Effects of dopamine antagonists in a two-way active avoidance procedure in rats: interactions with 8-OH-DPAT, ritanserin, and prazosin.

abstract：:The release of serotonin (5-HT) at serotonergic nerve terminals is regulated by 5-HT(1B) autoreceptors. Several studies have reported that the effects of selective 5-HT reuptake inhibitors (SSRIs) on extracellular 5-HT are augmented by 5-HT(1B) receptor antagonists, whereas administration of these antagonists alone do...

journal_title：Psychopharmacology

authors： de Groote L,Klompmakers AA,Olivier B,Westenberg HG

更新日期：2003-05-01 00:00:00

abstract：RATIONALE:Previous work has shown that environmental enrichment alters amphetamine-induced locomotor activity and conditioned place preference. OBJECTIVE:The present study examined the effect of environmental enrichment on amphetamine self-administration. METHODS:Female and male rats were raised from 21 days of age i...

journal_title：Psychopharmacology

authors： Bardo MT,Klebaur JE,Valone JM,Deaton C

更新日期：2001-05-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:We previously found that systemic injections of the 5-HT uptake blocker fluoxetine attenuate intermittent footshock stress-induced reinstatement of alcohol seeking in rats, while inhibition of 5-HT neurons in the median raphe induces reinstatement of alcohol seeking. In this study, we further e...

journal_title：Psychopharmacology

authors： Lê AD,Funk D,Harding S,Juzytsch W,Fletcher PJ,Shaham Y

更新日期：2006-05-01 00:00:00

abstract：RATIONALE:Neurosteroids are implicated in various stages of drug dependence, including the acquisition phase, tolerance, and withdrawal. The neurosteroid allopregnanolone is also able to substitute for drugs with abuse potential and possesses reinforcing properties. OBJECTIVES:The effects of acute treatment with, and ...

journal_title：Psychopharmacology

authors： Concas A,Sogliano C,Porcu P,Marra C,Brundu A,Biggio G

更新日期：2006-06-01 00:00:00

abstract：:Previous studies have shown that dihydropyridine (DHP) calcium channel blockers can potentiate yawning induced by apomorphine in rats. The present study was undertaken to examine whether or not this interaction was seen with other compounds that induce yawning or if it represented a specific interaction with dopaminer...

journal_title：Psychopharmacology

authors： Bourson A,Moser PC

更新日期：1990-01-01 00:00:00

abstract：:The effects of the antiepilepsy drugs methsuximide and mephenytoin were examined in pigeons responding under a fixed-consecutive-number (FCN) schedule with and without an added external discriminative stimulus. On this schedule, food was delivered whenever subjects responded between 8 and 12 times on one response key ...

journal_title：Psychopharmacology

authors： Schlinger H,Wilkenfield J,Poling A

更新日期：1988-01-01 00:00:00

abstract：:This study evaluated the effects of two central nicotinic-cholinergic receptor agonists and an antagonist on performance accuracy of a rat, delayed stimulus discrimination task (DSDT). Rats were trained to discriminate between an auditory and visual stimulus by pressing a right or left lever. To diminish the rat's abi...

journal_title：Psychopharmacology

authors： Terry AV Jr,Buccafusco JJ,Jackson WJ,Zagrodnik S,Evans-Martin FF,Decker MW

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Opioid neurotransmission mediates hedonic value of sweet tastants; their intake may be exaggerated by the consumption of exogenous opioids (e.g., opioid dependence). Sweet Taste Test (STT) is a validated quantitative instrument assessing taste perception and hedonic features of sugar (sucrose) using a random...

journal_title：Psychopharmacology

authors： Langleben DD,Busch EL,O'Brien CP,Elman I

更新日期：2012-04-01 00:00:00

abstract：RATIONALE:Quetiapine extended release (XR) has been used to treat various psychiatric disorders, including depressive episodes associated with bipolar I and II disorders. Quetiapine XR is the first approved drug in China for the treatment of bipolar disorder. OBJECTIVES:The study evaluated the efficacy and safety of s...

journal_title：Psychopharmacology

authors： Li H,Gu N,Zhang H,Wang G,Tan Q,Yang F,Ning Y,Zhang H,Lu Z,Xu X,Shi J,Gao C,Li L,Zhang K,Tian H,Wang X,Li K,Li H,Xu Y,Xie S,Yu X

更新日期：2016-04-01 00:00:00

abstract：RATIONALE:Dysfunction of executive neuropsychological performance, mediated by the prefrontal cortex, has been the central focus of recent attention deficit/ hyperkinetic disorder (AD-HKD) research. The role of other potential neuropsychological "risk factors", such as recognition memory, remains understudied. Further,...

