Electrophysiological indices of acute effects of ethanol on involuntary attention shifting.

abstract：:In a test of conditioned punishment, saline-treated controls showed a moderate bias in responding away from a lever producing a response-contingent auditory conditioned stimulus (CS) that had been paired with mild footshock during training and towards a lever producing a neutral auditory CS. Systemic treatment with th...

journal_title：Psychopharmacology

authors： Killcross AS,Everitt BJ,Robins TW

更新日期：1997-01-01 00:00:00

abstract：RATIONALE:F17464, a dopamine D3 receptor antagonist with relatively high D3 selectivity (70 fold vs D2 in vitro), exhibits an antipsychotic profile in preclinical studies, and therapeutic efficacy was demonstrated in a randomized placebo-controlled clinical trial in patients with schizophrenia (Bitter et al. Neuropsych...

journal_title：Psychopharmacology

authors： Slifstein M,Abi-Dargham A,Girgis RR,Suckow RF,Cooper TB,Divgi CR,Sokoloff P,Leriche L,Carberry P,Oya S,Joseph SK,Guiraud M,Montagne A,Brunner V,Gaudoux F,Tonner F

更新日期：2020-02-01 00:00:00

abstract：RATIONALE:Delta-opioid agonists produce a number of behavioral effects, including convulsions, antinociception, locomotor stimulation, and antidepressant-like effects. The development of these compounds as treatments for depression is limited by their convulsive effects. Therefore, determining how to separate the convu...

journal_title：Psychopharmacology

authors： Jutkiewicz EM,Rice KC,Traynor JR,Woods JH

更新日期：2005-11-01 00:00:00

abstract：:The effects of meperidine on operant behavioral thermoregulation were investigated using a convective thermal controller and mice trained to alternate at will the thermal-drive condition, changing it from an air flow of 15 degrees C to one of 45 degrees C, and vice versa. Administration of 15 mg/kg meperidine resulted...

journal_title：Psychopharmacology

authors： Gessner PK,Clarke CC

更新日期：1979-09-01 00:00:00

abstract：RATIONALE:The beneficial effects of psychostimulant drugs in the treatment of psychiatric disorders occur because they increase the extracellular dopamine concentration by inhibiting re-uptake of extracellular dopamine at dopamine transporters. However, the psychological effects at low dopamine transporter occupancy ha...

journal_title：Psychopharmacology

authors： Kimura Y,Maeda J,Yamada M,Takahata K,Yokokawa K,Ikoma Y,Seki C,Ito H,Higuchi M,Suhara T

更新日期：2017-02-01 00:00:00

abstract：:To confirm the conclusions from a previous study supporting the usefullness of electropupillogram (E.P.G.) in predicting clinical response, data from three separate studies with hyperkinetic and learning disabled (L.D.) children treated with stimulants were surveyed. Change in extent of pupillary contraction (E.C.) af...

journal_title：Psychopharmacology

authors： Bhatara V,Arnold LE,Knopp W,Smeltzer DJ

更新日期：1978-04-28 00:00:00

abstract：:Dosage regimen adjustments because of poor renal function are often assumed to be unnecessary for extensively metabolized antidepressants. This assumption is being increasingly questioned in recognition of the role of active drug metabolites. The purpose of this study was to assess the steady-state accumulation of the...

journal_title：Psychopharmacology

authors： DeVane CL,Laizure SC,Cameron DF

更新日期：1986-01-01 00:00:00

abstract：INTRODUCTION:Alcohol has been shown to increase smoking urges and smoking behavior. However, alcohol's effects on specific components of smoking behavior for nicotine versus non-nicotine factors and potential sex differences in this response have not been investigated. METHODS:Forty-two young male and female non-depen...

journal_title：Psychopharmacology

authors： King A,McNamara P,Conrad M,Cao D

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVES:In recent years, there has been growing research interest in using nicotine replacement medications to aid smoking reduction prior to a quit attempt. Gaining a better understanding of how treatments influence smoking reduction may allow for better tailoring of treatments and, ultimately, better cessation out...

journal_title：Psychopharmacology

authors： Lu W,Chappell K,Walters JAE,Jacobson GA,Patel R,Schüz N,Ferguson SG

更新日期：2017-07-01 00:00:00

abstract：:Two enantiomers (1S and 1R) of delta-3-tetrahydrocannabinol were assayed in man for psychoactivity. The 1S enantiomer had definite psychic actions, qualitatively similar to those of delta-1-tetrahydrocannabinol, but quantitatively less potent (1:3 to 1:6). Adding the two enantiomers together did not increase the effec...

