Abstract：
:In previous research, sensitization of stereotypy induced by injections of 2.5 mg/kg amphetamine did not interfere with subsequent tolerance development to the hypophagic effect of 2 mg/kg. This study examined the effect of a higher sensitizing dose. Rats given intermittent injections of 5 mg/kg amphetamine and then challenged with various doses of amphetamine showed focused head scanning at 2 mg/kg and oral stereotypy at 4 mg/kg. In contrast, saline controls showed diffuse sniffing and head scanning at 2 and 4 mg/kg. Subgroups from each condition were then given daily injections of either amphetamine (2 mg/kg) or saline and access to milk for 30 min. Dose-response tests revealed that both drugged groups learned to suppress stereotypy in order to feed at 2 mg/kg, but only the non-sensitized group could do so at 4 mg/kg. These results demonstrate that (1) rats learn to suppress only those stereotyped movements that they experience in the context of feeding and (2) instrumental contingencies can influence the expression of behavioral sensitization.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Hughes KM,Popi L,Wolgin DLdoi
10.1007/s002130050788subject
Has Abstractpub_date
1998-12-01 00:00:00pages
445-9issue
4eissn
0033-3158issn
1432-2072journal_volume
140pub_type
杂志文章abstract：:The effect of postethanol treatment with L-Dopa, aminophylline and/or ephedrine was investigated. In one experiment, healthy, male, moderate drinkers ingested ethanol (0.8 g/kg) and then either L-Dopa (1.5 g), or placebo. In a second experiment, subjects ingested ethanol followed by aminophylline (200 mg), ephedrine (...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00497849
更新日期：1977-12-28 00:00:00
abstract：RATIONALE:Acute ethanol administration induces hypothermia in genetically susceptible animals. Tolerance to this effect may develop with repeated administration. Allopregnanolone is an endogenously produced neuroactive steroid that acts at the GABA-A receptor. We postulated that allopregnanolone would induce hypothermi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1106-2
更新日期：2002-07-01 00:00:00
abstract：:In order to assess the possible effects of central GABA activation on the consolidation of shock avoidance, the GABA-T inhibitor amino-oxyacetic acid (AOAA) was administered posttrial to adult male rats. Learning was assessed over nine widely spaced sessions of 20 trials each. AOAA-treated animals showed learning with...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431848
更新日期：1978-03-01 00:00:00
abstract：:There is increasing interest in the potential functional role of the octapeptide angiotensin II (AII) in psychiatric and cognitive disorders. The novel angiotensin II (AII) receptor antagonists, losartan and PD123177, selective for the AT1 and AT2 receptor subtypes respectively, constitute important pharmacological to...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246450
更新日期：1996-08-01 00:00:00
abstract：:After publication of this paper, the authors determined an error in Fig. 2C. ...
