Modification of the behavioral effects of morphine in rats by serotonin 5-HT₁A and 5-HT₂A receptor agonists: antinociception, drug discrimination, and locomotor activity.

abstract：BACKGROUND:A history of brief intermittent social defeat stress can escalate cocaine self-administration and induce long-term adaptations in the mesolimbic dopamine system. Extra-hypothalamic corticotrophin releasing factor (CRF) has been shown to be closely associated with stress-induced escalation of drug use. How re...

journal_title：Psychopharmacology

authors： Han X,DeBold JF,Miczek KA

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The rise in heroin addiction has heightened the need for novel and effective treatments. Physical exercise has been shown as an effective treatment for stimulant abuse in clinical and pre-clinical research. However, this treatment has not yet been tested on opioid addiction. This study examined the effects o...

journal_title：Psychopharmacology

authors： Smethells JR,Greer A,Dougen B,Carroll ME

更新日期：2020-02-01 00:00:00

abstract：INTRODUCTION:Marchigian Sardinian alcohol-preferring (msP) rats exhibit innate preference for alcohol along with anxious phenotype. In these animals, two single-nucleotide polymorphisms in position -1,836 and -2,097 from the first start codon of the CRF1-R transcript have been found. MATERIALS AND METHODS:Here, we exa...

journal_title：Psychopharmacology

authors： Cippitelli A,Ayanwuyi LO,Barbier E,Domi E,Lerma-Cabrera JM,Carvajal F,Scuppa G,Li H,Ubaldi M,Heilig M,Roberto M,Ciccocioppo R

更新日期：2015-03-01 00:00:00

abstract：RATIONALE:Subthreshold smokers (who smoke < or =5 cigarettes/day) experience withdrawal symptoms, yet they smoke less than is required to maintain serum nicotine levels. OBJECTIVES:For study 1, our aim was to determine (1) if adult subthreshold smokers report withdrawal symptoms; (2) how they rate symptom severity; (3...

journal_title：Psychopharmacology

authors： Fernando WW,Wellman RJ,Difranza JR

更新日期：2006-10-01 00:00:00

abstract：RATIONALE:Electronic cigarettes (ECs) are becoming popular alternatives for smokers, but there has been limited study of their abuse liability. OBJECTIVES:The objective of this study was to evaluate the abuse liability of three Vuse Solo ECs, ranging from 14 to 36 mg in nicotine content, relative to high- and low-abus...

journal_title：Psychopharmacology

authors： Stiles MF,Campbell LR,Graff DW,Jones BA,Fant RV,Henningfield JE

更新日期：2017-09-01 00:00:00

abstract：:Previous work in this and another laboratory has shown that nicotine tablets improve the performance of a rapid information processing task and reduce the Stroop effect, whereas scopolamine has the opposite effects. The purpose of this study was to extend these previous findings by determining whether, when administer...

journal_title：Psychopharmacology

authors： Wesnes K,Revell A

更新日期：1984-01-01 00:00:00

abstract：:3,4-Methylenedioxymethamphetamine (MDMA) is a psychoactive phenylisopropylamine which is structurally similar to both amphetamine-related sympathomimetics and the hallucinogen, mescaline. MDMA produces pleasurable effects which include euphoria, and recent reports continue to demonstrate its widespread recreational us...

journal_title：Psychopharmacology

authors： Hubner CB,Bird M,Rassnick S,Kornetsky C

更新日期：1988-01-01 00:00:00

abstract：:The objective of the present study was to determine whether the development of behavioral sensitization to apomorphine could be blocked by either D1 or D2 selective dopamine antagonists. In three experiments, male rats received 10-21 daily injections of a selective D1 (SCH 23390; 0 or 0.5 mg/kg IP) or D2 (sulpiride; 0...

journal_title：Psychopharmacology

authors： Mattingly BA,Rowlett JK,Graff JT,Hatton BJ

更新日期：1991-01-01 00:00:00

abstract：:This study examined the role of the strychnine-insensitive glycine binding site of the NMDA receptor in prepulse inhibition (PPI) of the acoustic startle response (ASR) in rats. PPI is an operational measure of gating processes which normally lead to a diminished ASR when a startling stimulus is preceded by a weak pre...

journal_title：Psychopharmacology

authors： Kretschmer BD,Koch M

更新日期：1997-03-01 00:00:00

abstract：RATIONALE:We recently reported that simultaneous exposure to amphetamine and various stressors resulted in reduced hypothalamic-pituitary-adrenal (HPA) and glycemic responses to the stressors. Since this is a new and relevant phenomenon, we wanted to further explore this interaction. OBJECTIVES:This study aims (i) to ...

