Pharmacokinetics of haloperidol and fluphenazine decanoates in chronic schizophrenia.

abstract：RATIONALE:Alcohol-associated cues elicit craving in human addicts but little is known about craving mechanisms. Current animal models focus on relapse and this may confound the effect of environmental cues. OBJECTIVES. To develop a model to study the effects of environmental cues on alcohol consumption in animals not e...

journal_title：Psychopharmacology

authors： Pickering C,Liljequist S

更新日期：2003-07-01 00:00:00

abstract：RATIONALE:The startle reflex to a sudden intense acoustic pulse stimulus is attenuated if the pulse is shortly preceded by a weak prepulse stimulus. This represents a form of sensory gating, known as prepulse inhibition (PPI), observable across species. PPI is modulated by dopamine and readily disrupted by acute amphet...

journal_title：Psychopharmacology

authors： Peleg-Raibstein D,Hauser J,Llano Lopez LH,Feldon J,Gargiulo PA,Yee BK

更新日期：2013-01-01 00:00:00

abstract：RATIONALE:In humans, the retrieval of memories associated with an alcohol-related experience frequently evokes alcohol-seeking behaviour. The reconsolidation hypothesis states that a consolidated memory could again become labile and susceptible to disruption after memory retrieval. OBJECTIVES:The aim of our study was ...

journal_title：Psychopharmacology

authors： von der Goltz C,Vengeliene V,Bilbao A,Perreau-Lenz S,Pawlak CR,Kiefer F,Spanagel R

更新日期：2009-08-01 00:00:00

abstract：:Shaking movements of the body, similar to that made by a dog when wet ('wet-dog shakes'), occur in rats in response to pharmacological stimuli and in response to stimuli associated with cold and skin irritation. In this study, shaking movements, elicited by a variety of stimuli, were inhibited by central administratio...

journal_title：Psychopharmacology

authors： Wei ET

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:The touchscreen continuous trial-unique non-matching-to-location task (cTUNL) has been developed to optimise a battery of tasks under NEWMEDS (Novel Methods leading to New Medication in Depression and Schizophrenia, http://www.newmeds-europe.com ). It offers novel task features of both a practical and a theor...

journal_title：Psychopharmacology

authors： Oomen CA,Hvoslef-Eide M,Kofink D,Preusser F,Mar AC,Saksida LM,Bussey TJ

更新日期：2015-11-01 00:00:00

abstract：RATIONALE:Electronic cigarettes (ECs) are becoming popular alternatives for smokers, but there has been limited study of their abuse liability. OBJECTIVES:The objective of this study was to evaluate the abuse liability of three Vuse Solo ECs, ranging from 14 to 36 mg in nicotine content, relative to high- and low-abus...

journal_title：Psychopharmacology

authors： Stiles MF,Campbell LR,Graff DW,Jones BA,Fant RV,Henningfield JE

更新日期：2017-09-01 00:00:00

abstract：RATIONALE:Preclinical experimental models of pathological aggressive behavior are a sorely understudied and difficult research area. OBJECTIVES:How valid, reliable, productive, and informative are the most frequently used animal models of excessive aggressive behavior? METHODS:The rationale, key methodological featur...

journal_title：Psychopharmacology

authors： Miczek KA,de Boer SF,Haller J

更新日期：2013-04-01 00:00:00

abstract：:Quetiapine (Seroquel, ICI 204,636) is an atypical antipsychotic that is effective in the treatment of both positive and negative symptoms of schizophrenia, and has a low propensity to cause extrapyramidal symptoms. The compound has a relatively short plasma elimination half-life (approximately 7 h). However, since dop...

journal_title：Psychopharmacology

authors： King DJ,Link CG,Kowalcyk B

更新日期：1998-05-01 00:00:00

abstract：:The effects of ethanol on locomotor activity and rotarod performance were measured in the rat. Apomorphine (4 mg/kg s.c.) antagonized and pimozide (0.75 - 1.50 mg/kg s.c.) enhanced the effects of a 2 g/kg dose of ethanol on rotarod performance. No such interaction was seen with pentobarbital, 25 mg/kg, a dose sufficie...

journal_title：Psychopharmacology

authors： Bacopoulos NG,Bize I,Levine J,Van Orden LS 3rd

更新日期：1979-01-31 00:00:00

abstract：:Amphetamine stimulates locomotor activity, in large part by activating central dopaminergic systems. Serotonin shares on overlapping distribution with dopamine and has been shown to modulate dopaminergic function and dopamine-mediated behaviors. The present study examined whether increasing serotonergic function, via ...