journal_title：Psychopharmacology

authors： Hollister LE,Gillespie HK,Mechoulam R,Srebnik M

更新日期：1987-01-01 00:00:00

abstract：RATIONALE:Fluoxetine improves affect in clinical syndromes such as depression and premenstrual dysphoric disorder. Little is known about fluoxetine's influence on mood changes after quitting smoking, which often resemble sub-clinical depression. OBJECTIVES:The present study, a re-analysis of previously published data ...

journal_title：Psychopharmacology

authors： Cook JW,Spring B,McChargue DE,Borrelli B,Hitsman B,Niaura R,Keuthen NJ,Kristeller J

更新日期：2004-04-01 00:00:00

abstract：:The augmentation effect of (-)pindolol as used in combination with SSRI to treat major depression has been ascribed to blocking of dorsal raphe nucleus cell body 5-HT autoreceptors. In this study, the radioligand [carbonyl-11C]WAY-100635 and positron emission tomography were used to establish whether pindolol at a cli...

journal_title：Psychopharmacology

authors： Andrée B,Thorberg SO,Halldin C,Farde L

更新日期：1999-06-01 00:00:00

abstract：RATIONALE:Carrageenan-induced hyperalgesia is a widely used pain model in rodents. However, characteristics of carrageenan-induced hyperalgesia and effects of analgesic drugs under these conditions are unknown in nonhuman primates. OBJECTIVE:The aims of this study were to develop carrageenan-induced hyperalgesia in rh...

journal_title：Psychopharmacology

authors： Sukhtankar DD,Lee H,Rice KC,Ko MC

更新日期：2014-04-01 00:00:00

abstract：RATIONALE:Information is sparse on neurotransmitter deficiencies in frontotemporal dementia (FTD), in particular with reference to distinct histological subgroups and Alzheimer's disease (AD). OBJECTIVES:To evaluate in FTD with the major histologies, and compare with AD and controls, neurotransmission indices, as thes...

journal_title：Psychopharmacology

authors： Bowen DM,Procter AW,Mann DM,Snowden JS,Esiri MM,Neary D,Francis PT

更新日期：2008-03-01 00:00:00

abstract：:The administration of trycyclic antidepressants followed by reserpine-like drugs elicits a pattern of stereotyped locomotor activity. Using desmethylimipramine (DMI) followed by tetrabenazine (TBZ), activity could be reliably elicited only in young rats, and only by using very high doses of TBZ. The latency of onset o...

journal_title：Psychopharmacology

authors： Willner P,Clark D

更新日期：1978-06-15 00:00:00

abstract：RATIONALE:The nicotine delivery rate is a key feature of tobacco product design, yet there have been limited human studies examining the effects of nicotine as a function of delivery rate. OBJECTIVE:We developed an intravenous nicotine infusion protocol to evaluate differential effects of nicotine delivery rate on sub...

journal_title：Psychopharmacology

authors： Jensen KP,Valentine G,Gueorguieva R,Sofuoglu M

更新日期：2020-05-01 00:00:00

abstract：RATIONALE:Medication and illicit drugs can have detrimental side effects which impair driving performance. A drug's impairing potential should be determined by well-validated, reliable, and sensitive tests and ideally be calibrated by benchmark drugs and doses. To date, no consensus has been reached on the issue of whi...

journal_title：Psychopharmacology

authors： Jongen S,Vuurman E,Ramaekers J,Vermeeren A

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Delivering nicotine in the way smokers seek is likely to be the key factor in e-cigarette (EC) success in replacing cigarettes. We examined to what degree different types of EC mimic nicotine intake from cigarettes. METHODS:Twelve participants ('dual users' of EC and cigarettes) used their own brand cigaret...

journal_title：Psychopharmacology

authors： Hajek P,Przulj D,Phillips A,Anderson R,McRobbie H

更新日期：2017-03-01 00:00:00

abstract：:We investigated the possible role of dopamine receptors in the mediation of copulatory disorder induced by defeat experience in male mice, using L-dopa and apomorphine. To generate the copulatory disorder, male mice were attacked 20 times daily for 5 consecutive days, as intruders in confrontation with an aggressive r...

journal_title：Psychopharmacology

authors： Sugiura K,Yoshimura H,Yokoyama M

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Marijuana intoxication appears to impair response inhibition, but it is unclear if impaired inhibition and associated brain abnormalities persist after prolonged abstinence among adolescent users. We hypothesized that brain activation during a go/no-go task would show persistent abnormalities in adolescent m...

journal_title：Psychopharmacology

authors： Tapert SF,Schweinsburg AD,Drummond SP,Paulus MP,Brown SA,Yang TT,Frank LR

