Abstract:
:A continuous intravenous infusion of the opiate receptor antagonist naloxone, at doses ranging from 0.7 to 1.0 micrograms/kg/min (total dose 8.8-13.2 mg), was performed in eight normal subjects during the first 240 min of night sleep. A significant reduction in stage REM and in stage 4 percent duration was observed. Pretreatment with the dopamine receptor blocking agent haloperidol (2 mg intramuscularly before sleep onset) partially prevented the naloxone effect, suggesting that it is due, at least in part, to the stimulation of dopamine receptors.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Cianchetti C,Masala C,Olivari P,Giordano Gdoi
10.1007/BF00429731subject
Has Abstractpub_date
1984-01-01 00:00:00pages
179-82issue
2eissn
0033-3158issn
1432-2072journal_volume
83pub_type
临床试验,杂志文章,随机对照试验abstract::The issue of whether tolerance develops to the motivational effects of opioids was addressed by use of an unbiased place preference conditioning procedure. Administration of the mu-opioid agonists morphine or fentanyl produced dose-related preferences for the drug-associated place in control rats. In contrast, the kap...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02431542
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abstract::The performance of healthy volunteer subjects on an auditory latent inhibition (LI) paradigm was assessed following administration of a single oral dose of d-amphetamine or placebo. It was predicted that a low (5 mg), but not a high (10 mg), dose of d-amphetamine would disrupt LI. The prediction was supported with lef...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02245170
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abstract:BACKGROUND:Abnormalities of membrane phospholipid metabolism have been described in Alzheimer's disease (AD). We investigated, with the aid of (31)P magnetic resonance spectroscopy, the in vivo intracerebral availability of phosphomonoesters (PME) and phosphodiesters (PDE) in patients with AD. METHODS:Eighteen outpati...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-2168-8
更新日期:2005-07-01 00:00:00
abstract::Benztropine mesylate (Cogentin) and physostigmine salicylate (Antilirium), were tested for changes in tongue protrusions, retrusions, and swallowing acts in rats anesthetized with a 100 mg/kg IM injection of ketamine hydrochloride. These ketamine-induced linguopharyngeal events were monitored by means of a force displ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02180028
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abstract::Quantitative receptor autoradiography was used to study the effects of the selective serotonin reuptake inhibitors citalopram and fluoxetine and the tricyclic antidepressant imipramine on the regulation of beta 1-adrenergic receptors in the rat brain. Rats were treated with saline, citalopram (10 mg kg-1), fluoxetine ...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02245579
更新日期:1994-08-01 00:00:00
abstract::Nicotine (6 mg/kg/day) was administered subcutaneously via Alzet osmotic pumps to rats for 28 days. Nociception was measured by the hot-plate and tail-flick methods. A significant antinociceptive effect was demonstrated during the first week of the treatment; after that tolerance developed, lasting for the remaining p...
journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:1981-01-01 00:00:00
abstract:RATIONALE:Research on the effects of nicotine abstinence and nicotine replacement has not provided consistent information about the impact of replacement therapies on tobacco withdrawal and craving. OBJECTIVE:. This study investigated craving and withdrawal symptoms over a 72-h period of abstinence from cigarettes. M...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2008-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2006-12-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-010-1827-6
更新日期:2010-06-01 00:00:00
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
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更新日期:1998-04-01 00:00:00
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
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journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1512-0
更新日期:2003-10-01 00:00:00
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journal_title:Psychopharmacology
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pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1998-08-01 00:00:00
abstract::The effect of long-term treatment with clozapine in schizophrenia and schizoaffective disorder was evaluated in a retrospective study comprising 96 patients treated with the drug during the period 1974-1986 at the Psychiatric Research Center in Uppsala. All patients had previously been treated with different kinds of ...
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journal_title:Psychopharmacology
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更新日期:2014-08-01 00:00:00
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journal_title:Psychopharmacology
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更新日期:2004-11-01 00:00:00
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journal_title:Psychopharmacology
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