journal_title：Psychopharmacology

authors： Sills TL,Greenshaw AJ,Baker GB,Fletcher PJ

更新日期：1999-02-01 00:00:00

abstract：:Primiparous rats received 0.05, 0.25, 0.50, or 1.50 mg d-amphetamine/kg body weight, injected IP, when offspring reached 3-4 and 10-11 days of age. A multidimensional analysis of their maternal behavior revealed that at doses as low as 0.25 mg/kg, amphetamine had a disruptive effect on mother-pup intercontact interval...

journal_title：Psychopharmacology

authors： Piccirillo M,Alpert JE,Cohen DJ,Shaywitz BA

更新日期：1980-01-01 00:00:00

abstract：:The effects of amphetamine on the partial punishment effect (PPE) at one trial per day, were examined. Two groups of animals were trained to run in a straight alley. The continuously reinforced (CRF) group received food reward on every trial. The partially punished (PP) group received food reward on every trial but in...

journal_title：Psychopharmacology

authors： Weiner I,Bercovitz H,Feldon J

更新日期：1986-01-01 00:00:00

abstract：:Rats that are placed in a novel environment containing a probe will explore the environment and the probe. Exploration of the probe is reduced when the probe is electrified. We here report that chlordiazepoxide blocks this inhibition, and have determined some of the pharmacological features of this new experimental pr...

journal_title：Psychopharmacology

authors： Meert TF,Colpaert FC

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:The motivational impetuses underlying self-administration of cocaine and other drugs of abuse are not fully understood. One emerging factor is affect. Both positive and negative affective states have been hypothesized to influence drug seeking and drug taking. In parallel, it has been posited that the ultraso...

journal_title：Psychopharmacology

authors： Barker DJ,Root DH,Ma S,Jha S,Megehee L,Pawlak AP,West MO

更新日期：2010-09-01 00:00:00

abstract：RATIONALE:Schizophrenia is a complex psychiatric disorder comprised of three main classes of symptoms: positive, negative and cognitive symptoms. Currently, no approved treatment exists for the cognitive symptoms. There is thus a great need for research aiming at identifying novel targets for treatment of this indicati...

journal_title：Psychopharmacology

authors： Damgaard T,Plath N,Neill JC,Hansen SL

更新日期：2011-03-01 00:00:00

abstract：:The effects of fixed-ratio (FR) size, scopolamine, and the interactions between FR size and scopolamine were investigated in male F344 rats on working memory as assessed by spatial alternation behavior maintained under FR schedules of food presentation where the interval between trials was varied among values of 2, 4,...

journal_title：Psychopharmacology

authors： Shannon HE,Bemis KG,Hart JC

更新日期：1990-01-01 00:00:00

abstract：:The effects of olanzapine [LY 170053; 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2, 3b] [1,5]benzodiazepine), a potential atypical antipsychotic, were determined in pigeons whose keypeck responding was punished. These effects were compared to the anxiolytic agents chlordiazepoxide and pentobarbital, and to other a...

journal_title：Psychopharmacology

authors： Benvenga MJ,Leander JD

更新日期：1995-05-01 00:00:00

abstract：RATIONALE:The endogenous oxytocin system has emerged as an inhibitor of drug-seeking and stress in preclinical models. OBJECTIVES:The goal of this study was to examine whether systemic oxytocin administration attenuated methamphetamine (METH)-seeking in rats pre-exposed to a predator odor threat. METHODS:In Experimen...

journal_title：Psychopharmacology

authors： Ferland CL,Reichel CM,McGinty JF

更新日期：2016-03-01 00:00:00

abstract：:The effects of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801, on cocaine self-administration were investigated. Forty-six male Wistar rats were trained to intravenously self-administer four unit doses of cocaine (0.19, 0.38, 0.75 and 1.5 mg/kg per injection) on a progressive-ratio schedule...

journal_title：Psychopharmacology

authors： Ranaldi R,French E,Roberts DC

更新日期：1996-11-01 00:00:00

abstract：RATIONALE:Behavioral disturbances (BD) are prevalent in patients with substance use disorders (SUD). OBJECTIVES:To test the hypothesis that chronic exposure to cocaine could favor the acquisition of BD that were not present in childhood. METHODS:We used child and adult ADHD self-report screening scales (WURS-25 and A...

journal_title：Psychopharmacology

authors： Vorspan F,de Witt P,Zerdazi EH,Karsinti E,Ksouda K,Icick R,Bellivier F,Marie N,Brousse G,Bloch V

