Abstract:
BACKGROUND:Acute administration of selective serotonin and noradrenaline re-uptake blockers to healthy volunteers affects the processing of emotional information but it is not known if similar effects occur with antidepressants acting through other pharmacological mechanisms. Mirtazapine is a clinically established antidepressant with complex actions involving blockade of noradrenaline alpha(2)-adrenoceptors as well as a number of 5-HT receptor subtypes. The aim of the present study was to test whether, like monoamine re-uptake inhibitors, mirtazapine would also produce positive biases in emotional processing. METHODS:We studied 30 healthy volunteers who received either a single dose of mirtazapine (15 mg) or placebo in a parallel group, double-blind study. Two hours following medication administration, participants completed a battery of tasks testing various aspects of emotional processing including facial expression recognition, emotion potentiated startle, and emotional categorization and memory. RESULTS:Compared to placebo, mirtazapine significantly impaired the recognition of fearful facial expressions and reduced eye-blink responses in the emotion potentiated startle task. Participants receiving mirtazapine were also significantly quicker to respond to emotional self-relevant information in the categorization task and showed a positive bias in memory recall compared to those receiving placebo. CONCLUSIONS:Our findings indicate that mirtazapine reduces fear processing in healthy volunteers, an effect similar to that produced by repeated administration of selective serotonin re-uptake inhibitors. In addition, mirtazapine increased memory for likeable versus dislikeable self-relevant information suggesting an induction of positive bias in emotional memory. Such effects may be important for our understanding of the neuropsychological mechanisms of antidepressant action in both anxiety and depressive disorders.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Arnone D,Horder J,Cowen PJ,Harmer CJdoi
10.1007/s00213-008-1410-6subject
Has Abstractpub_date
2009-05-01 00:00:00pages
685-91issue
4eissn
0033-3158issn
1432-2072journal_volume
203pub_type
杂志文章,随机对照试验abstract::Nicotine (6 mg/kg/day) was administered subcutaneously via Alzet osmotic pumps to rats for 28 days. Nociception was measured by the hot-plate and tail-flick methods. A significant antinociceptive effect was demonstrated during the first week of the treatment; after that tolerance developed, lasting for the remaining p...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245428
更新日期:1992-01-01 00:00:00
abstract::These experiments examined the neurochemical mechanisms involved in the development and expression of place conditioning produced by heroin. Conditioned place preferences (CPP) lasting up to 8 weeks were obtained with doses of 50-1000 micrograms/kg heroin, using a regimen shown not to produce physical dependence. Nalo...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00442007
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:The rapid membrane actions of neuroactive steroids, particularly via an enhancement of γ-aminobutyric acidA receptors (GABAARs), participate in the regulation of central nervous system excitability. Prior evidence suggests an inverse relationship between endogenous GABAergic neuroactive steroid levels and beh...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3618-y
更新日期:2014-09-01 00:00:00
abstract:INTRODUCTION:Non-medical use of prescription opioids such as the mu opioid receptor (MOP-r) agonist oxycodone is a growing problem in the USA and elsewhere. There is limited information about oxycodone's impact on diverse gene systems in the brain. OBJECTIVES:The current study was designed to examine how chronic oxyco...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-017-4657-y
更新日期:2017-08-01 00:00:00
abstract::An error in Fig. 3 was introduced in the production process which the authors have asked to be rectified. Below is the correct figure. ...
