Is the forced swimming test a suitable model for revealing antidepressant activity?

Abstract:

:The forced swimming test is reviewed. This test appears to be suitable for detecting antidepressant activity in rats but not in mice. Difference in experimental procedure may account for the different sensitivity to drugs of the two animal species.

journal_title

Psychopharmacology

authors

Borsini F,Meli A

doi

10.1007/BF00176837

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

147-60

issue

2

eissn

0033-3158

issn

1432-2072

journal_volume

94

pub_type

杂志文章,评审
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    abstract::This study compared the ability of the novel atypical antipsychotic olanzapine with that of clozapine to reverse the d-amphetamine-induced inhibition of substantia nigra (A9) and ventral tegmental area (A10) dopamine (DA) cells. Extracellular single-unit recordings were made from A9 and A10 DA cells in anesthetized ra...

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    doi:10.1007/BF02245605

    authors: Stockton ME,Rasmussen K

    更新日期:1996-03-01 00:00:00

  • Reversible metabolism of haloperidol and reduced haloperidol in Chinese schizophrenic patients.

    abstract::Haloperidol disposition has been associated with reversible metabolism: it is reversibly reduced to its metabolite, reduced haloperidol, which has less pharmacologic activity than the parent compound. To characterize the interconversion process, six healthy male schizophrenics were administered a single dose of 10 mg ...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02253726

    authors: Jann MW,Lam YW,Chang WH

    更新日期:1990-01-01 00:00:00

  • Tolerance to morphine stimulus control: role of morphine maintenance dose.

    abstract::Experiments assessed the development of tolerance to morphine stimulus control during treatment with selected maintenance doses of morphine. Separate groups of rats were trained to discriminate saline and either 3.2 mg/kg or 5.6 mg/kg morphine under fixed-ratio schedules of food delivery. Dose-response functions for g...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02245745

    authors: Young AM,Sannerud CA,Steigerwald ES,Doty MD,Lipinski WJ,Tetrick LE

    更新日期:1990-01-01 00:00:00

  • Relationship between variations in estradiol and progesterone levels across the menstrual cycle and human performance.

    abstract:RATIONALE:Studies about whether or not the cognitive performance of women is influenced by changes in levels of sex steroid hormones across the menstrual cycle have produced ambiguous results. OBJECTIVES:This study tested whether flight simulator performance differs significantly between the menstrual and the luteal p...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130100700

    authors: Mumenthaler MS,O'Hara R,Taylor JL,Friedman L,Yesavage JA

    更新日期:2001-05-01 00:00:00

  • High dose transdermal nicotine therapy for heavy smokers: safety, tolerability and measurement of nicotine and cotinine levels.

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    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02246542

    authors: Fredrickson PA,Hurt RD,Lee GM,Wingender L,Croghan IT,Lauger G,Gomez-Dahl L,Offord KP

    更新日期:1995-12-01 00:00:00

  • Mood responses of remitted schizophrenics to methylphenidate infusion.

    abstract::To investigate the mood response of schizophrenic subjects to psychostimulant challenge, 29 neuroleptic-treated subjects (22 with schizophrenia and 7 with schizoaffective disorder) in clinical remission received two infusions, one with methylphenidate 0.5 mg/kg and the other with normal saline, under double-blind cond...

    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02244317

    authors: Robinson D,Mayerhoff D,Alvir J,Cooper T,Lieberman J

    更新日期:1991-01-01 00:00:00

  • Partial 5-HT1A receptor agonist properties of (-)pindolol in combination with citalopram on serotonergic dorsal raphe cell firing in vivo.

    abstract:RATIONALE:Pindolol has been reported to shorten the onset of antidepressant action of selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) as well as to increase their efficacy. It has been postulated that pindolol enhances the antidepressant effect of SSRIs by blocking somatodendritic 5-HT1A aut...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130000470

    authors: Arborelius L,Linnér L,Wallsten C,Ahlenius S,Svensson TH

    更新日期:2000-07-01 00:00:00

  • The effects of chronic administration and withdrawal of (+)-amphetamine on seizure threshold and endogenous catecholamine concentrations and their rates of biosynthesis in mice.

    abstract::The i.v. pentylenetetrazol seizure threshold was increased by 2.5 mg/kg and decreased by 15 mg/kg of a single (+)-amphetamine dose. After 7 consecutive days of amphetamine administration, tolerance developed to the decrease but not to the increase in seizure threshold. At 12--48 h after the last dose of 2.5 mg/kg seiz...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00431736

    authors: Riffee WH,Gerald MC

    更新日期:1977-01-31 00:00:00

  • Noradrenergic and behavioural effects of naloxone injected in the locus coeruleus of morphine-dependent rats and their control by clonidine.

