Prepulse inhibition of the startle reflex and response to antipsychotic treatments in two outbred mouse strains in comparison to the inbred DBA/2 mouse.

abstract：RATIONALE:Latent inhibition (LI), namely, poorer performance on a learning task involving a previously pre-exposed non-reinforced stimulus, is disrupted in the rat by the dopamine (DA) releaser amphetamine which produces and exacerbates psychotic (positive) symptoms, and this is reversed by treatment with typical and a...

journal_title：Psychopharmacology

authors： Weiner I

更新日期：2003-09-01 00:00:00

abstract：:Haloperidol disposition has been associated with reversible metabolism: it is reversibly reduced to its metabolite, reduced haloperidol, which has less pharmacologic activity than the parent compound. To characterize the interconversion process, six healthy male schizophrenics were administered a single dose of 10 mg ...

journal_title：Psychopharmacology

authors： Jann MW,Lam YW,Chang WH

更新日期：1990-01-01 00:00:00

abstract：RATIONALE:Memantine is a potential treatment for alcoholic patients, yet few studies investigate the effect of concurrent treatment with memantine and ethanol on aggression. We evaluated aggressive behavior following ethanol consumption and treatment with glutamatergic drugs to characterize interactions between these c...

journal_title：Psychopharmacology

authors： Newman EL,Chu A,Bahamón B,Takahashi A,Debold JF,Miczek KA

更新日期：2012-11-01 00:00:00

abstract：:The distinctive effects of ethanol on behavior suggest that certain parts of the CNS may be especially sensitive to it. One of the primary candidates is the hippocampal formation. Damage to this structure mimics acute ethanol treatment across a wide variety of behavioral tasks and processes. The possibility of a hippo...

journal_title：Psychopharmacology

authors： Devenport LD,Hale RL

更新日期：1989-01-01 00:00:00

abstract：:The effect of aluminum on levels of inorganic phosphorus and acetylcholinesterase in blood and brain and on permeability of the blood-brain barrier (BBB) in different regions of the brain to the neuropeptide delta-sleep-inducing peptide (DSIP) was studied in adult rats. Aluminum (100 mg/kg) significantly increased the...

journal_title：Psychopharmacology

authors： Banks WA,Kastin AJ

更新日期：1985-01-01 00:00:00

abstract：RATIONALE:The majority of volumetric magnetic resonance imaging (MRI) studies of the hippocampus in patients with bipolar disorder (BD) show no differences in hippocampal volume between patients and healthy controls. Significant variability, however, exists in the medication status of patients included in these studies...

journal_title：Psychopharmacology

authors： Yucel K,McKinnon MC,Taylor VH,Macdonald K,Alda M,Young LT,MacQueen GM

更新日期：2007-12-01 00:00:00

abstract：:The acute effect of ethanol upon the NSD (normalized slope descriptors) or Hjorth parameters of EEG were analyzed in 11 students. The maximal blood-alcohol concentration ranged from 1.0--1.7 mg/l. The activity (mean amplitude) increased and the complexity (frequency spread) decreased significantly as a function of tim...

journal_title：Psychopharmacology

authors： Lehtinen I,Lang AH,Keskinen E

更新日期：1978-12-15 00:00:00

abstract：RATIONALE:Relapse to smoking is often precipitated by stress, yet little is known about the effects of nicotine withdrawal on responses to acute stress, or whether nicotine replacement reverses withdrawal-induced changes in stress response. OBJECTIVES:The aim of the present study is to use an effective social stressor...

journal_title：Psychopharmacology

authors： Wardle MC,Munafò MR,de Wit H

更新日期：2011-11-01 00:00:00

abstract：:Animal experimental studies suggest that the therapeutic effect of selective serotonin re-uptake inhibitors (SSRIs) may involve neuroadaptive changes in pre- and post-synaptic serotonin1A (5-HT1A) receptors. We used the endocrine and hypothermic responses to the 5-HT1A receptor agonist, gepirone (20 mg orally), to ass...

journal_title：Psychopharmacology

authors： Sargent P,Williamson DJ,Pearson G,Odontiadis J,Cowen PJ

更新日期：1997-08-01 00:00:00

abstract：RATIONALE:A recent report described sex differences in the effects of nicotine use and withdrawal on prepulse inhibition of acoustic startle (PPI), but no sex differences in PPI in non-smokers. OBJECTIVE:To determine whether previously reported male>female acoustic PPI reflect sex differences in smoking effects on PPI...

journal_title：Psychopharmacology

authors： Swerdlow NR,Geyer MA,Hartman PL,Sprock J,Auerbach PP,Cadenhead K,Perry W,Braff DL