journal_title：Psychopharmacology

authors： Gagliano H,Ortega-Sanchez JA,Nadal R,Armario A

更新日期：2017-10-01 00:00:00

abstract：:Keypecking in one group of pigeons was maintained under schedules in which food was presented only when a specified number of responses was followed by a 30-s pause without a response. d-Amphetamine and pentobarbital increased low rates of responding (and, thus, decreased food presentation) only after initial injectio...

journal_title：Psychopharmacology

authors： Smith JB,McKearney JW

更新日期：1977-07-18 00:00:00

abstract：RATIONALE:Kratom is proposed to exhibit therapeutic potential as an opium substitute, but little is known about its dependence-producing profile, particularly of its main psychoactive compound, mitragynine (MG). OBJECTIVES:This study examined the dependence-producing effects of MG using operant-scheduled behaviour in ...

journal_title：Psychopharmacology

authors： Harun N,Johari IS,Mansor SM,Shoaib M

更新日期：2020-03-01 00:00:00

abstract：:Offensive and defensive components of aggressive behavior were determined in resident and intruder mice. Withdrawal aggression was measured after the removal of a subcutaneous morphine pellet or after precipitation by naloxone in naive mice and after removal of a morphine pellet in mice with prior fighting experience....

journal_title：Psychopharmacology

authors： Kantak KM,Miczek KA

更新日期：1986-01-01 00:00:00

abstract：:The effect of delta 9-tetrahydrocannabinol (THC) on the locomotor activity-stimulating action of morphine has been investigated in mice. THC (10 mg/kg) has been found to potentiate morphine-induced hyperactivity. On the other hand, the stimulating action of morphine on motor activity strongly diminished in mice render...

journal_title：Psychopharmacology

authors： Ulkü E,Ayhan IH,Tulunay FC,Uran B,Kaymakçalan S

更新日期：1980-01-01 00:00:00

abstract：:Methadone as the most prevalent opioid substitution medication has been shown to influence the neurophysiological functions among heroin addicts. However, there is no firm conclusion on acute neuroelectrophysiological changes among methadone-treated subjects as well as the effectiveness of methadone in restoring brain...

journal_title：Psychopharmacology

authors： Motlagh F,Ibrahim F,Rashid R,Shafiabady N,Seghatoleslam T,Habil H

更新日期：2018-11-01 00:00:00

abstract：RATIONALE:Glucocorticoids have been shown to affect declarative memory, an explicit form of memory for facts and events operated by medial temporal lobe structures. Recent neuroimaging data suggest that the medial temporal lobe (including the hippocampus) is also active in implicit sequence learning. OBJECTIVES:The ai...

journal_title：Psychopharmacology

authors： Römer S,Schulz A,Richter S,Lass-Hennemann J,Schächinger H

更新日期：2011-05-01 00:00:00

abstract：RATIONALE:The precise neural circuitry that encodes fear memory and its extinction within the brain are not yet fully understood. Fearful memories can be persistent, resistant to extinction, and associated with psychiatric disorders, especially post-traumatic stress disorder (PTSD). Here, we investigated the microtopog...

journal_title：Psychopharmacology

authors： Jacques A,Chaaya N,Hettiarachchi C,Carmody ML,Beecher K,Belmer A,Chehrehasa F,Bartlett S,Battle AR,Johnson LR

更新日期：2019-01-01 00:00:00

abstract：:The effect of diazepam on spatial visualization was studied using a double-blind crossover design. Diazepam 10 mg (or placebo) was given orally to 12 healthy young men at bedtime, followed again by 10 mg (or placebo) the next morning. One hour after the administration of the morning dose, the subjects performed a ment...

journal_title：Psychopharmacology

authors： Taylor J,Hunt E,Coggan P

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Hypericum perforatum L., known as St. John's wort (SJW), is used as a phytotherapeutic agent for the treatment of mild to moderate forms of depression. OBJECTIVES:The aim of the present study was to evaluate the effect of SJW extract (STW 3-VI; 250 and 500 mg/kg; p.o.) and fluoxetine (10 mg/kg, p.o.) on gene...

journal_title：Psychopharmacology

authors： Jungke P,Ostrow G,Li JL,Norton S,Nieber K,Kelber O,Butterweck V

更新日期：2011-02-01 00:00:00

abstract：:Chronic treatment of rats with the antipsychotic drug molindone (2.5 mg/kg) did not elicit behavioral supersensitivity to apomorphine (AP) (0.25 mg/kg) or increased striatal 3H-spiroperidol binding, whereas treatment with haloperidol (0.5-1.0 mg/kg) produced manifestations of dopaminergic supersensitivity in both para...

