The effect of chronic in vivo infusion of forskolin on noradrenergic receptor sensitivity.

abstract：:The title of this article is "Effect of a dual orexin receptor antagonist (DORA-12) on sleep and event-related oscillations in rats exposed to ethanol vapor during adolescence". ...

journal_title：Psychopharmacology

authors： Ehlers CL,Benedict J,Wills D,Sanchez-Alavez M

更新日期：2020-11-01 00:00:00

abstract：RATIONALE:The progesterone metabolite 5alpha-pregnane-3alpha-ol-20-one (3alpha,5alpha-THP) is an important modulator of the hypothalamic-pituitary-adrenal axis and stress-induced corticosterone response. Typically, 3alpha,5alpha-THP levels are increased in response to acute stress, which may then reduce corticosterone ...

journal_title：Psychopharmacology

authors： Frye CA,Rhodes ME,Raol YH,Brooks-Kayal AR

更新日期：2006-06-01 00:00:00

abstract：INTRODUCTION:Casein kinase I epsilon/delta phosphorylates certain clock-related proteins as part of a complex arrangement of transcriptional/translational feedback loops that comprise the circadian oscillator in mammals. Pharmacologic inhibition leads to a delay of the oscillations with the magnitude of this effect dep...

journal_title：Psychopharmacology

authors： Sprouse J,Reynolds L,Kleiman R,Tate B,Swanson TA,Pickard GE

更新日期：2010-07-01 00:00:00

abstract：RATIONALE:Previous studies indicate that the rewarding effect of D-1 dopamine receptor stimulation in nucleus accumbens (NAc) shell is greater in food-restricted (FR) than in ad libitum fed (AL) rats. The D-1 receptor is positively coupled to adenylyl cyclase and activates protein kinase A (PKA). OBJECTIVES:The purpos...

journal_title：Psychopharmacology

authors： de Vaca SC,Peng XX,Concors S,Farin C,Lascu E,Carr KD

更新日期：2012-06-01 00:00:00

abstract：:Quetiapine (Seroquel, ICI 204,636) is an atypical antipsychotic that is effective in the treatment of both positive and negative symptoms of schizophrenia, and has a low propensity to cause extrapyramidal symptoms. The compound has a relatively short plasma elimination half-life (approximately 7 h). However, since dop...

journal_title：Psychopharmacology

authors： King DJ,Link CG,Kowalcyk B

更新日期：1998-05-01 00:00:00

abstract：:NNC 756 is a new benzazepine with high affinity and selectivity for D1-dopamine receptors. In a double-blind, placebo controlled, cross-over study, positron emission tomography and the radioligand [11C]SCH 23390 were used to determine central D1-dopamine receptor occupancy after a single oral dose of 80 mg NNC 756 in ...

journal_title：Psychopharmacology

authors： Karlsson P,Farde L,Halldin C,Sedvall G,Ynddal L,Sloth-Nielsen M

更新日期：1995-05-01 00:00:00

abstract：RATIONALE:Children and adolescents will readily abuse household products that contain solvents such as toluene. It is likely that reinforcing exposures to toluene alter brain glucose metabolism. OBJECTIVE:Using an animal model of drug reinforcement, we sought to identify a metabolic signature of toluene abuse in the a...

journal_title：Psychopharmacology

authors： Schiffer WK,Lee DE,Alexoff DL,Ferrieri R,Brodie JD,Dewey SL

更新日期：2006-06-01 00:00:00

abstract：RATIONALE:During the last few decades, alcohol use disorders (AUD) have reached an epidemic prevalence, yet social influences on alcoholism have not been fully addressed. Several factors can modulate alcohol intake. On one hand, stress can reinforce ethanol-induced behaviors and be an important component in AUD and alc...

journal_title：Psychopharmacology

authors： Bahi A,Dreyer JL

更新日期：2020-03-01 00:00:00

abstract：RATIONALE:It has been demonstrated that major differences between mice of the C57BL/6J and DBA/2J inbred strains for amphetamine-induced place conditioning (preference and avoidance, respectively) are evident in standard housing conditions but abolished by temporary restricted feeding. This gene-experience model may be...

journal_title：Psychopharmacology

authors： Orsini C,Buchini F,Piazza PV,Puglisi-Allegra S,Cabib S

更新日期：2004-03-01 00:00:00

abstract：:The topography of stereotyped behaviour produced by apomorphine in rats was studied by using either a scoring system, based on observation in a wire cage, or by quantification of horizontal and vertical activities, and of the total distances run in an open field, using an automatic recording system. The latter design ...

