Abstract：
:Monoamine neurotransmitter systems, along with cholinergic systems, are known to play important roles in cognition, and are disrupted in at least some patients with dementia of the Alzheimer type (DAT). This suggests that monoamine-enhancing drugs might ameliorate cognitive symptoms in certain patients with DAT. L-Deprenyl is a monoamine oxidase (MAO) inhibitor which may selectively inhibit MAO-B at low doses, while at high doses it nonselectively inhibits MAO-A as well as MAO-B. We studied its effects on several types of cognitive function in 17 patients with DAT. Two doses of L-deprenyl (10 mg/day and 40 mg/day) and placebo were compared in a double-blind, serial treatment design. Episodic learning and memory, knowledge memory, attention, recognition, and performance on a continuous performance task were assessed at baseline and under these drug and placebo conditions. Statistically significant improvement was noted in performance on an episodic memory and learning task requiring complex information processing and sustained conscious effort during treatment with L-deprenyl 10 mg/day. Knowledge memory, intrusions, and other cognitive functions relevant to DAT were not altered by L-deprenyl at either dose.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Tariot PN,Sunderland T,Weingartner H,Murphy DL,Welkowitz JA,Thompson K,Cohen RMdoi
10.1007/BF00216016subject
Has Abstractpub_date
1987-01-01 00:00:00pages
489-95issue
4eissn
0033-3158issn
1432-2072journal_volume
91pub_type
临床试验,杂志文章abstract：:The number of nerve cells in two different areas of the corpus striatum (i.e., ventrolateral and dorsomedial) was estimated in rat brain after long-term (36 weeks) treatment with the neuroleptic flupenthixol. Nine rats were given weekly injections of 4 mg/kg flupenthixol dissolved in Viscoleo i.m., and seven rats rece...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00428036
更新日期：1978-09-15 00:00:00
abstract：:Rats were made hyperphagic by 6-hydroxydopamine (6-OHDA) injected bilaterally into the ventral midbrain; then they were restricted to a 6 h/day feeding schedule and tested for appetite suppression with amphetamine and fenfluramine in randomized order. Amphetamine anorexia was diminished while fenfluramine anorexia was...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426393
更新日期：1984-01-01 00:00:00
abstract：RATIONALE:Clinical trials show that chronic cocaine users suffer from sleep disturbances and preclinical research has shown that acute sleep deprivation increases the rate of cocaine self-administration in rats. OBJECTIVE:This study examined the effect of cocaine self-administration on behavioral indices of sleep and ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3101-1
更新日期：2013-09-01 00:00:00
abstract：:Following the stereotaxic implantation of chronic cannulae for intracerebroventricular (ICV) infusion, rats were given an alcohol preference test to establish their preferred concentration in comparison with water. After alcohol was removed, 15 mg/kg cyanamide was then injected subcutaneously for 4 days in order to ma...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00444688
更新日期：1989-01-01 00:00:00
abstract：:The effect of two subcutaneous injections of 0.6 mg nicotine, administered 40 min apart, was compared with placebo in four non-smoking subjects in a counter-balanced double-blind crossover design. The nicotine injections produced mean peak plasma nicotine concentrations of 5.3 ng/ml 10 min after the first injection an...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02244767
更新日期：1994-06-01 00:00:00
abstract：RATIONALE:Flumazenil, a competitive antagonist of benzodiazepine receptors (BZRs), has been used as a probe to detect effects of putative endogenous ligands for BZRs in anxiety. Flumazenil is renowned for its highly inconsistent behavioral effects. OBJECTIVE:To ascertain effects of flumazenil in the social conflict te...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-003-1583-y
更新日期：2004-01-01 00:00:00
abstract：:The distinctive effects of ethanol on behavior suggest that certain parts of the CNS may be especially sensitive to it. One of the primary candidates is the hippocampal formation. Damage to this structure mimics acute ethanol treatment across a wide variety of behavioral tasks and processes. The possibility of a hippo...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00445554
更新日期：1989-01-01 00:00:00
