Characterization of the discriminative stimulus effects of buprenorphine in pigeons.

abstract：RATIONALE:Antidepressants are known to modify human sleep patterns. OBJECTIVES:Duloxetine is a new antidepressant with a mechanism of action involving reuptake inhibition of both serotonin (5-HT) and norepinephrine (NE). In this study, the effects of two dosing regimens of duloxetine on sleep electroencephalography (E...

journal_title：Psychopharmacology

authors： Chalon S,Pereira A,Lainey E,Vandenhende F,Watkin JG,Staner L,Granier LA

更新日期：2005-02-01 00:00:00

abstract：RATIONALE:Chronic stress and corticosterone have been shown to affect serotonin (5-HT) neurotransmission; however, the influence of stress on the activity of the dorsal raphe nucleus (DRN), the main source of 5-HT in the forebrain, is not well understood. In particular, it is unknown if and how stress modifies DRN 5-HT...

journal_title：Psychopharmacology

authors： Sowa J,Kusek M,Siwiec M,Sowa JE,Bobula B,Tokarski K,Hess G

更新日期：2018-12-01 00:00:00

abstract：RATIONALE:Cue-elicited craving and stress responses have been identified as predictors of relapse in drug dependence, but little research exists on the contribution of these factors to marijuana use specifically. OBJECTIVES:The aims of the present study were to evaluate (1) responses to a psychological stressor, (2) r...

journal_title：Psychopharmacology

authors： McRae-Clark AL,Carter RE,Price KL,Baker NL,Thomas S,Saladin ME,Giarla K,Nicholas K,Brady KT

更新日期：2011-11-01 00:00:00

abstract：:Patients who develop persistent parkinsonism while on chronic neuroleptic therapy may be predisposed towards the development of tardive dyskinesia (TD). We investigated this issue in an animal model of TD by examining the association between catalepsy and the syndrome of neuroleptic-induced vacuous chewing movements (...

journal_title：Psychopharmacology

authors： Hyde TM,Egan MF,Wing LL,Wyatt RJ,Weinberger DR,Kleinman JE

更新日期：1995-03-01 00:00:00

abstract：:Seven neuroleptic-free schizophrenic patients received bromocriptine and eight schizophrenic patients received CF 25-397, both ergot derivatives with dopamine agonist activity. Psychosis failed to improve in response to either drug at the relatively low doses administered. Unlike the antipsychotic property of apomorph...

journal_title：Psychopharmacology

authors： Tamminga CA,Schaffer MH

更新日期：1979-01-01 00:00:00

abstract：RATIONALE:Although environmental enrichment renders rats more sensitive to the neurobehavioral effects of acute amphetamine, a previous study found that enriched rats self-administer less amphetamine than isolated rats at a low unit dose (0.03 mg/kg per infusion). In that study, however, acquisition of self-administrat...

journal_title：Psychopharmacology

authors： Green TA,Gehrke BJ,Bardo MT

更新日期：2002-08-01 00:00:00

abstract：RATIONALE:Dysfunction of glutamatergic neurotransmission has been implicated in the pathophysiology of obsessive-compulsive disorder (OCD) and recent clinical reports suggest that some glutamate modulating agents are efficacious in the treatment of this disorder. N-acetylcysteine (NAC) is a readily available amino acid...

journal_title：Psychopharmacology

authors： Lafleur DL,Pittenger C,Kelmendi B,Gardner T,Wasylink S,Malison RT,Sanacora G,Krystal JH,Coric V

更新日期：2006-01-01 00:00:00

abstract：RATIONALE:Studies about whether or not the cognitive performance of women is influenced by changes in levels of sex steroid hormones across the menstrual cycle have produced ambiguous results. OBJECTIVES:This study tested whether flight simulator performance differs significantly between the menstrual and the luteal p...

journal_title：Psychopharmacology

authors： Mumenthaler MS,O'Hara R,Taylor JL,Friedman L,Yesavage JA

更新日期：2001-05-01 00:00:00

abstract：:Each morning eight adults with caffeine versus placebo discrimination histories ingested letter-coded capsules containing 100 mg caffeine or placebo and then engaged in a relaxation or vigilance activity. Subjects were first exposed to caffeine and placebo once each with each activity. Then each day for 10 days subjec...

journal_title：Psychopharmacology

authors： Silverman K,Mumford GK,Griffiths RR

更新日期：1994-04-01 00:00:00

abstract：:In a 4 week study of the response of neurotic outpatients to treatment with amitriptyline, diazepam, amitriptyline and diazepam, or placebo clinical and psychophysiological variables and plasma levels of the drug were assessed. Clinical improvements were substantial in all treatment groups but clear relationships betw...