journal_title：Psychopharmacology

authors： Havemann U,Magnus B,Möller HG,Kuschinsky K

更新日期：1986-01-01 00:00:00

abstract：:The ventral tegmental area (VTA) evaluates salience of environmental stimuli and provides dopaminergic innervation to many brain areas affected by acute and chronic ethanol exposure. While primarily associated with rewarding and reinforcing stimuli, recent evidence indicates a role for the VTA in aversion as well. Eth...

journal_title：Psychopharmacology

authors： You C,Vandegrift B,Brodie MS

更新日期：2018-06-01 00:00:00

abstract：RATIONALE:3,4-Methylenedioxypyrovalerone (MDPV) and 3,4-methylenedioxy-N-methylcathinone (methylone) are synthetic drugs found in so-called "bath salts" products. Both drugs exert their effects by interacting with monoamine transporter proteins. MDPV is a potent uptake blocker at transporters for dopamine and norepinep...

journal_title：Psychopharmacology

authors： Schindler CW,Thorndike EB,Goldberg SR,Lehner KR,Cozzi NV,Brandt SD,Baumann MH

更新日期：2016-05-01 00:00:00

abstract：RATIONALE:Animal models of relapse to drug abuse typically assess the ability of various manipulations to reinstate responding that has ceased due to non-reinforcement (extinction). However, there is a lack of information concerning the reinstatement of responding that has ceased for reasons other than extinction. OBJ...

journal_title：Psychopharmacology

authors： Panlilio LV,Thorndike EB,Schindler CW

更新日期：2003-07-01 00:00:00

abstract：RATIONALE:The antidepressant nortriptyline is a second-line pharmacotherapy for smoking cessation. Given that there is limited preclinical data available on the effects of nortriptyline on responses to nicotine, the present study sought to evaluate its effects on the reinforcing, discriminative stimulus (DS) and aversi...

journal_title：Psychopharmacology

authors： Wing VC,Shoaib M

更新日期：2012-02-01 00:00:00

abstract：:The effect of long-term treatment with clozapine in schizophrenia and schizoaffective disorder was evaluated in a retrospective study comprising 96 patients treated with the drug during the period 1974-1986 at the Psychiatric Research Center in Uppsala. All patients had previously been treated with different kinds of ...

journal_title：Psychopharmacology

authors： Lindström LH

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Chronic stress and corticosterone have been shown to affect serotonin (5-HT) neurotransmission; however, the influence of stress on the activity of the dorsal raphe nucleus (DRN), the main source of 5-HT in the forebrain, is not well understood. In particular, it is unknown if and how stress modifies DRN 5-HT...

journal_title：Psychopharmacology

authors： Sowa J,Kusek M,Siwiec M,Sowa JE,Bobula B,Tokarski K,Hess G

更新日期：2018-12-01 00:00:00

abstract：:Metergoline given IP reduced the response to noxious stimulation in the mouse formalin test. Tolerance to this effect developed after a chronic treatment schedule consisting of ten daily injections of 5 mg/kg. Twenty four hours after the last injection a test dose of metergoline (2.5 mg/kg) reduced the licking time in...

journal_title：Psychopharmacology

authors： Fasmer OB,Berge OG,Hole K

更新日期：1987-01-01 00:00:00

abstract：INTRODUCTION:Alcohol has been shown to increase smoking urges and smoking behavior. However, alcohol's effects on specific components of smoking behavior for nicotine versus non-nicotine factors and potential sex differences in this response have not been investigated. METHODS:Forty-two young male and female non-depen...

journal_title：Psychopharmacology

authors： King A,McNamara P,Conrad M,Cao D

更新日期：2009-11-01 00:00:00

abstract：RATIONALE:Intramuscular (IM) conventional antipsychotics and/or benzodiazepines are effective in the short-term treatment of acutely agitated psychotic patients but may be associated with adverse effects. A short-acting IM formulation of the novel antipsychotic, ziprasidone, which may offer advantages over conventional...

journal_title：Psychopharmacology

authors： Daniel DG,Potkin SG,Reeves KR,Swift RH,Harrigan EP

更新日期：2001-05-01 00:00:00

abstract：RATIONAL:It has been suggested that phosphodiesterase 5 inhibitors such as sildenafil may be effective in the treatment of negative symptoms of schizophrenia. OBJECTIVE:This study was designed to investigate the effect of sildenafil added to risperidone as augmentation therapy in patients with chronic schizophrenia an...

journal_title：Psychopharmacology

authors： Akhondzadeh S,Ghayyoumi R,Rezaei F,Salehi B,Modabbernia AH,Maroufi A,Esfandiari GR,Naderi M,Ghebleh F,Tabrizi M,Rezazadeh SA

