Platelet membrane fluidity and treatment response in cognitively-impaired, depressed elderly: initial results.

abstract：:Recent studies indicate that some aspects of memory can be enhanced by the administration of oxygen or glucose. Considering the dependency of glucose metabolism upon oxygen supply, the present study predicted that administering a combination of 100% oxygen with glucose would have greater memory-enhancing effects than ...

journal_title：Psychopharmacology

authors： Winder R,Borrill J

更新日期：1998-04-01 00:00:00

abstract：INTRODUCTION:Nearly 25% of American adults remain regular smokers. Current smokers may be especially likely to possess characteristics that impair their ability to quit, such as impulsivity. Impulsive individuals may be overly prone to smoke because they are particularly drawn to rewarding stimuli and related cues. The...

journal_title：Psychopharmacology

authors： Doran N,Spring B,McChargue D

更新日期：2007-10-01 00:00:00

abstract：RATIONALE:The use and misuse of prescription opiates in adolescent populations, and in particular, adolescent female populations, has increased dramatically in the past two decades. Given the significant role that opioids play in neuroendocrine function, exposure to opiates during this critical developmental period cou...

journal_title：Psychopharmacology

authors： Byrnes JJ,Johnson NL,Carini LM,Byrnes EM

更新日期：2013-05-01 00:00:00

abstract：RATIONALE:Abnormalities of cortical evoked potentials and background electroencephalographic (EEG) frequencies occur in several psychiatric disorders, some of which, especially depression, are associated with hypercortisolaemia. However, there have been few investigations of the effects of exogenously administered cort...

journal_title：Psychopharmacology

authors： Ashton CH,Lunn B,Marsh VR,Young AH

更新日期：2000-09-01 00:00:00

abstract：:Intraperitoneal (IP) administration of the acetylcholinesterase inhibitor, soman (10-40 micrograms/kg), suppressed in a dose-related manner response rates in rats maintained under a multiple fixed-interval 50-s fixed-ratio 25 schedule of food delivery. Chronic administration of soman at weekly intervals resulted in to...

journal_title：Psychopharmacology

authors： Hymowitz N,Brezenoff HE,McGee J,Campbell K,Knight V

更新日期：1985-01-01 00:00:00

abstract：INTRODUCTION:Alcohol has been shown to increase smoking urges and smoking behavior. However, alcohol's effects on specific components of smoking behavior for nicotine versus non-nicotine factors and potential sex differences in this response have not been investigated. METHODS:Forty-two young male and female non-depen...

journal_title：Psychopharmacology

authors： King A,McNamara P,Conrad M,Cao D

更新日期：2009-11-01 00:00:00

abstract：:Using a conditioned avoidance procedure in rats, the present study examined the ability of 8-OH-DPAT, ritanserin, and prazosin to alter the effects of the dopamine antagonists, raclopride and haloperidol, on avoidance- and on escape responding. The 5-HT1A agonist 8-OH-DPAT (0.16 mg/kg) significantly enhanced the inhib...

journal_title：Psychopharmacology

authors： Prinssen EP,Kleven MS,Koek W

更新日期：1996-11-01 00:00:00

abstract：:The anxiolytic activity of diazepam (DZP) (0.25-1 mg/kg) was investigated in streptozotocin (STZ)-induced diabetic adult Charles Foster albino rats of either sex. Diabetes was induced by injecting STZ IP (50 mg/kg; in citrate buffer, pH 4.5). Experiments were performed 72 h later. The rats were subjected to various an...

journal_title：Psychopharmacology

authors： Ramanathan M,Jaiswal AK,Bhattacharya SK

更新日期：1998-02-01 00:00:00

abstract：RATIONALE:Using a rat relapse model, recent studies reported time dependent increases in cocaine seeking induced by re-exposure to cocaine cues, but not cocaine itself, over withdrawal periods of up to 3 months. OBJECTIVES:In the present study, we explored the time course of cocaine seeking induced by priming injectio...

journal_title：Psychopharmacology

authors： Lu L,Dempsey J

更新日期：2004-10-01 00:00:00

abstract：RATIONALE:Animal models aimed to mimic mania have in common the lack of genuine affective parameters. Although rodent amphetamine-induced hyperlocomotion is a frequently used behavioral model of mania, locomotor activity is a rather unspecific target for developing new pharmacological therapies, and does not necessaril...

journal_title：Psychopharmacology

authors： Pereira M,Andreatini R,Schwarting RK,Brenes JC

更新日期：2014-07-01 00:00:00

abstract：RATIONALE:Previous studies have shown that buspirone, a partial 5-HT(1A) receptor agonist, produces antinociceptive effects in rats and mice; Ca(2+) plays a critical role as a second messenger in mediating nociceptive transmission. 5-HT(1A) receptors have been proven to be coupled functionally with various types of Ca(...

