Acute and chronic opiate effects on single units and EEG of medial thalamus and hippocampus: a latency analysis.

abstract：RATIONALE:Only a small percentage of individuals seeking treatment for their marijuana use achieves sustained abstinence, suggesting more treatment options are needed. OBJECTIVES:We investigated the effects of baclofen (study 1) and mirtazapine (study 2) in a human laboratory model of marijuana intoxication, withdrawa...

journal_title：Psychopharmacology

authors： Haney M,Hart CL,Vosburg SK,Comer SD,Reed SC,Cooper ZD,Foltin RW

更新日期：2010-08-01 00:00:00

abstract：RATIONALE:Research on the effects of nicotine abstinence and nicotine replacement has not provided consistent information about the impact of replacement therapies on tobacco withdrawal and craving. OBJECTIVE:. This study investigated craving and withdrawal symptoms over a 72-h period of abstinence from cigarettes. M...

journal_title：Psychopharmacology

authors： Teneggi V,Tiffany ST,Squassante L,Milleri S,Ziviani L,Bye A

更新日期：2002-11-01 00:00:00

abstract：RATIONALE:There is evidence that events early in post-weaning life influence brain development and subsequent adult behaviour and therefore play an important role in the causation of certain psychiatric disorders in later life. Exposing rodents to stressors during the juvenile period has been suggested as a model of in...

journal_title：Psychopharmacology

authors： Peleg-Raibstein D,Feldon J

更新日期：2011-03-01 00:00:00

abstract：:The effects of morphine, ketocyclazocine, cyclazocine, and SKF-10,047 were tested alone and in conjunction with naltrexone or naloxone, in rats responding under a multiple fixed-interval 3-min schedule of food presentation. Under this paradigm, electric shock was delivered on a fixed-ratio schedule for responses occur...

journal_title：Psychopharmacology

authors： Snell D,Harris RA

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:Intermittent footshock stress reliably reinstates extinguished alcohol-taking behavior in drug-free rats, but the neurochemical events involved in this effect are not known. OBJECTIVE:We studied here whether two main modulators of stress responses, corticotropin-releasing factor (CRF) and corticosterone, are...

journal_title：Psychopharmacology

authors： Lê AD,Harding S,Juzytsch W,Watchus J,Shalev U,Shaham Y

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Traumatic events are associated with alcohol use problems with increased alcohol craving as a potential mediator. There is still a lack of knowledge regarding the causal nature of this association and its underlying mechanisms. This study investigated the effects of acute trauma exposure on alcohol craving i...

journal_title：Psychopharmacology

authors： Trautmann S,Kräplin A,Dieterich R,Richter J,Muehlhan M

更新日期：2018-10-01 00:00:00

abstract：RATIONALE:Anxiety and aggression are associated with ethanol self-administration, but these behaviors can serve as either risk factors for or consequences of heavy drinking in rodents and humans. Baseline levels of aggressive-like and anxious-like behavior in non-human primates have not yet been characterized in relati...

journal_title：Psychopharmacology

authors： McClintick MN,Grant KA

更新日期：2016-12-01 00:00:00

abstract：:In a 4 week study of the response of neurotic outpatients to treatment with amitriptyline, diazepam, amitriptyline and diazepam, or placebo clinical and psychophysiological variables and plasma levels of the drug were assessed. Clinical improvements were substantial in all treatment groups but clear relationships betw...

journal_title：Psychopharmacology

authors： Johnstone EC,Bourne RC,Crow TJ,Frith CD,Gamble S,Lofthouse R,Owen F,Owens DG,Robinson J,Stevens M

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Alcoholics report persistent alcohol craving that is heightened by cognitive cues, stressful situations, and abstinence. The role of endogenous cannabinoids in human alcohol craving--though long suspected--remains elusive. MATERIALS AND METHODS:We employed laboratory exposure to stress, alcohol cue, and neu...

journal_title：Psychopharmacology

authors： Mangieri RA,Hong KI,Piomelli D,Sinha R

更新日期：2009-07-01 00:00:00

abstract：RATIONALE:Nicotine displays rewarding and aversive effects, and while dopamine has been linked with nicotine's reward, the neurotransmitter(s) involved with aversion remains speculative. The kappa-dynorphinergic system has been associated with negative motivational and affective states, and whether dynorphin (Dyn) cont...

