Abstract：
:This study examined the role of the serotonin 5-HT2 receptor in motor function by examining the effect of antagonists on the motor performance of a cranial nerve reflex, the nictitating membrane (NM) reflex of the rabbit. The NM reflex was elicited by varying intensities of a tactile stimulus and the magnitudes of the elicited responses were measured at each intensity. Dose-response curves were obtained for the effects of several 5-HT2 receptor antagonists on response magnitude. d-Bro-molysergic acid diethylamide (BOL), LY-53,857 and ketanserin had no significant effect on the magnitude of the NM reflex, indicating that they are neutral antagonists. However, the 5-HT2 receptor antagonists ritanserin, MDL-11,939 and mianserin produced a significant reduction in response magnitude with no significant effects on response frequency, suggesting that they were acting as inverse agonists at the 5-HT2 receptor. The reduction in reflex magnitude produced by mianserin (10 micromol/kg) was fully blocked by BOL (5.8 micromol/kg), supporting the conclusion that mianserin was producing a reduction in reflex magnitude through an effect at the 5-HT2 receptor. The occurrence of inverse agonism suggests the possible existence of constitutive activity in vivo. We conclude that the 5-HT2 receptor (either 2A or 2C) plays an important role in motor function, perhaps by providing a tonic influence on motor systems.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Harvey JA,Welsh SE,Hood H,Romano AGdoi
10.1007/s002130050820subject
Has Abstractpub_date
1999-01-01 00:00:00pages
162-8issue
2eissn
0033-3158issn
1432-2072journal_volume
141pub_type
杂志文章abstract：INTRODUCTION:Dysfunction of brain dopamine systems is involved in various neuropsychiatric disorders. Challenge studies with dopamine receptor agonists have been performed to assess dopamine receptor functioning, classically using the release of growth hormone (GH) from the hindbrain as primary outcome measure. The obj...
journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：2005-07-01 00:00:00
abstract：BACKGROUND:Marijuana intoxication appears to impair response inhibition, but it is unclear if impaired inhibition and associated brain abnormalities persist after prolonged abstinence among adolescent users. We hypothesized that brain activation during a go/no-go task would show persistent abnormalities in adolescent m...
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journal_title：Psychopharmacology
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更新日期：1989-01-01 00:00:00
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journal_title：Psychopharmacology
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journal_title：Psychopharmacology
pub_type： 杂志文章
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journal_title：Psychopharmacology
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更新日期：1997-02-01 00:00:00
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更新日期：2015-08-01 00:00:00
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journal_title：Psychopharmacology
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00431455
更新日期：1984-01-01 00:00:00
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journal_title：Psychopharmacology
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doi：10.1007/s002130051077
更新日期：1999-08-01 00:00:00
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更新日期：1999-03-01 00:00:00
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journal_title：Psychopharmacology
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doi：10.1007/BF02244411
更新日期：1990-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02180028
更新日期：1988-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Psychopharmacology
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journal_title：Psychopharmacology
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doi：10.1007/BF00427955
更新日期：1983-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：2002-12-01 00:00:00
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更新日期：2004-09-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：1999-06-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：1993-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-016-4322-x
更新日期：2016-07-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050363
更新日期：1997-08-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130051063
更新日期：1999-08-01 00:00:00
