The role of childhood trauma and stress reactivity for increased alcohol craving after induced psychological trauma: an experimental analogue study.

abstract：:The tricyclic anticonvulsant carbamazepine (CBZ) is effective in pain and affective disorder, but the mechanism of action for this drug has not been defined. Recently it was reported that CBZ had interaction with adenosine receptor, which is related to the inhibition of release of neurotransmitter. In the present stud...

journal_title：Psychopharmacology

authors： Fujiwara Y,Sato M,Otsuki S

更新日期：1986-01-01 00:00:00

abstract：:Primiparous rats received 0.05, 0.25, 0.50, or 1.50 mg d-amphetamine/kg body weight, injected IP, when offspring reached 3-4 and 10-11 days of age. A multidimensional analysis of their maternal behavior revealed that at doses as low as 0.25 mg/kg, amphetamine had a disruptive effect on mother-pup intercontact interval...

journal_title：Psychopharmacology

authors： Piccirillo M,Alpert JE,Cohen DJ,Shaywitz BA

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Cocaine and opioids are often co-abused. As yet, however, there is no clear evidence that the drugs interact to make the mixture a more effective reinforcer. OBJECTIVE:The present study examined the relative reinforcing potency and maximum effectiveness of the cocaine-opioid combination in monkeys given a ch...

journal_title：Psychopharmacology

authors： Freeman KB,Woolverton WL

更新日期：2011-05-01 00:00:00

abstract：:Doses of eight phenylethylamines were substituted for cocaine on a drug-maintained behavior baseline in baboons. Intravenous infusions of drug were contingent upon completion of 160 lever presses (a 160-response fixed-ratio schedule; FR 160). A 3-h time-out period followed each infusion, permitting a maximum of 8 infu...

journal_title：Psychopharmacology

authors： Griffiths RR,Winger G,Brady JV,Snell JD

更新日期：1976-11-24 00:00:00

abstract：RATIONALE:Coping styles are fundamental characteristics of behavior that affect susceptibility to, and resilience during, mental and physical illness. Shifts from passive to active coping are considered therapeutic goals in many stress-related disorders, but the neural control of coping is poorly understood. Based on e...

journal_title：Psychopharmacology

authors： Haller J,Goldberg SR,Pelczer KG,Aliczki M,Panlilio LV

更新日期：2013-12-01 00:00:00

abstract：RATIONALE:Tryptophan depletion is used to reduce central serotonergic function and to investigate its role in psychiatric illness. Despite widespread clinical use, its effects on serotonin (5-HT) receptors have not been well characterized. OBJECTIVE:The aim of this study was to examine the effect of acute (ATD) and ch...

journal_title：Psychopharmacology

authors： Cahir M,Ardis T,Reynolds GP,Cooper SJ

更新日期：2007-03-01 00:00:00

abstract：RATIONALE:Nicotine replacement is commonly used to treat tobacco use in heavy-drinking smokers. However, few studies have examined the effect of nicotine replacement on subjective and physiological responses to alcohol and alcohol drinking behavior. OBJECTIVE:The primary aim of this within-subject, double-blind study ...

journal_title：Psychopharmacology

authors： McKee SA,O'Malley SS,Shi J,Mase T,Krishnan-Sarin S

更新日期：2008-02-01 00:00:00

abstract：INTRODUCTION:Casein kinase I epsilon/delta phosphorylates certain clock-related proteins as part of a complex arrangement of transcriptional/translational feedback loops that comprise the circadian oscillator in mammals. Pharmacologic inhibition leads to a delay of the oscillations with the magnitude of this effect dep...

journal_title：Psychopharmacology

authors： Sprouse J,Reynolds L,Kleiman R,Tate B,Swanson TA,Pickard GE

更新日期：2010-07-01 00:00:00

abstract：RATIONALE:The precise neural circuitry that encodes fear memory and its extinction within the brain are not yet fully understood. Fearful memories can be persistent, resistant to extinction, and associated with psychiatric disorders, especially post-traumatic stress disorder (PTSD). Here, we investigated the microtopog...

journal_title：Psychopharmacology

authors： Jacques A,Chaaya N,Hettiarachchi C,Carmody ML,Beecher K,Belmer A,Chehrehasa F,Bartlett S,Battle AR,Johnson LR

更新日期：2019-01-01 00:00:00

abstract：:In a double-blind comparison of haloperidol decanoate and fluphenazine decanoate given 4-weekly for 60 weeks as maintenance therapy in 38 chronic schizophrenic in-patients, plasma haloperidol, fluphenazine and prolactin levels were measured at regular intervals by radioimmunoassay. After the first injection, the mean ...

