Abstract:
:Ferret predation on rats was examined in an arena. One hour before the test one of the following drugs was administered. d-Amphetamine (0.8 and 1.4 mg/kg IM), MAPROTILINE (10 AND 40 Mg/kg orally), L-dopa (30 and 60 mg/kg orally), or haloperidol (0.14 and 0.6 mg/kg IM). Provided that capture was successful, the sequence of the behavioral components was not changed by these drugs. With the exceptions of paw movements and rolling over, which were not affected by the drugs, the components of predatory behavior were influenced differently. This leads to the assumption that a drug affects different mechanisms which control behavior. It is assumed that dopamine is involved in the control of capture elicitation as well as in the control of pursuit and biting. Capture elicitation was inhibited by d-amphetamine and L-dopa, but not by maprotiline, and was even facilitated by haloperidol. The orientation of pursuit movements and biting was impaired by L-dopa and improved by haloperidol, whereas maprotiline did not influence these components.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Schmidt WJdoi
10.1007/BF00427524subject
Has Abstractpub_date
1979-09-01 00:00:00pages
355-9issue
3eissn
0033-3158issn
1432-2072journal_volume
64pub_type
杂志文章abstract::When tested in adulthood, male rats that had been treated daily with 50 mg/kg hydroxyzine HCl SC at 10--29 or 23--29 days of age were significantly facilitated in performance of delayed spontaneous alternation relative to saline-injected rats. Treatment at 10--16 days of age did not produce significant facilitation in...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00427646
更新日期:1980-01-01 00:00:00
abstract::The current study examined whether stimuli predictive of heroin availability were capable of inducing a relapse of drug-seeking behavior in an operant runway task. Olfactory stimuli (orange and almond food extract) served as discriminative cues about the availability (S+) or unavailability (S-) of heroin reinforcement...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050269
更新日期:1997-05-01 00:00:00
abstract:RATIONALE:Cotreatment with clorgyline shifts the development of sensitization to the D2/D3 dopamine receptor agonist quinpirole from locomotion to mouthing, an effect apparently unrelated to the monoamine oxidase inhibition property of clorgyline. This phenomenon was demonstrated in rats examined in small activity cham...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0377-4
更新日期:2006-07-01 00:00:00
abstract:RATIONALE:Cocaine dependence is a major health concern and there are no effective pharmacotherapies currently available. Although cocaine is an indirect DA agonist that binds to all three monoamine transporters, there is much evidence implicating a greater role for the dopamine (DAT) than norepinephrine (NET) and serot...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130100891
更新日期:2001-12-01 00:00:00
abstract:INTRODUCTION:Alcohol has been shown to increase smoking urges and smoking behavior. However, alcohol's effects on specific components of smoking behavior for nicotine versus non-nicotine factors and potential sex differences in this response have not been investigated. METHODS:Forty-two young male and female non-depen...
