Abstract:
:This study describes specific behaviours in guinea-pigs after dopamine D-1 and D-2 receptor activation which differed to those described in other rodent species. Intraperitoneal (IP) administration of the dopamine D-2 receptor agonist quinpirole (1.5, 3 and 6 mg/kg) to guinea-pigs dose-dependently initiated locomotor activity and other behaviours including rearing, head-down sniffing, chewing, circling, licking and head/body shaking. Locomotor activity induced by quinpirole (3 mg/kg) was reduced by the D-2 receptor antagonists sulpiride, (100 mg/kg IP) and raclopride (10 mg/kg IP). The dopamine D-1 receptor agonist SKF 38393 (8, 16 and 32 mg/kg IP) produced little or no behavioural effect, nor did the D-1 receptor antagonist SCH 23390 (0.2 and 0.4 mg/kg IP). A 16 mg/kg dose of SKF 38393, given in combination with 3 mg/kg quinpirole, produced responses similar to quinpirole alone, whereas 32 mg kg SKF 38393 combined with quinpirole induced vacuous oral chewing, with attenuation of locomotor activity and circling, but not other behaviours produced by this dose of quinpirole. In contrast to previous studies in rats, the responses to quinpirole (3 mg/kg) were not significantly affected by SCH 23390 (0.2 and 0.4 mg/kg). It is concluded that the guinea-pig may be a useful and interesting species for study of the behavioural effects of D-1 and D-2 agonists and antagonists, as its responses appear to differ from those of other rodent species, but are similar to some responses to D-1 agonists observed in primates.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Brent PJdoi
10.1007/BF02244179subject
Has Abstractpub_date
1991-01-01 00:00:00pages
201-7issue
2eissn
0033-3158issn
1432-2072journal_volume
104pub_type
杂志文章abstract::We examined the possibility that anoxia at birth can alter behavioral sensitization to amphetamine during adulthood. Male rats born either vaginally or by Cesarean section with or without an additional 15-min period of anoxia received five once-daily injections of either d-amphetamine (2.0 mg/kg, i.p.) or vehicle or n...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050419
更新日期:1997-10-01 00:00:00
abstract:RATIONALE:Memories can return to a labile state and become amenable to modification by pharmacological and behavioral manipulations after retrieval. This process may reduce the impact of aversive memories and provide a promising therapeutic technique for the treatment of anxiety disorders. A growing body of evidence su...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-018-5074-6
更新日期:2019-01-01 00:00:00
abstract:RATIONALE:It has been demonstrated that major differences between mice of the C57BL/6J and DBA/2J inbred strains for amphetamine-induced place conditioning (preference and avoidance, respectively) are evident in standard housing conditions but abolished by temporary restricted feeding. This gene-experience model may be...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1647-z
更新日期:2004-03-01 00:00:00
abstract::The effects of alcohol on locomotor activity of group- and individually-housed mice were studied using direct ethological observations, including a detailed postural analysis and measures of both locomotion and immobility. Ethanol (0, 0.5, 1.0 and 2.0 g/kg, IP) was given to subjects placed alone in a novel cage, and v...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00464793
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:Marijuana and alcohol, when used separately and in combination, contribute to automobile accidents and failed sobriety tests of standing balance. However, the extent to which the drugs have additive effects on both of these measures is unknown. OBJECTIVES:This study was designed to compare directly the separ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-002-1124-0
更新日期:2002-10-01 00:00:00
abstract::The tricyclic anticonvulsant carbamazepine (CBZ) is effective in pain and affective disorder, but the mechanism of action for this drug has not been defined. Recently it was reported that CBZ had interaction with adenosine receptor, which is related to the inhibition of release of neurotransmitter. In the present stud...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00179186
更新日期:1986-01-01 00:00:00
abstract::Fluctuations in extracellular dopamine and DOPAC levels in nucleus accumbens septi (NAS) were monitored in 1-min microdialysis samples taken from rats engaged in intravenous cocaine self-administration. For four rats the dose per injection was fixed at 2.0 mg/kg; for four others the dose per injection was varied irreg...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246140
更新日期:1995-07-01 00:00:00