journal_title：Psychopharmacology

authors： Meller E

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Alcohol intoxication produces effects that can impair judgment and increase engagement in risky behaviors, including alcohol-impaired driving (AID). Real-world AID decisions are informed by contextual circumstances and judgments of associated risk. How individuals vary in their AID decision-making across cont...

journal_title：Psychopharmacology

authors： Motschman CA,Warner OM,Wycoff AM,Davis-Stober CP,McCarthy DM

更新日期：2020-12-01 00:00:00

abstract：:Fifty-nine depressed female inpatients were treated with 100 mg amitriptyline (AMT) IM for 4 weeks. Depression ratings and determinations of the parent drug and nortriptyline (NT) were performed weekly. No direct relationship between plasma AMT + NT concentrations and therapeutic response was apparent, but beneficial ...

journal_title：Psychopharmacology

authors： Corona GL,Cucchi ML,Frattini P,Santagostino G,Schinelli S,Zerbi F,Savoldi F

更新日期：1990-01-01 00:00:00

abstract：:Progabide inhibited male rat sexual behavior at a dose of 200 mg/kg. This dose had only modest effects on ambulatory activity and no effect at all on motor coordination as evaluated by a rotarod test. The GABAA antagonist bicuculline, at a dose of 1 mg/kg, blocked the effects of progabide on sex behavior. In contrast,...

journal_title：Psychopharmacology

authors： Agmo A,Paredes RG,Sierra L,Garcés I

更新日期：1997-01-01 00:00:00

abstract：:In an operant learning lever-pressing procedure on an FR10 schedule of milk reinforcement, male Wistar rats were trained to discriminate between saline and 3 mg/kg IP DN-2327, a new anxiolytic which acts on benzodiazepine receptors, 3 mg/kg IP diazepam or 15 mg/kg IP pentylenetetrazol (PTZ). More than 80% appropriate ...

journal_title：Psychopharmacology

authors： Wada T,Fukuda N

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:Exposure to extreme stress has been suggested to produce long-term, detrimental alterations in the hypothalamic-pituitary-adrenal (HPA) axis leading to the development of mental disorders such as depression. Therefore, compounds that block the effects of stress hormones were investigated as potential therapeu...

journal_title：Psychopharmacology

authors： Jutkiewicz EM,Wood SK,Houshyar H,Hsin LW,Rice KC,Woods JH

更新日期：2005-07-01 00:00:00

abstract：:The effects of the CCKB-receptor agonist pentagastrin, a synthetic analogue of the cholecystokinin tetrapeptide (CCK-4), were studied in seven patients suffering from obsessive compulsive disorder (OCD) and seven healthy controls. All subjects were challenged with an IV dose of 0.6 micrograms/kg pentagastrin or placeb...

journal_title：Psychopharmacology

authors： de Leeuw AS,Den Boer JA,Slaap BR,Westenberg HG

更新日期：1996-08-01 00:00:00

abstract：:Twenty-nine subjects performed a reaction time task with four levels of choice-task complexity under non-smoking, sham smoking, and low, medium and high nicotine cigarette conditions. Nicotine reduced decision time, while sham smoking increased decision time. This effect was independent of subjects' habitual levels of...

journal_title：Psychopharmacology

authors： Bates T,Pellett O,Stough C,Mangan G

更新日期：1994-03-01 00:00:00

abstract：:Augmentation with low-dose fluvoxamine (50-100 mg/day) to antipsychotic treatment may improve the negative symptoms in schizophrenic patients, but involves a risk of drug-drug interaction. We studied the effects of fluvoxamine on plasma concentrations of haloperidol and reduced haloperidol, and their clinical symptoms...

journal_title：Psychopharmacology

authors： Yasui-Furukori N,Kondo T,Mihara K,Inoue Y,Kaneko S

更新日期：2004-01-01 00:00:00

abstract：RATIONALE:Synthesis of ligands inactive or with low activity at α₁ GABA(A) receptors has become the key concept for development of novel, more tolerable benzodiazepine (BZ)-like drugs. WYS8, a remarkably (105 times) α₁-subtype selective partial positive modulator, may serve as a pharmacological tool for refining the ro...

journal_title：Psychopharmacology

authors： Joksimović S,Varagic Z,Kovačević J,Van Linn M,Milić M,Rallapalli S,Timić T,Sieghart W,Cook JM,Savić MM

更新日期：2013-11-01 00:00:00

abstract：:Nine depressed patients were treated with alaproclate, a selective 5-HT uptake inhibitor, for 3 weeks in a dose of 400 mg daily. The pupillary responses to tyramine, phenylephrine, and pilocarpine eye drops were measured on consecutive days before, after 1 week and after 3 weeks of treatment. The tyramine-induced mydr...

journal_title：Psychopharmacology

authors： Thompson C,Checkley SA

更新日期：1985-01-01 00:00:00