Abstract:
:In neuroleptic therapy for psychotic illness, clinical improvement is produced more slowly than is central dopamine blockade, and its time course is highly variable between patients. A theory of neuroleptic-responsive psychotic illness thus requires more than dopamine blockade, though that appears to be the first step in the therapeutic process. Some previous explanations given for the protracted time course of neuroleptic therapy are discussed, with emphasis on the hypothesis of delayed inactivation of midbrain dopamine neurones. For various reasons all explanations are unsatisfactory. An alternative hypothesis is proposed in which neuroleptic-responsive psychoses are seen as arising from a hyperactivity of the associations of thought. Such psychoses thus involve a disorder of a high-level learning process, namely the elaboration of memories of thoughts and beliefs. Neuroleptic drugs are envisaged to remedy this process, but not to eradicate the abnormal memories already formed. Psychotic symptoms may thus outlast the start of neuroleptic therapy by many weeks. It is suggested that the pharmacological characteristics of the hypothetical learning process involved in generating psychotic symptoms are analogous to those of a simpler learning process, defineable in animal experiments - namely, the reward component in instrumental conditioning. A preliminary case is made that the relative potency of different neuroleptic drugs in antipsychotic therapy can better be predicted by their relative potency in retarding such a variety of learning, than by other behavioural tests of these drugs.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Miller Rdoi
10.1007/BF00176470subject
Has Abstractpub_date
1987-01-01 00:00:00pages
405-15issue
4eissn
0033-3158issn
1432-2072journal_volume
92pub_type
杂志文章,评审abstract::The effects of long-term amphetamine treatment were evaluated on responding supported by self-stimulation of the substantia nigra. Rats repeatedly treated with d-amphetamine, and tested with a low dose of the drug that ordinarily has no behavioral effect, showed higher response rates than animals repeatedly treated wi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426653
更新日期:1980-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/BF00310526
更新日期:1986-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1007/BF02246668
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journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-009-1544-1
更新日期:2009-08-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2004-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00422418
更新日期:1981-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02245204
更新日期:1994-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439271
更新日期:1983-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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更新日期:2008-07-01 00:00:00
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更新日期:2015-06-01 00:00:00
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更新日期:2002-03-01 00:00:00
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更新日期:2013-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
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更新日期:2002-10-01 00:00:00
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更新日期:2017-02-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433038
更新日期:1979-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-002-1202-3
更新日期:2002-10-01 00:00:00