Abstract：
:In a series of experiments, rats received the noncompetitive N-methyl-D-aspartate (NMDA) antagonist MK-801 and measures were made of motor behavior, spatial navigation in a swimming pool, and electroencephalographic (EEG) activity. High doses (0.25-10 mg/kg IV) produced somnolence and akinesia, impaired food consumption, locomotion and swimming, and also impaired navigation to a hidden platform but complete recovery on all measures was obtained between 3 and 5 days postinjection. Lower doses (0.05-0.10 mg/kg, IV) impaired acquisition of a new place response in a swimming pool and produced hyperactivity but did not impair performance on a new cue response or on a well-learned place response. Two forms of hippocampal EEG activity, atropine-sensitive and atropine-resistant EEG were present with the low doses. The results demonstrate that a single dose of MK-801 causes changes in motor behavior and learning lasting a few days, but complete recovery occurs within 5 days of administration of even very high doses of MK-801. They further demonstrate that low doses of the drug selectively impair acquisition of new place responses. Although the general changes in behavior produced by MK-801 suggest that NMDA receptors are involved in many aspects of the control of behavior, the results additionally suggest that NMDA receptors are important for place learning.
journal_name
Psychopharmacology (Berl)journal_title
Psychopharmacologyauthors
Whishaw IQ,Auer RNdoi
10.1007/BF00441949subject
Has Abstractpub_date
1989-01-01 00:00:00pages
500-7issue
4eissn
0033-3158issn
1432-2072journal_volume
98pub_type
杂志文章abstract：:A variety of behaviors were studied in an open-field setting after i.v. amphetamine (0.5, 2.0, 8.0 mg/kg), phenmetrazine (1.0, 4.0, 16.0 mg/kg), or fenfluramine (1.0, 4.0, 16.0 mg/kg). Amphetamine and phenmetrazine increased ambulation initially and rearing during the whole experiment, and decreased grooming. At 30 an...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF01457847
更新日期：1977-12-19 00:00:00
abstract：:Food reward has been associated with activation of noradrenergic mechanisms in the brain. Using rats trained to press a lever for food reward, we have investigated the effects of 6-hydroxydopamine lesions, which severly depleted hypothalamic noradrenaline, on the willingness of the rats to press the lever for food rew...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00427343
更新日期：1979-06-28 00:00:00
abstract：RATIONALE:The non-selective nicotinic acetylcholine receptor (nAChR) agonist nicotine has been argued to improve attention via enhanced filtering of irrelevant stimuli. Here, we tested this hypothesis in the context of smooth pursuit eye movements (SPEMs), an oculomotor function previously shown to improve with nicotin...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-019-05223-1
更新日期：2019-07-01 00:00:00
abstract：RATIONALE:Reductions in cue-induced craving and subjective response to drugs of abuse are commonly used as initial outcome measures when testing novel medications for the treatment of addiction. Yet neither the relationship between these two measures at the individual level nor the moderating effects of pharmacotherapi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-017-4607-8
更新日期：2017-07-01 00:00:00
abstract：RATIONALE:Carrageenan-induced hyperalgesia is a widely used pain model in rodents. However, characteristics of carrageenan-induced hyperalgesia and effects of analgesic drugs under these conditions are unknown in nonhuman primates. OBJECTIVE:The aims of this study were to develop carrageenan-induced hyperalgesia in rh...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-013-3341-0
更新日期：2014-04-01 00:00:00
abstract：:To analyze the involvement of dopamine (DA) and serotonin (5-HT) release in the stimulus properties of methamphetamine, two amphetamine analogs that selectively release either brain DA (phentermine) or 5-HT (fenfluramine) were tested for their ability to substitute for methamphetamine in rats discriminating methamphet...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130050836
更新日期：1999-01-01 00:00:00
abstract：RATIONALE:The administration of heroin has been shown to inhibit the induction of nitric oxide, a molecule known to play a critical role in immune function. Previous research has shown that this alteration can be conditioned to environmental stimuli that have been associated with drug administration. However, it remain...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-006-0673-z
更新日期：2007-05-01 00:00:00
