Abstract：
RATIONALE:In Koriat's accessibility model (Koriat, Psychol Rev, 100:609-639, 1993; Koriat, J Exp Psychol Gen, 124:311-333, 1995), when a person fails to recall a required target, he or she can nevertheless provide some partial information about the target. Moreover, individuals are able to provide feeling-of-knowing (FOK) judgments about the availability of the target in memory. The cues for the FOK evaluations reside in the products of the retrieval process itself. It was shown that the benzodiazepine lorazepam drug induces some impairment of memory. OBJECTIVES:The effects of the amnesic benzodiazepine lorazepam on the total and partial recall of recently learned material and on FOK ratings were investigated in healthy volunteers. METHODS:Twenty-eight healthy volunteers participated in the study: 14 of these received a capsule containing lorazepam (0.038 mg/kg) and 14 a placebo capsule. The material to be learned consisted of four-letter nonsense tetragrams with each letter providing partial information with regard to the four-letter target (Koriat, Psychol Rev, 100:609-639, 1993). RESULTS:The number of incorrect letters reported was higher for the lorazepam than for the placebo condition. The FOK magnitude was higher for the placebo participants than for the lorazepam participants. The predictive value of FOK for recognition was preserved by the drug. CONCLUSION:When studying four-letter nonsense letter strings, lorazepam participants present an impairment of episodic short-term memory and the drug has an effect on FOK estimates but not on the predictive accuracy of the FOK. The accessibility hypothesis of FOK was confirmed in this study and seems to retain some validity even under the effect of an amnesic drug.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Izaute M,Bacon Edoi
10.1007/s00213-006-0492-2subject
Has Abstractpub_date
2006-11-01 00:00:00pages
472-81issue
4eissn
0033-3158issn
1432-2072journal_volume
188pub_type
杂志文章,随机对照试验abstract：:Interactions of amygdala kindling and drug effects were explored in two experiments. Pretreatment with cocaine (40 mg/kg, IP) for 10 days did not significantly affect the rate of amygdala kindling compared to saline or non-kindled controls. In contrast, daily amygdala kindling with 200 microA for 0.5 s for 20 days sub...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431655
更新日期：1981-01-01 00:00:00
abstract：RATIONALE:Latent inhibition (LI), namely, poorer performance on a learning task involving a previously pre-exposed non-reinforced stimulus, is disrupted in the rat by the dopamine (DA) releaser amphetamine which produces and exacerbates psychotic (positive) symptoms, and this is reversed by treatment with typical and a...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-002-1313-x
更新日期：2003-09-01 00:00:00
abstract：:The benzodiazepines are typified by a profile of side effects which includes drowsiness, ataxia and incoordination. Ro 15-1788, an imidazodiazepine derivative, exhibits marked antagonism of the behavioural and biochemical effects of the benzodiazepines in animals and man. It is devoid of any behavioural activity in an...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00427969
更新日期：1983-01-01 00:00:00
abstract：RATIONALE:Rivastigmine patches are used for patients with Alzheimer's disease (AD), but little is known about the serum concentration of rivastigmine and its metabolite or clinical adherence in relation to skinfold thickness after rivastigmine patch application. OBJECTIVES:The aim of this study was to examine the asso...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5135-x
更新日期：2019-04-01 00:00:00
abstract：:Maternal pup searching behaviour of lactating house mice treated with apomorphine, haloperidol or saline was examined on a running board with a central depression as a nest. Pup searching was elicited by artificial ultrasonic stimuli: a female moved out from the nest either towards a 50 kHz tone (key stimulus) which i...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00174523
更新日期：1988-01-01 00:00:00
abstract：:In neuroleptic therapy for psychotic illness, clinical improvement is produced more slowly than is central dopamine blockade, and its time course is highly variable between patients. A theory of neuroleptic-responsive psychotic illness thus requires more than dopamine blockade, though that appears to be the first step...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/BF00176470
更新日期：1987-01-01 00:00:00
abstract：RATIONALE:Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression is limited by their convulsive effects. Therefore, determining how to separate the convu...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-0138-9
更新日期：2005-11-01 00:00:00