更新日期：1999-09-01 00:00:00

abstract：INTRODUCTION:Marchigian Sardinian alcohol-preferring (msP) rats exhibit innate preference for alcohol along with anxious phenotype. In these animals, two single-nucleotide polymorphisms in position -1,836 and -2,097 from the first start codon of the CRF1-R transcript have been found. MATERIALS AND METHODS:Here, we exa...

journal_title：Psychopharmacology

authors： Cippitelli A,Ayanwuyi LO,Barbier E,Domi E,Lerma-Cabrera JM,Carvajal F,Scuppa G,Li H,Ubaldi M,Heilig M,Roberto M,Ciccocioppo R

更新日期：2015-03-01 00:00:00

abstract：:In the present study a cross-familiarisation conditioned taste aversion (CTA) paradigm was utilized to reveal stimulus resemblance between the selective 5-HT1A agonist 8-OHDPAT and a variety of serotonergic and non-serotonergic drugs. In male mice, a 0.22 mg/kg dose of 8-OHDPAT was used as the reference compound induc...

journal_title：Psychopharmacology

authors： De Beun R,Rijk HW,Broekkamp CL

更新日期：1993-01-01 00:00:00

abstract：:The effects of the enantiomers of 3-PPP on the maintenance of conditioned avoidance responding (CAR) were studied. The weak classical dopamine (DA) agonist (+)-3-PPP failed to interfere with CAR at any dose tested (0.8-13.6 mg/kg). Low doses of the drug produced sedation, while high doses produced behavioural stimulat...

journal_title：Psychopharmacology

authors： Clark D,Carlsson A,Hjorth S,Engel J,Lindberg P

更新日期：1983-01-01 00:00:00

abstract：:The effects of four indirect dopamine agonists, d-amphetamine (0.25-4.0 mg/kg), cocaine (2.5-40.0 mg/kg), GBR 12909 (10.0-30.0 mg/kg), and nomifensine (5.0-20.0 mg/kg), on the behavioral organization of movements in an unconditioned motor paradigm were investigated in rats. The extended scaling hypothesis using the fl...

journal_title：Psychopharmacology

authors： Paulus MP,Callaway CW,Geyer MA

更新日期：1993-01-01 00:00:00

abstract：:Lymphocyte beta adrenergic receptor binding using [125I]CNP was determined in patients with panic disorder (N = 4) or agoraphobia with panic attacks (N = 17) and age- and sex-matched healthy subjects (N = 22). The patients showed a significantly lower number of beta-adrenergic receptor binding sites and a significantl...

journal_title：Psychopharmacology

authors： Brown SL,Charney DS,Woods SW,Heninger GR,Tallman J

更新日期：1988-01-01 00:00:00

abstract：RATIONAL:Caloric restriction increases the risk of relapse in abstinent drug users. Hormones involved in the regulation of energy balance and food intake, such as leptin and ghrelin, are implicated in drug-related behaviors. OBJECTIVES:We investigated the role of leptin and ghrelin in the augmentation of heroin seekin...

journal_title：Psychopharmacology

authors： D'Cunha TM,Chisholm A,Hryhorczuk C,Fulton S,Shalev U

更新日期：2020-03-01 00:00:00

abstract：RATIONALE:Paired-associate learning (PAL), as part of the Cambridge Neuropsychological Test Automated Battery, is able to predict who from an at-risk population will develop Alzheimer's disease. Schizophrenic patients are also impaired on this same task. An automated rodent model of PAL would be extremely beneficial in...

journal_title：Psychopharmacology

authors： Talpos JC,Winters BD,Dias R,Saksida LM,Bussey TJ

更新日期：2009-07-01 00:00:00

abstract：RATIONALE:Results from clinical studies have shown that topiramate effectively reduces alcohol consumption in a population of heavy-drinking alcohol-dependent humans. OBJECTIVES:We undertook this preclinical study in order to establish topiramate's efficacy in a rodent model and to determine whether topiramate's effic...

journal_title：Psychopharmacology

authors： Breslin FJ,Johnson BA,Lynch WJ

更新日期：2010-01-01 00:00:00

abstract：RATIONALE:Previous studies have postulated functional links between GABA and cannabinoid systems in the hippocampus. The aim of the present study was to investigate any possible interaction between these systems in spatial change and object novelty discrimination memory consolidation in the dorsal hippocampus (CA1 regi...

journal_title：Psychopharmacology

authors： Nasehi M,Alaghmandan-Motlagh N,Ebrahimi-Ghiri M,Nami M,Zarrindast MR

更新日期：2017-10-01 00:00:00

abstract：:Two 2-(di-n-propylamino)tetralin (DPAT) compounds, 8-OH-DPAT and 5-OH-DPAT, with reported effects on central 5-HT and DA receptors respectively, were tested for their effects on the acoustic startle response in rats. 8-OH-DPAT was given in doses of 0.25-2.0 mg/kg IP and 5-OH-DPAT in doses of 1.0-8.0 mg/kg IP. Both com...