更新日期：2020-11-01 00:00:00

abstract：:These experiments examined the neurochemical mechanisms involved in the development and expression of place conditioning produced by heroin. Conditioned place preferences (CPP) lasting up to 8 weeks were obtained with doses of 50-1000 micrograms/kg heroin, using a regimen shown not to produce physical dependence. Nalo...

journal_title：Psychopharmacology

authors： Hand TH,Stinus L,Le Moal M

更新日期：1989-01-01 00:00:00

abstract：:In order to study experimental alcohol intake that leads to heightened aggression, we established ethanol self-administration in aggressive rats. The focus was on low doses of self-administered ethanol and to assess their effects on aggressive behavior in resident rats, using a limited access paradigm followed by a 5-...

journal_title：Psychopharmacology

authors： van Erp AM,Miczek KA

更新日期：1997-06-01 00:00:00

abstract：:The behavioral effects of repeated methylphenidate (MPH) treatment were assessed in the adult rat. Protein kinase A (PKA) and adenylyl cyclase (basal and DA-stimulated) activity in the dorsal striatum (i.e., caudate-putamen) were measured to determine whether MPH-induced alterations in these enzymes correlate with the...

journal_title：Psychopharmacology

authors： Crawford CA,McDougall SA,Meier TL,Collins RL,Watson JB

更新日期：1998-03-01 00:00:00

abstract：:To investigate the role of D1 dopamine receptors in the discriminative stimulus effects of cocaine, two rhesus monkeys were trained in a two-lever, food-reinforced, drug discrimination paradigm to discriminate cocaine (0.2 mg/kg, IM) from saline. Administration of various doses of cocaine resulted in a dose-related in...

journal_title：Psychopharmacology

authors： Kleven MS,Anthony EW,Goldberg LI,Woolverton WL

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Toluene exposure during brain growth spurt has been shown to elevate the seizure susceptibility induced by N-methyl-D: -aspartate (NMDA). In the present study, behavioral responses to NMDA antagonists were studied to determine whether neonatal toluene exposure produces residual deficits in the NMDA glutamater...

journal_title：Psychopharmacology

authors： Chien TH,Chan MH,Tang YC,Chen HH

更新日期：2005-11-01 00:00:00

abstract：RATIONALE:Multiple low doses of cocaine (COC) may cause intermittent vasoconstriction and reperfusion, leading to elevations in damaging reactive oxygen species, such as hydroxyl free radicals (*OH). Salicylate may offer protection because it reacts with *OH and/or because of its anti-inflammatory actions. OBJECTIVE:T...

journal_title：Psychopharmacology

authors： Castelli MC,Venturini L,Sparber SB

更新日期：2001-06-01 00:00:00

abstract：:Continuous low-level (0.825 mg/kg/h for 20 h) administration of AP through SC in-dwelling silicone reservoirs in the rat induced behavioral and biochemical changes that were similar to those induced by low levels (0.1 mg/kg) of acutely administered AP (decreased behavioral activity and decreased dopamine metabolism in...

journal_title：Psychopharmacology

authors： Davis RE,Sant WW,Ellison G

更新日期：1985-01-01 00:00:00

abstract：:A venous blood sample and an umbilical cord blood sample were obtained from five young women treated with the neuroleptic drug, cis(Z)-flupentixol decanoate in Viscoleo (intramuscularly) or flupentixol (orally) at the time of giving birth. In two cases amniotic fluid was also obtained, and from three of the mothers mi...

journal_title：Psychopharmacology

authors： Kirk L,Jørgensen A

更新日期：1980-01-01 00:00:00

abstract：:The effects of chronic lithium treatment on methylphenidate-, D1 dopamine receptor agonist (A-77636)-, and tactile stimulation-induced increases in frontal cortical acetylcholine release were studied in the rat using in vivo brain microdialysis. Cortical acetylcholine release in control rats was maximally stimulated b...

journal_title：Psychopharmacology

authors： Acquas E,Fibiger HC

更新日期：1996-05-01 00:00:00

abstract：RATIONALE:The dopaminergic system, particularly D2-like dopamine receptors, has been strongly implicated in reward processing. Animal studies have emphasized the role of phasic dopamine (DA) signaling in reward-related learning, but these processes remain largely unexplored in humans. OBJECTIVES:To evaluate the effect...

journal_title：Psychopharmacology

authors： Pizzagalli DA,Evins AE,Schetter EC,Frank MJ,Pajtas PE,Santesso DL,Culhane M

更新日期：2008-02-01 00:00:00