abstract：RATIONALE:Alcohol intoxication can dampen negative affective reactions to stressors. Recently, it has been proposed that these acute anxiolytic effects of alcohol may extend to dampening of negative affective reactions to error commission during cognitive control tasks. Nonetheless, empirical verification of this claim...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05619-4
更新日期：2020-11-01 00:00:00
abstract：RATIONALE:Most adult smokers start smoking during their adolescence. This adolescent initiation may be due to multiple factors, but little evidence is available regarding whether their brains are differentially sensitive to the addictive effects of nicotine during adolescence. OBJECTIVE:To test the hypothesis that ado...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1758-6
更新日期：2004-07-01 00:00:00
abstract：OBJECTIVES:Early onset of heroin use during adolescence might increase chances of later drug addiction. Prior work from our laboratory suggests, however, that adolescent male rats are actually less sensitive than adults to some enduring effects of heroin self-administration. In the present study, we tested two likely c...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2847-1
更新日期：2013-02-01 00:00:00
abstract：:In previous research, sensitization of stereotypy induced by injections of 2.5 mg/kg amphetamine did not interfere with subsequent tolerance development to the hypophagic effect of 2 mg/kg. This study examined the effect of a higher sensitizing dose. Rats given intermittent injections of 5 mg/kg amphetamine and then c...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050788
更新日期：1998-12-01 00:00:00
abstract：INTRODUCTION:Understanding an individual's vulnerability to drug addiction has important implications for the development of effective personal treatment plans. Although theories acknowledge impulsive behaviour as a key component of drug addiction, little is known about the influence of trait impulsivity on an individu...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3270-y
更新日期：2014-02-01 00:00:00
abstract：:Oral movements (OMs) in rats administered chronic haloperidol (HAL) were quantified simultaneously by a human observer and via a computerized video analysis system which monitored the distance between the upper and low lips using TV images. The human observer data indicated that during HAL administration the total dur...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00215492
更新日期：1987-01-01 00:00:00
abstract：:Dose-dependent effects of intravenously administered lorazepam on haemodynamic fluctuations were studied by means of spectral analysis, in order to elucidate sympathetic and parasympathetic components in cardiovascular control during situations of rest and mental stress after benzodiazepine administration. In a double...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02245447
更新日期：1994-02-01 00:00:00
abstract：RATIONALE:The widespread deficits in cognitive flexibility observed across psychiatric disorders call for improved rodent tests to understand the biology of cognitive flexibility and development of better psychotherapeutics. Current reversal learning paradigms have a forced-choice setup that challenges the interpretati...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05687-6
更新日期：2021-02-01 00:00:00
abstract：RATIONALE:The administration of heroin has been shown to inhibit the induction of nitric oxide, a molecule known to play a critical role in immune function. Previous research has shown that this alteration can be conditioned to environmental stimuli that have been associated with drug administration. However, it remain...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0673-z
更新日期：2007-05-01 00:00:00
abstract：:Animal experimental studies suggest that the therapeutic effect of selective serotonin re-uptake inhibitors (SSRIs) may involve neuroadaptive changes in pre- and post-synaptic serotonin1A (5-HT1A) receptors. We used the endocrine and hypothermic responses to the 5-HT1A receptor agonist, gepirone (20 mg orally), to ass...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130050348
更新日期：1997-08-01 00:00:00
abstract：RATIONALE:The exact role of delta opioid receptors in drug-induced conditioned place preference (CPP) remains debated. Under classical experimental conditions, morphine-induced CPP is decreased in mice lacking delta opioid receptors (Oprd1 (-/-)). Morphine self-administration, however, is maintained, suggesting that dr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2693-1
更新日期：2012-09-01 00:00:00
abstract：:Rats chronically treated with increasing daily doses of delta 9-tetrahydrocannabinol (delta 9-THC) for up to 5 or 10 days exhibit a withdrawal-like behavioural response when challenged with clomipramine, a potent inhibitor of serotonin (5-hydroxytryptamine) reuptake, at the time when the next injection of delta 9-THC ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431112