journal_title:Psychopharmacology
pub_type: 已发布勘误
doi:10.1007/s00213-019-05340-x
更新日期:2019-11-01 00:00:00
abstract::We have previously demonstrated that depletion of forebrain norepinephrine (NE) led to an attenuation of neophobia in a novel environment, as defined by a greater preference for novel food over familiar food. To study further the role of forebrain NE in neophobia we chronically infused noradrenergic receptor ligands o...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02253601
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:Neuroactive derivatives of steroid hormones, neurosteroids, can act on GABAA receptors (GABAARs) to potentiate the effects of GABA on these receptors. Neurosteroids become elevated to physiologically relevant levels under conditions characterized by increased steroid hormones. There is considerable evidence f...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-013-3423-z
更新日期:2014-09-01 00:00:00
abstract:RATIONALE:Memantine is a potential treatment for alcoholic patients, yet few studies investigate the effect of concurrent treatment with memantine and ethanol on aggression. We evaluated aggressive behavior following ethanol consumption and treatment with glutamatergic drugs to characterize interactions between these c...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-012-2734-9
更新日期:2012-11-01 00:00:00
abstract::Augmentation with low-dose fluvoxamine (50-100 mg/day) to antipsychotic treatment may improve the negative symptoms in schizophrenic patients, but involves a risk of drug-drug interaction. We studied the effects of fluvoxamine on plasma concentrations of haloperidol and reduced haloperidol, and their clinical symptoms...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-003-1567-y
更新日期:2004-01-01 00:00:00
abstract::In mice, quipazine has shown several behavioral effects: It antagonizes hypothermia induced by a high dose of apomorphine without altering climbing or stereotyped behavior; it antagonizes oxotremorine-induced hypothermia without altering tremors or peripheral signs; and it increases the toxicity of yohimbine. These th...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00431273
更新日期:1980-01-01 00:00:00
abstract::Two experiments investigated the effect of alcohol on retrieval of lexical information. In each, volunteers received alcohol (1 ml per kg body weight) in one session and no alcohol in another in counterbalanced order. Experiment 1 was a computerised version of the Mill Hill vocabulary test in which subjects were requi...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00212779
更新日期:1988-01-01 00:00:00
abstract:RATIONALE:Previous observations revealed that defeated and subsequently individually housed rats do not display behavioral anticipatory responses to the conditioned presentation of a bell/light stimulus associated with free access to a 5% sucrose solution reward. The absence of the appetitive responses suggests a decre...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1093-3
更新日期:2002-07-01 00:00:00
abstract::Mood disorders, despite the widespread availability of monoamine-based antidepressant treatments, are associated with persistently high rates of disability, together with elevated rates of mortality due to suicide, cardiovascular disease, and other causes. The development of more effective treatments has been hindered...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-016-4214-0
更新日期:2016-05-01 00:00:00
abstract::Various doses of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, MK-801 (0.1-0.5 mg/kg) and ketamine (2.5-10 mg/kg), produced a dose-dependent increase in stereotypic behaviour in naive mice. MK-801 (0.1 mg/kg) and ketamine (2.5 mg/kg) potentiated the stereotypic response of apomorphine (0.1-0.5 ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245171
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:The administration of heroin has been shown to inhibit the induction of nitric oxide, a molecule known to play a critical role in immune function. Previous research has shown that this alteration can be conditioned to environmental stimuli that have been associated with drug administration. However, it remain...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0673-z
更新日期:2007-05-01 00:00:00
abstract:RATIONALE:(+)-HA-966, a partial agonist at the glycine/NMDA modulatory site, significantly reduced i.v. cocaine self-administration in a fixed-ratio (FR) schedule. Since this effect was observed studying only one dose of cocaine and considering the characteristic bell-shaped curve generated by cocaine in self-administr...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1703-8
更新日期:2004-04-01 00:00:00
abstract:RATIONALE:Little is known about the smoking topography characteristics of heavy cannabis users. Such measures may be able to predict cannabis use-related outcomes and could be used to validate self-reported measures of cannabis use. OBJECTIVES:The current study was conducted to measure cannabis smoking topography char...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-011-2480-4
更新日期:2012-03-01 00:00:00