journal_title：Psychopharmacology

authors： Isola R,Zhang H,Tejwani GA,Neff NH,Hadjiconstantinou M

更新日期：2009-01-01 00:00:00

abstract：:Single oral and intramuscular (i.m.) doses of imipramine (IMI) were administered to four normal males. Serum and urine concentrations of IMI, desipramine (DMI) and their unconjugated 2-hydroxy metabolites were measured by high-pressure liquid chromatography (HPLC). Urinary conjugated 2-hydroxy metabolites were also me...

journal_title：Psychopharmacology

authors： Sutfin TA,DeVane CL,Jusko WJ

更新日期：1984-01-01 00:00:00

abstract：:The acute effect of ethanol upon the NSD (normalized slope descriptors) or Hjorth parameters of EEG were analyzed in 11 students. The maximal blood-alcohol concentration ranged from 1.0--1.7 mg/l. The activity (mean amplitude) increased and the complexity (frequency spread) decreased significantly as a function of tim...

journal_title：Psychopharmacology

authors： Lehtinen I,Lang AH,Keskinen E

更新日期：1978-12-15 00:00:00

abstract：RATIONALE:Endogenous γ-aminobutyric acidA receptor (GABAAR)-active neurosteroids (e.g., allopregnanolone) regulate central nervous system excitability and many physiological functions, so fluctuations are implicated in several neuropsychiatric disorders. Pertinently, evidence supports an inverse relationship between en...

journal_title：Psychopharmacology

authors： Jensen JP,Nipper MA,Helms ML,Ford MM,Crabbe JC,Rossi DJ,Finn DA

更新日期：2017-09-01 00:00:00

abstract：RATIONALE:Considerable research indicates that "ecstasy" users perceive their memory for future intentions (prospective memory) to be impaired. However, only one empirical study to date has directly tested how this capacity is affected by ecstasy use, and this study provided relatively limited information regarding the...

journal_title：Psychopharmacology

authors： Rendell PG,Gray TJ,Henry JD,Tolan A

更新日期：2007-11-01 00:00:00

abstract：RATIONALE:Attentional bias for alcohol-related cues is associated with the motivation to drink alcohol, possibly because attentional bias increases craving. OBJECTIVES:We examined whether an experimentally induced attentional bias would influence subjective and behavioural indices of the motivation to drink. METHODS:...

journal_title：Psychopharmacology

authors： Field M,Eastwood B

更新日期：2005-12-01 00:00:00

abstract：:Nine depressed patients were treated with alaproclate, a selective 5-HT uptake inhibitor, for 3 weeks in a dose of 400 mg daily. The pupillary responses to tyramine, phenylephrine, and pilocarpine eye drops were measured on consecutive days before, after 1 week and after 3 weeks of treatment. The tyramine-induced mydr...

journal_title：Psychopharmacology

authors： Thompson C,Checkley SA

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:Inattentional blindness (IB) is the inability to detect a salient yet unexpected task irrelevant stimulus in one's visual field when attention is engaged in an ongoing primary task. The present study is the first to examine the impact of both task difficulty and alcohol consumption on IB and primary task perf...

journal_title：Psychopharmacology

authors： Harvey AJ,Bayless SJ,Hyams G

更新日期：2018-01-01 00:00:00

abstract：RATIONALE:Drug addiction is a chronically relapsing disorder characterised by compulsive drug use and loss of control over drug intake. Although several theories propose impulsivity as a key component of addiction, the precise nature of this relationship remains unclear. OBJECTIVES:This study aims to investigate the s...

journal_title：Psychopharmacology

authors： Kolokotroni KZ,Rodgers RJ,Harrison AA

更新日期：2012-01-01 00:00:00

abstract：:Ten rats were trained to lever press for food reward on a schedule of differential reinforcement of low rates of response with a 20-s criterion (DRL 20). Ten more were trained on a new schedule of punishment, designed to be comparable to DRL 20 - differential punishment of high rates of response (DPH 20). Under this s...

journal_title：Psychopharmacology

authors： Salmon P,Gray JA

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:The aim of our study was to test whether ketamine produces an antidepressant effect in animal model of olfactory bulbectomy and assess the role of mammalian target of rapamycin (mTOR) pathway in ketamine's antidepressant effect. METHODS:Bulbectomized (OBX) rats and sham controls were assigned to four subgrou...

journal_title：Psychopharmacology

authors： Holubova K,Kleteckova L,Skurlova M,Ricny J,Stuchlik A,Vales K

更新日期：2016-06-01 00:00:00

abstract：:Progabide inhibited male rat sexual behavior at a dose of 200 mg/kg. This dose had only modest effects on ambulatory activity and no effect at all on motor coordination as evaluated by a rotarod test. The GABAA antagonist bicuculline, at a dose of 1 mg/kg, blocked the effects of progabide on sex behavior. In contrast,...

