Unequal interactions between alcohol and nicotine co-consumption: suppression and enhancement of concurrent drug intake.

abstract：:NNC 756 is a new benzazepine with high affinity and selectivity for D1-dopamine receptors. In a double-blind, placebo controlled, cross-over study, positron emission tomography and the radioligand [11C]SCH 23390 were used to determine central D1-dopamine receptor occupancy after a single oral dose of 80 mg NNC 756 in ...

journal_title：Psychopharmacology

authors： Karlsson P,Farde L,Halldin C,Sedvall G,Ynddal L,Sloth-Nielsen M

更新日期：1995-05-01 00:00:00

abstract：:Brain 5-hydroxytryptamine (5-HT) was depleted in rats by intraventricular injection with 5,7-dihyroxytryptamine (5,7-DHT) prior to feeding rats a liquid diet containing ethanol. After withdrawal of ethanol, withdrawal reactions were significantly less severe in 5-HT-depleted rats than control rats. Sleeping times afte...

journal_title：Psychopharmacology

authors： Wood JM

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Perospirone is a novel second-generation antipsychotic drug with high affinity to dopamine D(2) receptor and short half-life of plasma concentration. There has been no investigation of dopamine D(2) receptor occupancy in patients with schizophrenia and the time course of occupancy by antipsychotics with peros...

journal_title：Psychopharmacology

authors： Arakawa R,Ito H,Takano A,Okumura M,Takahashi H,Takano H,Okubo Y,Suhara T

更新日期：2010-05-01 00:00:00

abstract：:In the present study we have investigated the effects of diazepam (DZP) (10 mg/kg) treatment of rat dams during different periods of gestation or during lactation on the development and behavior of their offspring. The results show that DZP exposure during different phases of early development has differing effects on...

journal_title：Psychopharmacology

authors： Frieder B,Epstein S,Grimm VE

更新日期：1984-01-01 00:00:00

abstract：RATIONALE:The effects of adolescent marijuana use on the developing brain remain unclear, despite its prevalence. Arterial spin labeling (ASL) is a noninvasive imaging technique that characterizes neurovascular status and cerebral blood flow (CBF), potentially revealing contributors to neuropathological alterations. No...

journal_title：Psychopharmacology

authors： Jacobus J,Goldenberg D,Wierenga CE,Tolentino NJ,Liu TT,Tapert SF

更新日期：2012-08-01 00:00:00

abstract：RATIONALE:Using a rat relapse model, recent studies reported time dependent increases in cocaine seeking induced by re-exposure to cocaine cues, but not cocaine itself, over withdrawal periods of up to 3 months. OBJECTIVES:In the present study, we explored the time course of cocaine seeking induced by priming injectio...

journal_title：Psychopharmacology

authors： Lu L,Dempsey J

更新日期：2004-10-01 00:00:00

abstract：:The central effects of acetylsalicylic acid (ASA) are discussed controversially. In animal models, it has been shown that ASA can interact with the central serotonergic and catecholaminergic neuronal system. However, the relevance of this interaction for humans is still unknown. We performed a study on the influence o...

journal_title：Psychopharmacology

authors： Austermann M,Grotemeyer KH,Evers S,Rödding D,Husstedt IW

更新日期：1998-08-01 00:00:00

abstract：:The action of copper (CuSO4, 5 mg/kg, oral) on selected neuropharmacological actions of cannabis resin (CI, oral) was studied on albino rats and mice. Copper potentiated the barbiturate hypnosis-potentiating activity of CI in albino rats and mice and had no effect on hypothermic activity in albino rats. Single doses o...

journal_title：Psychopharmacology

authors： Singh PP,Das PK

更新日期：1978-04-11 00:00:00

abstract：RATIONALE:Brain waves reflect collective behavior of neurons and provide insight into distributed network processing. Frontal and hippocampal theta oscillations (4-7 Hz) were linked to cognitive tasks and animal studies have suggested an involvement of glutamatergic neurotransmission in integrative frontal-hippocampal ...

journal_title：Psychopharmacology

authors： Gallinat J,Kunz D,Senkowski D,Kienast T,Seifert F,Schubert F,Heinz A

更新日期：2006-07-01 00:00:00

abstract：:DL-2-amino-5-phosphonovaleric acid (AP-5), which blocks glutamatergic transmission at the NMDA-preferring receptor, was injected into the antero-dorsal striatum of rats. AP-5-induced behavioural changes were assessed i) using a stereotypy rating scale and ii) using an experimental chamber designed to quantify sniffing...