journal_title：Psychopharmacology

authors： Johnstone EC,Bourne RC,Crow TJ,Frith CD,Gamble S,Lofthouse R,Owen F,Owens DG,Robinson J,Stevens M

更新日期：1981-01-01 00:00:00

abstract：:The glutamatergic cortico-striatal and subthalamo-entopeduncular pathways are both overactive in parkinsonism. Previous behavioural investigations have shown that intra-entopeduncular injection of either NMDA-site or glycine-site antagonists results in alleviation of parkinsonian symptoms, although injection of the fo...

journal_title：Psychopharmacology

authors： Carroll CB,Holloway V,Brotchie JM,Mitchell IJ

更新日期：1995-05-01 00:00:00

abstract：RATIONALE:The cholinergic system is linked extensively to memory, but its exact role remains controversial. In particular, scopolamine-induced impairment in rodents is not task specific, which may be due to difficulty in developing rodent protocols to assess deficits in recent memory, in which the remembered event is b...

journal_title：Psychopharmacology

authors： Araujo JA,Chan AD,Winka LL,Seymour PA,Milgram NW

更新日期：2004-08-01 00:00:00

abstract：:Intact male and ovariectomized female rats were trained to lever press under a random ratio (RR) schedule of food reinforcement. Effects of different doses of pentobarbital (1-16 mg/kg) and progesterone (10-80 mg/kg) on response output were studied. Low doses of pentobarbital increased responding, high doses decreased...

journal_title：Psychopharmacology

authors： Heinsbroek RP,van Haaren F,Zantvoord F,van de Poll NE

更新日期：1987-01-01 00:00:00

abstract：:Administration of drugs that reduce the influence of dopamine at its receptor site can lead to postsynaptic supersensitivity, whereas treatment with dopamine (DA) agonists can cause postsynaptic subsensitivity. Both unaltered and enhanced postsynaptic responses to DA have been shown after pretreatment with DA agonists...

journal_title：Psychopharmacology

authors： Castro R,Abreu P,Calzadilla CH,Rodriguez M

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:The elevated plus-maze and the light/dark box are two established anxiety tests in rodents, which are useful to screen putative anxiogenic effects of drugs. OBJECTIVE:Caffeine is well known to promote anxious behaviour in humans and animal models, but the precise site of action of the drug is still a matter ...

journal_title：Psychopharmacology

authors： El Yacoubi M,Ledent C,Parmentier M,Costentin J,Vaugeois JM

更新日期：2000-02-01 00:00:00

abstract：:A neutral stimulus can acquire conditioned rewarding properties through association with an intrinsically rewarding stimulus. The acquisition of responding for conditioned rewards requires that environmental stimuli and reward processes interact in a highly specific manner; analyses of this phenomenon may provide valu...

journal_title：Psychopharmacology

authors： Sutton MA,Beninger RJ

更新日期：1999-05-01 00:00:00

abstract：:This study investigated behavioural effects of very potent 5-HT reuptake inhibitors after acute treatment (cianopramine and citalopram), as well as after chronic treatment (cianopramine), in two behavioural models of anxiety: 1) the light/dark choice procedure in mice and 2) the elevated plus-maze test in rats. In add...

journal_title：Psychopharmacology

authors： Griebel G,Moreau JL,Jenck F,Misslin R,Martin JR

更新日期：1994-01-01 00:00:00

abstract：:The mesolimbic dopamine (DA) system has been implicated in conditioned reward (CR), locomotor sensitization, and the reinforcing properties of psychomotor stimulants. Stimuli with formerly motivationally neutral properties that gain incentive properties by their predictive association with primary reinforcers are term...

journal_title：Psychopharmacology

authors： Taylor JR,Horger BA

更新日期：1999-02-01 00:00:00

abstract：RATIONALE:Vasopressin (AVP) plays a role in regulating anxiety, which is thought to be partially mediated through the V1a receptor. Recently, JNJ-17308616 was identified as a V1a antagonist. OBJECTIVES:The purpose of this work was to assess V1a receptor affinity and selectivity of JNJ-17308616 and in vivo efficacy in ...

journal_title：Psychopharmacology

authors： Bleickardt CJ,Mullins DE,Macsweeney CP,Werner BJ,Pond AJ,Guzzi MF,Martin FD,Varty GB,Hodgson RA

