Voraciousness induced in cats by benzodiazepines.

abstract：RATIONALE:Recent animal research has shown that, aside from its primary and secondary reinforcing effects, nicotine may enhance reinforcement from stimuli unrelated to nicotine intake. Little human research has directly examined this potentially important influence of nicotine. OBJECTIVES:We report two virtually ident...

journal_title：Psychopharmacology

authors： Perkins KA,Grottenthaler A,Wilson AS

更新日期：2009-09-01 00:00:00

abstract：:The effects of phencyclidine (PCP) on locomotor activity were compared to those of the stereoisomers of N-allylnormetazocine (NAN) after acute administration to rats. PCP produced swaying and falling movements, increased sniffing behavior, and enhanced horizontal locomotor activity. d-NAN also induced swaying, falling...

journal_title：Psychopharmacology

authors： Iwamoto ET

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:2-Bromoterguride, a dopamine D2 receptor partial agonist with antagonist properties at serotonin 5-HT2A receptors and α2C-adrenoceptors, meets the prerequisites of a putative atypical antipsychotic drug (APD). We recently showed that 2-bromoterguride is effective in tests of positive symptoms of schizophrenia...

journal_title：Psychopharmacology

authors： Tarland E,Franke RT,Fink H,Pertz HH,Brosda J

更新日期：2018-01-01 00:00:00

abstract：RATIONALE:Salvinorin A, the primary psychoactive derivative of the hallucinogenic herb Salvia divinorum, is a potent and highly selective kappa-opioid receptor (KOR) agonist. Several recent studies, however, have suggested endocannabinoid system mediation of some of its effects. OBJECTIVES:This study represents a syst...

journal_title：Psychopharmacology

authors： Walentiny DM,Vann RE,Warner JA,King LS,Seltzman HH,Navarro HA,Twine CE Jr,Thomas BF,Gilliam AF,Gilmour BP,Carroll FI,Wiley JL

更新日期：2010-06-01 00:00:00

abstract：:In a one-trial step-through passive avoidance task, pretraining administration of ethanol was shown to decrease the latencies to step through at both training (day 1) and testing (day 2) for both rats and mice. A detailed analysis of these effects showed that they differed from those reported previously by others. The...

journal_title：Psychopharmacology

authors： Bammer G,Chesher GB

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Inhibition of glutamatergic N-methyl-D-aspartate (NMDA) receptors following the administration of NMDA receptor antagonists results in psychotic-like behaviour. Whereas it is known that pharmacological manipulation of dopaminergic and serotonergic pathways affect this drug-induced psychosis, a role for noradr...

journal_title：Psychopharmacology

authors： Harkin A,Morris K,Kelly JP,O'Donnell JM,Leonard BE

更新日期：2001-03-01 00:00:00

abstract：:Sixty-two DSM III chronic schizophrenic inpatients were selected for a double-blind, placebo controlled, multi-centre, relapse prevention study of remoxipride, a selective dopamine (D2)-receptor antagonist. After a 1 month placebo washout, 23 patients had relapsed and were withdrawn. Of the remaining patients 19 were ...

journal_title：Psychopharmacology

authors： King DJ,Blomqvist M,Cooper SJ,Doherty MM,Mitchell MJ,Montgomery RC

更新日期：1992-01-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Previous studies have demonstrated that sensitization to repeated doses of cocaine results in prolonged changes in glutamate transmission. However, little is known about long-term changes in glutamate transmission following a single dose of cocaine. Our laboratory has previously reported that a...

journal_title：Psychopharmacology

authors： Kozell B,Meshul K

更新日期：2003-02-01 00:00:00

abstract：:A prospective study of response to treatment with nortriptyline was carried out in a group of 14 inpatients with mixed symptoms of depression and dementia. Platelet membrane fluidity, as reflected by the fluorescence anisotropy of DPH labeled membranes, was determined for all 14 drug-free subjects prior to treatment b...

journal_title：Psychopharmacology

authors： Zubenko GS,Reynolds CF 3rd,Perel JM,Decker C,Malinakova I

更新日期：1988-01-01 00:00:00

abstract：:Different venlafaxine doses (1, 5, and 10 mg/kg) and saline solution were administered to ten male Wistar rats (Latin-Square design). Compared with saline, venlafaxine produced a dose-related suppression of REM sleep and an increase in wake time while slow wave sleep was reduced. This effect is similar to the one that...