abstract::We examined whether any locus postsynaptic to the GABAergic striatonigral projection might be involved in the enhancement of behavioral response to dopaminergic stimulants induced by chronic treatment with either neuroleptic drugs or stimulants. Rats exposed chronically to either chlorpromazine or cocaine were tested ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00212767
更新日期:1988-01-01 00:00:00
abstract::Preclinical studies have exploded our knowledge about the behavioral and biological underpinnings of alcoholism. These studies suggest that certain neurotransmitters, particularly those interacting with the opioid, N-methyl-D-aspartate, and monoamine systems, may play a critical role in the expression of alcohol-drink...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s002130000371
更新日期:2000-05-01 00:00:00
abstract::Pigeons trained under a two-key drug discrimination procedure eventually learned to discriminate 5 mg/kg phenytoin from saline injections. When 1.25-20 mg/kg doses of phenytoin were substituted for the training dose, the percentage of responses directed to the phenytoin-appropriate key varied directly with dose. Chlor...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433021
更新日期:1983-01-01 00:00:00
abstract:RATIONALE:Neuroactive derivatives of steroid hormones, neurosteroids, can act on GABAA receptors (GABAARs) to potentiate the effects of GABA on these receptors. Neurosteroids become elevated to physiologically relevant levels under conditions characterized by increased steroid hormones. There is considerable evidence f...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-013-3423-z
更新日期:2014-09-01 00:00:00
abstract:RATIONALE:Both methylphenidate (MPH), a catecholamine reuptake blocker, and guanfacine, an alpha2A agonist, are used to treat attention-deficit hyperactivity disorder (ADHD). Childhood impulsivity, including delay discounting, is associated with increased substance use during adolescence. These effects can be mitigated...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5096-0
更新日期:2019-02-01 00:00:00
abstract::Phencyclidine (PCP) and sigma ligands produce a typical excitatory behaviour in rats, characterized by circling and head- and body-weaving. Excitatory amino acid antagonists such as 2-amino 5-phosphonovaleric acid (AP5) or 3-(+/-)-2-carboxypiperazin-4-yl)propyl-l-phosphonic acid (CPP) also produce a PCP-like excitator...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244368
更新日期:1991-01-01 00:00:00
abstract::Male volunteer subjects smoked one marijuana cigarette containing 100, 200, or 250 micrograms/kg delta-9-tetrahydrocannabinol (THC) and were tested on three perceptual-motor performance measures related to driving. Performance was measured and blood samples were collected for 24 h after smoking. The covariation betwee...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00427321
更新日期:1985-01-01 00:00:00
abstract:RATIONALE:Cortisol levels rise sharply immediately after electroconvulsive therapy (ECT); the resultant stimulation of steroid receptors in the hippocampus may be beneficial or harmful to cognition, depending on the magnitude of the stimulation. Steroid mechanisms may therefore modulate ECT-induced amnesia. OBJECTIVES...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0593-y
更新日期:2007-01-01 00:00:00
abstract:RATIONALE:The positive modulation of gamma-aminobutyric acid type-A (GABAA) receptors is a putative mechanism via which alcohol escalates aggressive behavior. Broad-spectrum benzodiazepine antagonists block alcohol-heightened aggression in rats and monkeys. However, the degree to which GABAA subunit composition plays a...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1661-1
更新日期:2004-03-01 00:00:00
abstract::The interaction between pimozide (a selective D2-dopamine receptor antagonist) and d-amphetamine on the operant performance of rats maintained under variable-interval schedules of positive reinforcement was examined. In Experiment 1, eight rats responded under variable-interval 30-s and variable-interval 300-s. Pimozi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00217071
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:The nicotine delivery rate is a key feature of tobacco product design, yet there have been limited human studies examining the effects of nicotine as a function of delivery rate. OBJECTIVE:We developed an intravenous nicotine infusion protocol to evaluate differential effects of nicotine delivery rate on sub...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05463-6
更新日期:2020-05-01 00:00:00
abstract:RATIONALE:Developmental lead exposure may alter responsiveness to cocaine well into adulthood, and ultimately influence drug-use patterns. OBJECTIVES:The present study examined the effect of perinatal lead exposure on the discriminative stimulus properties of cocaine. METHODS:Female rats were treated with 0, 8, or 16...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100877