更新日期：2007-10-01 00:00:00

abstract：:The behavioral consequences of prolonged continuous exposure to cocaine were examined in rhesus monkeys. Operant behavior was sampled for 0.5 h every 6 h, and cocaine was continuously infused through an intravenous catheter. Cocaine (4.0-32 mg/kg/day) initially caused reductions in the rate of responding for food and ...

journal_title：Psychopharmacology

authors： Woolverton WL,Kleven MS

更新日期：1988-01-01 00:00:00

abstract：RATIONALE:Negative mood states are characterized by both stress hormone dysregulation and serotonergic dysfunction, reflected by altered thalamic serotonin transporter (5-HTT) levels. However, so far, no study examined the individual association between cortisol response and cerebral in vivo 5-HTT levels in patients su...

journal_title：Psychopharmacology

authors： Reimold M,Knobel A,Rapp MA,Batra A,Wiedemann K,Ströhle A,Zimmer A,Schönknecht P,Smolka MN,Weinberger DR,Goldman D,Machulla HJ,Bares R,Heinz A

更新日期：2011-02-01 00:00:00

abstract：:The action of copper (CuSO4, 5 mg/kg, oral) on selected neuropharmacological actions of cannabis resin (CI, oral) was studied on albino rats and mice. Copper potentiated the barbiturate hypnosis-potentiating activity of CI in albino rats and mice and had no effect on hypothermic activity in albino rats. Single doses o...

journal_title：Psychopharmacology

authors： Singh PP,Das PK

更新日期：1978-04-11 00:00:00

abstract：RATIONALE:The cholinergic system is linked extensively to memory, but its exact role remains controversial. In particular, scopolamine-induced impairment in rodents is not task specific, which may be due to difficulty in developing rodent protocols to assess deficits in recent memory, in which the remembered event is b...

journal_title：Psychopharmacology

authors： Araujo JA,Chan AD,Winka LL,Seymour PA,Milgram NW

更新日期：2004-08-01 00:00:00

abstract：:This study evaluated the effects of two central nicotinic-cholinergic receptor agonists and an antagonist on performance accuracy of a rat, delayed stimulus discrimination task (DSDT). Rats were trained to discriminate between an auditory and visual stimulus by pressing a right or left lever. To diminish the rat's abi...

journal_title：Psychopharmacology

authors： Terry AV Jr,Buccafusco JJ,Jackson WJ,Zagrodnik S,Evans-Martin FF,Decker MW

更新日期：1996-01-01 00:00:00

abstract：:The metabolism of the tricyclic antidepressants amitriptyline (AMI), imipramine (IMI), chlorimipramine (CMI) and some of their metabolites was studied in vitro in isolated liver microsomes of female Spraque-Dawley rats. Nine metabolites of AMI, seven metabolites of IMI, and 11 metabolites of CMI were quantitatively de...

journal_title：Psychopharmacology

authors： Krüger R,Hölzl G,Kuss HJ,Schefold L

更新日期：1986-01-01 00:00:00

abstract：RATIONALE:Consumption of alcohol begins during late adolescence in a majority of humans, and the greatest drinking occurs at 18-25 years then decreases with age. OBJECTIVES:The present study measured the differences in ethanol intake in relation to age at the onset of ethanol access among nonhuman primates to control ...

journal_title：Psychopharmacology

authors： Helms CM,Rau A,Shaw J,Stull C,Gonzales SW,Grant KA

更新日期：2014-04-01 00:00:00

abstract：RATIONALE:Reduced serotonin neurotransmission is implicated in disorders of impulse control, but the involvement of serotonin in inhibitory processes in healthy human subjects remains unclear. OBJECTIVES:To investigate the effects of an acute manipulation of serotonin and genotype at a functional polymorphism in a gen...

journal_title：Psychopharmacology

authors： Clark L,Roiser JP,Cools R,Rubinsztein DC,Sahakian BJ,Robbins TW

更新日期：2005-11-01 00:00:00

abstract：:We examined the possibility that anoxia at birth can alter behavioral sensitization to amphetamine during adulthood. Male rats born either vaginally or by Cesarean section with or without an additional 15-min period of anoxia received five once-daily injections of either d-amphetamine (2.0 mg/kg, i.p.) or vehicle or n...

journal_title：Psychopharmacology

authors： Brake WG,Boksa P,Gratton A

更新日期：1997-10-01 00:00:00

abstract：:Rats were made hyperphagic by 6-hydroxydopamine (6-OHDA) injected bilaterally into the ventral midbrain; then they were restricted to a 6 h/day feeding schedule and tested for appetite suppression with amphetamine and fenfluramine in randomized order. Amphetamine anorexia was diminished while fenfluramine anorexia was...

journal_title：Psychopharmacology

authors： Ahlskog JE,Randall PK,Hernandez L,Hoebel BG

更新日期：1984-01-01 00:00:00