abstract：RATIONALE:Considerable research indicates that "ecstasy" users perceive their memory for future intentions (prospective memory) to be impaired. However, only one empirical study to date has directly tested how this capacity is affected by ecstasy use, and this study provided relatively limited information regarding the...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-007-0859-z
更新日期：2007-11-01 00:00:00
abstract：RATIONALE:The aversive effects of ∆(9)-tetrahydrocannabinol (THC) are mediated by activity at the kappa opioid receptor (KOR) as assessed in adult animals; however, no studies have assessed KOR involvement in the aversive effects of THC in adolescents. Given that adolescents have been reported to be insensitive to the ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-015-3970-6
更新日期：2015-09-01 00:00:00
abstract：RATIONALE:Training in research ethics is crucial for psychiatric investigators. Addressing ethical dimensions of human subjects research requires knowledge about the rules and norms governing research; sensitivity to ethical implications of actions; and skills in ethics problem solving. Investigators in training who ar...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-003-1500-4
更新日期：2003-12-01 00:00:00
abstract：RATIONALE:Although the effects of D: -cycloserine (DCS) and valproic acid (VPA) on the facilitation of the extinction of fear-conditioned memory have been elucidated in animals, these effects have not been clearly confirmed in humans. OBJECTIVE:This study aimed to determine the effect of DCS (100 mg) and VPA (400 mg) ...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-011-2353-x
更新日期：2011-12-01 00:00:00
abstract：:The effects of morphine, ketocyclazocine, cyclazocine, and SKF-10,047 were tested alone and in conjunction with naltrexone or naloxone, in rats responding under a multiple fixed-interval 3-min schedule of food presentation. Under this paradigm, electric shock was delivered on a fixed-ratio schedule for responses occur...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00435274
更新日期：1982-01-01 00:00:00
abstract：RATIONALE:There is a close relationship between arousal and pupil diameter, decrease in the level of arousal being accompanied by constriction of the pupil (miosis), probably reflecting the attenuation of sympathetic outflow as sedation sets in. Paradoxically, sedation induced by benzodiazepines is not accompanied by m...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-007-0884-y
更新日期：2007-11-01 00:00:00
abstract：RATIONALE AND OBJECTIVE:Drug-associated memories are hypothesized to underlie the high risk of relapse in addiction. Recent studies show that post-retrieval extinction training erases fear memories by reconsolidation blockade. Here, we examine the efficacy of this non-invasive procedure in rats with drug-associated mem...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-011-2545-4
更新日期：2012-05-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426958
更新日期：1978-04-14 00:00:00
abstract：RATIONALE:Cortical gamma-aminobutyric acid (GABA)ergic neurons contribute to the orchestration of pyramidal neuron population firing as follows: (1) by releasing GABA on GABA(A) and GABA(B) receptors, (2) by releasing reelin in the proximity of integrin receptors located on cortical pyramidal neuron dendritic spines, a...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-005-2212-8
更新日期：2005-07-01 00:00:00
abstract：:The effect of the intracerebroventricular (ICV) administration of taurine on amnesia, convulsions and death caused by hypoxia was investigated in mice. Taurine in doses of 80-100 micrograms/mouse impaired acquisition of a single trial in passive avoidance performance, but protected mice from the learning impairment in...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00451681
更新日期：1989-01-01 00:00:00
abstract：RATIONALE:Cocaine addiction is a relapsing psychiatric disorder with a high prevalence in developed countries. To date, the reinstatement model has been difficult to implement in mice. The design of an appropriate reinstatement model in mice is required in order to use genetically modified animals with the aim of clari...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-008-1184-x
更新日期：2008-09-01 00:00:00
abstract：INTRODUCTION:Nearly 25% of American adults remain regular smokers. Current smokers may be especially likely to possess characteristics that impair their ability to quit, such as impulsivity. Impulsive individuals may be overly prone to smoke because they are particularly drawn to rewarding stimuli and related cues. The...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s00213-007-0832-x
更新日期：2007-10-01 00:00:00