journal_title：Psychopharmacology

authors： Rhodes SM,Coghill DR,Matthews K

更新日期：2004-09-01 00:00:00

abstract：:A recent study from our laboratory has demonstrated that C57BL/6 male mice that are chronically injected with nicotine develop a profound tolerance to nicotine that is not associated with changes in brain nicotinic receptors. We have proposed that alterations in the secretion of corticosterone (CCS) may regulate toler...

journal_title：Psychopharmacology

authors： Grun EA,Pauly JR,Collins AC

更新日期：1992-01-01 00:00:00

abstract：:Different groups of rats received combined or separate administration of different doses of piracetam (P1:100, P2:200, and P4:400 mg/kg) and choline (C1:100 and C2:200 mg/kg). Compared to control treatment, C1 significantly improved performance in a delayed alternation (DA) task, while P1, P2, P4 or P1C1 had no effect...

journal_title：Psychopharmacology

authors： Ennaceur A,Delacour J

更新日期：1987-01-01 00:00:00

abstract：:Intravenous cocaine self-administration behavior in rats was investigated using a progressive ratio (PR) schedule of reinforcement. The first response on the lever each day produced a drug infusion, whereupon the requirements of the schedule escalated with each reinforcement until the behavior extinguished. The final ...

journal_title：Psychopharmacology

authors： Roberts DC,Loh EA,Vickers G

更新日期：1989-01-01 00:00:00

abstract：:Most post-mortem autoradiographic studies have described striatal dopamine D(2) receptor up-regulation due to chronic neuroleptic exposure. The aim of our study was to compare in-vivo striatal D(2) receptor density in neuroleptic-naive and neuroleptic-free schizophrenic patients. We included 28 young (mean age: 28+/-8...

journal_title：Psychopharmacology

authors： Lomeña F,Catafau AM,Parellada E,Bernardo M,Font M,Gutiérrez F,Pavía J

更新日期：2004-03-01 00:00:00

abstract：:The effects of single and repeated electroconvulsive treatment (ECT) on beta-endorphin (beta-EP), cortisol, growth hormone (GH) and prolactin (Prl) plasma levels were investigated in nine depressed patients. Blood samples were monitored a day before ECT, the day of the first and sixth ECT (0, 30, 60 and 90 min after s...

journal_title：Psychopharmacology

authors： Weizman A,Gil-Ad I,Grupper D,Tyano S,Laron Z

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Using a rat relapse model, recent studies reported time dependent increases in cocaine seeking induced by re-exposure to cocaine cues, but not cocaine itself, over withdrawal periods of up to 3 months. OBJECTIVES:In the present study, we explored the time course of cocaine seeking induced by priming injectio...

journal_title：Psychopharmacology

authors： Lu L,Dempsey J

更新日期：2004-10-01 00:00:00

abstract：RATIONALE:Exposure to a single session of uncontrollable inescapable shock (IS), but not to identical controllable escapable shock, produces a potentiation of morphine's rewarding properties that is unusual in that the stressor can be given a number of days before the drug administration in an environment quite differe...

journal_title：Psychopharmacology

authors： Will MJ,Der-Avakian A,Bland ST,Grahn RE,Hammack SE,Sparks PD,Pepin JL,Watkins LR,Maier SF

更新日期：2004-01-01 00:00:00

abstract：:EEG measures have been shown to differ in human subjects who are at genetically increased risk for the development of alcoholism. In the present study, EEG was recorded in rats that were selectively bred for alcohol-preferring (P) and nonpreferring (NP) behaviors during an ethanol self-administration paradigm. In this...

journal_title：Psychopharmacology

authors： Robledo P,Lumeng L,Li TK,Ehlers CL

更新日期：1993-01-01 00:00:00

abstract：RATIONALE:There is a requirement to ensure that UK armed forces are provided with the best possible medical countermeasures to prevent or mitigate the effects of exposure to nerve agents. When pretreatments are under consideration, it is of particular importance to ensure that they do not in themselves give rise to adv...

journal_title：Psychopharmacology

authors： Muggleton NG,Bowditch AP,Crofts HS,Scott EA,Pearce PC

更新日期：2003-03-01 00:00:00

abstract：RATIONALE:Acute tryptophan depletion (ATD) transiently lowers central serotonin levels and can induce depressive mood states and cognitive defects. Previous studies have shown that ATD impairs object recognition in rats. OBJECTIVES:As individual differences exist in central serotonin neurotransmission, the impact of A...