journal_title:Psychopharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00213-009-1638-9
更新日期:2009-11-01 00:00:00
abstract:RATIONALE:F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical trial in patients with schizophrenia (Bitter et al. Neuropsych...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-019-05387-w
更新日期:2020-02-01 00:00:00
abstract::Predicting what will happen in the future in terms of potential reward is essential in daily life. The aim of the current study was to investigate the neurotransmitter systems involved in the anticipation of reward value and probability. We hypothesized that dopaminergic and noradrenergic antagonism would affect antic...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-020-05515-x
更新日期:2020-07-01 00:00:00
abstract::The effects of d-fenfluramine and morphine on various nociceptive responses of rats were investigated. Unlike morphine, which inhibited all the responses examined, d-fenfluramine inhibited jumping and paw licking of rats on a hot plate, but did not increase the latency of tail withdrawal from hot water. The effects of...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00435276
更新日期:1982-01-01 00:00:00
abstract::3,4-Methylenedioxymethamphetamine (MDMA) is a psychoactive phenylisopropylamine which is structurally similar to both amphetamine-related sympathomimetics and the hallucinogen, mescaline. MDMA produces pleasurable effects which include euphoria, and recent reports continue to demonstrate its widespread recreational us...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00212765
更新日期:1988-01-01 00:00:00
abstract::Chronic nicotine infusion has been found in a series of studies in our laboratory to significantly improve choice accuracy of rats in the eight-arm radial maze. The current study was designed to compare the effects of chronic nicotine infusion on working and reference memory in a 16-arm radial maze. Nicotine was admin...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02805971
更新日期:1996-09-01 00:00:00
abstract:RATIONALE:An acute challenge with delta-9-tetrahydrocannabinol (THC) can induce psychotic symptoms including delusions. High electroencephalography (EEG) frequencies, above 20 Hz, have previously been implicated in psychosis and schizophrenia. OBJECTIVES:The objective of this study is to determine the effect of intrav...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3684-1
更新日期:2015-02-01 00:00:00
abstract:RATIONALE:Manipulations of the endocannabinoid system could potentially produce therapeutic effects with minimal risk of adverse cannabis-like side effects. Inhibitors of fatty acid amide hydrolase (FAAH) increase endogenous levels of the cannabinoid-receptor agonist, anandamide, and show promise for treating a wide ra...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-015-4140-6
更新日期:2016-05-01 00:00:00
abstract::MA rats, bred for greater motor impairment following subhypnotic doses of ethanol, were found to be more sensitive to the hypnotic effects of phenobarbital and chloral hydrate than were LA rats. In addition, the previously reported finding of a difference between the two lines of rats in duration of loss of righting r...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00426674
更新日期:1979-02-28 00:00:00
abstract:RATIONALE:Dopamine (DA) D2-like antagonists block several effects of cocaine, including its locomotor stimulant and interoceptive discriminative-stimulus effects. Because these compounds generally lack selectivity among the D2-like DA receptors, the specific roles of the subtypes remain unclear. OBJECTIVES:DA D2 recep...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-002-1142-y
更新日期:2002-08-01 00:00:00
abstract::In a series of experiments, rats received the noncompetitive N-methyl-D-aspartate (NMDA) antagonist MK-801 and measures were made of motor behavior, spatial navigation in a swimming pool, and electroencephalographic (EEG) activity. High doses (0.25-10 mg/kg IV) produced somnolence and akinesia, impaired food consumpti...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00441949
更新日期:1989-01-01 00:00:00
abstract::Twenty-nine subjects performed a reaction time task with four levels of choice-task complexity under non-smoking, sham smoking, and low, medium and high nicotine cigarette conditions. Nicotine reduced decision time, while sham smoking increased decision time. This effect was independent of subjects' habitual levels of...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF02244860
更新日期:1994-03-01 00:00:00
abstract::The present dose-response study investigated the effects of the benzodiazepine oxazepam (Serax) on anxiety as measured by autonomic and self-report indices in a nonclinical sample. Given Fowles' (1980, 1988) theory that electrodermal activity primarily reflects the activity of the behavioral inhibition system (BIS) wh...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02244346
更新日期:1993-01-01 00:00:00
abstract::When injected IP, the M1 muscarinic receptor antagonist pirenzepine dose-dependently induced a deficit in passive avoidance learning in rats. This activity was optimal at 75 mg/kg injected 1 h before the acquisition session. The deficit induced by pirenzepine was antagonized by oxotremorine (0.03-0.3 mg/kg SC) and phy...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00444707
更新日期:1989-01-01 00:00:00
abstract:RATIONALE:Studies have shown that social drinkers are poor estimators of alcohol-induced impairment. Underestimates of blood alcohol concentration and other indices of intoxication are associated with decisions to perform risky behaviors, such as operating a motor vehicle. It is possible that self-evaluations of impair...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/s00213-004-1964-x
更新日期:2005-02-01 00:00:00
abstract:RATIONALE:Previous studies from our laboratory and others have indicated a role for the hypothalamo-pituitary-adrenal (HPA) axis in the extinction/reinstatement animal model of cocaine relapse OBJECTIVE:This present study was designed to investigate the potential role for the HPA axis in the cue- and methamphetamine-i...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-006-0625-7
更新日期:2007-02-01 00:00:00
abstract::A double-blind, placebo-controlled, cross-over study in ten normal volunteers assessed the effects of the subcutaneous administration of adrenaline on platelet MAO activity, in an attempt to replicate previous findings of increased MAO activity following adrenaline. Platelet counts, cortisol plasma concentrations, and...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00430491
更新日期:1976-11-10 00:00:00
abstract::Elderly normal volunteers (N = 12, mean age 70.4 years) were administered placebo or diazepam 2.5, 5, 10 mg in four consecutive sessions separated by at least a 1-week interval. Memory and psychomotor performance and plasma diazepam concentrations were assessed at baseline and at 1 and 3 h following drug administratio...