abstract：:The effect of diazepam on spatial visualization was studied using a double-blind crossover design. Diazepam 10 mg (or placebo) was given orally to 12 healthy young men at bedtime, followed again by 10 mg (or placebo) the next morning. One hour after the administration of the morning dose, the subjects performed a ment...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章
doi：10.1007/BF00518193
更新日期：1987-01-01 00:00:00
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journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s002130100833
更新日期：2001-10-01 00:00:00
abstract：INTRODUCTION:Smoking rates among depressed individuals is higher than among healthy subjects, and nicotine alleviates depressive symptoms. Nicotine increases serotonergic and noradrenergic neuronal activity and facilitates serotonin and noradrenaline release. In mice, acute nicotine administration enhances the activity...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-009-1560-1
更新日期：2009-08-01 00:00:00
abstract：:In a shuttle-box self-stimulation paradigm, analgesic doses of morphine increase the amount of time a rat leaves rewarding brain stimulation on, without altering average OFF times. This paradigm may serve as a model for the euphoria induced by narcotic drugs and as a useful tool for evaluating the reinforcing effects ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00426581
更新日期：1977-11-15 00:00:00
abstract：RATIONALE:Selective serotonin reuptake inhibitor (SSRI) antidepressants are increasingly prescribed during pregnancy. Changes in serotonergic signaling during human fetal development have been associated with changes in brain development and with changes in affective behavior in adulthood. The suprachiasmatic nucleus (...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-020-05556-2
更新日期：2020-08-01 00:00:00
abstract：:N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON 954) causes a reproducible rest tremor in mice, of rapid onset and short duration with no associated rigidity or akinesia and in the absence of any marked changes in body temperature or accompanying peripheral parasympathomimetic effects. This tremor ca...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00439104
更新日期：1977-04-29 00:00:00
abstract：:Benztropine mesylate (Cogentin) and physostigmine salicylate (Antilirium), were tested for changes in tongue protrusions, retrusions, and swallowing acts in rats anesthetized with a 100 mg/kg IM injection of ketamine hydrochloride. These ketamine-induced linguopharyngeal events were monitored by means of a force displ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02180028
更新日期：1988-01-01 00:00:00
abstract：RATIONALE:Delaying presentation of a drug can decrease its effectiveness as a reinforcer, but the effect of delaying punishment of drug self-administration is unknown. OBJECTIVE:This study examined whether a histamine injection could punish cocaine self-administration in a drug-drug choice, whether delaying histamine ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-011-2501-3
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Several different animal models are currently used to research the neurodegenerative movement disorder Parkinson's disease (PD). RESULTS:Models based on the genetic deficits associated with a small percentage of sufferers demonstrate the pathological accumulation of alpha-synuclein characteristic of the dis...
journal_title：Psychopharmacology
pub_type： 杂志文章,评审
doi：10.1007/s00213-007-0931-8
更新日期：2008-08-01 00:00:00
abstract：:Mice ran in a circular runway. Some received milk at every third circuit in a designated direction, clockwise or counterclockwise, in daily 1000-s sessions. Under control conditions, about 10 times as many circuits were made in the reinforced direction as in the non-reinforced direction. Cocaine (10, 30, 100 microM/kg...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02244125
更新日期：1990-01-01 00:00:00
abstract：RATIONALE:Understanding the mechanisms responsible for stress-induced relapse is important for guiding treatment strategies aimed at minimizing the contribution of stress to addiction. Evidence suggests that these mechanisms involve interactions between noradrenergic systems and the neuropeptide corticotropin-releasing...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3535-0
更新日期：2014-10-01 00:00:00
abstract：RATIONALE:Intermittent social defeat stress can induce neuroadaptations that promote compulsive drug taking. Within the mesocorticolimbic circuit, repeated cocaine administration activates extracellular signal-regulated kinase (ERK). OBJECTIVE:The present experiments examine whether changes in ERK phosphorylation are ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-014-3796-7
更新日期：2015-05-01 00:00:00