journal_title：Psychopharmacology

authors： Wiles DH,McCreadie RG,Whitehead A

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Inattentional blindness (IB) is the inability to detect a salient yet unexpected task irrelevant stimulus in one's visual field when attention is engaged in an ongoing primary task. The present study is the first to examine the impact of both task difficulty and alcohol consumption on IB and primary task perf...

journal_title：Psychopharmacology

authors： Harvey AJ,Bayless SJ,Hyams G

更新日期：2018-01-01 00:00:00

abstract：RATIONALE:Working memory performance may be improved or decreased by amphetamine, depending on baseline working memory capacity and amphetamine dosage. This variable effect suggests an optimal range of monaminergic activity for working memory, either below or above which it is compromised. We directly tested this possi...

journal_title：Psychopharmacology

authors： Tipper CM,Cairo TA,Woodward TS,Phillips AG,Liddle PF,Ngan ET

更新日期：2005-08-01 00:00:00

abstract：:In a one-trial step-through passive avoidance task, pretraining administration of ethanol was shown to decrease the latencies to step through at both training (day 1) and testing (day 2) for both rats and mice. A detailed analysis of these effects showed that they differed from those reported previously by others. The...

journal_title：Psychopharmacology

authors： Bammer G,Chesher GB

更新日期：1982-01-01 00:00:00

abstract：RATIONALE:(+/-) 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is an amphetamine analog and drug of abuse. In animals, MDMA damages brain serotonin (5-HT) neurons at doses that overlap with those used recreationally by some humans. To date, few functional sequelae of MDMA-induced 5-HT damage have been identified. ...

journal_title：Psychopharmacology

authors： McCann UD,Mertl M,Eligulashvili V,Ricaurte GA

更新日期：1999-04-01 00:00:00

abstract：:This was a 4-week, three-center, double-blind, randomized, parallel, placebo-controlled evaluation of the efficacy and safety of bupropion in hospitalized depressed patients. Results from 27 placebo and 48 bupropion-treated patients were analyzed for efficacy and safety. Assessments of efficacy and safety were made at...

journal_title：Psychopharmacology

authors： Zung WW,Brodie HK,Fabre L,McLendon D,Garver D

更新日期：1983-01-01 00:00:00

abstract：:Behavioral performances of normotensive and hypertensive adult male baboons were tested before, during, and following chronic oral dosing with nifedipine. Performances during a five-color simultaneous match-to-sample task were measured during three dosing schedules (0.20, 0.68, and 1.14 mg/kg/day) and vehicle. Each do...

journal_title：Psychopharmacology

authors： Turkkan JS,Hienz RD

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:The cAMP-dependent protein kinase A (PKA) signaling transduction pathway has been shown to play an important role in the modulation of several ethanol-induced behaviors. Different studies have demonstrated intracellular calcium (Ca(2+))-dependent activation of the PKA cascade after ethanol administration. Thu...

journal_title：Psychopharmacology

authors： Baliño P,Ledesma JC,Aragon CM

更新日期：2014-12-01 00:00:00

abstract：:The effects of methaqualone on isonicotinic acid hydrazide, 6-mercapto propionic acid, picrotoxin, and strychnine-induced convulsion were studied in mice and the results compared with diazepam. Methaqualone, like diazepam, was found to be a selective antagonist of isoniazid-induced convulsion and a much less effective...

journal_title：Psychopharmacology

authors： Naik SR,Naid PR,Sheth UK

更新日期：1978-04-14 00:00:00

abstract：RATIONALE:Children and adolescents will readily abuse household products that contain solvents such as toluene. It is likely that reinforcing exposures to toluene alter brain glucose metabolism. OBJECTIVE:Using an animal model of drug reinforcement, we sought to identify a metabolic signature of toluene abuse in the a...

journal_title：Psychopharmacology

authors： Schiffer WK,Lee DE,Alexoff DL,Ferrieri R,Brodie JD,Dewey SL

更新日期：2006-06-01 00:00:00

abstract：RATIONALE:The zebrafish dopaminergic system is thought to be evolutionarily conserved and may be amenable to pharmacological manipulation using drugs developed for mammalian receptors. However, only few studies have examined the role of specific receptor subtypes in behaviour of adult zebrafish. OBJECTIVES:The objecti...