journal_title：Psychopharmacology

authors： Salin-Pascual RJ,Moro-Lopez ML

更新日期：1997-02-01 00:00:00

abstract：:Triadimefon is a triazole fungicide that produces hyperactivity in both mice and rats similar to that seen following administration of compounds with catecholaminergic activity (e.g., d-amphetamine). To determine whether the triadimefon-induced hyperactivity is due to an action on CNS catecholaminergic systems, we eva...

journal_title：Psychopharmacology

authors： Crofton KM,Boncek VM,MacPhail RC

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Repeated intermittent exposure to ketamine has rapid and long-lasting antidepressant effects, but the abuse potential has only been assessed at high doses. Furthermore, while females are more susceptible to depression and more sensitive to ketamine's antidepressant-like effects, the abuse potential for ketami...

journal_title：Psychopharmacology

authors： Wright KN,Strong CE,Addonizio MN,Brownstein NC,Kabbaj M

更新日期：2017-02-01 00:00:00

abstract：:The effects of a new alpha-2 adrenoceptor antagonist on erectile function was assessed in 12 normal volunteers (mean age 28.7, range 20-42), using a double blind, placebo controlled design with two doses of drug and three testing sessions. The drug was administered by intravenous infusion and erectile responses to ero...

journal_title：Psychopharmacology

authors： Munoz M,Bancroft J,Turner M

更新日期：1994-08-01 00:00:00

abstract：RATIONALE:Methylphenidate is a psychostimulant given for extended periods of time as a treatment of attention-deficit/hyperactivity disorder (ADHD). The long-term effects of the drug are not yet known, and it is speculated that repeated exposure may produce drug dependence. OBJECTIVE:To investigate the effects of repe...

journal_title：Psychopharmacology

authors： dela Peña I,Yoon SY,Lee JC,dela Peña JB,Sohn AR,Ryu JH,Shin CY,Cheong JH

更新日期：2012-05-01 00:00:00

abstract：RATIONALE:Clozapine is a unique antipsychotic with very low propensity to cause motor side effects. In contrast to most other antipsychotics that block more than 70% of dopamine D(2) receptors at therapeutic doses, clozapine occupies less than 70%. Furthermore, even at maximum occupancy, 70% is not exceeded. Several me...

journal_title：Psychopharmacology

authors： Suhara T,Okauchi T,Sudo Y,Takano A,Kawabe K,Maeda J,Kapur S

更新日期：2002-02-01 00:00:00

abstract：:The selective serotonin reuptake inhibitor fluvoxamine interferes with the metabolism of tricyclic antidepressants. The present investigation was set out to characterize these interactions in vitro using rat liver microsomes and in vivo by analysing levels of clomipramine and metabolites in sera of depressed patients ...

journal_title：Psychopharmacology

authors： Härtter S,Arand M,Oesch F,Hiemke C

更新日期：1995-01-01 00:00:00

abstract：:Muscimol, a structural analog of GABA, significantly potentiated pilocarpine-induced analgesia in rats, but failed to alter pilocarpine-induced catalepsy. It also failed to affect pilocarpine-elicited increase in homovanillic acid levels in the striatum. These findings suggest that the potentiation of pilocarpine-indu...

journal_title：Psychopharmacology

authors： Naik SR,Kelkar MR,Amladi SR,Sheth UK

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Opioid use disorder (OUD) is a major epidemic in the USA. Despite evidence indicating that OUD may be particularly severe for women, preclinical models have yet to establish sex as a major factor in OUD. OBJECTIVES:Here, we examined sex differences in vulnerability to relapse following intermittent access fe...

journal_title：Psychopharmacology

authors： Bakhti-Suroosh A,Towers EB,Lynch WJ

更新日期：2021-01-06 00:00:00

abstract：:The effect of lithium and rubidium on curiosity rearing, and locomotor activity in isolated and group-housed male mice (DBA/2 Han) was investigated. LiCl and RbCl were given with the drinking water (30 mol/l) during 3 weeks. The behaviour of the animals was tested before and after the chronical application of either l...

journal_title：Psychopharmacology

authors： Weischer ML

更新日期：1979-03-28 00:00:00

abstract：:Methaqualone produces a dose- and time-dependent increase in plasma corticosterone concentration in mice. Acute studies showed that this effect is largely independent of methaqualone-induced hypothermia but can be blocked by pretreatment with dexamethasone, thus demonstrating that the adrenal cortex is not being direc...