journal_title：Psychopharmacology

authors： Schmidt WJ

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:We previously demonstrated that the addition of the selective norepinephrine reuptake inhibitor reboxetine attenuates olanzapine-induced weight gain. Using the same study sample, we also sought to determine whether reboxetine's weight-attenuating effect was accompanied by a beneficial effect on metabolic and ...

journal_title：Psychopharmacology

authors： Amrami-Weizman A,Maayan R,Gil-Ad I,Pashinian A,Fuchs C,Kotler M,Poyurovsky M

更新日期：2013-11-01 00:00:00

abstract：RATIONALE:Available neurochemical probes that lower brain dopamine (DA) levels in man are limited by their tolerability and efficacy. For instance, the acute lowering of brain tyrosine is well tolerated, but only modestly lowers brain DA levels. Modification of tyrosine depletion to robustly lower DA levels would provi...

journal_title：Psychopharmacology

authors： Brodnik Z,Double M,Jaskiw GE

更新日期：2013-05-01 00:00:00

abstract：:The administration of large doses of probenecid has been used to study the central nervous system metabolism of catecholamines and indoleamines in patients with affective disease. It has been reported that alterations of the binding of L-tryptophan to plasma albumin binding sites occur during probenecid administration...

journal_title：Psychopharmacology

authors： Dunner DL,Heiber S,Perel JM

更新日期：1977-08-16 00:00:00

abstract：RATIONALE:Selective serotonin reuptake inhibitor (SSRI) antidepressants are increasingly prescribed during pregnancy. Changes in serotonergic signaling during human fetal development have been associated with changes in brain development and with changes in affective behavior in adulthood. The suprachiasmatic nucleus (...

journal_title：Psychopharmacology

authors： Houwing DJ,de Waard J,Ramsteijn AS,Woelders T,de Boer SF,Wams EJ,Olivier JDA

更新日期：2020-08-01 00:00:00

abstract：RATIONALE:The non-selective nicotinic acetylcholine receptor (nAChR) agonist nicotine has been argued to improve attention via enhanced filtering of irrelevant stimuli. Here, we tested this hypothesis in the context of smooth pursuit eye movements (SPEMs), an oculomotor function previously shown to improve with nicotin...

journal_title：Psychopharmacology

authors： Meyhöfer I,Kasparbauer AM,Steffens M,Ettinger U

更新日期：2019-07-01 00:00:00

abstract：:The effects of naltrexone methobromide, a quaternary derivative of the opioid antagonist naltrexone, were investigated on deprivation (24 h)-induced water intake in the unilaterally cannulated rats. Naltrexone methobromide reduced post-deprivational water intake with an ED50 of 7.3 micrograms when tested at 30 min (pe...

journal_title：Psychopharmacology

authors： Ukai M,Holtzman SG

更新日期：1987-01-01 00:00:00

abstract：:Serotonin (5-HT) afferents may modulate the dopamine mesoaccumbens circuit, which has been shown to be critically involved in the locomotor stimulatory, discriminative stimulus, and rewarding properties of cocaine. In the present study, we investigated the role of 5-HT1A receptors in the ventral tegmental area (VTA) i...

journal_title：Psychopharmacology

authors： De La Garza R 2nd,Callahan PM,Cunningham KA

更新日期：1998-05-01 00:00:00

abstract：RATIONALE:In animal studies, the common club drug 3,4-methylendioxymethamphetamine (MDMA, "Ecstasy") consistently caused a prolonged loss of presynaptic serotonergic neurons, and evidence suggests that MDMA consumption may also affect the human serotonergic system. Serotonin (5-HT) has been implicated in the regulation...

journal_title：Psychopharmacology

authors： Quednow BB,Kühn KU,Hoppe C,Westheide J,Maier W,Daum I,Wagner M

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:It has recently been shown that acute alcohol globally impairs 'prospective memory' (PM)-remembering to do something in the future (Leitz et al. in Psychopharmacology 205:379-387, 2009). In healthy, sober individuals, simulating future events at encoding enhances PM performance. AIMS:We therefore aimed to d...

journal_title：Psychopharmacology

authors： Paraskevaides T,Morgan CJ,Leitz JR,Bisby JA,Rendell PG,Curran HV

更新日期：2010-02-01 00:00:00

abstract：RATIONALE:Recent studies have shown that metabotropic glutamate receptor 5 (mGluR5) can modulate N-methyl-D-aspartate (NMDA) receptor function in vivo. For example, the mGluR5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine (MPEP) can potentiate PCP (phencyclidine)-evoked hyperactivity and PCP-induced disruptions in pr...

