Abstract:
:The forced swimming test is reviewed. This test appears to be suitable for detecting antidepressant activity in rats but not in mice. Difference in experimental procedure may account for the different sensitivity to drugs of the two animal species.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Borsini F,Meli Adoi
10.1007/BF00176837subject
Has Abstractpub_date
1988-01-01 00:00:00pages
147-60issue
2eissn
0033-3158issn
1432-2072journal_volume
94pub_type
杂志文章,评审abstract::This study compared the ability of the novel atypical antipsychotic olanzapine with that of clozapine to reverse the d-amphetamine-induced inhibition of substantia nigra (A9) and ventral tegmental area (A10) dopamine (DA) cells. Extracellular single-unit recordings were made from A9 and A10 DA cells in anesthetized ra...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245605
更新日期:1996-03-01 00:00:00
abstract::Haloperidol disposition has been associated with reversible metabolism: it is reversibly reduced to its metabolite, reduced haloperidol, which has less pharmacologic activity than the parent compound. To characterize the interconversion process, six healthy male schizophrenics were administered a single dose of 10 mg ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02253726
更新日期:1990-01-01 00:00:00
abstract::Experiments assessed the development of tolerance to morphine stimulus control during treatment with selected maintenance doses of morphine. Separate groups of rats were trained to discriminate saline and either 3.2 mg/kg or 5.6 mg/kg morphine under fixed-ratio schedules of food delivery. Dose-response functions for g...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245745
更新日期:1990-01-01 00:00:00
abstract:RATIONALE:Studies about whether or not the cognitive performance of women is influenced by changes in levels of sex steroid hormones across the menstrual cycle have produced ambiguous results. OBJECTIVES:This study tested whether flight simulator performance differs significantly between the menstrual and the luteal p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100700
更新日期:2001-05-01 00:00:00
abstract::Transdermal nicotine has been shown to relieve nicotine withdrawal and to double smoking cessation rates compared to placebo in clinical trials. A 21 or 22 mg/day dose provides a steady state serum nicotine that is less than obtained from smoking. Limited information is available about higher nicotine patch doses. To ...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02246542
更新日期:1995-12-01 00:00:00
abstract::To investigate the mood response of schizophrenic subjects to psychostimulant challenge, 29 neuroleptic-treated subjects (22 with schizophrenia and 7 with schizoaffective disorder) in clinical remission received two infusions, one with methylphenidate 0.5 mg/kg and the other with normal saline, under double-blind cond...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02244317
更新日期:1991-01-01 00:00:00
abstract:RATIONALE:Pindolol has been reported to shorten the onset of antidepressant action of selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) as well as to increase their efficacy. It has been postulated that pindolol enhances the antidepressant effect of SSRIs by blocking somatodendritic 5-HT1A aut...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130000470
更新日期:2000-07-01 00:00:00
abstract::The i.v. pentylenetetrazol seizure threshold was increased by 2.5 mg/kg and decreased by 15 mg/kg of a single (+)-amphetamine dose. After 7 consecutive days of amphetamine administration, tolerance developed to the decrease but not to the increase in seizure threshold. At 12--48 h after the last dose of 2.5 mg/kg seiz...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431736
更新日期:1977-01-31 00:00:00
abstract::Naloxone HCl (10 micrograms/0.5 ml) was injected in the locus coeruleus (LC) of morphine-dependent rats and the behavioural manifestations of morphine withdrawal and the cortical levels of 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4) were measured 30 min later. Naloxone precipitated a withdrawal syndrome...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00187263
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Soda manufacturers claim that caffeine is added to soda as a flavor enhancer, but many researchers have speculated that caffeine is added to increase the hedonic and reinforcing properties of the soda. Studies in adults have demonstrated that caffeine can condition flavor preferences when added to novel-flav...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-012-2684-2
更新日期:2012-09-01 00:00:00
abstract::Ro 15-4513, a partial inverse agonist at the benzodiazepine (BZ) receptor site was labelled with 11C and used for in vitro autoradiography on human post mortem brain sections and for positron emission tomography (PET) on Cynomolgus monkeys. The total radiochemical yield of [11C]Ro 15-4513 was 30-40% with an overall sy...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245279
更新日期:1992-01-01 00:00:00
abstract::Risperidone was studied in a 0.16 mg/kg LSD-saline drug discrimination test procedure. At doses varying from 0.0025 to 0.63 mg/kg, no LSD-like agonist effects were observed. Studies on the antagonism of the LSD-cue indicated that risperidone was able to completely block the discriminative stimulus properties of LSD wi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00442251
更新日期:1989-01-01 00:00:00
abstract::The intracerebroventricular administration of carbachol chloride induced a characteristic wet dog shake response in rats. Neither 5,6-dihydroxytryptamine, a serotonergic depletor, nor DL-p-chlorophenylalanine, an inhibitor of 5-HT synthesis, affected wet dog shakes induced by carbachol. Putative antiserotonergic drugs...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426469
更新日期:1981-01-01 00:00:00
abstract:RATIONALE:Neuroanatomical evidence suggests that GABAergic deficits and progressive cortical atrophy occur with schizophrenia. OBJECTIVE:To evaluate the hypothesis that neurodevelopmental deficits affect neurodegeneration occurring with schizophrenia, this study examined a novel animal model for schizophrenia-related ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2269-5
更新日期:2011-06-01 00:00:00