journal_title：Psychopharmacology

authors： Meyer JS,Boggan WO

更新日期：1977-08-31 00:00:00

abstract：RATIONALE:Prepulse inhibition (PPI) and locomotor activity have been used to investigate the effects of antipsychotic and stimulant drugs and their underlying dopaminergic mechanisms. Whereas D2-like agonists consistently decreased PPI and increased locomotion in rats in previous studies, we recently reported that thes...

journal_title：Psychopharmacology

authors： Ralph RJ,Caine SB

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:This laboratory study investigated the mechanisms by which the opioid antagonist, naltrexone, reduces the risk of relapse to heavy drinking in individuals with alcohol dependence. METHODS:Eighteen alcohol-dependent, non-treatment-seeking volunteers were randomized to 50 mg naltrexone or placebo for 6 days a...

journal_title：Psychopharmacology

authors： O'Malley SS,Krishnan-Sarin S,Farren C,Sinha R,Kreek MJ

更新日期：2002-02-01 00:00:00

abstract：RATIONALE:Dopamine (DA) plays an important role in working memory. However, the precise functions supported by different DA receptor subtypes in different neural regions remain unclear. OBJECTIVE:The present study used pharmacological, event-related fMRI to test the hypothesis that striatal dopamine is important for t...

journal_title：Psychopharmacology

authors： Dodds CM,Clark L,Dove A,Regenthal R,Baumann F,Bullmore E,Robbins TW,Müller U

更新日期：2009-11-01 00:00:00

abstract：RATIONALE:Like other monoamine releasers such as D-amphetamine, chronic treatment with phenmetrazine can attenuate cocaine self-administration in monkeys. OBJECTIVES:The present studies extended this finding to rodents and to cocaine-primed reinstatement, a putative laboratory animal model of relapse. METHODS:In expe...

journal_title：Psychopharmacology

authors： Czoty PW,Tran P,Thomas LN,Martin TJ,Grigg A,Blough BE,Beveridge TJ

更新日期：2015-07-01 00:00:00

abstract：:Monoamine neurotransmitter systems, along with cholinergic systems, are known to play important roles in cognition, and are disrupted in at least some patients with dementia of the Alzheimer type (DAT). This suggests that monoamine-enhancing drugs might ameliorate cognitive symptoms in certain patients with DAT. L-Dep...

journal_title：Psychopharmacology

authors： Tariot PN,Sunderland T,Weingartner H,Murphy DL,Welkowitz JA,Thompson K,Cohen RM

更新日期：1987-01-01 00:00:00

abstract：:The thymoleptics potentiate and modify the behavioral effects of apomorphine (probably the most specific dopaminergic agonist) as well as those of Dopa. The effect of the thymoleptics is not abolished by emptying of amine stores, and this together with other evidence suggests that these drugs facilitate the access of ...

journal_title：Psychopharmacology

authors： Molander L,Randrup A

更新日期：1976-09-17 00:00:00

abstract：:This study was conducted in order to investigate the level of amitriptyline (AT) and its metabolites. Three separate experiments were carried out. In two of these experiments, rats were treated over 7 days with IP doses of AT (10 mg/kg in experiment A and 2 X 20 mg/kg in experiment C). The rats were sacrificed either ...

journal_title：Psychopharmacology

authors： Baumann P,Gaillard JM,Jonzier-Perey M,Gerber C,Bouras C

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Research in pediatric psychopharmacology has expanded considerably in the last 10 years. Still, controversy remains about the effectiveness and safety of commonly used psychotropics and their role in child treatment, thus pointing to the need for more in-depth and targeted investigations. OBJECTIVES:To revie...

journal_title：Psychopharmacology

authors： Vitiello B

更新日期：2007-03-01 00:00:00

abstract：:Chronic treatment of rats with choline caused a decrease in the hypothermic response to pilocarpine. The action of choline on the muscarinic receptors is consistent with electrophysiological and binding studies, supporting a direct muscarinic action for choline. Administration of direct muscarinic agonists has been sh...

journal_title：Psychopharmacology

authors： Pomara N,Block R,Demetriou S,Fucek F,Stanley M,Gershon S

更新日期：1983-01-01 00:00:00

abstract：:N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON 954) causes a reproducible rest tremor in mice, of rapid onset and short duration with no associated rigidity or akinesia and in the absence of any marked changes in body temperature or accompanying peripheral parasympathomimetic effects. This tremor ca...

journal_title：Psychopharmacology

authors： Coward DM,Doggett NS

更新日期：1977-04-29 00:00:00