Anxiolytic-like action of the 3-PPP enantiomers in the Vogel conflict paradigm.

abstract：:Platelet adenylate cyclase activity was measured in 16 control subjects and 16 patients who developed post-traumatic stress disorder (PTSD) as a result of damage inflicted on their homes during the Iraqi Scud missile attacks on Israel which occurred during the 1991 Gulf War. There were no differences in basal, NaF-sti...

journal_title：Psychopharmacology

authors： Weizmann R,Gur E,Laor N,Reiss A,Muller U,Yoresh A,Lerer B,Newman ME

更新日期：1994-04-01 00:00:00

abstract：RATIONALE:The role of endogenous opiate systems in cigarette smoking remains unclear. In laboratory animals, opiate antagonists block many of the effects of nicotine, but in humans they do not consistently alter smoking behavior. OBJECTIVE:This study explored the effects of naltrexone, alone and in combination with ni...

journal_title：Psychopharmacology

authors： Brauer LH,Behm FM,Westman EC,Patel P,Rose JE

更新日期：1999-04-01 00:00:00

abstract：RATIONALE:Prepulse inhibition (PPI) refers to the reduction of the startle response magnitude when a startling stimulus is closely preceded by a weak stimulus. PPI is commonly used to measure sensorimotor gating. In rats, the PPI reduction induced by the dopamine agonist apomorphine can be reversed by systemic administ...

journal_title：Psychopharmacology

authors： Larrauri JA,Burke DA,Hall BJ,Levin ED

更新日期：2015-08-01 00:00:00

abstract：RATIONALE:Vasopressin (AVP) plays a role in regulating anxiety, which is thought to be partially mediated through the V1a receptor. Recently, JNJ-17308616 was identified as a V1a antagonist. OBJECTIVES:The purpose of this work was to assess V1a receptor affinity and selectivity of JNJ-17308616 and in vivo efficacy in ...

journal_title：Psychopharmacology

authors： Bleickardt CJ,Mullins DE,Macsweeney CP,Werner BJ,Pond AJ,Guzzi MF,Martin FD,Varty GB,Hodgson RA

更新日期：2009-03-01 00:00:00

abstract：:Various doses of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, MK-801 (0.1-0.5 mg/kg) and ketamine (2.5-10 mg/kg), produced a dose-dependent increase in stereotypic behaviour in naive mice. MK-801 (0.1 mg/kg) and ketamine (2.5 mg/kg) potentiated the stereotypic response of apomorphine (0.1-0.5 ...

journal_title：Psychopharmacology

authors： Verma A,Kulkarni SK

更新日期：1992-01-01 00:00:00

abstract：:The effects of chronic lithium treatment on methylphenidate-, D1 dopamine receptor agonist (A-77636)-, and tactile stimulation-induced increases in frontal cortical acetylcholine release were studied in the rat using in vivo brain microdialysis. Cortical acetylcholine release in control rats was maximally stimulated b...

journal_title：Psychopharmacology

authors： Acquas E,Fibiger HC

更新日期：1996-05-01 00:00:00

abstract：RATIONALE:Medication and illicit drugs can have detrimental side effects which impair driving performance. A drug's impairing potential should be determined by well-validated, reliable, and sensitive tests and ideally be calibrated by benchmark drugs and doses. To date, no consensus has been reached on the issue of whi...

journal_title：Psychopharmacology

authors： Jongen S,Vuurman E,Ramaekers J,Vermeeren A

更新日期：2014-06-01 00:00:00

abstract：INTRODUCTION:Locomotor sensitization, defined as the progressive and enduring enhancement of the motor stimulant effects elicited by repeated exposure to drugs of abuse, is the consequence of drug-induced cellular neuroadaptations that likely contribute to addictive behavior. Neuroadaptations within the dopaminergic sy...

journal_title：Psychopharmacology

authors： Morice E,Denis C,Giros B,Nosten-Bertrand M

更新日期：2010-01-01 00:00:00

abstract：RATIONALE:Opioid use disorder (OUD) is a major epidemic in the USA. Despite evidence indicating that OUD may be particularly severe for women, preclinical models have yet to establish sex as a major factor in OUD. OBJECTIVES:Here, we examined sex differences in vulnerability to relapse following intermittent access fe...

journal_title：Psychopharmacology

authors： Bakhti-Suroosh A,Towers EB,Lynch WJ

更新日期：2021-01-06 00:00:00

abstract：RATIONALE:(+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, significantly reduced i.v. cocaine self-administration in a fixed-ratio (FR) schedule. Since this effect was observed studying only one dose of cocaine and considering the characteristic bell-shaped curve generated by cocaine in self-administr...