abstract：:Dose-related effects of ethanol (placebo, 0.30, and 0.60 g/kg) on behavioral and event-related brain potential (ERP) indices of involuntary attention shifting of audition were investigated. ERPs were recorded from 11 healthy social drinkers during a forced-choice reaction-time (RT) task. Subjects were presented with 1...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130050801
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:There is evidence that mGlu2/3 receptors regulate 5-HT2A signaling, interactions that have been theorized to play a role in the antipsychotic-like effects of mGlu2/3 agonists as well as the hallucinogenic effects of 5-HT2A agonists. One approach to unraveling this interaction is through the chronic administr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-018-5118-y
更新日期：2019-02-01 00:00:00
abstract：RATIONALE:Although most opioid self-administration research has been conducted with laboratory animals, such research with humans is necessary to answer questions unique to human drug-taking behavior. OBJECTIVE:We investigated the influence of morphine dose and an alternative non-drug reinforcer on choice between morp...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002130050051
更新日期：2000-02-01 00:00:00
abstract：:Plasma fluphenazine levels and plasma total neuroleptic activity (as quantitated by the neuroleptic receptor binding assay) were related to therapeutic response in 15 DSM-III schizophrenic patients who received a predetermined, fixed dose of fluphenazine for 14 days. Mean neuroleptic activity of the plasma was 84% gre...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00181256
更新日期：1986-01-01 00:00:00
abstract：:After initial exposure to 80 mg/kg, pigeons trained on a two-key drug discrimination procedure rapidly learned to discriminate 120 mg/kg ethosuximide from saline. When 40-160 mg/kg doses of ethosuximide were administered during generalization tests, the percentage of responses directed to the ethosuximide-appropriate ...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00207236
更新日期：1987-01-01 00:00:00
abstract：:The subtype of dopamine (DA) receptors mediating the yawning response to DA agonists was determined in rats. Yawning was elicited both by the mixed D1-D2 agonist apomorphine and by the specific D2 agonist LY 171555, but not by the selective D1 agonist SKF 38393. Both apomorphine- and LY 171555-induced yawning were ant...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00518186
更新日期：1987-01-01 00:00:00
abstract：:Few studies have examined the association between ethanol use and cigarette smoking topography. In particular, no study has objectively investigated the relationship between chronic ethanol exposure and cigarette smoking. The aim of this study was to quantify the relationship between cigarette smoking and past and cur...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF02245794
更新日期：1990-01-01 00:00:00
abstract：RATIONALE:The exact role of delta opioid receptors in drug-induced conditioned place preference (CPP) remains debated. Under classical experimental conditions, morphine-induced CPP is decreased in mice lacking delta opioid receptors (Oprd1 (-/-)). Morphine self-administration, however, is maintained, suggesting that dr...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/s00213-012-2693-1
更新日期：2012-09-01 00:00:00
abstract：:In a randomised, double-blind, parallel groups study, 40 patients referred for surgical removal of impacted third molars received either (a) temazepam 40 mg orally followed at 35 min by IV saline or (b) oral placebo followed by IV diazepam 10 mg (Diazemuls). Patients were divided into High-Anxious and Low-Anxious grou...
journal_title：Psychopharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00652245
更新日期：1986-01-01 00:00:00
abstract：RATIONALE:Functional interactions between limbic regions that process emotions and frontal networks that guide response functions provide a substrate for emotional cues to influence behavior. Stimulation of postsynaptic α₂ adrenoceptors enhances the function of prefrontal regions in these networks. However, the impact ...
journal_title：Psychopharmacology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00213-012-2893-8
更新日期：2013-03-01 00:00:00
abstract：:Four-day-old chicks respond to isolation with distress calling. A decrease in distress calling during isolation seems to reflect some general aspect of depressive syndrome and appears to be sensitive to pharmacological manipulation. Diverse clinically active antidepressants are able to counteract this decrease with hi...
journal_title：Psychopharmacology
pub_type： 杂志文章
doi：10.1007/BF00442235
更新日期：1989-01-01 00:00:00
