Acute fluoxetine treatment potentiates amphetamine hyperactivity and amphetamine-induced nucleus accumbens dopamine release: possible pharmacokinetic interaction.

abstract：:The influence of practice while under intoxication was tested on the development of acute tolerance to the motor impairment effect of ethanol. In experiment 1, the motor impairment effect induced by an IP injection of 1.8 g/kg ethanol was quantified after various intervals in separate groups of animals. Lower impairme...

journal_title：Psychopharmacology

authors： Lê AD,Kalant H

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:(1S,3aS)-8-(2,3,3,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198), a non-peptidic agonist for the opioid receptor-like1 (ORL1) receptor, exhibits anxiolytic properties in stressful conditions. OBJECTIVE:The present study was aimed at evaluating whether activation of ...

journal_title：Psychopharmacology

authors： Ciccocioppo R,Biondini M,Antonelli L,Wichmann J,Jenck F,Massi M

更新日期：2002-05-01 00:00:00

abstract：:Self-injection of phencyclidine HCI (PCP) and four of its analogues was examined in baboons. IV injections of drug were dependent upon completion of 160 lever presses (a 160-response fixed-ratio schedule). A 3-h time-out period followed each injection, permitting a maximum of eight injections per day. Self-injection p...

journal_title：Psychopharmacology

authors： Lukas SE,Griffiths RR,Brady JV,Wurster RM

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Pindolol has been reported to shorten the onset of antidepressant action of selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors (SSRIs) as well as to increase their efficacy. It has been postulated that pindolol enhances the antidepressant effect of SSRIs by blocking somatodendritic 5-HT1A aut...

journal_title：Psychopharmacology

authors： Arborelius L,Linnér L,Wallsten C,Ahlenius S,Svensson TH

更新日期：2000-07-01 00:00:00

abstract：RATIONALE:Buprenorphine is a partial mu opioid agonist under development as a sublingual (SL) medication for opioid dependence treatment in the United States. Because buprenorphine may be abused, tablets combining buprenorphine with naloxone in a 4:1 ratio have been developed to reduce that risk. Low doses of injected ...

journal_title：Psychopharmacology

authors： Stoller KB,Bigelow GE,Walsh SL,Strain EC

更新日期：2001-03-01 00:00:00

abstract：:The novel dopamine autoreceptor antagonists (-)-DS 121 and (+)-UH 232 were tested for their ability to alter cocaine self-administration behavior in rats reinforced on a progressive ratio (PR) schedule. (-)-DS 121 (15 mg/kg) and (+)-UH 232 (30 mg/kg) produced significant decreases in breaking point. (-)-DS 121 produce...

journal_title：Psychopharmacology

authors： Smith A,Piercey M,Roberts DC

更新日期：1995-07-01 00:00:00

abstract：:Rhesus monkeys were trained in a discrete-trials choice procedure and allowed to choose between intravenous injections of cocaine (0.01-1.0 mg/kg/injection) and food presentation (1 or 4 pellets; 1 g/pellet) during daily 7-h experimental sessions. When each reinforcer was available under a fixed-ratio (FR) 30 schedule...

journal_title：Psychopharmacology

authors： Nader MA,Woolverton WL

更新日期：1992-01-01 00:00:00

abstract：RATIONALE:Recent studies have shown that pharmacological inhibition of the 12-lipoxygenase pathway selectively blocks opioid inhibition of GABAergic synaptic currents. A similar mechanism has been shown for the regulation of glutamate release in the ventral tegmental area (VTA) during acute withdrawal from morphine, al...

journal_title：Psychopharmacology

authors： Walters CL,Wang BC,Godfrey M,Sun D,Funk CD,Blendy JA

更新日期：2003-11-01 00:00:00

abstract：:This study examined the role of the serotonin 5-HT2 receptor in motor function by examining the effect of antagonists on the motor performance of a cranial nerve reflex, the nictitating membrane (NM) reflex of the rabbit. The NM reflex was elicited by varying intensities of a tactile stimulus and the magnitudes of the...

journal_title：Psychopharmacology

authors： Harvey JA,Welsh SE,Hood H,Romano AG

更新日期：1999-01-01 00:00:00

abstract：RATIONALE:Accumulating evidence for the presence of GABA(A) ρ receptors within the amygdala which differ from other members of the GABA(A) receptor family in both subunit composition and functional properties has been recently obtained. OBJECTIVES:This work was conducted to study whether GABA(A) ρ receptors may have a...

journal_title：Psychopharmacology

authors： Flores-Gracia C,Nuche-Bricaire A,Crespo-Ramírez M,Miledi R,Fuxe K,Pérez de la Mora M