journal_title：Psychopharmacology

authors： Cervo L,Cocco A,Carnovali F

更新日期：2004-04-01 00:00:00

abstract：:Ten rats were trained to lever press for food reward on a schedule of differential reinforcement of low rates of response with a 20-s criterion (DRL 20). Ten more were trained on a new schedule of punishment, designed to be comparable to DRL 20 - differential punishment of high rates of response (DPH 20). Under this s...

journal_title：Psychopharmacology

authors： Salmon P,Gray JA

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:The beneficial effects of psychostimulant drugs in the treatment of psychiatric disorders occur because they increase the extracellular dopamine concentration by inhibiting re-uptake of extracellular dopamine at dopamine transporters. However, the psychological effects at low dopamine transporter occupancy ha...

journal_title：Psychopharmacology

authors： Kimura Y,Maeda J,Yamada M,Takahata K,Yokokawa K,Ikoma Y,Seki C,Ito H,Higuchi M,Suhara T

更新日期：2017-02-01 00:00:00

abstract：RATIONALE:Carrageenan-induced hyperalgesia is a widely used pain model in rodents. However, characteristics of carrageenan-induced hyperalgesia and effects of analgesic drugs under these conditions are unknown in nonhuman primates. OBJECTIVE:The aims of this study were to develop carrageenan-induced hyperalgesia in rh...

journal_title：Psychopharmacology

authors： Sukhtankar DD,Lee H,Rice KC,Ko MC

更新日期：2014-04-01 00:00:00

abstract：RATIONALE:Repeated high doses of morphine in the rat cause stereotypic gnawing behavior that can be re-expressed by a low dose of morphine weeks and even months after the initial treatment. The determination of the role of serotonin in this sensitized morphine-induced behavior has both empirical and theoretical relevan...

journal_title：Psychopharmacology

authors： Wennemer HK,Kornetsky C

更新日期：1999-09-01 00:00:00

abstract：RATIONALE:Cocaine addiction is a relapsing psychiatric disorder with a high prevalence in developed countries. To date, the reinstatement model has been difficult to implement in mice. The design of an appropriate reinstatement model in mice is required in order to use genetically modified animals with the aim of clari...

journal_title：Psychopharmacology

authors： Soria G,Barbano MF,Maldonado R,Valverde O

更新日期：2008-09-01 00:00:00

abstract：:Cocaine and amphetamine produce several behavioral effects, most notably locomotor stimulation. Biochemically, evidence suggests specific involvement of dopaminergic systems, although not necessarily identical sites, in mediating cocaine- and amphetamine-induced locomotor stimulation. This study examined the effects o...

journal_title：Psychopharmacology

authors： George FR,Porrino LJ,Ritz MC,Goldberg SR

更新日期：1991-01-01 00:00:00

abstract：RATIONALE:Clinically, nicotine improves attention, but this has proven difficult to demonstrate preclinically. We tested nicotine in Sprague-Dawley (SD) and Lister hooded (LH) rats in the five-choice serial reaction time task. Since SD rats demonstrate lower asymptotic performance than LH rats, we surmised that nicotin...

journal_title：Psychopharmacology

authors： Mirza NR,Bright JL

更新日期：2001-02-01 00:00:00

abstract：RATIONALE:Patients with obsessive compulsive disorder (OCD) demonstrate impaired cognition in some selected domains. Although serotoninergic dysfunction has been implicated in OCD, recent evidence suggests that dopamine may play a role as well. OBJECTIVE:The aim of the study was to evaluate learning and working memory...

journal_title：Psychopharmacology

authors： Morein-Zamir S,Craig KJ,Ersche KD,Abbott S,Muller U,Fineberg NA,Bullmore ET,Sahakian BJ,Robbins TW

更新日期：2010-10-01 00:00:00

abstract：:Food intake of four adult male baboons (Papio c. anubis) was monitored during daily experimental sessions lasting 22 h. Food was available under a two-component operant schedule. Following completion of the first "procurement component" response requirement, access to food, i.e., a meal, became available under the sec...

journal_title：Psychopharmacology

authors： Foltin RW,Fischman MW,Byrne MF

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:During the course of our investigation of antalarmin, a corticotropin-releasing hormone (CRH) antagonist, in rhesus monkeys, we noticed that large, intravenous doses of antalarmin resulted in behavioral changes that resembled intoxication. OBJECTIVES:Antalarmin was evaluated in rhesus monkeys for its reinfor...