abstract:RATIONALE:Reductions in cue-induced craving and subjective response to drugs of abuse are commonly used as initial outcome measures when testing novel medications for the treatment of addiction. Yet neither the relationship between these two measures at the individual level nor the moderating effects of pharmacotherapi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4607-8
更新日期:2017-07-01 00:00:00
abstract:RATIONALE:Atypical antipsychotic drug (APD)-induced weight gain causes non-compliance, increasing the risk of relapse and medical complications. OBJECTIVES:In an animal model, we assessed body weights, food intake, body fat/lean body mass contents and blood serum levels of glucose and lipids in female rats treated wit...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0081-9
更新日期:2005-10-01 00:00:00
abstract::The anxiolytic activity of diazepam (DZP) (0.25-1 mg/kg) was investigated in streptozotocin (STZ)-induced diabetic adult Charles Foster albino rats of either sex. Diabetes was induced by injecting STZ IP (50 mg/kg; in citrate buffer, pH 4.5). Experiments were performed 72 h later. The rats were subjected to various an...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050523
更新日期:1998-02-01 00:00:00
abstract::Spontaneous and amphetamine-elicited locomotor activity in rats is reduced by most clinically effective antipsychotic drugs. We have recently demonstrated that intracerebroventricular infusion of kainic acid (KA), which produces cell loss in the hippocampus and other limbic-cortical brain regions, increases spontaneou...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050509
更新日期:1998-02-01 00:00:00
abstract::Nine depressed patients were treated with alaproclate, a selective 5-HT uptake inhibitor, for 3 weeks in a dose of 400 mg daily. The pupillary responses to tyramine, phenylephrine, and pilocarpine eye drops were measured on consecutive days before, after 1 week and after 3 weeks of treatment. The tyramine-induced mydr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427324
更新日期:1985-01-01 00:00:00
abstract::Rats were trained on a fixed ratio 10, food-reinforced schedule to recognize a discriminative stimulus (DS) elicited by the selective serotonin (5-HT) reuptake inhibitor (SSRI), citalopram (2.5 mg/kg, IP). The preferential, high efficacy agonist at 5-HT2C receptors, Ro60-0175, dose-dependently generalized to citalopra...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050910
更新日期:1999-03-01 00:00:00
abstract::The concurrent influence of dopaminergic, sigma and muscarinic neurotransmitter systems in mediating cocaine-induced lethality is predicted by previous receptor binding results from our laboratories. The present results demonstrate that pharmacological manipulations of these predicted neurotransmitter systems alter th...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050198
更新日期:1997-02-01 00:00:00
abstract:RATIONALE:Acute nicotine abstinence is associated with disruption of executive function and reward processes; however, the neurobiological basis of these effects has not been fully elucidated. METHODS:The effects of nicotine abstinence on brain function during reward-based probabilistic decision making were preliminar...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2404-3
更新日期:2012-01-01 00:00:00
abstract:RATIONALE:Pavlovian conditioning with a discrete reward-predictive visual cue can elicit two classes of behaviors: "sign-tracking" (approach toward and contact with the cue) and "goal-tracking" (approach toward the site of reward delivery). Sign-tracking has been proposed to be linked to behavioral disorders involving ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1353-y
更新日期:2009-03-01 00:00:00
abstract::Amphetamine (AMP) administered in high doses suppresses feeding. However, in low doses AMP has been shown to both suppress and facilitate feeding. Further, there is some indication of individual differences in the feeding response to low doses of AMP. Evidence indicates that AMP's effects on feeding are dopamine-media...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244426
更新日期:1991-01-01 00:00:00
abstract::The ability of 5-HT1 receptor agonists to modulate a chemically induced defence response has been studied in Lister hooded rats. Microinjections of the excitatory amino acid D,L-homocysteic acid (DLH) in both rostral and caudal dorsal periaqueductal gray matter (PAG) caused explosive motor behaviour characteristic of ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245294
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:Compared to men, the smoking behavior of women may be less responsive to nicotine and more responsive to nonpharmacological factors, perhaps including verbal information (e.g., dose instructions). OBJECTIVE:This study compared the influence of the presence vs absence of dose instructions on the subjective an...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-005-0103-7
更新日期:2006-03-01 00:00:00
abstract:RATIONALE:Acute tryptophan depletion (ATD) transiently lowers central serotonin levels and can induce depressive mood states and cognitive defects. Previous studies have shown that ATD impairs object recognition in rats. OBJECTIVES:As individual differences exist in central serotonin neurotransmission, the impact of A...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-008-1201-0
更新日期:2008-10-01 00:00:00
abstract::The effect of two subcutaneous injections of 0.6 mg nicotine, administered 40 min apart, was compared with placebo in four non-smoking subjects in a counter-balanced double-blind crossover design. The nicotine injections produced mean peak plasma nicotine concentrations of 5.3 ng/ml 10 min after the first injection an...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02244767
更新日期:1994-06-01 00:00:00
abstract::A novel self-stimulation methodology involving a fixed-interval (FI-5 s) schedule of reinforcement, microanalysis and threshold evaluation was used to investigate the effects of cocaine on rats lever pressing for electrical stimulation of the prefrontal cortex. Cocaine (15 mg/kg) increased medial prefrontal cortex (MP...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02801979
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:Delaying presentation of a drug can decrease its effectiveness as a reinforcer, but the effect of delaying punishment of drug self-administration is unknown. OBJECTIVE:This study examined whether a histamine injection could punish cocaine self-administration in a drug-drug choice, whether delaying histamine ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2501-3
更新日期:2012-04-01 00:00:00