更新日期：2010-12-01 00:00:00

abstract：:Efforts to find a correlation between serum levels of chlorpromazine (CPZ) and clinical effect have been rather unsuccessful, which could be due to fluctuations of CPZ and CPZ metabolite levels during treatment, the complicated metabolism of CPZ, or to varying degrees of protein binding. Using a mass fragmentographic ...

journal_title：Psychopharmacology

authors： Wode-Helgodt B,Alfredsson G

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:The drug discrimination procedure has proven to be a valuable tool for studying the mechanism of action of psychoactive drugs. Recently, mice with targeted gene mutations have been developed that may also prove useful in evaluating the role of specific receptors in mediating the actions of drugs. We were inte...

journal_title：Psychopharmacology

authors： Smith RL,Barrett RJ,Sanders-Bush E

更新日期：2003-02-01 00:00:00

abstract：RATIONALE:Orexins A and B have recently been discovered and shown to be derived from preproorexin, primarily expressed in the rat hypothalamus. Orexin-A has been ascribed a number of in vivo functions in the rat after intracerebroventricular (ICV) administration, including hyperphagia, neuroendocrine modulation and, mo...

journal_title：Psychopharmacology

authors： Duxon MS,Stretton J,Starr K,Jones DN,Holland V,Riley G,Jerman J,Brough S,Smart D,Johns A,Chan W,Porter RA,Upton N

更新日期：2001-01-01 00:00:00

abstract：:This study compared the ability of the novel atypical antipsychotic olanzapine with that of clozapine to reverse the d-amphetamine-induced inhibition of substantia nigra (A9) and ventral tegmental area (A10) dopamine (DA) cells. Extracellular single-unit recordings were made from A9 and A10 DA cells in anesthetized ra...

journal_title：Psychopharmacology

authors： Stockton ME,Rasmussen K

更新日期：1996-03-01 00:00:00

abstract：RATIONALE:The positive modulation of gamma-aminobutyric acid type-A (GABAA) receptors is a putative mechanism via which alcohol escalates aggressive behavior. Broad-spectrum benzodiazepine antagonists block alcohol-heightened aggression in rats and monkeys. However, the degree to which GABAA subunit composition plays a...

journal_title：Psychopharmacology

authors： de Almeida RM,Rowlett JK,Cook JM,Yin W,Miczek KA

更新日期：2004-03-01 00:00:00

abstract：RATIONALE:Prepulse inhibition (PPI) of the startle response in mice is increasingly used as a paradigm of sensory gating with potential predictive and construct validity towards schizophrenia. OBJECTIVES:Establishment of a mouse PPI paradigm in which typical and atypical antipsychotic drugs directly improve a low perf...

journal_title：Psychopharmacology

authors： Olivier B,Leahy C,Mullen T,Paylor R,Groppi VE,Sarnyai Z,Brunner D

更新日期：2001-07-01 00:00:00

abstract：:Two groups of schizophrenic outpatients were treated with perphenazine decanoate (N = 20) and cis(z)-flupentixol decanoate (N = 24) respectively. Every 3 months the dose was gradually reduced until symptoms appeared that were suggestive of a prodromal phase of a psychotic episode. A slightly higher dose was then promp...

journal_title：Psychopharmacology

authors： Kistrup K,Gerlach J,Aaes-Jørgensen T,Larsen NE

更新日期：1991-01-01 00:00:00

abstract：:Two sets of experiments were carried out to compare the effects of fenfluramine and fluoxetine on consummatory and operant behaviour. In food-deprived rats allowed access to a 35% sucrose solution, an initial period of sucrose consumption was followed by a short period of grooming and exploratory behaviour, later supe...

journal_title：Psychopharmacology

authors： Willner P,McGuirk J,Phillips G,Muscat R

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Early life exposure to stress and to GABAA receptor modulators have well-defined and persistent behavioral effects. A single neonatal injection of the GABAergic neurosteroid allopregnanolone (3alpha-hydroxy,5alpha-pregnane-20-one, 10 mg/kg, i.p.) alters the localization of prefrontal cortex (PFC) interneurons...

journal_title：Psychopharmacology

authors： Gizerian SS,Moy SS,Lieberman JA,Grobin AC

更新日期：2006-06-01 00:00:00

abstract：:The effects of the benzomorphan antagonist Mr 2266 and the selective delta-antagonist ICI 154,129 on the body weight gain of 6-day-old suckling rat pups was observed. Mr 2266 significantly reduced body weight gain in these animals, though ICI 154,129 had no affect on this variable. These findings suggest that mu- and ...

