Restoration of brain myo-inositol levels in rats increases latency to lithium-pilocarpine seizures.

Abstract:

:Lithium pretreatment in rats potentiates the epileptogenic effects of pilocarpine and other cholinergic agonists. In order to determine if this effect of lithium could be reversed by myo-inositol, rats were pretreated with intracerebroventricular (ICV) injections of myoinositol, artificial CSF or L-chiro-inositol. Lithium chloride, 3 meq/kg was administered intraperitoneally 20-24 h prior to the subcutaneous injection of pilocarpine, 20 or 30 mg/kg. In both experiments, myo-inositol significantly prolonged the latency to the appearance of clonic seizures and lowered the pilocarpine seizure score. myo-Inositol prevented the development of clonic seizures in 50% of the rats receiving pilocarpine, 20 mg/kg. The levels of cortical myo-inositol in rats injected with myo-inositol were approximately double those of the CSF and L-chiro-inositol groups.

journal_title

Psychopharmacology

authors

Kofman O,Sherman WR,Katz V,Belmaker RH

doi

10.1007/BF02246978

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

229-34

issue

1-2

eissn

0033-3158

issn

1432-2072

journal_volume

110

pub_type

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