journal_title：Psychopharmacology

authors： Svensson L,Ahlenius S

更新日期：1983-01-01 00:00:00

abstract：:The action of copper (CuSO4, 5 mg/kg, oral) on selected neuropharmacological actions of cannabis resin (CI, oral) was studied on albino rats and mice. Copper potentiated the barbiturate hypnosis-potentiating activity of CI in albino rats and mice and had no effect on hypothermic activity in albino rats. Single doses o...

journal_title：Psychopharmacology

authors： Singh PP,Das PK

更新日期：1978-04-11 00:00:00

abstract：:The effect of the intracerebroventricular (ICV) administration of taurine on amnesia, convulsions and death caused by hypoxia was investigated in mice. Taurine in doses of 80-100 micrograms/mouse impaired acquisition of a single trial in passive avoidance performance, but protected mice from the learning impairment in...

journal_title：Psychopharmacology

authors： Malcangio M,Bartolini A,Ghelardini C,Bennardini F,Malmberg-Aiello P,Franconi F,Giotti A

更新日期：1989-01-01 00:00:00

abstract：:Two principal oblique factors are identified in the Bass Social Acquiescence Scale, a measure previously shown to correlate positively with placebo response and negatively with anxiolytic drug response. The two factors appeared very similar in separate analyses of data from samples of 941 psychiatric outpatients and 1...

journal_title：Psychopharmacology

authors： McNair DM,Barrett JE

更新日期：1979-10-01 00:00:00

abstract：:The present studies were undertaken to investigate the neuroactive steroidal modulation of feeding behavior and possible involvement of gamma-aminobutyric acid type-A (GABA-A) and mitochondrial diazepam binding inhibitor (DBI) receptors (MDR) in food-deprived male mice. Allopregnanolone (0.5-2 mg/kg), a neurosteroid, ...

journal_title：Psychopharmacology

authors： Reddy DS,Kulkarni SK

更新日期：1998-06-01 00:00:00

abstract：:ApolipoproteinE (ApoE) genotype has recently been identified as a major risk factor for Alzheimer's disease (AD) but the mechanism(s) by which ApoE isoforms influence this disease remain unclear. Recent studies suggest that mice deficient in ApoE may exhibit impaired central cholinergic function. Since this neurotrans...

journal_title：Psychopharmacology

authors： Anderson R,Higgins GA

更新日期：1997-07-01 00:00:00

abstract：RATIONALE:Cocaine dependence is a major health concern and there are no effective pharmacotherapies currently available. Although cocaine is an indirect DA agonist that binds to all three monoamine transporters, there is much evidence implicating a greater role for the dopamine (DAT) than norepinephrine (NET) and serot...

journal_title：Psychopharmacology

authors： Cook CD,Carroll IF,Beardsley PM

更新日期：2001-12-01 00:00:00

abstract：RATIONALE:In patients, ketamine is a fast-acting antidepressant that can induce long-lasting symptom relief. Similar rapid effects have been reported in rodents, but reports of lasting effects are limited. OBJECTIVES:We sought to extend past findings by examining dose-response curves that overlap with the individual d...

journal_title：Psychopharmacology

authors： Bechtholt-Gompf AJ,Smith KL,John CS,Kang HH,Carlezon WA Jr,Cohen BM,Ongür D

更新日期：2011-06-01 00:00:00

abstract：:The effects of ibogaine (40 and 80 mg/kg, i.p.), an indole alkaloid proposed for the treatment of drug abuse, were determined in three different groups of rats responding under an FR10 schedule of food, cocaine or heroin reinforcement. Ibogaine (80 mg/kg, i.p.) given 60 min before the start of the session resulted in ...

journal_title：Psychopharmacology

authors： Dworkin SI,Gleeson S,Meloni D,Koves TR,Martin TJ

更新日期：1995-02-01 00:00:00

abstract：RATIONALE:Many of the biochemical, physiological, and behavioral effects of ethanol are known to be mediated by ionotropic glutamate receptors. Emerging evidence implicates metabotropic glutamate receptors (mGluRs) in the biobehavioral effects of ethanol and other drugs of abuse, but there is little information regardi...

journal_title：Psychopharmacology

authors： Hodge CW,Miles MF,Sharko AC,Stevenson RA,Hillmann JR,Lepoutre V,Besheer J,Schroeder JP

更新日期：2006-01-01 00:00:00

abstract：:In a randomised, double-blind, parallel groups study, 40 patients referred for surgical removal of impacted third molars received either (a) temazepam 40 mg orally followed at 35 min by IV saline or (b) oral placebo followed by IV diazepam 10 mg (Diazemuls). Patients were divided into High-Anxious and Low-Anxious grou...

journal_title：Psychopharmacology

authors： O'Boyte CA,Harris D,Barry H,Cullen JH

更新日期：1986-01-01 00:00:00