journal_title：Psychopharmacology

authors： Jackson HC,Sewell RD

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:Repeated intermittent exposure to ketamine has rapid and long-lasting antidepressant effects, but the abuse potential has only been assessed at high doses. Furthermore, while females are more susceptible to depression and more sensitive to ketamine's antidepressant-like effects, the abuse potential for ketami...

journal_title：Psychopharmacology

authors： Wright KN,Strong CE,Addonizio MN,Brownstein NC,Kabbaj M

更新日期：2017-02-01 00:00:00

abstract：:The cataleptogenic effect of delta 9-THC was compared to its discriminative stimulus effects in rats. The ED50s for the discriminative stimulus and catalepsy were 0.8 and 4.0 mg/kg, respectively, while their time courses were very similar. The ED50 of delta 9-THC for catalepsy in experimentally naive rats was not diff...

journal_title：Psychopharmacology

authors： Prescott WR,Gold LH,Martin BR

更新日期：1992-01-01 00:00:00

abstract：:The effects of methylglucamine orotate (MGO) were studied on polygraphic sleep recordings in rats for 8 h per day between 8 a.m. and 4 p.m. MGO (225 mg/kg) was injected intraperitoneally immediately prior to the onset of recording. In the acute experiment, the effect of MGO was compared to pre- and post-drug control d...

journal_title：Psychopharmacology

authors： Wetzel W,Ott T,Matthies HK,Matthies H

更新日期：1984-01-01 00:00:00

abstract：:The effects of intraperitoneal administrations of the deoxycorticosterone metabolite, 5 alpha-pregnane-, 21 diol-20-one (3 alpha, 5 alpha-tetrahydrodeoxycorticosterone; alpha-THDOC) on the responses to aggression and defeat-induced analgesia were examined in subordinate intruder male mice in "resident-intruder" pairin...

journal_title：Psychopharmacology

authors： Kavaliers M

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Clinically, nicotine improves attention, but this has proven difficult to demonstrate preclinically. We tested nicotine in Sprague-Dawley (SD) and Lister hooded (LH) rats in the five-choice serial reaction time task. Since SD rats demonstrate lower asymptotic performance than LH rats, we surmised that nicotin...

journal_title：Psychopharmacology

authors： Mirza NR,Bright JL

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:Several lines of evidence suggest that brain-derived neurotrophic factor (BDNF) plays a critical role in activity-dependent neuroplasticity underlying learning and memory in the hippocampus. Schizophrenia has a range of cognitive deficits that may evolve from decreased BDNF, and this study examines this assoc...

journal_title：Psychopharmacology

authors： Zhang XY,Liang J,Chen DC,Xiu MH,Yang FD,Kosten TA,Kosten TR

更新日期：2012-07-01 00:00:00

abstract：:Platelet adenylate cyclase activity was measured in 16 control subjects and 16 patients who developed post-traumatic stress disorder (PTSD) as a result of damage inflicted on their homes during the Iraqi Scud missile attacks on Israel which occurred during the 1991 Gulf War. There were no differences in basal, NaF-sti...

journal_title：Psychopharmacology

authors： Weizmann R,Gur E,Laor N,Reiss A,Muller U,Yoresh A,Lerer B,Newman ME

更新日期：1994-04-01 00:00:00

abstract：:The relationship between nicotine yield as determined by the FTC method and nicotine absorption was examined in 72 smokers in a more rigorous repetition of a previous study of 33 smokers. For this study, 113 smokers evenly distributed across four FTC "tar" yield ranges were recruited, only 72 demonstrated reasonable c...

journal_title：Psychopharmacology

authors： Byrd GD,Davis RA,Caldwell WS,Robinson JH,deBethizy JD

更新日期：1998-10-01 00:00:00

abstract：:Nine depressed patients were treated with alaproclate, a selective 5-HT uptake inhibitor, for 3 weeks in a dose of 400 mg daily. The pupillary responses to tyramine, phenylephrine, and pilocarpine eye drops were measured on consecutive days before, after 1 week and after 3 weeks of treatment. The tyramine-induced mydr...

journal_title：Psychopharmacology

authors： Thompson C,Checkley SA

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:Alcohol and nicotine addiction are prevalent conditions that co-occur. Despite the prevalence of co-use, factors that influence the suppression and enhancement of concurrent alcohol and nicotine intake are largely unknown. OBJECTIVES:Our goals were to assess how nicotine abstinence and availability influence...

journal_title：Psychopharmacology

authors： DeBaker MC,Moen JK,Robinson JM,Wickman K,Lee AM

更新日期：2020-04-01 00:00:00