更新日期:2001-11-01 00:00:00
abstract:RATIONALE:Cessation of daily caffeine consumption produces a withdrawal syndrome comprised of subjective symptoms and functional impairment. Few controlled studies have examined the physiological effects of caffeine withdrawal. OBJECTIVE:The present study examined the effect of caffeine withdrawal on cerebral blood fl...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002130050005
更新日期:2000-01-01 00:00:00
abstract:RATIONALE:Indirect-acting serotonin (5-HT) receptor agonists (e.g., selective 5-HT reuptake inhibitors [SSRI]) stimulate multiple 5-HT receptors, although the role of particular receptors as well as interaction(s) among different receptors in the therapeutic effects of SSRIs is not fully understood. OBJECTIVES:Relativ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-2136-9
更新日期:2011-02-01 00:00:00
abstract::We are performing a double-blind trial with inward psychiatric patients. The indication for our psychotropic or psychotherapeutic intervention is mainly severe depression (= major depressive disorders DSM III). For a 3-week trial course trazodone (400 mg daily), amitriptyline (150 mg/die) or placebo capsules were give...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00172621
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:There is evidence that mGlu2/3 receptors regulate 5-HT2A signaling, interactions that have been theorized to play a role in the antipsychotic-like effects of mGlu2/3 agonists as well as the hallucinogenic effects of 5-HT2A agonists. One approach to unraveling this interaction is through the chronic administr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-018-5118-y
更新日期:2019-02-01 00:00:00
abstract::To test the Pavlovian conditioning model of alcohol tolerance, two groups of eight male social drinkers each received five administrations of alcohol and five administrations of an equal volume of tonic each, on an alternating basis, during the initial 10-session tolerance development phase of the study. Group 1 recei...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00310519
更新日期:1986-01-01 00:00:00
abstract::Male Sprague-Dawley rats were evaluated between ages 18 and 825 days for responses to doses of haloperidol (0 and 0.05-10 mg/kg, IP). Catalepsy, ptosis, and inhibition of general motor activity showed steady decreases in sensitivity to the drug with age during the first 1.5 years of maturation, while rats older than 1...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00422406
更新日期:1981-01-01 00:00:00
abstract::The relationship between premenstrual dysphoria and alcohol acquistion and use patterns was studied in 14 women over 35 days on a clinical research ward. A 7-day drug-free baseline was followed by 21 days of alcohol availability and a post-alcohol drug-free period of 7 days. Women could earn alcohol or 50 cents for 30...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244221
更新日期:1990-01-01 00:00:00
abstract::Intact male and ovariectomized female rats were trained to lever press under a random ratio (RR) schedule of food reinforcement. Effects of different doses of pentobarbital (1-16 mg/kg) and progesterone (10-80 mg/kg) on response output were studied. Low doses of pentobarbital increased responding, high doses decreased...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00179930
更新日期:1987-01-01 00:00:00
abstract::Rats treated weekly with cumulative doses (1-100 mg/kg, IP) of naltrexone develop an enhanced sensitivity to the operant response-rate decreasing effect of naltrexone. In the present experiment the pharmacological specificity of that enhanced sensitivity was determined by testing a variety of drugs for cross-sensitivi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246951
更新日期:1993-01-01 00:00:00
abstract::Paradoxical sleep (PS) in the rat, cat and mouse is preceded and sometimes followed by a short-lasting intermediate stage (IS) characterized by high amplitude cortical spindles and low frequency theta rhythm. This stage, which is mimicked by an intercollicular transection, is massively extended at the expense of PS by...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245333
更新日期:1994-11-01 00:00:00
abstract::The relationship between changes in IV tyramine pressor sensitivity accompanying selective monoamine oxidase (MAO) inhibitor treatment and estimates of MAO-A and MAO-B inhibition in vivo were studied. Reductions in platelet MAO activity provided an index of MAO-B inhibition, while changes in plasma 3-methoxy-4-hydroxy...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431748
更新日期:1981-01-01 00:00:00