE) genotype has recently been identified as a major risk factor for Alzheimer's disease (AD) but the mechanism(s) by which ApoE isoforms influence this disease remain unclear. Recent studies suggest that mice deficient in ApoE may exhibit impaired central cholinergic function. Since this neurotrans...

journal_title：Psychopharmacology

authors： Anderson R,Higgins GA

更新日期：1997-07-01 00:00:00

abstract：:This study describes specific behaviours in guinea-pigs after dopamine D-1 and D-2 receptor activation which differed to those described in other rodent species. Intraperitoneal (IP) administration of the dopamine D-2 receptor agonist quinpirole (1.5, 3 and 6 mg/kg) to guinea-pigs dose-dependently initiated locomotor ...

journal_title：Psychopharmacology

authors： Brent PJ

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:It has been suggested that GABA(B) receptors may be part of a neural substrate mediating some of the effects of ethanol. OBJECTIVE:The purpose of this experiment was to investigate, in mice, the effects of ethanol on working memory in a delayed matching-to position (DMTP) task, and additionally to determine ...

journal_title：Psychopharmacology

authors： Escher T,Mittleman G

更新日期：2004-11-01 00:00:00

abstract：RATIONALE:Orexins A and B have recently been discovered and shown to be derived from preproorexin, primarily expressed in the rat hypothalamus. Orexin-A has been ascribed a number of in vivo functions in the rat after intracerebroventricular (ICV) administration, including hyperphagia, neuroendocrine modulation and, mo...

journal_title：Psychopharmacology

authors： Duxon MS,Stretton J,Starr K,Jones DN,Holland V,Riley G,Jerman J,Brough S,Smart D,Johns A,Chan W,Porter RA,Upton N

更新日期：2001-01-01 00:00:00

abstract：RATIONALE:Perphenazine, a classical antipsychotic drug, has the potential to induce extrapyramidal side effects (EPS). Dopaminergic and serotonergic pathways are involved in the therapeutic and adverse effects of the drug. OBJECTIVES:To evaluate the impact of polymorphisms in the dopamine D(2) and D(3) and serotonin 2...

journal_title：Psychopharmacology

authors： Gunes A,Scordo MG,Jaanson P,Dahl ML

更新日期：2007-03-01 00:00:00

abstract：:Recent studies indicate that some aspects of memory can be enhanced by the administration of oxygen or glucose. Considering the dependency of glucose metabolism upon oxygen supply, the present study predicted that administering a combination of 100% oxygen with glucose would have greater memory-enhancing effects than ...

journal_title：Psychopharmacology

authors： Winder R,Borrill J

更新日期：1998-04-01 00:00:00

abstract：RATIONALE:A glutamate-dopamine interaction has been implicated in the psychosis-like effects of glutamate N-methyl- D-aspartate (NMDA) receptor antagonists, such as phencyclidine and ketamine. However, recent imaging studies addressing striatal glutamate-dopamine interaction directly in vivo in man have been controvers...

journal_title：Psychopharmacology

authors： Aalto S,Hirvonen J,Kajander J,Scheinin H,Någren K,Vilkman H,Gustafsson L,Syvälahti E,Hietala J

更新日期：2002-12-01 00:00:00