Effects of selective dopamine D1-like and D2-like agonists on prepulse inhibition of startle in inbred C3H/HeJ, SPRET/EiJ, and CAST/EiJ mice.

abstract：:On the heels of clozapine, we now have a number of newer agents (risperidone, olanzapine, quetiapine, sertindole, and ziprasidone). Are they all the same? What are the differences? How do we best understand them? In this article we review current clinical evidence to compare these issues on four measures of atypicalit...

journal_title：Psychopharmacology

authors： Remington G,Kapur S

更新日期：2000-01-01 00:00:00

abstract：:The effects of morphine, ketocyclazocine, cyclazocine, and SKF-10,047 were tested alone and in conjunction with naltrexone or naloxone, in rats responding under a multiple fixed-interval 3-min schedule of food presentation. Under this paradigm, electric shock was delivered on a fixed-ratio schedule for responses occur...

journal_title：Psychopharmacology

authors： Snell D,Harris RA

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:The antidepressant nortriptyline is a second-line pharmacotherapy for smoking cessation. Given that there is limited preclinical data available on the effects of nortriptyline on responses to nicotine, the present study sought to evaluate its effects on the reinforcing, discriminative stimulus (DS) and aversi...

journal_title：Psychopharmacology

authors： Wing VC,Shoaib M

更新日期：2012-02-01 00:00:00

abstract：RATIONALE:Previous studies have shown that the effect of setting on drug-taking is substance specific in both humans and rats. In particular, we have shown that when the setting of drug self-administration (SA) coincides with the home environment of the rats (resident rats), the rats tend to prefer heroin to cocaine. T...

journal_title：Psychopharmacology

authors： Montanari C,Stendardo E,De Luca MT,Meringolo M,Contu L,Badiani A

更新日期：2015-07-01 00:00:00

abstract：:The behavioral profile of corticotropin-releasing factor (CRF) in mediating anxiogenic-like and aversive responses to stressors may be particularly relevant for dependence and withdrawal in drug-experienced organisms. Moreover, stressful aspects of drug exposure in the drug naive organism may also induce CRF system ac...

journal_title：Psychopharmacology

authors： Heinrichs SC,Klaassen A,Koob GF,Schulteis G,Ahmed S,De Souza EB

更新日期：1998-04-01 00:00:00

abstract：RATIONALE:The majority of pharmacotherapies proposed for cocaine dependence have been marginally effective and frequently have undesirable side effects. We recently demonstrated that short-term treatment with citicoline decreased self-reported desire to use cocaine in crack cocaine users. OBJECTIVE:The present study w...

journal_title：Psychopharmacology

authors： Lukas SE,Kouri EM,Rhee C,Madrid A,Renshaw PF

更新日期：2001-09-01 00:00:00

abstract：RATIONALE:The party drug ecstasy is frequently used in combination with other drugs like marihuana and alcohol. In addition, a substantial proportion of the MDMA users has claimed to drive a car when under the influence of MDMA and/or other drugs. OBJECTIVE:To assess the effects of MDMA and alcohol, combined and alone...

journal_title：Psychopharmacology

authors： Kuypers KP,Samyn N,Ramaekers JG

更新日期：2006-09-01 00:00:00

abstract：:It has previously been shown that serotonergic [5-hydroxytryptamine (5-HT)] neurons of the median raphe nucleus (MR) are critically involved in the control of the hippocampal electroencephalogram (EEG). Activation of MR 5-HT neurons desynchronizes the hippocampal EEG, whereas inhibition of MR 5-HT activity produces hi...

journal_title：Psychopharmacology

authors： Kinney GG,Kocsis B,Vertes RP

更新日期：1995-08-01 00:00:00

abstract：:In a phase II study the antidepressive effect of citalopram, a selective and potent serotonin reuptake inhibitor, was examined in 20 endogenously and three non-endogenously depressed hospitalized patients. Four endogenously depressed patients dropped out due to deterioration early in the treatment period. The remainin...

journal_title：Psychopharmacology

authors： Pedersen OL,Kragh-Sørensen P,Bjerre M,Overø KF,Gram LF

更新日期：1982-01-01 00:00:00

abstract：:The effects of the selective 5-HT1A agonists 8-OH-DPAT and flesinoxan and the selective 5-HT2 antagonists ritanserin and ketanserin on immobility time in rats bred for predisposition to catalepsy have been studied. Treatment with 8-OH-DPAT as well as flesinoxan caused a marked dose-dependent decrease in immobility tim...