journal_title：Psychopharmacology
pub_type： 已发布勘误
doi：10.1007/s00213-019-05269-1
更新日期：2019-07-01 00:00:00
abstract：:The effects of lormetazepam (0.03 mg/kg IV) a benzodiazepine (BZ) derivative in combination with ZK 93 426 (0.04 mg/kg IV) a beta-carboline, benzodiazepine receptor antagonist were evaluated in humans. Independently, the effects of ZK 93 426 on its own were investigated. A psychometric test battery to evaluate sedatio...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00172956
更新日期：1988-01-01 00:00:00
abstract：:Previous studies indicate that some aspects of endotoxin-induced sickness behavior in rats may be mediated by interleukin-1 stimulated events and can be attenuated by corticosteroids, cyclooxygenase inhibitors and the interleukin-1-receptor antagonist. In the current studies, we replicate and extend these findings in ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050353
更新日期：1997-08-01 00:00:00
abstract：:Rats were chronically administered either haloperidol (HAL) or fluphenazine (FLU) via depot injections for 8 months, given these same drugs in their drinking water for the next 2 months, and then withdrawn from the drugs. Throughout the experiment the animals were tested repeatedly in an enclosed tube using a computer...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00174701
更新日期：1988-01-01 00:00:00
abstract：:Rats that are placed in a novel environment containing a probe will explore the environment and the probe. Exploration of the probe is reduced when the probe is electrified. We here report that chlordiazepoxide blocks this inhibition, and have determined some of the pharmacological features of this new experimental pr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00178505
更新日期：1986-01-01 00:00:00
abstract：:Lu 25-109 [5-(2-ethyl-2H-tetrazol-5-yl)-1,2,3,6-tetrahydro-1-methylpyridine] , has M agonistic and M2/M3 antagonistic effects at muscarinic receptors in vitro; a pharmacological profile that may be beneficial in treatment of Alzheimer's disease. In the present study, we compare functional in vivo effects of Lu 25-109 ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050615
更新日期：1998-06-01 00:00:00
abstract：RATIONALE:Greater incidence of anxiety and depressive disorders of women compared to men may be due in part to progesterone (P) and its neuroactive metabolite, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP), acting in limbic regions, such as the amygdala. OBJECTIVE:If P's metabolism via 5alpha-reduction to 3alpha...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-0100-x
更新日期：2006-06-01 00:00:00
abstract：:Different benzodiazepines, when administered to fasting cats, increased both the total amount of food eaten and also the rate at which food was ingested. Moreover, when injected to foodsatiated cats, these compounds made them resume eating voraciously. Pentobarbital also stimulated food intake, but was much less poten...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00428710
更新日期：1976-05-05 00:00:00
abstract：RATIONALE:Although newer interview methods such as Structured Interview Guide for the Montgomery-Asberg Depression Rating Scale (SIGMA; MADRS) with audiotaping and Rater Applied Performance Scale (RAPS) appraisal have been introduced to improve reliability of ratings in antidepressant clinical trials, there is limited ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3584-4
更新日期：2014-11-01 00:00:00
abstract：:Elderly normal volunteers (N = 12, mean age 70.4 years) were administered placebo or diazepam 2.5, 5, 10 mg in four consecutive sessions separated by at least a 1-week interval. Memory and psychomotor performance and plasma diazepam concentrations were assessed at baseline and at 1 and 3 h following drug administratio...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00555210
更新日期：1984-01-01 00:00:00
abstract：:While chronic intermittent administration of stimulants often induces behavioral sensitization in adulthood, stimulant sensitization has rarely been reported prior to weaning [around postnatal day (P) 21]. Consistent pairing of drug administration with the test context often facilitates sensitization in adults, yet yo...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050653
更新日期：1998-07-01 00:00:00
abstract：RATIONALE:Selective attention deficit, characterised by the inability to differentiate relevant from irrelevant information, is considered to underlie many cognitive deficits of schizophrenia, and appears to be only marginally responsive to treatment with current antipsychotics. OBJECTIVES:We compared the activity of ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-005-2268-5
更新日期：2005-08-01 00:00:00
abstract：RATIONALE:The amygdala and insular cortex are integral to the processing of emotionally salient stimuli. We have shown in healthy volunteers that an anxiolytic agent, lorazepam, dose-dependently attenuates activation of limbic structures. OBJECTIVE:The current study investigated whether administration of a selective s...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-007-1004-8
更新日期：2008-03-01 00:00:00
