Abstract：
:Rats chronically treated with increasing daily doses of delta 9-tetrahydrocannabinol (delta 9-THC) for up to 5 or 10 days exhibit a withdrawal-like behavioural response when challenged with clomipramine, a potent inhibitor of serotonin (5-hydroxytryptamine) reuptake, at the time when the next injection of delta 9-THC was due. To determine whether this response is indeed a withdrawal syndrome, different groups of rats were injected IV twice daily for up to 5 days with either delta 9-THC, in doses increasing from 2-6 mg/kg, or polyvinyl-pyrrolidone (PVP), the vehicle in which delta 9-THC was suspended. On day 6, an acute dose of 6 mg/kg delta 9-THC was given 30 min before IP clomipramine (15 mg/kg). The total behavioural response, which included writhing, backward kicking, jumping, head shaking, and paw tremor, was attenuated in rats chronically treated with delta 9-THC, but not in rats which received an acute dose of PVP. These results lend further evidence to our hypothesis that chronically administered delta 9-THC produces a state of physical dependence in the rat.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Verberne AJ,Taylor DA,Fennessy MRdoi
10.1007/BF00431112subject
Has Abstractpub_date
1981-01-01 00:00:00pages
97-8issue
1eissn
0033-3158issn
1432-2072journal_volume
73pub_type
杂志文章abstract：:The behavioral effects of the benzodiazepine (BZP)-receptor partial inverse agonists, beta-CCE and FG 7142, are reviewed and the claim that these compounds possess "anxiogenic" properties is examined. Results obtained from human studies and global observations in animals, as well as those from experiments on aggressio...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/BF00212837
更新日期：1988-01-01 00:00:00
abstract：RATIONALE:Drug addiction is a chronically relapsing disorder characterised by compulsive drug use and loss of control over drug intake. Although several theories propose impulsivity as a key component of addiction, the precise nature of this relationship remains unclear. OBJECTIVES:This study aims to investigate the s...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-011-2558-z
更新日期：2012-01-01 00:00:00
abstract：RATIONALE:Withdrawal seizure-prone and withdrawal seizure-resistant mice were selectively bred to exhibit differences in handling-induced convulsion severity during ethanol withdrawal. The glutamatergic system has been implicated in seizure activity as well as ethanol withdrawal symptoms. OBJECTIVE:This study assessed...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050933
更新日期：1999-04-01 00:00:00
abstract：RATIONALE:Little is known about patterns of opiate use by heroin addicts. OBJECTIVES:To describe opiate use over time among heroin addicts who had access to legally prescribed intravenous heroin and oral opiates. METHODS:Analysis of daily drug administration records of 37 patients enrolled in the Geneva heroin mainte...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s002130000492
更新日期：2000-09-01 00:00:00
abstract：:A continuing challenge for preclinical research on anxiolytic drugs is to capture the affective dimension that characterizes anxiety and aggression, either in their adaptive forms or when they become of clinical concern. Experimental protocols for the preclinical study of anxiolytic drugs typically involve the suppres...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/BF02245590
更新日期：1995-09-01 00:00:00
abstract：RATIONALE:Glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) are gut derived hormones. GLP-1 and GLP-2 were shown to have pleiotropic effects in intestinal and pancreatic diseases. OBJECTIVE:We aimed to investigate the activities of GLP-1 and GLP-2 on nociception and inflammation in mice, involving th...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5154-7
更新日期：2019-06-01 00:00:00
abstract：:Serotonin receptors of the 5HT2 type were labeled on platelet membranes using tritiated ketanserin. Blood was collected from the umbilical cord of newborns and venous samples were collected from 6-year-old children as well as junior-high and high school students (ages 13 through 18) to determine age-related changes in...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245309
更新日期：1992-01-01 00:00:00
abstract：RATIONALE:The intake of psychostimulant drugs may induce cognitive dysfunction and negative affective-like states, and is associated with increased activity of stress-responsive systems. The corticotropin-releasing factor (CRF) system mediates neuroendocrine, behavioural and autonomic responses to stressors, and might ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3534-1
更新日期：2014-10-01 00:00:00
abstract：RATIONALE:The integrity of cortical cholinergic transmission is vital to attentional processing. A growing literature suggests that alterations in attentional processing accompany addictive drug use. This study examined the effects of acute and repeated administration of nicotine on cortical acetylcholine release. OBJ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1260-6
更新日期：2003-02-01 00:00:00
abstract：:Peak saccadic eye movement velocity (SEV) and average smooth pursuit gain (SP) are reduced in a dose-dependent manner by diazepam and provide reliable, quantitative measures of benzodiazepine agonist effects. To evaluate the specificity of these eye movement effects for agents acting at the central GABA-benzodiazepine...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02245956
更新日期：1995-04-01 00:00:00
abstract：RATIONALE:Repeated exposure to psychostimulants that either increase dopamine (DA) release or target N-methyl-D-aspartate (NMDA) receptors can induce behavioural sensitisation, a phenomenon that may be important for the processes of addiction and even psychosis. A critical component of behavioural sensitisation is an i...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3689-9
更新日期：2015-02-01 00:00:00
abstract：RATIONALE:Repeated intermittent exposure to ketamine has rapid and long-lasting antidepressant effects, but the abuse potential has only been assessed at high doses. Furthermore, while females are more susceptible to depression and more sensitive to ketamine's antidepressant-like effects, the abuse potential for ketami...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4470-z
更新日期：2017-02-01 00:00:00
abstract：:Fourteen rats were trained to discriminate the effects of gamma-hydroxybutyrate (GHB) (sodium salt, 200 mg/kg) and saline in a two-lever choice task using a fixed ratio 10 schedule of water reinforcement. Intermediate responding, i.e., responding not fully appropriate for either training condition was observed in test...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426468
更新日期：1981-01-01 00:00:00
