Abstract:
:After initial exposure to 80 mg/kg, pigeons trained on a two-key drug discrimination procedure rapidly learned to discriminate 120 mg/kg ethosuximide from saline. When 40-160 mg/kg doses of ethosuximide were administered during generalization tests, the percentage of responses directed to the ethosuximide-appropriate key varied directly with dose. Time-effect determinations revealed that the discriminable properties of ethosuximide were evident as early as 15 min after, and as late as 2 h after, intramuscular injection. The discriminative stimulus properties of ethosuximide failed to generalize to the anticonvulsant compounds clonazepam (0.5-4 mg/kg), methsuximide (25-200 mg/kg), and phenytoin (5-15 mg/kg). Generalization was apparent with certain doses of primidone (250, 300 mg/kg) and mephenytoin (80, 160, 240 mg/kg). The concomitant administration of pentylenetetrazol (5, 10, 20 mg/kg) partially blocked the discriminable properties of the training dose of ethosuximide.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Clark RD,Schlinger H,Poling Adoi
10.1007/BF00207236subject
Has Abstractpub_date
1987-01-01 00:00:00pages
466-9issue
4eissn
0033-3158issn
1432-2072journal_volume
93pub_type
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更新日期:2013-01-01 00:00:00
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更新日期:2011-02-01 00:00:00
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更新日期:1978-04-14 00:00:00
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