journal_title：Psychopharmacology

authors： Campbell UC,Lalwani K,Hernandez L,Kinney GG,Conn PJ,Bristow LJ

更新日期：2004-09-01 00:00:00

abstract：:Chronic treatment of rats with the antipsychotic drug molindone (2.5 mg/kg) did not elicit behavioral supersensitivity to apomorphine (AP) (0.25 mg/kg) or increased striatal 3H-spiroperidol binding, whereas treatment with haloperidol (0.5-1.0 mg/kg) produced manifestations of dopaminergic supersensitivity in both para...

journal_title：Psychopharmacology

authors： Meller E

更新日期：1982-01-01 00:00:00

abstract：:Development of tolerance to neuroleptic compounds tested in the conditional avoidance model was investigated. Since tolerance may manifest itself by a diminished potency and/or a shortened duration of effect, the complete time course of effect was registered in these experiments. Rats were pretreated approximately 2 w...

journal_title：Psychopharmacology

authors： Danneskiold-Samsøoe P,Pedersen V

更新日期：1976-12-21 00:00:00

abstract：:Nine depressed patients were treated with alaproclate, a selective 5-HT uptake inhibitor, for 3 weeks in a dose of 400 mg daily. The pupillary responses to tyramine, phenylephrine, and pilocarpine eye drops were measured on consecutive days before, after 1 week and after 3 weeks of treatment. The tyramine-induced mydr...

journal_title：Psychopharmacology

authors： Thompson C,Checkley SA

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:The thalamus is a major target of dopaminergic projections and is densely connected with the prefrontal cortex. A better understanding of how dopamine changes thalamo-cortical communication may shed light on how dopamine supports cognitive function. Methylphenidate has been shown to facilitate cognitive proc...

journal_title：Psychopharmacology

authors： Gorka AX,Lago TR,Balderston N,Torrisi S,Fuchs B,Grillon C,Ernst M

更新日期：2020-06-01 00:00:00

abstract：:Acute and chronic effects of ethosuximide (40, 80, and 120 mg/kg), phenytoin (2.5, 5, and 7.5 mg/kg), clonazepam (0.25, 0.5, and 0.75 mg/kg), and valproic acid (40, 80, and 120 mg/kg) were examined in pigeons performing under a delayed-matching-to-sample procedure. Acute administration of clonazepam or valproic acid p...

journal_title：Psychopharmacology

authors： Poling A,Picker M,Vande Polder D,Clark R

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND AND RATIONALE:Despite the popularity of polysubstance abuse among recreational methylendioxymethamphetamine (MDMA) users, relatively few controlled experimental studies have documented the neurobehavioral effects of MDMA in combination with other abused substances. OBJECTIVE:In this study, the combined acut...

journal_title：Psychopharmacology

authors： Panos JJ,Baker LE

更新日期：2010-03-01 00:00:00

abstract：RATIONALE:So-called atypical antipsychotics (AAPs) are associated with varying levels of weight gain and associated metabolic disturbances, which in patients with serious mental illness (SMI) have been linked to non-compliance and poor functional outcomes. Mechanisms underlying AAP-induced metabolic abnormalities are o...

journal_title：Psychopharmacology

authors： Benarroch L,Kowalchuk C,Wilson V,Teo C,Guenette M,Chintoh A,Nesarajah Y,Taylor V,Selby P,Fletcher P,Remington GJ,Hahn MK

更新日期：2016-07-01 00:00:00

abstract：RATIONALE:Alcohol intoxication can dampen negative affective reactions to stressors. Recently, it has been proposed that these acute anxiolytic effects of alcohol may extend to dampening of negative affective reactions to error commission during cognitive control tasks. Nonetheless, empirical verification of this claim...

journal_title：Psychopharmacology

authors： Cofresí RU,Bartholow BD

更新日期：2020-11-01 00:00:00

abstract：RATIONALE:Clinical data with 3,4-methylenedioxymethamphetamine (MDMA) in post-traumatic stress disorder (PTSD) patients recently stimulated interest on the potential therapeutic use of psychedelics in disorders characterized by maladaptive memories, including substance use disorders (SUD). The rationale for the use of ...

journal_title：Psychopharmacology

authors： Fattore L,Piva A,Zanda MT,Fumagalli G,Chiamulera C

更新日期：2018-02-01 00:00:00

abstract：RATIONALE:The neuronal actions of methamphetamine (MA) include an increase in extracellular levels of monoamines, presumably via reverse transport involving the monoamine transporters. This action is thought to play an important role in the effects of MA. Therefore, in the present experiment, it was hypothesized that a...

journal_title：Psychopharmacology

authors： Ranaldi R,Anderson KG,Carroll FI,Woolverton WL

更新日期：2000-12-01 00:00:00