    abstract::Naloxone HCl (10 micrograms/0.5 ml) was injected in the locus coeruleus (LC) of morphine-dependent rats and the behavioural manifestations of morphine withdrawal and the cortical levels of 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4) were measured 30 min later. Naloxone precipitated a withdrawal syndrome...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00187263

    authors: Esposito E,Kruszewska A,Ossowska G,Samanin R

    更新日期:1987-01-01 00:00:00

  • Influence of caffeine on the liking of novel-flavored soda in adolescents.

    abstract:BACKGROUND:Soda manufacturers claim that caffeine is added to soda as a flavor enhancer, but many researchers have speculated that caffeine is added to increase the hedonic and reinforcing properties of the soda. Studies in adults have demonstrated that caffeine can condition flavor preferences when added to novel-flav...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00213-012-2684-2

    authors: Temple JL,Ziegler AM,Graczyk A,Bendlin A,O'Leary S,Schnittker YS

    更新日期:2012-09-01 00:00:00

  • [11C]Ro 15-4513, a ligand for visualization of benzodiazepine receptor binding. Preparation, autoradiography and positron emission tomography.

    abstract::Ro 15-4513, a partial inverse agonist at the benzodiazepine (BZ) receptor site was labelled with 11C and used for in vitro autoradiography on human post mortem brain sections and for positron emission tomography (PET) on Cynomolgus monkeys. The total radiochemical yield of [11C]Ro 15-4513 was 30-40% with an overall sy...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02245279

    authors: Halldin C,Farde L,Litton JE,Hall H,Sedvall G

    更新日期:1992-01-01 00:00:00

  • Risperidone (R 64 766), a potent and complete LSD antagonist in drug discrimination by rats.

    abstract::Risperidone was studied in a 0.16 mg/kg LSD-saline drug discrimination test procedure. At doses varying from 0.0025 to 0.63 mg/kg, no LSD-like agonist effects were observed. Studies on the antagonism of the LSD-cue indicated that risperidone was able to completely block the discriminative stimulus properties of LSD wi...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00442251

    authors: Meert TF,de Haes P,Janssen PA

    更新日期:1989-01-01 00:00:00

  • Evidence against the involvement of serotonergic mechanisms in wet dog shake behavior induced by carbachol chloride in rats.

    abstract::The intracerebroventricular administration of carbachol chloride induced a characteristic wet dog shake response in rats. Neither 5,6-dihydroxytryptamine, a serotonergic depletor, nor DL-p-chlorophenylalanine, an inhibitor of 5-HT synthesis, affected wet dog shakes induced by carbachol. Putative antiserotonergic drugs...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00426469

    authors: Turski L,Turski W,Czuczwar SJ,Kleinrok Z

    更新日期:1981-01-01 00:00:00

  • Developmental GABAergic deficit enhances methamphetamine-induced apoptosis.

    abstract:RATIONALE:Neuroanatomical evidence suggests that GABAergic deficits and progressive cortical atrophy occur with schizophrenia. OBJECTIVE:To evaluate the hypothesis that neurodevelopmental deficits affect neurodegeneration occurring with schizophrenia, this study examined a novel animal model for schizophrenia-related ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-011-2269-5

    authors: Abekawa T,Ito K,Nakato Y,Koyama T

    更新日期:2011-06-01 00:00:00

  • Naltrexone moderates the relationship between cue-induced craving and subjective response to methamphetamine in individuals with methamphetamine use disorder.

    abstract:RATIONALE:Reductions in cue-induced craving and subjective response to drugs of abuse are commonly used as initial outcome measures when testing novel medications for the treatment of addiction. Yet neither the relationship between these two measures at the individual level nor the moderating effects of pharmacotherapi...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-017-4607-8

    authors: Roche DJO,Worley MJ,Courtney KE,Bujarski S,London ED,Shoptaw S,Ray LA

    更新日期:2017-07-01 00:00:00

  • Characterisation of olanzapine-induced weight gain and effect of aripiprazole vs olanzapine on body weight and prolactin secretion in female rats.

    abstract:RATIONALE:Atypical antipsychotic drug (APD)-induced weight gain causes non-compliance, increasing the risk of relapse and medical complications. OBJECTIVES:In an animal model, we assessed body weights, food intake, body fat/lean body mass contents and blood serum levels of glucose and lipids in female rats treated wit...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s00213-005-0081-9

    authors: Kalinichev M,Rourke C,Daniels AJ,Grizzle MK,Britt CS,Ignar DM,Jones DN

    更新日期:2005-10-01 00:00:00

  • Differential effects of diazepam on anxiety in streptozotocin induced diabetic and non-diabetic rats.

    abstract::The anxiolytic activity of diazepam (DZP) (0.25-1 mg/kg) was investigated in streptozotocin (STZ)-induced diabetic adult Charles Foster albino rats of either sex. Diabetes was induced by injecting STZ IP (50 mg/kg; in citrate buffer, pH 4.5). Experiments were performed 72 h later. The rats were subjected to various an...

    journal_title:Psychopharmacology

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    doi:10.1007/s002130050523

    authors: Ramanathan M,Jaiswal AK,Bhattacharya SK

    更新日期:1998-02-01 00:00:00

  • The effects of kainic acid lesions on locomotor responses to haloperidol and clozapine.

    abstract::Spontaneous and amphetamine-elicited locomotor activity in rats is reduced by most clinically effective antipsychotic drugs. We have recently demonstrated that intracerebroventricular infusion of kainic acid (KA), which produces cell loss in the hippocampus and other limbic-cortical brain regions, increases spontaneou...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

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    更新日期:1998-02-01 00:00:00

  • The effects of alaproclate on the pupillary responses to tyramine, phenylephrine and pilocarpine in depressed patients.