更新日期：1981-01-01 00:00:00
abstract：RATIONALE:Developmental lead exposure may alter responsiveness to cocaine well into adulthood, and ultimately influence drug-use patterns. OBJECTIVES:The present study examined the effect of perinatal lead exposure on the discriminative stimulus properties of cocaine. METHODS:Female rats were treated with 0, 8, or 16...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100877
更新日期：2001-11-01 00:00:00
abstract：:The present study was undertaken to evaluate the effects of single and repeated doses of triazolam (1 mg/kg IP) and desipramine (DMI) (10 mg/kg IP) alone and in combination on certain pharmacologic responses and brain catecholamine levels in rats. The significant findings were: (1) triazolam and DMI given alone and in...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427882
更新日期：1980-01-01 00:00:00
abstract：:A recent study from our laboratory has demonstrated that C57BL/6 male mice that are chronically injected with nicotine develop a profound tolerance to nicotine that is not associated with changes in brain nicotinic receptors. We have proposed that alterations in the secretion of corticosterone (CCS) may regulate toler...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245877
更新日期：1992-01-01 00:00:00
abstract：:Three recently arrived drug naive Cebus apella monkeys with "spontaneous" stereotyped oral movements were treated with apomorphine and haloperidol using a wide dose range. Low doses of apomorphine (0.05-0.1 mg/kg) suppressed the oral stereotypies without affecting normal behaviour such as grooming and scratching. High...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00428423
更新日期：1985-01-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Blood oxygen level dependent (BOLD) contrast pharmacological magnetic resonance imaging (phMRI) is an increasingly popular technique that allows the non-invasive investigation of spatial and temporal changes in rat brain function in response to pharmacological stimulation in vivo. Rat brain BOL...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-005-2213-7
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND:Abnormalities of membrane phospholipid metabolism have been described in Alzheimer's disease (AD). We investigated, with the aid of (31)P magnetic resonance spectroscopy, the in vivo intracerebral availability of phosphomonoesters (PME) and phosphodiesters (PDE) in patients with AD. METHODS:Eighteen outpati...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-2168-8
更新日期：2005-07-01 00:00:00
abstract：RATIONALE:We have recently shown that post-extinction exposure of rats to a sub-threshold reminder shock can reactivate extinguished context-related freezing and found that chronic treatment with fluoxetine before fear extinction prevents this phenomenon. OBJECTIVES:In the present study, we examined whether these find...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-2134-y
更新日期：2011-05-01 00:00:00
abstract：BACKGROUND:Acute administration of selective serotonin and noradrenaline re-uptake blockers to healthy volunteers affects the processing of emotional information but it is not known if similar effects occur with antidepressants acting through other pharmacological mechanisms. Mirtazapine is a clinically established ant...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-008-1410-6
更新日期：2009-05-01 00:00:00
abstract：:Serotonin is a neurotransmitter that is widely distributed throughout the central nervous system. The role of serotonin in schizophrenia is still unclear. Postmortem studies of serotonin receptor subtypes in schizophrenia have been inconclusive for the most part. The most promising findings involve a reduction in 5-HT...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/BF02245003
更新日期：1993-01-01 00:00:00
abstract：:In a double-blind, balanced crossover study, eight healthy male volunteers ingested either DL-308 (10 mg), DL-308 (20 mg), oxazepam (30 mg) or placebo. Subjective estimates of coordination and anxiety, objective performance measurements and cardiovascular measurements were taken at 1, 3, 5 and 8 h after ingestion. DL-...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00427573
更新日期：1983-01-01 00:00:00
abstract：:The concurrent influence of dopaminergic, sigma and muscarinic neurotransmitter systems in mediating cocaine-induced lethality is predicted by previous receptor binding results from our laboratories. The present results demonstrate that pharmacological manipulations of these predicted neurotransmitter systems alter th...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050198
更新日期：1997-02-01 00:00:00