更新日期：2011-02-01 00:00:00

abstract：RATIONALE:The extent to which non-α4β2 versus α4β2* nAChRs contribute to the behavioral effects of varenicline and other nAChR agonists is unclear. OBJECTIVES:The purpose of this study was to characterize the discriminative stimulus effects of varenicline and nicotine using various nAChR agonists and antagonists to el...

journal_title：Psychopharmacology

authors： de Moura FB,McMahon LR

更新日期：2017-03-01 00:00:00

abstract：RATIONALE:Previous studies have shown that the effect of setting on drug-taking is substance specific in both humans and rats. In particular, we have shown that when the setting of drug self-administration (SA) coincides with the home environment of the rats (resident rats), the rats tend to prefer heroin to cocaine. T...

journal_title：Psychopharmacology

authors： Montanari C,Stendardo E,De Luca MT,Meringolo M,Contu L,Badiani A

更新日期：2015-07-01 00:00:00

abstract：:Preclinical studies have exploded our knowledge about the behavioral and biological underpinnings of alcoholism. These studies suggest that certain neurotransmitters, particularly those interacting with the opioid, N-methyl-D-aspartate, and monoamine systems, may play a critical role in the expression of alcohol-drink...

journal_title：Psychopharmacology

authors： Johnson BA,Ait-Daoud N

更新日期：2000-05-01 00:00:00

abstract：RATIONALE:Although some aspects of memory functions are known to be acutely impaired by delta(9)-tetrahydrocannabinol (delta(9)-THC; the main active constituent of marijuana), effects on other aspects of memory are not known and the time course of functional impairments is unclear. OBJECTIVE:The present study aimed to...

journal_title：Psychopharmacology

authors： Curran HV,Brignell C,Fletcher S,Middleton P,Henry J

更新日期：2002-10-01 00:00:00

abstract：:A continuing challenge for preclinical research on anxiolytic drugs is to capture the affective dimension that characterizes anxiety and aggression, either in their adaptive forms or when they become of clinical concern. Experimental protocols for the preclinical study of anxiolytic drugs typically involve the suppres...

journal_title：Psychopharmacology

authors： Miczek KA,Weerts EM,Vivian JA,Barros HM

更新日期：1995-09-01 00:00:00

abstract：RATIONALE:Naturally low prepulse inhibition (PPI) in DBA/2 mice is increased by marketed antipsychotics and compounds acting at novel targets relevant to schizophrenia. Whether other mouse strains with naturally low PPI respond similarly and could be translational models of schizophrenia is unknown. OBJECTIVE:Baseline...

journal_title：Psychopharmacology

authors： Flood DG,Zuvich E,Marino MJ,Gasior M

更新日期：2011-06-01 00:00:00

abstract：:The present study assessed the discriminative stimulus effects of the delta-opioid agonist [D-Pen2-D-Pen5]enkephalin (DPDPE) in pigeons. Food-restricted pigeons were trained to discriminate between i.c.v injections of 100 micrograms [D-Pen2-D-Pen5]enkephalin (DPDPE) and saline in a two-key operant procedure; acquisiti...

journal_title：Psychopharmacology

authors： Jewett DC,Mosberg HI,Woods JH

更新日期：1996-10-01 00:00:00

abstract：:We investigated the possibility that repeated electrical stimulation of the basolateral amygdala (kindling) would increase punished behavior, a pre-clinical indicator of anti-anxiety activity. Male Sprague-Dawley rats, prepared with electrodes in the left basolateral nucleus and frontal cortex, were trained to bar-pre...

journal_title：Psychopharmacology

authors： Witkin JM,Lee MA,Walczak DD

更新日期：1988-01-01 00:00:00

abstract：:BIMT 17, the only compound reported to be a full 5-HT1A agonist and a 5-HT2A antagonist at the frontal cortex, was assessed in three animal paradigms sensitive to antidepressants in rats: olfactory bulbectomy (OB), differential-reinforcement-of-low rate 72-s (DRL 72-s) and learned helplessness (LH). In the OB rats, BI...

journal_title：Psychopharmacology

authors： Borsini F,Cesana R,Kelly J,Leonard BE,McNamara M,Richards J,Seiden L

更新日期：1997-12-01 00:00:00

abstract：RATIONALE:Paired-associate learning (PAL), as part of the Cambridge Neuropsychological Test Automated Battery, is able to predict who from an at-risk population will develop Alzheimer's disease. Schizophrenic patients are also impaired on this same task. An automated rodent model of PAL would be extremely beneficial in...

journal_title：Psychopharmacology

authors： Talpos JC,Winters BD,Dias R,Saksida LM,Bussey TJ

更新日期：2009-07-01 00:00:00