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    doi:10.1007/BF00427324

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  • 5-HT2C receptors are involved in the discriminative stimulus effects of citalopram in rats.

    abstract::Rats were trained on a fixed ratio 10, food-reinforced schedule to recognize a discriminative stimulus (DS) elicited by the selective serotonin (5-HT) reuptake inhibitor (SSRI), citalopram (2.5 mg/kg, IP). The preferential, high efficacy agonist at 5-HT2C receptors, Ro60-0175, dose-dependently generalized to citalopra...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/s002130050910

    authors: Millan MJ,Girardon S,Dekeyne A

    更新日期:1999-03-01 00:00:00

  • Cocaine toxicity: concurrent influence of dopaminergic, muscarinic and sigma receptors in mediating cocaine-induced lethality.

    abstract::The concurrent influence of dopaminergic, sigma and muscarinic neurotransmitter systems in mediating cocaine-induced lethality is predicted by previous receptor binding results from our laboratories. The present results demonstrate that pharmacological manipulations of these predicted neurotransmitter systems alter th...

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    更新日期:1997-02-01 00:00:00

  • Smoking withdrawal is associated with increases in brain activation during decision making and reward anticipation: a preliminary study.

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    更新日期:2012-01-01 00:00:00

  • Effects of prior amphetamine exposure on approach strategy in appetitive Pavlovian conditioning in rats.

    abstract:RATIONALE:Pavlovian conditioning with a discrete reward-predictive visual cue can elicit two classes of behaviors: "sign-tracking" (approach toward and contact with the cue) and "goal-tracking" (approach toward the site of reward delivery). Sign-tracking has been proposed to be linked to behavioral disorders involving ...

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    doi:10.1007/s00213-008-1353-y

    authors: Simon NW,Mendez IA,Setlow B

    更新日期:2009-03-01 00:00:00

  • Facilitation and inhibition of feeding by a single dose of amphetamine: relationship to baseline intake and accumbens cholecystokinin.

    abstract::Amphetamine (AMP) administered in high doses suppresses feeding. However, in low doses AMP has been shown to both suppress and facilitate feeding. Further, there is some indication of individual differences in the feeding response to low doses of AMP. Evidence indicates that AMP's effects on feeding are dopamine-media...

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    pub_type: 杂志文章

    doi:10.1007/BF02244426

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    更新日期:1991-01-01 00:00:00

  • Attenuation of chemically induced defence response by 5-HT1 receptor agonists administered into the periaqueductal gray.

    abstract::The ability of 5-HT1 receptor agonists to modulate a chemically induced defence response has been studied in Lister hooded rats. Microinjections of the excitatory amino acid D,L-homocysteic acid (DLH) in both rostral and caudal dorsal periaqueductal gray matter (PAG) caused explosive motor behaviour characteristic of ...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02245294

    authors: Beckett SR,Lawrence AJ,Marsden CA,Marshall PW

    更新日期:1992-01-01 00:00:00

  • Sex differences in the influence of nicotine dose instructions on the reinforcing and self-reported rewarding effects of smoking.

    abstract:RATIONALE:Compared to men, the smoking behavior of women may be less responsive to nicotine and more responsive to nonpharmacological factors, perhaps including verbal information (e.g., dose instructions). OBJECTIVE:This study compared the influence of the presence vs absence of dose instructions on the subjective an...

    journal_title:Psychopharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00213-005-0103-7

    authors: Perkins KA,Doyle T,Ciccocioppo M,Conklin C,Sayette M,Caggiula A

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  • Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knockout rats.

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    journal_title:Psychopharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02244767

    authors: Foulds J,McSorley K,Sneddon J,Feyerabend C,Jarvis MJ,Russell MA

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  • Cocaine facilitation of prefrontal cortex self-stimulation: a microstructural and pharmacological analysis.

    abstract::A novel self-stimulation methodology involving a fixed-interval (FI-5 s) schedule of reinforcement, microanalysis and threshold evaluation was used to investigate the effects of cocaine on rats lever pressing for electrical stimulation of the prefrontal cortex. Cocaine (15 mg/kg) increased medial prefrontal cortex (MP...

    journal_title:Psychopharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02801979

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    pub_type: 杂志文章

    doi:10.1007/s00213-011-2501-3

    authors: Woolverton WL,Freeman KB,Myerson J,Green L

    更新日期:2012-04-01 00:00:00