abstract::ApolipoproteinE (ApoE) genotype has recently been identified as a major risk factor for Alzheimer's disease (AD) but the mechanism(s) by which ApoE isoforms influence this disease remain unclear. Recent studies suggest that mice deficient in ApoE may exhibit impaired central cholinergic function. Since this neurotrans...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050329
更新日期:1997-07-01 00:00:00
abstract::Peripheral administration of the unsulphated cholecystokinin octapeptide (CCK-8us) led to an anxiogenic-like action in the elevated plus-maze model of anxiety in rats. Devazepide and L-365,260 showed potent anxiolytic-like effects at similar doses. The fact that devazepide is 1000 times more potent as a CCK-A receptor...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244646
更新日期:1993-01-01 00:00:00
abstract::In experiment 1, rats (n = 12) were trained to discriminate the benzodiazepine (BDZ) compound chlordiazepoxide (CDP, 20 mg/kg, IP) from saline in a two-lever food-reinforced procedure, and subsequently were tested for stimulus control with different doses of CDP, Ro 15-1788 (a proposed BDZ receptor antagonist) and Ro ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00652236
更新日期:1986-01-01 00:00:00
abstract:RATIONALE:F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical trial in patients with schizophrenia (Bitter et al. Neuropsych...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05387-w
更新日期:2020-02-01 00:00:00
abstract:RATIONAL:In recent years, evidence suggests that modafinil may be useful for certain symptom domains of schizophrenia, especially for the negative and cognitive symptoms. However, the results are not consistent. OBJECTIVE:This study was designed to investigate the effect of modafinil added to risperidone in patients w...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-011-2513-z
更新日期:2012-04-01 00:00:00
abstract:RATIONALE:Research in pediatric psychopharmacology has expanded considerably in the last 10 years. Still, controversy remains about the effectiveness and safety of commonly used psychotropics and their role in child treatment, thus pointing to the need for more in-depth and targeted investigations. OBJECTIVES:To revie...
journal_title:Psychopharmacology
pub_type: 杂志文章,评审
doi:10.1007/s00213-006-0414-3
更新日期:2007-03-01 00:00:00
abstract::A novel self-stimulation methodology involving a fixed-interval (FI-5 s) schedule of reinforcement, microanalysis and threshold evaluation was used to investigate the effects of cocaine on rats lever pressing for electrical stimulation of the prefrontal cortex. Cocaine (15 mg/kg) increased medial prefrontal cortex (MP...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02801979
更新日期:1992-01-01 00:00:00
abstract:RATIONALE:Noncontingent administration of amphetamine into the ventral striatum or systemic nicotine increases responses rewarded by inconsequential visual stimuli. When these drugs are contingently administered, rats learn to self-administer them. We recently found that rats self-administer the GABA(B) receptor agonis...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-011-2450-x
更新日期:2012-03-01 00:00:00
abstract:INTRODUCTION:A growing number of studies have found evidence that anxiety and depressive disorders are associated with atypical amygdala hyperactivation, which decreases with effective treatment. Interest has emerged in this phenomenon as a possible biological marker for individuals who are likely to benefit from tailo...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-006-0542-9
更新日期:2007-03-01 00:00:00
abstract::Monoamine neurotransmitter systems, along with cholinergic systems, are known to play important roles in cognition, and are disrupted in at least some patients with dementia of the Alzheimer type (DAT). This suggests that monoamine-enhancing drugs might ameliorate cognitive symptoms in certain patients with DAT. L-Dep...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00216016
更新日期:1987-01-01 00:00:00
abstract:RATIONALE:Thousands of adolescents start smoking daily but information on the effects of tobacco exposure on this age group is scarce. Moreover, the available animal models rely on the effects of nicotine, neglecting other neuroactive components of tobacco. OBJECTIVES:We investigated the effects of exposure of adolesc...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3801-1
更新日期:2015-05-01 00:00:00
abstract:RATIONALE:Exposure to a single session of uncontrollable inescapable shock (IS), but not to identical controllable escapable shock, produces a potentiation of morphine's rewarding properties that is unusual in that the stressor can be given a number of days before the drug administration in an environment quite differe...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1572-1
更新日期:2004-01-01 00:00:00
abstract::The effect of lithium on serotonin (5-HT)-mediated responses in the brain was assessed by measuring changes in the prolactin (PRL) and growth hormone (GH) responses to L-tryptophan (LTP) in eight normal subjects. On the 4th day of lithium treatment the PRL responses were significantly enhanced, and this enhancement wa...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00179198
更新日期:1986-01-01 00:00:00