Studies on the interactions of copper and cannabis.

abstract：:In a series of experiments, rats received the noncompetitive N-methyl-D-aspartate (NMDA) antagonist MK-801 and measures were made of motor behavior, spatial navigation in a swimming pool, and electroencephalographic (EEG) activity. High doses (0.25-10 mg/kg IV) produced somnolence and akinesia, impaired food consumpti...

journal_title：Psychopharmacology

authors： Whishaw IQ,Auer RN

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Psychostimulant sensitization heightens behavioral and motivational responses to reward-associated stimuli; however, its effects on stimuli associated with reward absence are less understood. OBJECTIVES:We examined whether amphetamine sensitization alters performance during Pavlovian-instrumental transfer (P...

journal_title：Psychopharmacology

authors： Shiflett MW,Riccie M,DiMatteo R

更新日期：2013-11-01 00:00:00

abstract：RATIONALE:The low self-administration (LS)/Kgras (LS) and high self-administration (HS)/Kgras (HS) rat lines were generated by selective breeding for low- and high-intravenous cocaine self-administration, respectively, from a common outbred Wistar stock (Crl:WI). This trait has remained stable after 13 generations of b...

journal_title：Psychopharmacology

authors： Xu H,Das S,Sturgill M,Hodgkinson C,Yuan Q,Goldman D,Grasing K

更新日期：2017-08-01 00:00:00

abstract：:The protective effects of acute and chronic diazepam administration (4 mg/kg) against seizures induced by pentylenetetrazole (PTZ) and picrotoxin were investigated. Considering the incidence of tonic-clonic convulsions, tolerance to the protective effects of diazepam was evident by day 5 if the mice were challenged wi...

journal_title：Psychopharmacology

authors： File SE

更新日期：1983-01-01 00:00:00

abstract：RATIONALE:Neurobiological models of addiction suggest that abnormalities of brain reward circuitry distort salience attribution and inhibitory control processes, which in turn contribute to high relapse rates. OBJECTIVES:The aim of this study is to determine whether impairments of salience attribution and inhibitory c...

journal_title：Psychopharmacology

authors： Powell J,Dawkins L,West R,Powell J,Pickering A

更新日期：2010-12-01 00:00:00

abstract：:In mice, quipazine has shown several behavioral effects: It antagonizes hypothermia induced by a high dose of apomorphine without altering climbing or stereotyped behavior; it antagonizes oxotremorine-induced hypothermia without altering tremors or peripheral signs; and it increases the toxicity of yohimbine. These th...

journal_title：Psychopharmacology

authors： Francès H,Lecrubier Y,Puech AJ,Simon P

更新日期：1980-01-01 00:00:00

abstract：:Several studies have demonstrated a paradoxical form of antinociception induced by the repeated administration of opioid antagonists accompanied by exposure to a painful stimulus. The underlying mechanism of this naloxone-induced antinociception (NIA) is still unknown, but the results of several studies suggest that i...

journal_title：Psychopharmacology

authors： Walker MJ,Poulos CX,Le AD

更新日期：1994-01-01 00:00:00

abstract：:A continuous intravenous infusion of the opiate receptor antagonist naloxone, at doses ranging from 0.7 to 1.0 micrograms/kg/min (total dose 8.8-13.2 mg), was performed in eight normal subjects during the first 240 min of night sleep. A significant reduction in stage REM and in stage 4 percent duration was observed. P...

journal_title：Psychopharmacology

authors： Cianchetti C,Masala C,Olivari P,Giordano G

更新日期：1984-01-01 00:00:00

abstract：:Methamphetamine (MAP: 1 and 2 mg/kg SC) and caffeine (CAF: 1, 3, 10 and 30 mg/kg SC) dose-dependently increased ambulation in mice. Repeated administration (5 times at 3 to 4-day intervals) of MAP, but not CAF, induced sensitization to its effect. Furthermore, the mice repeatedly receiving CAF showed no significant ch...

journal_title：Psychopharmacology

authors： Kuribara H

更新日期：1994-10-01 00:00:00

abstract：:Phenelzine (PLZ) is a non-selective monoamine oxidase (MAO) inhibitor commonly used to treat depression and panic disorder. In addition to increasing levels of biogenic amines in the brain, PLZ elevates brain levels of the amino acid gamma-aminobutyric acid (GABA; Baker et al. 1991; present study). Given the extensive...