abstract：RATIONALE:The antidepressant action of acute nicotine administration in clinical and animal studies is well recognized. But the underlying mechanism for this effect has not been carefully discovered. OBJECTIVES:We attempted to evaluate the possible role of N-Methyl-D-aspartate (NMDA) receptors in the antidepressant-li...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-4004-0
更新日期：2015-10-01 00:00:00
abstract：:This study examined and compared withdrawal signs and symptoms from cessation of 0, 2 and 4 mg nicotine gum. In addition, a comparison was made between nicotine gum versus cigarette withdrawal symptoms. Smokers first underwent cigarette deprivation for 4 days and then were randomly assigned to 0 (N = 16), 2 (N = 25), ...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02245656
更新日期：1991-01-01 00:00:00
abstract：:Several behaviors associated with the serotonin syndrome have been reported in rats following administration of the 5-HT1A receptor agonist 8-OH-DPAT. The present investigation approached this phenomenon from an ethopharmacological perspective, and provided a detailed temporal analysis of the behavioral effects of thi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02247363
更新日期：1993-01-01 00:00:00
abstract：:The binding kinetics of tritiated quinuclidinyl benzilate (QNB) were studied in membrane preparations from human parotid and rabbit submandibular glands. Inhibition of 3H-QNB was then used to compare the anticholinergic activity of lofepramine, desipramine, imipramine and amitriptyline for muscarinic receptor in the s...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00172861
更新日期：1986-01-01 00:00:00
abstract：RATIONALE:Hypofunction of striatal dopamine neurotransmission, or hypodopaminergia, is a consequence of excessive ethanol use and is hypothesized to be a critical component of alcoholism, driving alcohol intake in an attempt to restore dopamine levels; however, the neurochemical mechanisms involved in these dopaminergi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-016-4239-4
更新日期：2016-04-01 00:00:00
abstract：:Two principal oblique factors are identified in the Bass Social Acquiescence Scale, a measure previously shown to correlate positively with placebo response and negatively with anxiolytic drug response. The two factors appeared very similar in separate analyses of data from samples of 941 psychiatric outpatients and 1...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433044
更新日期：1979-10-01 00:00:00
abstract：:DL-2-amino-5-phosphonovaleric acid (AP-5), which blocks glutamatergic transmission at the NMDA-preferring receptor, was injected into the antero-dorsal striatum of rats. AP-5-induced behavioural changes were assessed i) using a stereotypy rating scale and ii) using an experimental chamber designed to quantify sniffing...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00172883
更新日期：1986-01-01 00:00:00
abstract：RATIONALE:Understanding factors contributing to individual differences in vulnerability to opioid addiction is essential for developing more effective preventions and treatments, yet few reliable behavioral predictors of subsequent opioid self-administration have been identified in rodents. Sensitivity to the acute eff...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05532-w
更新日期：2020-08-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-007-0959-9
更新日期：2008-02-01 00:00:00
abstract：:The suggestions that dopamine (DA) systems are involved in "motor control" and "reward" represent the classic working hypotheses on the behavioral functions of these systems. The research generated by these hypotheses has yielded results that are far more complicated than the simplest form of either hypothesis would i...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/BF02245133
更新日期：1992-01-01 00:00:00
abstract：RATIONALE:3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) is a potent and selective serotonin neurotoxin whose use is growing among adolescents. Although cognitive deficits among adult MDMA users are well documented, little is known of the cognitive and brain functional sequelae of MDMA use during adolescence. OBJ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1679-4
更新日期：2004-05-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Functional (pharmacodynamic) ethanol tolerance can be evidenced within a single session of exposure to ethanol (acute or within-session tolerance), or after repeated ethanol exposures (chronic or between-session tolerance). To investigate whether acute and chronic tolerance to ethanol are inter...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100722
更新日期：2001-06-01 00:00:00
abstract：:Cholecystokinin (CCK) and dopamine (DA) coexist in both cell body and terminal areas of a mesolimbic pathway that projects from the ventral tegmental area (VTA) to the nucleus accumbens (N ACC). Autoradiography reveals extensive CCK binding sites in the N ACC, but not in the VTA. However, iontophoresis of CCK into the...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00445571
更新日期：1989-01-01 00:00:00
abstract：RATIONALE:Recent studies have shown that pharmacological inhibition of the 12-lipoxygenase pathway selectively blocks opioid inhibition of GABAergic synaptic currents. A similar mechanism has been shown for the regulation of glutamate release in the ventral tegmental area (VTA) during acute withdrawal from morphine, al...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1526-7
更新日期：2003-11-01 00:00:00
abstract：:The administration of trycyclic antidepressants followed by reserpine-like drugs elicits a pattern of stereotyped locomotor activity. Using desmethylimipramine (DMI) followed by tetrabenazine (TBZ), activity could be reliably elicited only in young rats, and only by using very high doses of TBZ. The latency of onset o...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426790
更新日期：1978-06-15 00:00:00
abstract：RATIONALE:Severe, traumatic stress or repeated exposure to stress can result in long-term deleterious effects, including hippocampal cell atrophy and death, which, in turn, result in memory impairments and behavioural abnormalities. The dopaminergic D(2) receptor agonist, bromocriptine, has been shown to modulate learn...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-007-0801-4
更新日期：2007-08-01 00:00:00
abstract：RATIONALE:Serotonin (5-HT) and norepinephrine (NE) re-uptake inhibitors (SNRIs) have been proposed to have a higher efficacy and/or faster onset of action than previously available antidepressants. OBJECTIVES:We examined in biochemical, electrophysiological and behavioural assays the antidepressant properties of (S)-(...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-0087-3
更新日期：2005-11-01 00:00:00