abstract：INTRODUCTION:Understanding an individual's vulnerability to drug addiction has important implications for the development of effective personal treatment plans. Although theories acknowledge impulsive behaviour as a key component of drug addiction, little is known about the influence of trait impulsivity on an individu...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3270-y
更新日期：2014-02-01 00:00:00
abstract：:Adult rats that were gestationally exposed to cocaine and control offspring were examined for their sensitivity to challenge doses of cocaine. Offspring were derived from Sprague-Dawley dams that had received subcutaneous injections of 40 mg/kg per 3 cc cocaine hydrochloride daily on gestational days 8-20, pair-fed da...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244870
更新日期：1994-09-01 00:00:00
abstract：RATIONALE:Spontaneous fluctuations in the size of the pupil in darkness are a recognized index of sleepiness, and these fluctuations can be quantitatively measured using the pupillographic sleepiness test (PST). The central noradrenergic system is believed to play a role in the maintenance of alertness, and there is ev...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/s002130000398
更新日期：2000-05-01 00:00:00
abstract：:In the present study a cross-familiarisation conditioned taste aversion (CTA) paradigm was utilized to reveal stimulus resemblance between the selective 5-HT1A agonist 8-OHDPAT and a variety of serotonergic and non-serotonergic drugs. In male mice, a 0.22 mg/kg dose of 8-OHDPAT was used as the reference compound induc...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02247372
更新日期：1993-01-01 00:00:00
abstract：:The cognitive deficits, particularly memory impairment, observed in association with organic brain damage caused by chronic alcohol ingestion, are consistent with the profile of benzodiazepine-induced amnesia. This study examined the cognitive capabilities of a group of heavy social drinkers (n = 11) and a group of lo...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02244897
更新日期：1993-01-01 00:00:00
abstract：RATIONALE:Dronabinol (Δ(9)tetrahydrocannabinol) is approved for HIV-related anorexia, yet, little is known about its effects in HIV-positive marijuana smokers. HIV-negative marijuana smokers require higher than recommended dronabinol doses to experience expected effects. OBJECTIVES:Employing a within-subjects, double-...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-010-1995-4
更新日期：2010-12-01 00:00:00
abstract：:To investigate the mood response of schizophrenic subjects to psychostimulant challenge, 29 neuroleptic-treated subjects (22 with schizophrenia and 7 with schizoaffective disorder) in clinical remission received two infusions, one with methylphenidate 0.5 mg/kg and the other with normal saline, under double-blind cond...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02244317
更新日期：1991-01-01 00:00:00
abstract：AIM:It is widely assumed that the upcoming therapeutics for Alzheimer's disease will require to act on more than one target to be effective. We investigated here whether a combination of the nicotinic receptor allosteric modulator/cholinesterase inhibitor galantamine can act synergistically with the type 4 serotonin re...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4664-z
更新日期：2017-08-01 00:00:00
abstract：:In two experiments, phenobarbitone sodium (30 mg/kg) reliably enhanced water consumption and extended the duration of drinking in 24h water-deprived male rats. The opiate receptor antagonists naloxone (0.1-10 mg/kg) and naltrexone (0.1-10 mg/kg) both decreased water intake and reduced the duration of drinking. When th...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00433011
更新日期：1983-01-01 00:00:00
abstract：RATIONALE:Performance on progressive ratio schedules has been proposed as a means of assessing the effects of drugs on the value or "efficacy" of reinforcers. A mathematical model affords a basis for quantifying the effects of drugs on progressive ratio schedule performance. According to this model, the relation betwee...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-004-2049-6
更新日期：2005-05-01 00:00:00
abstract：:In a 4 week study of the response of neurotic outpatients to treatment with amitriptyline, diazepam, amitriptyline and diazepam, or placebo clinical and psychophysiological variables and plasma levels of the drug were assessed. Clinical improvements were substantial in all treatment groups but clear relationships betw...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00431822
更新日期：1981-01-01 00:00:00