journal_title：Psychopharmacology

authors： Parent MB,Habib MK,Baker GB

更新日期：1999-03-01 00:00:00

abstract：RATIONALE:Atypical antipsychotic drug (APD)-induced weight gain causes non-compliance, increasing the risk of relapse and medical complications. OBJECTIVES:In an animal model, we assessed body weights, food intake, body fat/lean body mass contents and blood serum levels of glucose and lipids in female rats treated wit...

journal_title：Psychopharmacology

authors： Kalinichev M,Rourke C,Daniels AJ,Grizzle MK,Britt CS,Ignar DM,Jones DN

更新日期：2005-10-01 00:00:00

abstract：:Pigeons were trained to peck each of two response keys. Periods during which pecks on one key (the food key) produced access to grain according to a random-ratio 80 schedule alternated irregularly with periods during which food-key responses had no scheduled consequences (extinction). Both keys remained amber unless a...

journal_title：Psychopharmacology

authors： Dearing ME,Branch MN

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Serotonin (5-HT) and norepinephrine (NE) re-uptake inhibitors (SNRIs) have been proposed to have a higher efficacy and/or faster onset of action than previously available antidepressants. OBJECTIVES:We examined in biochemical, electrophysiological and behavioural assays the antidepressant properties of (S)-(...

journal_title：Psychopharmacology

authors： Artaiz I,Zazpe A,Innerárity A,Del Olmo E,Díaz A,Ruiz-Ortega JA,Castro E,Pena R,Labeaga L,Pazos A,Orjales A

更新日期：2005-11-01 00:00:00

abstract：:Previous studies have shown that dihydropyridine (DHP) calcium channel blockers can potentiate yawning induced by apomorphine in rats. The present study was undertaken to examine whether or not this interaction was seen with other compounds that induce yawning or if it represented a specific interaction with dopaminer...

journal_title：Psychopharmacology

authors： Bourson A,Moser PC

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:This laboratory study investigated the mechanisms by which the opioid antagonist, naltrexone, reduces the risk of relapse to heavy drinking in individuals with alcohol dependence. METHODS:Eighteen alcohol-dependent, non-treatment-seeking volunteers were randomized to 50 mg naltrexone or placebo for 6 days a...

journal_title：Psychopharmacology

authors： O'Malley SS,Krishnan-Sarin S,Farren C,Sinha R,Kreek MJ

更新日期：2002-02-01 00:00:00

abstract：:During the third week of life, a hyperactive period for laboratory rat, the occurrence of 8 behavioral categories was recorded in individual littermates transferred to a novel environment. Neonatal destruction of the catecholaminergic system by intraventricular injection of 6-OH-DA resulted in increased motor activity...

journal_title：Psychopharmacology

authors： Stoof JC,Duijkstra H,Hillegers JP

更新日期：1978-04-28 00:00:00

abstract：:The selective serotonin reuptake inhibitor fluvoxamine interferes with the metabolism of tricyclic antidepressants. The present investigation was set out to characterize these interactions in vitro using rat liver microsomes and in vivo by analysing levels of clomipramine and metabolites in sera of depressed patients ...

journal_title：Psychopharmacology

authors： Härtter S,Arand M,Oesch F,Hiemke C

更新日期：1995-01-01 00:00:00

abstract：:The behavioural effects of selective mu-, kappa- and delta-opioid agonists in 5-, 10- and 20-day-old rats were investigated by observational analysis. The predominant response to mu-agonists was behavioural depression. High doses (10 mg/kg IP) of morphine and DAGO (D-Ala2, NMe-Phe4, Glyol5-enkephalin) produced overt s...

journal_title：Psychopharmacology

authors： Jackson HC,Kitchen I

更新日期：1989-01-01 00:00:00

abstract：RATIONALE:Little is known about patterns of opiate use by heroin addicts. OBJECTIVES:To describe opiate use over time among heroin addicts who had access to legally prescribed intravenous heroin and oral opiates. METHODS:Analysis of daily drug administration records of 37 patients enrolled in the Geneva heroin mainte...

journal_title：Psychopharmacology

authors： Perneger TV,Mino A,Giner F,Broers B

更新日期：2000-09-01 00:00:00

abstract：RATIONALE:Mesocorticolimbic reactivity to alcohol-associated cues has been shown to be associated with relapse to renewed drinking and to be decreased by cue-exposure-based extinction training (CET). Evidence from preclinical studies suggests that the extinction of conditioned alcohol-seeking behavior might be facilita...

journal_title：Psychopharmacology

authors： Kiefer F,Kirsch M,Bach P,Hoffmann S,Reinhard I,Jorde A,von der Goltz C,Spanagel R,Mann K,Loeber S,Vollstädt-Klein S