abstract：:Food reward has been associated with activation of noradrenergic mechanisms in the brain. Using rats trained to press a lever for food reward, we have investigated the effects of 6-hydroxydopamine lesions, which severly depleted hypothalamic noradrenaline, on the willingness of the rats to press the lever for food rew...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427343
更新日期：1979-06-28 00:00:00
abstract：:Brain 5-hydroxytryptamine (5-HT) was depleted in rats by intraventricular injection with 5,7-dihyroxytryptamine (5,7-DHT) prior to feeding rats a liquid diet containing ethanol. After withdrawal of ethanol, withdrawal reactions were significantly less severe in 5-HT-depleted rats than control rats. Sleeping times afte...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427597
更新日期：1980-01-01 00:00:00
abstract：RATIONALE:Emerging evidence from agonist-antagonist studies suggests a role for the dopamine D(3) receptor subtype in the regulation of PPI in animals, but such evidence is lacking for human subjects. OBJECTIVES:This study examines the effect of the preferential D(3) agonist ropinirole on PPI in humans. METHODS:PPI w...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-007-0843-7
更新日期：2007-10-01 00:00:00
abstract：:To investigate the mood response of schizophrenic subjects to psychostimulant challenge, 29 neuroleptic-treated subjects (22 with schizophrenia and 7 with schizoaffective disorder) in clinical remission received two infusions, one with methylphenidate 0.5 mg/kg and the other with normal saline, under double-blind cond...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02244317
更新日期：1991-01-01 00:00:00
abstract：RATIONALE:Lysergic acid diethylamide (LSD) differs from other types of hallucinogens in that it possesses direct dopaminergic effects. The exact nature of this component has not been elucidated. OBJECTIVE:The present study sought to characterize the effects of several dopamine D(4) agonists and antagonists on the disc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1238-0
更新日期：2009-04-01 00:00:00
abstract：:Several behaviors associated with the serotonin syndrome have been reported in rats following administration of the 5-HT1A receptor agonist 8-OH-DPAT. The present investigation approached this phenomenon from an ethopharmacological perspective, and provided a detailed temporal analysis of the behavioral effects of thi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02247363
更新日期：1993-01-01 00:00:00
abstract：:The purpose of this study was to examine the relationship between the development of tolerance to ethanol and the hypothalamic-pituitary-adrenal cortex (H-P-AC) system by modifying the H-P-AC system through the use of a synthetic glucocorticoid, dexamethasone. Also this study determined whether repeated drug administr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426602
更新日期：1977-03-23 00:00:00
abstract：:Aniamls were administered increasing doses of morphine for 16 days. During withdrawal they were challenged with an apomorphine ester or lergotrile. These dopamine agonists produced quantitatively different effects on behaviour. The results suggest that chronic morphine administration leads to dopamine supersensitivity...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433570
更新日期：1979-05-15 00:00:00
abstract：:The development of a differential tolerance to morphine was investigated with respect to the mean effective dose, the threshold dose of tolerance, the degree of tolerance after a fixed dose, and the speed of tolerance loss. The mean effective doses, the threshold doses of tolerance, and the degree of tolerance differe...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00428157
更新日期：1982-01-01 00:00:00
abstract：RATIONALE:Smokers show heightened activation toward smoking-related stimuli and experience increased cravings which can precipitate smoking cessation relapse. Exercise can be effective for modulating cigarette cravings and attenuating reactivity to smoking cues, but the mechanism by which these effects occur remains un...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-011-2610-z
更新日期：2012-06-01 00:00:00
abstract：:The name of Hayley Treloar Padovano was incorrectly tagged in the original version of this article. Instead of Padovano as family name and Hayley Treloar as given name, it should be Hayley as given name and Treloar Padovano as family name. Correct presentation of author name when online should be Treloar Padovano H. ...
journal_title：Psychopharmacology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00213-018-4967-8
更新日期：2018-09-01 00:00:00
abstract：RATIONALE:Converging evidence suggests that dopaminergic and serotonergic mechanisms affect distinct aspects of cognitive performance. Experiments using the rodent five-choice reaction time task have established a critical role for dopaminergic mechanisms in the rat medial prefrontal cortex (mPFC), but have yielded onl...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-002-1227-7
更新日期：2003-01-01 00:00:00
abstract：:This study evaluated the effects of two central nicotinic-cholinergic receptor agonists and an antagonist on performance accuracy of a rat, delayed stimulus discrimination task (DSDT). Rats were trained to discriminate between an auditory and visual stimulus by pressing a right or left lever. To diminish the rat's abi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02246174
更新日期：1996-01-01 00:00:00