journal_title：Psychopharmacology

authors： Broadbear JH,Winger G,Rice KC,Woods JH

更新日期：2002-11-01 00:00:00

abstract：RATIONALE:Alzheimer's disease (AD) is characterized by memory loss and synaptic damage. Previous studies suggested that xanthoceraside decreases glutamate-induced PC12 cell death, ameliorates memory deficits, and increases the number of dendritic spines in AD mice. These results indicated that xanthoceraside might have...

journal_title：Psychopharmacology

authors： Zhu L,Yang L,Zhao X,Liu D,Guo X,Liu P,Chi T,Ji X,Zou L

更新日期：2018-01-01 00:00:00

abstract：RATIONALE:Higher rates of delay discounting, or impulsive choice, may be related to relapse during abstinence reinforcement interventions for cigarette smoking, and a transdermal nicotine patch may attenuate delay discounting. OBJECTIVE:The objectives of this study are to assess the relation between delay discounting ...

journal_title：Psychopharmacology

authors： Dallery J,Raiff BR

更新日期：2007-03-01 00:00:00

abstract：:The antipsychotic drugs haloperidol and clozapine have the common action of increasing dopamine metabolism in the striatum (nucleus accumbens, caudate-putamen) of the rat. Intracerebroventricular administration of kainic acid (KA) produces neuronal loss in limbic-cortical brain regions which project directly or indire...

journal_title：Psychopharmacology

authors： Bardgett ME,Salaris SL,Jackson JL,Harding J,Csernansky JG

更新日期：1997-09-01 00:00:00

abstract：RATIONALE:Indirect-acting serotonin (5-HT) receptor agonists can enhance the antinociceptive effects of morphine; however, the specific 5-HT receptor subtype(s) mediating this enhancement is not established. OBJECTIVE:This study examined interactions between morphine and both 5-HT(1A) and 5-HT(2A) receptor agonists in...

journal_title：Psychopharmacology

authors： Li JX,Shah AP,Patel SK,Rice KC,France CP

更新日期：2013-02-01 00:00:00

abstract：RATIONALE:In Koriat's accessibility model (Koriat, Psychol Rev, 100:609-639, 1993; Koriat, J Exp Psychol Gen, 124:311-333, 1995), when a person fails to recall a required target, he or she can nevertheless provide some partial information about the target. Moreover, individuals are able to provide feeling-of-knowing (F...

journal_title：Psychopharmacology

authors： Izaute M,Bacon E

更新日期：2006-11-01 00:00:00

abstract：:We are performing a double-blind trial with inward psychiatric patients. The indication for our psychotropic or psychotherapeutic intervention is mainly severe depression (= major depressive disorders DSM III). For a 3-week trial course trazodone (400 mg daily), amitriptyline (150 mg/die) or placebo capsules were give...

journal_title：Psychopharmacology

authors： Klieser E,Lehmann E

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Multiple low doses of cocaine (COC) may cause intermittent vasoconstriction and reperfusion, leading to elevations in damaging reactive oxygen species, such as hydroxyl free radicals (*OH). Salicylate may offer protection because it reacts with *OH and/or because of its anti-inflammatory actions. OBJECTIVE:T...

journal_title：Psychopharmacology

authors： Castelli MC,Venturini L,Sparber SB

更新日期：2001-06-01 00:00:00

abstract：RATIONALE:Fluoxetine (Prozac®) is the most frequently prescribed drug to battle depression in pregnant women, but its safety in the unborn child has not yet been established. Fluoxetine, a selective serotonin reuptake inhibitor, crosses the placenta, leading to increased extracellular serotonin levels and potentially n...

journal_title：Psychopharmacology

authors： Olivier JD,Vallès A,van Heesch F,Afrasiab-Middelman A,Roelofs JJ,Jonkers M,Peeters EJ,Korte-Bouws GA,Dederen JP,Kiliaan AJ,Martens GJ,Schubert D,Homberg JR

更新日期：2011-10-01 00:00:00

abstract：:The effects of the antiepilepsy drugs methsuximide and mephenytoin were examined in pigeons responding under a fixed-consecutive-number (FCN) schedule with and without an added external discriminative stimulus. On this schedule, food was delivered whenever subjects responded between 8 and 12 times on one response key ...

journal_title：Psychopharmacology

authors： Schlinger H,Wilkenfield J,Poling A

更新日期：1988-01-01 00:00:00

abstract：:Recent clinical data suggest that buspirone may enhance the efficacy and/or reduce the latency to therapeutic effect of selective serotonin reuptake inhibitors (SSRIs) in unipolar major depressive disorder. The present study, using the mouse forced swimming test, was performed to investigate further the mechanisms inv...

journal_title：Psychopharmacology

authors： Redrobe JP,Bourin M

更新日期：1998-07-01 00:00:00