更新日期：2015-07-01 00:00:00

abstract：RATIONALE:Thousands of adolescents start smoking daily but information on the effects of tobacco exposure on this age group is scarce. Moreover, the available animal models rely on the effects of nicotine, neglecting other neuroactive components of tobacco. OBJECTIVES:We investigated the effects of exposure of adolesc...

journal_title：Psychopharmacology

authors： Abreu-Villaça Y,Filgueiras CC,Correa-Santos M,Cavina CC,Naiff VF,Krahe TE,Manhães AC,Ribeiro-Carvalho A

更新日期：2015-05-01 00:00:00

abstract：:The present study employed an animal model of drug relapse in which previously extinguished heroin self-administration behavior was reinstated following a single reinforced trial. Male albino rats were trained to traverse a straight-alley for a reinforcer consisting of a single IV injection of 0.06 mg/kg diacetylmorph...

journal_title：Psychopharmacology

authors： Ettenberg A,MacConell LA,Geist TD

更新日期：1996-04-01 00:00:00

abstract：:The effects of diazepam (10 mg orally) on the responding of normal human volunteers was studied in a procedure that involved the maintenance of operant behavior by monetary reinforcement and its suppression by monetary loss (punishment). Diazepam produced an antipunishment effect as shown by an increase in behavior su...

journal_title：Psychopharmacology

authors： Carlton PL,Siegel JL,Murphree HB,Cook L

更新日期：1981-01-01 00:00:00

abstract：RATIONALE:Decision-making is a complex cognitive process that is mediated, in part, by subregions of the medial prefrontal cortex (PFC). Decision-making is impaired in a number of psychiatric conditions including schizophrenia. Notably, people with schizophrenia exhibit reductions in GABA function in the same PFC areas...

journal_title：Psychopharmacology

authors： Paine TA,O'Hara A,Plaut B,Lowes DC

更新日期：2015-05-01 00:00:00

abstract：RATIONALE:Developmental lead exposure may alter responsiveness to cocaine well into adulthood, and ultimately influence drug-use patterns. OBJECTIVES:The present study examined the effect of perinatal lead exposure on the discriminative stimulus properties of cocaine. METHODS:Female rats were treated with 0, 8, or 16...

journal_title：Psychopharmacology

authors： Miller DK,Nation JR,Bratton GR

更新日期：2001-11-01 00:00:00

abstract：RATIONALE:Acute tryptophan depletion (ATD) transiently lowers central serotonin levels and can induce depressive mood states and cognitive defects. Previous studies have shown that ATD impairs object recognition in rats. OBJECTIVES:As individual differences exist in central serotonin neurotransmission, the impact of A...

journal_title：Psychopharmacology

authors： Olivier JD,Jans LA,Korte-Bouws GA,Korte SM,Deen PM,Cools AR,Ellenbroek BA,Blokland A

更新日期：2008-10-01 00:00:00

abstract：:The tricyclic anticonvulsant carbamazepine (CBZ) is effective in pain and affective disorder, but the mechanism of action for this drug has not been defined. Recently it was reported that CBZ had interaction with adenosine receptor, which is related to the inhibition of release of neurotransmitter. In the present stud...

journal_title：Psychopharmacology

authors： Fujiwara Y,Sato M,Otsuki S

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Several studies have demonstrated that males with a family history of alcoholism (FHP) show less of a response to alcohol (e.g. lower ratings of intoxication) than males without a family history of alcoholism (FHN). The purpose of this pilot study was to determine if FHP females also showed a reduced sensitiv...

journal_title：Psychopharmacology

authors： Evans SM,Levin FR

更新日期：2003-08-01 00:00:00

abstract：:It is commonly believed that repeated exposures diminish the pleasurable effects of drugs and hence that pleasure must have only a minor role in addiction. In six experiments with rats, repeated exposures to amphetamine, morphine, or cocaine were found to enhance the drug-induced rewarding effect as measured by condit...

journal_title：Psychopharmacology

authors： Lett BT

更新日期：1989-01-01 00:00:00

abstract：:The aim of the present study was to evaluate the effects of cholinergic receptor blockade in the rat prefrontal cortex on cognitive processes. The nicotinic antagonists neuronal bungarotoxin and dihydro-beta-erythroidine and the muscarinic antagonist scopolamine were injected into the prelimbic area of the prefrontal ...

journal_title：Psychopharmacology

authors： Granon S,Poucet B,Thinus-Blanc C,Changeux JP,Vidal C

更新日期：1995-05-01 00:00:00