journal_title：Psychopharmacology

authors： Kulikov AV,Kolpakov VG,Maslova GB,Kozintsev I,Popova NK

更新日期：1994-02-01 00:00:00

abstract：:Physostigmine (1.0mg) or placebo were administered intravenously over 1-h period to seven male normal volunteers beginning 35 min after sleep onset. The results indicate that physostigmine induced the onset of REM sleep but did not significantly alter the duration of individual REM sleep periods. Physostigmine signifi...

journal_title：Psychopharmacology

authors： Gillin JC,Sitaram N,Mendelson WB,Wyatt RJ

更新日期：1978-06-15 00:00:00

abstract：RATIONALE:Schizophrenia is a severe, persistent, and fairly common mental illness. Haloperidol is widely used and is effective against the symptoms of psychosis seen in schizophrenia. Chronic oral haloperidol administration decreased the number of astrocytes in the parietal cortex of macaque monkeys (Konopaske et al., ...

journal_title：Psychopharmacology

authors： Konopaske GT,Bolo NR,Basu AC,Renshaw PF,Coyle JT

更新日期：2013-11-01 00:00:00

abstract：RATIONALE:The α7 nicotinic acetylcholine receptor (nAChR) has been implicated as a target in modulating nicotine reward. However, the effect of pharmacological agents that have been shown to alter the channel properties of the α7 nAChR is not well understood in nicotine reward. OBJECTIVES:This study aimed to investiga...

journal_title：Psychopharmacology

authors： Jackson A,Alkhlaif Y,Papke RL,Brunzell DH,Damaj MI

更新日期：2019-12-01 00:00:00

abstract：:We have previously obtained evidence that the mesoamygdaloid dopamine projection modulates the acquisition of a conditioned response (CR) elicited by presentation of a conditioned stimulus (CS) predicting the availability of a natural (sucrose) reward. This property was found to be dependent upon D3, but not D1 or D2,...

journal_title：Psychopharmacology

authors： Hitchcott PK,Phillips GD

更新日期：1998-12-01 00:00:00

abstract：:The i.v. pentylenetetrazol seizure threshold was increased by 2.5 mg/kg and decreased by 15 mg/kg of a single (+)-amphetamine dose. After 7 consecutive days of amphetamine administration, tolerance developed to the decrease but not to the increase in seizure threshold. At 12--48 h after the last dose of 2.5 mg/kg seiz...

journal_title：Psychopharmacology

authors： Riffee WH,Gerald MC

更新日期：1977-01-31 00:00:00

abstract：BACKGROUND:Caffeine has a well-established effect on reaction times (RTs) but the neurocognitive mechanisms underlying this are unclear. METHODS:In the present study, 15 female participants performed an oddball task after ingesting caffeine or a placebo, and electroencephalographic data were obtained. Single-trial P3b...

journal_title：Psychopharmacology

authors： Saville CWN,de Morree HM,Dundon NM,Marcora SM,Klein C

更新日期：2018-03-01 00:00:00

abstract：RATIONALE:Anxiety and aggression are associated with ethanol self-administration, but these behaviors can serve as either risk factors for or consequences of heavy drinking in rodents and humans. Baseline levels of aggressive-like and anxious-like behavior in non-human primates have not yet been characterized in relati...

journal_title：Psychopharmacology

authors： McClintick MN,Grant KA

更新日期：2016-12-01 00:00:00

abstract：:The performance of healthy volunteer subjects on an auditory latent inhibition (LI) paradigm was assessed following administration of a single oral dose of d-amphetamine or placebo. It was predicted that a low (5 mg), but not a high (10 mg), dose of d-amphetamine would disrupt LI. The prediction was supported with lef...

journal_title：Psychopharmacology

authors： Gray NS,Pickering AD,Hemsley DR,Dawling S,Gray JA

更新日期：1992-01-01 00:00:00

abstract：:The problem of the advantage of using nortriptyline (NT) plasma level during treatment for endogenous depression has been approached. In an ordinary psychiatric department, 34 patients had their NT level checked the second week of treatment and their dosage subsequently adjusted, if it was outside the recommended ther...

journal_title：Psychopharmacology

authors： Sørensen B,Kragh-Sørensen P,Larsen NE,Hvidberg EF

更新日期：1978-09-15 00:00:00

abstract：RATIONALE:Antidepressants are known to modify human sleep patterns. OBJECTIVES:Duloxetine is a new antidepressant with a mechanism of action involving reuptake inhibition of both serotonin (5-HT) and norepinephrine (NE). In this study, the effects of two dosing regimens of duloxetine on sleep electroencephalography (E...

