Abstract:
:This study investigated behavioural effects of very potent 5-HT reuptake inhibitors after acute treatment (cianopramine and citalopram), as well as after chronic treatment (cianopramine), in two behavioural models of anxiety: 1) the light/dark choice procedure in mice and 2) the elevated plus-maze test in rats. In addition, the responses of mice to novelty in a free exploration paradigm were assessed after acute administration of both drugs. A single injection of cianopramine or citalopram increased neophobic reactions in the free exploration test. Furthermore, these drugs increased the avoidance reaction to a brightly illuminated chamber in the light/dark choice procedure as well as to open arms in the elevated plus-maze test. In contrast, after chronic treatment (10 mg/kg IP, once daily for 21 days) of cianopramine, anxiogenic-like effects were no longer produced in the light/dark choice paradigm whereas in the elevated plus-maze test, anxiolytic-like effects appeared. These results shed more light on the 5-HT hypothesis of anxiety, insofar as the increased availability of 5-HT resulting here from reuptake inhibition seems to initially result in an increased emotional reactivity which, however, subsequently disappears during chronic treatment.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Griebel G,Moreau JL,Jenck F,Misslin R,Martin JRdoi
10.1007/BF02245224subject
Has Abstractpub_date
1994-01-01 00:00:00pages
463-70issue
3-4eissn
0033-3158issn
1432-2072journal_volume
113pub_type
杂志文章abstract::Acamprosate (calcium-acetyl homotaurinate) is a new compound used in the treatment of alcohol abuse. Because of the putative link between alcoholism and the endogenous opioid systems in both humans and laboratory animals, we tested in rats the effects of acamprosate on behavioral and neurochemical effects of opioid dr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050730
更新日期:1998-10-01 00:00:00
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更新日期:2000-10-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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abstract:RATIONALE:Research suggests the experimental manipulation of oxytocin facilitates positive interactions, cooperation, and trust. The mechanism by which oxytocin influences social behavior is not well understood. OBJECTIVE:We explored the hypothesis that oxytocin alters how people perceive themselves, which could be on...
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pub_type: 杂志文章,随机对照试验
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doi:10.1007/BF02244569
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journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00433261
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1978-06-15 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1980-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00210846
更新日期:1987-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3793-x
更新日期:2015-05-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00439101
更新日期:1977-04-29 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-002-1364-z
更新日期:2003-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02246077
更新日期:1995-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00213-005-0100-x
更新日期:2006-06-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00212767
更新日期:1988-01-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1998-01-01 00:00:00
abstract:RATIONALE:Serotonin (5-HT) plays a key role in different aspects of value-based decision-making. A recent framework proposed that tonic 5-HT (together with dopamine, DA) codes future average reward expectations, providing a baseline against which possible choice outcomes are compared to guide decision-making. OBJECTIV...
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pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05418-6
更新日期:2020-03-01 00:00:00
abstract:RATIONALE:The startle reflex to a sudden intense acoustic pulse stimulus is attenuated if the pulse is shortly preceded by a weak prepulse stimulus. This represents a form of sensory gating, known as prepulse inhibition (PPI), observable across species. PPI is modulated by dopamine and readily disrupted by acute amphet...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2819-5
更新日期:2013-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431455
更新日期:1984-01-01 00:00:00
abstract:RATIONALE:In recent years, an increasing body of evidence points to the involvement of the glutamatergic system and specifically the glutamatergic ionotropic N-methyl-D-aspartate (NMDA) receptor in the pathophysiology of obsessive-compulsive disorder (OCD). OBJECTIVES:To test the role of NMDA receptors in compulsive b...
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pub_type: 杂志文章
doi:10.1007/s00213-010-1808-9
更新日期:2010-05-01 00:00:00
abstract::Twenty-one depressed patients participated in a study that assessed the predictability of amitriptyline (AT) dosage based on plasma drug concentrations after a single dose. In 11 patients maintained on a fixed dose regimen, the 18-h single-dose level was confirmed to be predictive of steady-state levels. The dose for ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431471
更新日期:1984-01-01 00:00:00
abstract::Both muscarinic antagonists, such as scopolamine, and benzodiazepine receptor (BZR) agonists, such as diazepam, produce a reliable impairment in the performance of one trial passive avoidance. Such deficits are frequently interpreted as drug-induced amnesia. However, these deficits could also result from a learning im...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245247
更新日期:1995-03-01 00:00:00
abstract:RATIONALE:Repeated administration of psychoactive drugs results in a progressive enhancement of the behavioral effects of these compounds, a phenomenon termed sensitization. OBJECTIVE:We tested whether repeated administration of the non-competitive NMDA receptor antagonist dizocilpine (MK-801) induces sensitization of...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100776
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Acute administration of selective serotonin and noradrenaline re-uptake blockers to healthy volunteers affects the processing of emotional information but it is not known if similar effects occur with antidepressants acting through other pharmacological mechanisms. Mirtazapine is a clinically established ant...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
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更新日期:2009-05-01 00:00:00