journal_title:Psychopharmacology
pub_type: 临床试验,杂志文章
doi:10.1007/BF00555210
更新日期:1984-01-01 00:00:00
abstract::EEG measures have been shown to differ in human subjects who are at genetically increased risk for the development of alcoholism. In the present study, EEG was recorded in rats that were selectively bred for alcohol-preferring (P) and nonpreferring (NP) behaviors during an ethanol self-administration paradigm. In this...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244335
更新日期:1993-01-01 00:00:00
abstract::The effects of bilateral nucleus accumbens microinjections of d-ala-met-enkephalinamide (DALA) were assessed in behavioral activation and lateral hypothalamic self-stimulation (LHSS) rate-frequency curve-shift paradigms in normal and accumbens 6-OHDA (4.0 micrograms) treated rats. Microinjections of DALA (2.5 microgra...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF02244999
更新日期:1994-05-01 00:00:00
abstract::The present experiment examined effects of nicotine on body weight of male and female rats when Oreo cookies, potato chips, laboratory chow, and water were available. Body weight and eating behavior were measured for 17-day periods before, during, and after nicotine or saline administration. There was an inverse relat...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00212851
更新日期:1988-01-01 00:00:00
abstract::Recent studies indicate that morphine dependence, assessed as the severity of naloxone-precipitated opiate withdrawal in rats, is attenuated by dizocipline, a non-competitive, excitatory amino acid antagonist. Because ethanol is a putative excitatory amino acid antagonist, the present study compared the effects of co-...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s002130050428
更新日期:1997-11-01 00:00:00
abstract:RATIONALE:Most adult smokers start smoking during their adolescence. This adolescent initiation may be due to multiple factors, but little evidence is available regarding whether their brains are differentially sensitive to the addictive effects of nicotine during adolescence. OBJECTIVE:To test the hypothesis that ado...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-003-1758-6
更新日期:2004-07-01 00:00:00
abstract:RATIONALE:Limited access nicotine self-administration decreases hippocampal neurogenesis, providing a mechanism for the deleterious effects of nicotine on hippocampal neuronal plasticity. However, recent studies have shown that limited access nicotine self-administration does not exhibit key features of nicotine depend...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-014-3685-0
更新日期:2015-01-01 00:00:00
abstract:RATIONALE:Atypical antipsychotic drug (APD)-induced weight gain causes non-compliance, increasing the risk of relapse and medical complications. OBJECTIVES:In an animal model, we assessed body weights, food intake, body fat/lean body mass contents and blood serum levels of glucose and lipids in female rats treated wit...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/s00213-005-0081-9
更新日期:2005-10-01 00:00:00
abstract::6-Hydroxydopamine (6OH-DA) pretreatment increased the aggressive behavior induced by marihuana in REM sleep-deprived rats. Brain catecholamine assays revealed that 6OH-DA depleted popamine (DA) and norepinephrine (NE) to a different extent, increasing the DA/NE ratio. Intraventricular injection of NE significantly dec...
journal_title:Psychopharmacology
pub_type: 杂志文章
doi:10.1007/BF00423257
更新日期:1976-07-28 00:00:00