journal_title：Psychopharmacology

authors： Chalon S,Pereira A,Lainey E,Vandenhende F,Watkin JG,Staner L,Granier LA

更新日期：2005-02-01 00:00:00

abstract：:This study demonstrates that the selective delta receptor antagonists ICI 174864 and naltrindole (NTI) attenuate alcohol intake in a dose-dependent manner, without altering water intake, in rats selectively bred for alcohol preference. ICI 174864 had a very limited duration of action, as evidenced by the fact that sup...

journal_title：Psychopharmacology

authors： Krishnan-Sarin S,Jing SL,Kurtz DL,Zweifel M,Portoghese PS,Li TK,Froehlich JC

更新日期：1995-07-01 00:00:00

abstract：:Peripheral administration of the unsulphated cholecystokinin octapeptide (CCK-8us) led to an anxiogenic-like action in the elevated plus-maze model of anxiety in rats. Devazepide and L-365,260 showed potent anxiolytic-like effects at similar doses. The fact that devazepide is 1000 times more potent as a CCK-A receptor...

journal_title：Psychopharmacology

authors： Chopin P,Briley M

更新日期：1993-01-01 00:00:00

abstract：:This pilot study was conducted to evaluate the potential of the new antidepressant moclobemide to inhibit the cytochrome enzyme P4502D6 (CYP2D6) using the cough suppressant dextromethorphan as a substrate in four extensive metabolizers (EM) of debrisoquine. The subjects received seven oral doses of 20 mg dextromethorp...

journal_title：Psychopharmacology

authors： Härtter S,Dingemanse J,Baier D,Ziegler G,Hiemke C

更新日期：1998-01-01 00:00:00

abstract：:The effects of different doses (0.03, 0.06, 0.12, 0.25, 1.0, 2.0, 4.0, and 8.0 mg/kg body weight) of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) were tested on the acoustic startle reflex in rats. Beginning at 0.12 mg/kg, 5-MeODMT increased startle monotonically up to the highest dose used. 5-MeODMT still increased st...

journal_title：Psychopharmacology

authors： Davis M,Astrachan DI,Gendelman PM,Gendelman DS

更新日期：1980-01-01 00:00:00

abstract：BACKGROUND AND RATIONALE:Pain is a complex sensory experience, involving cognitive factors, environment (setting, society, and culture), experience, and gender and is modulated significantly by the central nervous system (CNS). The mechanisms by which opioid analgesics work are understood, but this class of drugs is no...

journal_title：Psychopharmacology

authors： Kivell B,Prisinzano TE

更新日期：2010-06-01 00:00:00

abstract：RATIONALE:The endogenous opioid system has been implicated in substance abuse and response to pharmacotherapies for nicotine and alcohol addiction. We examined (1) the association of the functional OPRM1 A118G variant with the relative reinforcing value of nicotine and (2) the main and interacting effects of the mu-opi...

journal_title：Psychopharmacology

authors： Ray R,Jepson C,Patterson F,Strasser A,Rukstalis M,Perkins K,Lynch KG,O'Malley S,Berrettini WH,Lerman C

更新日期：2006-10-01 00:00:00

abstract：:A total of 97 patients, who participated in two studies on the relationship between the clinical effect and plasma levels of imipramine and clomipramine, were examined for improvement curves by use of weekly ratings on the Hamilton Depression Scale (HDS). Although we confirmed that our six-item HDS subscale, in contra...

journal_title：Psychopharmacology

authors： Bech P,Allerup P,Reisby N,Gram LF

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:During the last few decades, alcohol use disorders (AUD) have reached an epidemic prevalence, yet social influences on alcoholism have not been fully addressed. Several factors can modulate alcohol intake. On one hand, stress can reinforce ethanol-induced behaviors and be an important component in AUD and alc...

journal_title：Psychopharmacology

authors： Bahi A,Dreyer JL

更新日期：2020-03-01 00:00:00

abstract：:Food reward has been associated with activation of noradrenergic mechanisms in the brain. Using rats trained to press a lever for food reward, we have investigated the effects of 6-hydroxydopamine lesions, which severly depleted hypothalamic noradrenaline, on the willingness of the rats to press the lever for food rew...

journal_title：Psychopharmacology

authors： Kruk ZL,Millar J

更新日期：1979-06-28 00:00:00

abstract：RATIONALE:Temporal differentiation in the free-operant psychophysical procedure is sensitive to the 5-hydroxytryptamine (5-HT)1A receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) and the 5-HT2 receptor agonist 2,5-dimethoxy-4-iodo-amphetamine (DOI); both drugs shift the psychophysical curve leftwards...

journal_title：Psychopharmacology

authors： Body S,Kheramin S,Ho MY,Miranda Herrera F,Bradshaw CM,Szabadi E

更新日期：2004-11-01 00:00:00