journal_title：Psychopharmacology

authors： Liang JH,Wang XH,Liu RK,Sun HL,Ye XF,Zheng JW

更新日期：2003-03-01 00:00:00

abstract：RATIONALE:Recent studies have implicated an important role for the dorsal striatum during craving for cocaine and in cocaine-seeking after abstinence in rats. OBJECTIVES:We compared the effects of pharmacological inactivation of mesencephalic dopamine (DA) cell body regions and dorsal vs ventral striatal terminal fiel...

journal_title：Psychopharmacology

authors： See RE,Elliott JC,Feltenstein MW

更新日期：2007-10-01 00:00:00

abstract：RATIONALE:Oleoyl glycine (OlGly), a recently discovered fatty acid amide that is structurally similar to N- acylethanolamines, which include the endocannabinoid, anandamide (AEA), as well as endogenous peroxisome proliferator-activated receptor alpha (PPARα) agonists oleoylethanolamide (OEA) and palmitoylethanolamide (...

journal_title：Psychopharmacology

authors： Petrie GN,Wills KL,Piscitelli F,Smoum R,Limebeer CL,Rock EM,Humphrey AE,Sheppard-Perkins M,Lichtman AH,Mechoulam R,Di Marzo V,Parker LA

更新日期：2019-09-01 00:00:00

abstract：:Peak saccadic eye movement velocity (SEV) and average smooth pursuit gain (SP) are reduced in a dose-dependent manner by diazepam and provide reliable, quantitative measures of benzodiazepine agonist effects. To evaluate the specificity of these eye movement effects for agents acting at the central GABA-benzodiazepine...

journal_title：Psychopharmacology

authors： Hopfenbeck JR,Cowley DS,Radant A,Greenblatt DJ,Roy-Byrne PP

更新日期：1995-04-01 00:00:00

abstract：:Rats were maintained on a regimen of restricted access to water. Desipramine (DMI) IP 1 h prior to the access period dose-dependently reduced water intake. Following completion of the dose-response determination for the effect of desipramine or water intake, rats were divided into three groups for repeated administrat...

journal_title：Psychopharmacology

authors： O'Donnell JM,Rider DP,Somani S,Seiden LS

更新日期：1982-01-01 00:00:00

abstract：:The thymoleptics potentiate and modify the behavioral effects of apomorphine (probably the most specific dopaminergic agonist) as well as those of Dopa. The effect of the thymoleptics is not abolished by emptying of amine stores, and this together with other evidence suggests that these drugs facilitate the access of ...

journal_title：Psychopharmacology

authors： Molander L,Randrup A

更新日期：1976-09-17 00:00:00

abstract：RATIONALE:Recent studies suggest that orexin/hypocretin is involved in drug reward and drug-seeking behaviors, including ethanol self-administration. However, orexin's role in ethanol-induced seeking behaviors remains unclear. OBJECTIVE:These studies examined the role of orexin in the acquisition and expression of eth...

journal_title：Psychopharmacology

authors： Voorhees CM,Cunningham CL

更新日期：2011-04-01 00:00:00

abstract：:Cigarette smokers have a wide variety of "tar" and nicotine yields to choose from in the current market, ranging from 0.5 mg "tar" and less than 0.05 mg nicotine to 27 mg "tar" and 1.8 mg nicotine by the Federal Trade Commission (FTC) method. To understand better the relationship between FTC nicotine yields and actual...

journal_title：Psychopharmacology

authors： Byrd GD,Robinson JH,Caldwell WS,deBethizy JD

更新日期：1995-11-01 00:00:00

abstract：RATIONALE:Numerous preclinical and clinical studies have reported the rapid and sustained antidepressant effects of the NMDA receptor antagonist ketamine. Because ketamine induces several undesirable and dangerous effects, a variety of strategies have been suggested to avoid such effects. OBJECTIVES:Here, we propose t...

journal_title：Psychopharmacology

authors： Podkowa K,Pochwat B,Brański P,Pilc A,Pałucha-Poniewiera A

更新日期：2016-08-01 00:00:00

abstract：:Haloperidol disposition has been associated with reversible metabolism: it is reversibly reduced to its metabolite, reduced haloperidol, which has less pharmacologic activity than the parent compound. To characterize the interconversion process, six healthy male schizophrenics were administered a single dose of 10 mg ...