journal_title：Psychopharmacology

authors： Agmo A,Paredes RG,Sierra L,Garcés I

更新日期：1997-01-01 00:00:00

abstract：:Two sets of experiments were carried out to compare the effects of fenfluramine and fluoxetine on consummatory and operant behaviour. In food-deprived rats allowed access to a 35% sucrose solution, an initial period of sucrose consumption was followed by a short period of grooming and exploratory behaviour, later supe...

journal_title：Psychopharmacology

authors： Willner P,McGuirk J,Phillips G,Muscat R

更新日期：1990-01-01 00:00:00

abstract：:The aim of the present study was to evaluate the effects of cholinergic receptor blockade in the rat prefrontal cortex on cognitive processes. The nicotinic antagonists neuronal bungarotoxin and dihydro-beta-erythroidine and the muscarinic antagonist scopolamine were injected into the prelimbic area of the prefrontal ...

journal_title：Psychopharmacology

authors： Granon S,Poucet B,Thinus-Blanc C,Changeux JP,Vidal C

更新日期：1995-05-01 00:00:00

abstract：:Under the fixed-consecutive-number schedule (FCN), pigeons were reinforced for responding eight or more times on one response key (work key), and then responding once on a second response key. In one component of this schedule, an external stimulus signalled the completion of the response requirement on the work key (...

journal_title：Psychopharmacology

authors： Picker M,Dykstra LA

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Cotreatment with clorgyline shifts the development of sensitization to the D2/D3 dopamine receptor agonist quinpirole from locomotion to mouthing, an effect apparently unrelated to the monoamine oxidase inhibition property of clorgyline. This phenomenon was demonstrated in rats examined in small activity cham...

journal_title：Psychopharmacology

authors： Dvorkin A,Culver KE,Szechtman H

更新日期：2006-07-01 00:00:00

abstract：RATIONALE:The C57BL/6 is one of the most widely used mouse strains in behavioral, pharmacological, and genetic research but little is known about their response on tests for antidepressant drugs. OBJECTIVES:The behavior of C57BL/6 mice, and mice from other strains, was examined in the tail suspension test (TST), a com...

journal_title：Psychopharmacology

authors： Mayorga AJ,Lucki I

更新日期：2001-04-01 00:00:00

abstract：RATIONALE:Enhancement of dopamine (DA) release by corticosteroids may be of aetiological importance in substance misuse. OBJECTIVES:To examine the effect of sub-chronic administration of hydrocortisone on the response to amphetamine in healthy male volunteers. METHODS:Following baseline assessment, 20 volunteers were...

journal_title：Psychopharmacology

authors： Hearn AJ,Gallagher P,Owen BM,Smith MS,Watson S,Young AH

更新日期：2004-02-01 00:00:00

abstract：:In a double-blind, balanced crossover study, eight healthy male volunteers ingested either DL-308 (10 mg), DL-308 (20 mg), oxazepam (30 mg) or placebo. Subjective estimates of coordination and anxiety, objective performance measurements and cardiovascular measurements were taken at 1, 3, 5 and 8 h after ingestion. DL-...

journal_title：Psychopharmacology

authors： Herbert M,Standen PJ,Short AH,Birmingham AT

更新日期：1983-01-01 00:00:00

abstract：:Many behavioral effects of cocaine are attenuated by dopamine (DA) receptor antagonists. Yet, long-term DA antagonist administration enhances neuronal responsiveness to DA in several pathways, including the mesolimbic system. This study compared the effects of short-term versus long-term administration of the DA antag...

journal_title：Psychopharmacology

authors： Kosten TA,DeCaprio JL,Nestler EJ

更新日期：1996-12-01 00:00:00

abstract：RATIONALE:Mesocorticolimbic reactivity to alcohol-associated cues has been shown to be associated with relapse to renewed drinking and to be decreased by cue-exposure-based extinction training (CET). Evidence from preclinical studies suggests that the extinction of conditioned alcohol-seeking behavior might be facilita...

journal_title：Psychopharmacology

authors： Kiefer F,Kirsch M,Bach P,Hoffmann S,Reinhard I,Jorde A,von der Goltz C,Spanagel R,Mann K,Loeber S,Vollstädt-Klein S

更新日期：2015-07-01 00:00:00