Anxiolytic properties of amygdaloid kindling unrelated to benzodiazepine receptors.

Abstract:

:We investigated the possibility that repeated electrical stimulation of the basolateral amygdala (kindling) would increase punished behavior, a pre-clinical indicator of anti-anxiety activity. Male Sprague-Dawley rats, prepared with electrodes in the left basolateral nucleus and frontal cortex, were trained to bar-press under a multiple schedule in which either every 30th response produced food (no punishment) or every 10th response produce both food and a brief electric shock (punishment). Rates of punished responding were less than 10% of non-punished values. Brief electrical stimulation of the amygdala occurred biweekly, and the current levels were incremented from subconvulsive values (50 microA) to suprathreshold levels (150 microA). Electrical stimulation increased punished responding without concomitant changes in nonpunished behavior; increases were most pronounced in fully-kindled rats. Fully-kindled animals also demonstrated the largest primary afterdischarge. Electrical stimulation of the frontal cortex induced similar seizure and convulsive patterns but did not increase punished responding. Anxiolytic activity of amygdaloid stimulation was not prevented by the selective benzodiazepine antagonist Ro 15-1788, which antagonized similar behavioral effects of chlordiazepoxide. Thus, kindling of seizures in the amygdala results in behaviorally and neuroanatomically specific antianxiety actions which do not depend upon receptor sites blocked by Ro 15-1788 (benzodiazepine receptors).

journal_title

Psychopharmacology

authors

Witkin JM,Lee MA,Walczak DD

doi

10.1007/BF00216053

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

296-301

issue

3

eissn

0033-3158

issn

1432-2072

journal_volume

96

pub_type

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