更新日期：2009-03-01 00:00:00

abstract：:The pharmacokinetic and pharmacodynamic effects of concomitant administration of alprazolam and fluoxetine were studied in this double-blind parallel study in 80 healthy, male volunteers. Subjects were randomly assigned to one of four treatment groups. Drug treatments consisted of 4-day regimens of 1 mg alprazolam fou...

journal_title：Psychopharmacology

authors： Lasher TA,Fleishaker JC,Steenwyk RC,Antal EJ

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Paired-associate learning (PAL), as part of the Cambridge Neuropsychological Test Automated Battery, is able to predict who from an at-risk population will develop Alzheimer's disease. Schizophrenic patients are also impaired on this same task. An automated rodent model of PAL would be extremely beneficial in...

journal_title：Psychopharmacology

authors： Talpos JC,Winters BD,Dias R,Saksida LM,Bussey TJ

更新日期：2009-07-01 00:00:00

abstract：:The effects of diazepam (10 mg orally) on the responding of normal human volunteers was studied in a procedure that involved the maintenance of operant behavior by monetary reinforcement and its suppression by monetary loss (punishment). Diazepam produced an antipunishment effect as shown by an increase in behavior su...

journal_title：Psychopharmacology

authors： Carlton PL,Siegel JL,Murphree HB,Cook L

更新日期：1981-01-01 00:00:00

abstract：:Chlordiazepoxide (CDP) and amphetamine (AMPH) were tested, alone or in combination, in BALB/c mice pretreated with alpha-methyl-p-tyrosine (AMT) and subjected to shuttle-box avoidance training. CDP and AMPH, given alone, partly reversed avoidance depression induced by 50 mg/kg of AMT, but were ineffective in mice pret...

journal_title：Psychopharmacology

authors： Sansone M,Renzi P

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Abstinence from drug occurs in human addicts for several reasons, including the avoidance of adverse consequences. OBJECTIVES:To explore a model of drug use in the face of adverse consequences in rats through intermittent punishment of drug seeking and to investigate whether the ability to withhold seeking r...

journal_title：Psychopharmacology

authors： Pelloux Y,Everitt BJ,Dickinson A

更新日期：2007-09-01 00:00:00

abstract：:Offensive and defensive components of aggressive behavior were determined in resident and intruder mice. Withdrawal aggression was measured after the removal of a subcutaneous morphine pellet or after precipitation by naloxone in naive mice and after removal of a morphine pellet in mice with prior fighting experience....

journal_title：Psychopharmacology

authors： Kantak KM,Miczek KA

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Considerable research indicates that "ecstasy" users perceive their memory for future intentions (prospective memory) to be impaired. However, only one empirical study to date has directly tested how this capacity is affected by ecstasy use, and this study provided relatively limited information regarding the...

journal_title：Psychopharmacology

authors： Rendell PG,Gray TJ,Henry JD,Tolan A

更新日期：2007-11-01 00:00:00

abstract：:The pharmacokinetics of flumazenil in the rat were determined after 2.5 mg/kg intravenous and 25 mg/kg oral administration. Following intravenous administration flumazenil was rapidly eliminated with an extremely short terminal half-life (mean +/- SE, n = 8) of 8.3 +/- 0.3 min due to a large total blood clearance of 1...

journal_title：Psychopharmacology

authors： Mandema JW,Gubbens-Stibbe JM,Danhof M

更新日期：1991-01-01 00:00:00

abstract：:A simple new method, the "tape test" has been developed for studying the enhancement of learning by drugs in "learning-dull" rats. A piece of adhesive tape is pressed on the left front pad of the rats. The time of tape removal by the animal, i.e., the problem-solving time is measured. In our experiments the selected l...

journal_title：Psychopharmacology

authors： Ezer E,Szporny L

更新日期：1976-07-09 00:00:00

abstract：RATIONALE:It is widely assumed that various forms of neural and behavioral plasticity, including sensitization, are strongly dependent on the activation of N-methyl-D-aspartate (NMDA)-receptors, but evidence also exists to suggest that not all forms of sensitization are unequivocally blocked by NMDA-receptor antagonism...

journal_title：Psychopharmacology

authors： Tzschentke TM,Schmidt WJ

更新日期：2000-08-01 00:00:00

abstract：RATIONALE:Previous studies from our laboratory and others have indicated a role for the hypothalamo-pituitary-adrenal (HPA) axis in the extinction/reinstatement animal model of cocaine relapse OBJECTIVE:This present study was designed to investigate the potential role for the HPA axis in the cue- and methamphetamine-i...

journal_title：Psychopharmacology

authors： Moffett MC,Goeders NE

更新日期：2007-02-01 00:00:00