journal_title：Psychopharmacology

authors： Tran S,Nowicki M,Muraleetharan A,Gerlai R

更新日期：2015-02-01 00:00:00

abstract：:Intravenous cocaine self-administration behavior in rats was investigated using a progressive ratio (PR) schedule of reinforcement. The first response on the lever each day produced a drug infusion, whereupon the requirements of the schedule escalated with each reinforcement until the behavior extinguished. The final ...

journal_title：Psychopharmacology

authors： Roberts DC,Loh EA,Vickers G

更新日期：1989-01-01 00:00:00

abstract：:Preclinical studies have exploded our knowledge about the behavioral and biological underpinnings of alcoholism. These studies suggest that certain neurotransmitters, particularly those interacting with the opioid, N-methyl-D-aspartate, and monoamine systems, may play a critical role in the expression of alcohol-drink...

journal_title：Psychopharmacology

authors： Johnson BA,Ait-Daoud N

更新日期：2000-05-01 00:00:00

abstract：:Key-press responding of mice was maintained under a fixed-ratio (FR) 30-response schedule of food presentation. Successive 3-min periods during which the experimental chamber was illuminated and the schedule was in effect were preceded by 10-min time-out (TO) periods during which all lights were out and responses had ...

journal_title：Psychopharmacology

authors： Solomon RE,Goodrich JE,Katz JL

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Paired-associate learning (PAL), as part of the Cambridge Neuropsychological Test Automated Battery, is able to predict who from an at-risk population will develop Alzheimer's disease. Schizophrenic patients are also impaired on this same task. An automated rodent model of PAL would be extremely beneficial in...

journal_title：Psychopharmacology

authors： Talpos JC,Winters BD,Dias R,Saksida LM,Bussey TJ

更新日期：2009-07-01 00:00:00

abstract：RATIONALE:Previous work has shown that clozapine suppressed tacrine-induced jaw movements at lower doses than those required for suppression of lever pressing. OBJECTIVE:The novel atypical antipsychotic olanzapine was assessed in these behavioral tests. METHODS:The effect of acute olanzapine on the suppression of tac...

journal_title：Psychopharmacology

authors： Trevitt JT,Carlson BB,Salamone JD

更新日期：1999-08-01 00:00:00

abstract：:Twenty-one (three groups of seven), men and women, 25-50 years of age were studied to determine whether or not rebound insomnia would increase the likelihood of self administering a benzodiazepine (triazolam 0.25 mg) hypnotic. The groups compared were patients with insomnia and disturbed sleep, insomnia and normal sle...

journal_title：Psychopharmacology

authors： Roehrs T,Merlotti L,Zorick F,Roth T

更新日期：1992-01-01 00:00:00

abstract：:The thymoleptics potentiate and modify the behavioral effects of apomorphine (probably the most specific dopaminergic agonist) as well as those of Dopa. The effect of the thymoleptics is not abolished by emptying of amine stores, and this together with other evidence suggests that these drugs facilitate the access of ...

journal_title：Psychopharmacology

authors： Molander L,Randrup A

更新日期：1976-09-17 00:00:00

abstract：:Preclinical studies suggest that acoustic startle amplitude is increased during ethanol withdrawal. The current study evaluated the effects of intravenous infusion of the alpha 2-adrenergic antagonist, yohimbine (0.4 mg/kg), the serotonin partial agonist m-chlorophenylpiperazine (mCPP, 0.1 mg/kg), and placebo administ...

journal_title：Psychopharmacology

authors： Krystal JH,Webb E,Grillon C,Cooney N,Casal L,Morgan CA 3rd,Southwick SM,Davis M,Charney DS

更新日期：1997-06-01 00:00:00

abstract：:In previous research, sensitization of stereotypy induced by injections of 2.5 mg/kg amphetamine did not interfere with subsequent tolerance development to the hypophagic effect of 2 mg/kg. This study examined the effect of a higher sensitizing dose. Rats given intermittent injections of 5 mg/kg amphetamine and then c...

journal_title：Psychopharmacology

authors： Hughes KM,Popi L,Wolgin DL

更新日期：1998-12-01 00:00:00

abstract：RATIONALE:The synthetic progestin medroxyprogesterone acetate (MPA), widely used in hormone therapy (HT) and as the contraceptive Depo Provera, is implicated in detrimental cognitive effects in women. Recent evidence in aged ovariectomized (Ovx) rodents shows that short-term MPA treatment impairs cognition and alters t...

journal_title：Psychopharmacology

authors： Braden BB,Garcia AN,Mennenga SE,Prokai L,Villa SR,Acosta JI,Lefort N,Simard AR,Bimonte-Nelson HA

更新日期：2011-11-01 00:00:00