journal_title：Psychopharmacology

authors： Olivier JD,Jans LA,Korte-Bouws GA,Korte SM,Deen PM,Cools AR,Ellenbroek BA,Blokland A

更新日期：2008-10-01 00:00:00

abstract：:After initial exposure to 80 mg/kg, pigeons trained on a two-key drug discrimination procedure rapidly learned to discriminate 120 mg/kg ethosuximide from saline. When 40-160 mg/kg doses of ethosuximide were administered during generalization tests, the percentage of responses directed to the ethosuximide-appropriate ...

journal_title：Psychopharmacology

authors： Clark RD,Schlinger H,Poling A

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Studies have shown that social drinkers are poor estimators of alcohol-induced impairment. Underestimates of blood alcohol concentration and other indices of intoxication are associated with decisions to perform risky behaviors, such as operating a motor vehicle. It is possible that self-evaluations of impair...

journal_title：Psychopharmacology

authors： Harrison EL,Fillmore MT

更新日期：2005-02-01 00:00:00

abstract：RATIONALE:3-(4-Fluorophenylselenyl)-2,5-diphenylselenophene (F-DPS) is a promising organoselenium compound that shows antidepressant-like properties related to interaction with the serotonergic system. OBJECTIVES:In this study, a mouse model of anxiety/depressant-like behavior induced by long-term corticosterone treat...

journal_title：Psychopharmacology

authors： Gai BM,Bortolatto CF,Heck SO,Stein AL,Duarte MM,Zeni G,Nogueira CW

更新日期：2014-05-01 00:00:00

abstract：:The forced swimming test is reviewed. This test appears to be suitable for detecting antidepressant activity in rats but not in mice. Difference in experimental procedure may account for the different sensitivity to drugs of the two animal species. ...

journal_title：Psychopharmacology

authors： Borsini F,Meli A

更新日期：1988-01-01 00:00:00

abstract：:The cholinergic hypothesis of Alzheimer's disease (AD) has strongly influenced research on learning and memory over the last decade. However, there has been limited success treating AD dementia with cholinomimetics. Furthermore, there are indications that other neurotransmitter systems affected by this disease may be ...

journal_title：Psychopharmacology

authors： Camacho F,Smith CP,Vargas HM,Winslow JT

更新日期：1996-04-01 00:00:00

abstract：:A group of 14 schizophrenics who remained symptomatic after neuroleptic treatment received either 0.02 mcg/kg CCK-8 or saline placebo intravenously. Thereafter, 13 received the alternative infusion as a crossover treatment. A second group of 16 such patients received 0.04 mcg/kg CCK-8 or saline intravenously and, ther...

journal_title：Psychopharmacology

authors： Peselow E,Angrist B,Sudilovsky A,Corwin J,Siekierski J,Trent F,Rotrosen J

更新日期：1987-01-01 00:00:00

abstract：:The effects of a new alpha-2 adrenoceptor antagonist on erectile function was assessed in 12 normal volunteers (mean age 28.7, range 20-42), using a double blind, placebo controlled design with two doses of drug and three testing sessions. The drug was administered by intravenous infusion and erectile responses to ero...

journal_title：Psychopharmacology

authors： Munoz M,Bancroft J,Turner M

更新日期：1994-08-01 00:00:00

abstract：RATIONALE:The role of endogenous opiate systems in cigarette smoking remains unclear. In laboratory animals, opiate antagonists block many of the effects of nicotine, but in humans they do not consistently alter smoking behavior. OBJECTIVE:This study explored the effects of naltrexone, alone and in combination with ni...

journal_title：Psychopharmacology

authors： Brauer LH,Behm FM,Westman EC,Patel P,Rose JE

更新日期：1999-04-01 00:00:00

abstract：RATIONALE:During the course of our investigation of antalarmin, a corticotropin-releasing hormone (CRH) antagonist, in rhesus monkeys, we noticed that large, intravenous doses of antalarmin resulted in behavioral changes that resembled intoxication. OBJECTIVES:Antalarmin was evaluated in rhesus monkeys for its reinfor...

journal_title：Psychopharmacology

authors： Broadbear JH,Winger G,Rice KC,Woods JH

更新日期：2002-11-01 00:00:00

abstract：RATIONALE:The amygdala and insular cortex are integral to the processing of emotionally salient stimuli. We have shown in healthy volunteers that an anxiolytic agent, lorazepam, dose-dependently attenuates activation of limbic structures. OBJECTIVE:The current study investigated whether administration of a selective s...

journal_title：Psychopharmacology

authors： Arce E,Simmons AN,Lovero KL,Stein MB,Paulus MP

更新日期：2008-03-01 00:00:00