journal_title：Psychopharmacology

authors： Jann MW,Lam YW,Chang WH

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:So-called atypical antipsychotics (AAPs) are associated with varying levels of weight gain and associated metabolic disturbances, which in patients with serious mental illness (SMI) have been linked to non-compliance and poor functional outcomes. Mechanisms underlying AAP-induced metabolic abnormalities are o...

journal_title：Psychopharmacology

authors： Benarroch L,Kowalchuk C,Wilson V,Teo C,Guenette M,Chintoh A,Nesarajah Y,Taylor V,Selby P,Fletcher P,Remington GJ,Hahn MK

更新日期：2016-07-01 00:00:00

abstract：:Dopaminergic behavioral supersensitivity may be induced by chronic treatment with either dopaminergic agonists or antagonists. We demonstrate that the development of agonist-induced supersensitivity is resistant to chronic lithium exposure. Furthermore, chronic lithium alone enhances the stereotypic response to acute ...

journal_title：Psychopharmacology

authors： Rubin EH,Wooten GF

更新日期：1984-01-01 00:00:00

abstract：:Chronic treatment (2 weeks) with piracetam (500 mg/kg, once daily PO) elevated m-cholinoceptor density in the frontal cortex of aged (18 months) female mice by about 30-40%, but had no effect on m-cholinoceptor density in the frontal cortex of young (4 weeks) mice. The effect of piracetam on m-cholinoceptor density as...

journal_title：Psychopharmacology

authors： Pilch H,Müller WE

更新日期：1988-01-01 00:00:00

abstract：INTRODUCTION:Model psychosis is characterised by experimentally induced symptoms of withdrawal from reality, frequently accompanied by perceptual disturbances, thought disorders, delusional ideas and sometimes by hallucinations. These "altered states of consciousness" provide a long-standing and valid approach to enhan...

journal_title：Psychopharmacology

authors： Koethe D,Hoyer C,Leweke FM

更新日期：2009-11-01 00:00:00

abstract：RATIONALE:Temporal differentiation of operant behaviour is sensitive to dopaminergic manipulations. Studies using the fixed-interval peak procedure implicated D2 dopamine receptors in these effects. Less is known about the effects of dopaminergic manipulations on temporal differentiation in other timing schedules. OBJ...

journal_title：Psychopharmacology

authors： Cheung TH,Bezzina G,Asgari K,Body S,Fone KC,Bradshaw CM,Szabadi E

更新日期：2006-04-01 00:00:00

abstract：RATIONALE:Recently, we showed that 2-bromoterguride acted as a dopamine D2 receptor partial agonist, a serotonin 5-HT2A and α2C-adrenergic receptor antagonist, and exhibited antidopaminergic efficacy in amphetamine-induced locomotion (AIL) in rats without inducing catalepsy. OBJECTIVE:To extend our knowledge on the an...

journal_title：Psychopharmacology

authors： Franke RT,Tarland E,Fink H,Pertz HH,Brosda J

更新日期：2016-08-01 00:00:00

abstract：RATIONALE:Nicotine increases glutamate release in the ventral tegmental area and the nucleus accumbens, and thus enhances dopamine neurotransmission in the mesolimbic system that has been implicated in mediating the rewarding effects of drugs. Metabotropic glutamate receptors 5 (mGluR5) are found in the nucleus accumbe...

journal_title：Psychopharmacology

authors： Paterson NE,Semenova S,Gasparini F,Markou A

更新日期：2003-05-01 00:00:00

abstract：:Mice were trained on a one-trial inhibitory avoidance task and given immediate post-training intraperitoneal injections of cocaine (0.03-1.00 mg/kg). On a retention test 24 h later, the retention latencies of mice given the 0.10 mg/kg dose were significantly higher than those of the controls. The effect of cocaine on ...

journal_title：Psychopharmacology

authors： Introini-Collison IB,McGaugh JL

更新日期：1989-01-01 00:00:00

abstract：:The effects of the antiepilepsy drugs methsuximide and mephenytoin were examined in pigeons responding under a fixed-consecutive-number (FCN) schedule with and without an added external discriminative stimulus. On this schedule, food was delivered whenever subjects responded between 8 and 12 times on one response key ...

journal_title：Psychopharmacology

authors： Schlinger H,Wilkenfield J,Poling A

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Soda manufacturers claim that caffeine is added to soda as a flavor enhancer, but many researchers have speculated that caffeine is added to increase the hedonic and reinforcing properties of the soda. Studies in adults have demonstrated that caffeine can condition flavor preferences when added to novel-flav...

journal_title：Psychopharmacology

authors： Temple JL,Ziegler AM,Graczyk A,Bendlin A,O'Leary S,Schnittker YS

更新日期：2012-09-01 00:00:00